Lycopene protects against t-BHP-induced neuronal oxidative damage and apoptosis via activation of the PI3K/Akt pathway

JNK1 and JNK3 play a significant role in both neuronal apoptosis and necrosis. Evaluation based on in vitro approach using tert-butylhydroperoxide induced oxidative stress in neuro-2A cells and perturbation through 3-aminobenzamide

(2017) Vijaya Prakash Krishnan Muthaiah et al.   TOXICOLOGY IN VITRO

Luteolin, a natural flavonoid, inhibits methylglyoxal induced apoptosis via the mTOR/4E-BP1 signaling pathway

(2017) Yi Liu et al.   Scientific Reports

Nerve Growth Factor Protects Against Alcohol-Induced Neurotoxicity in PC12 Cells via PI3K/Akt/mTOR Pathway

(2016) Liping Liu et al.   ALCOHOL AND ALCOHOLISM

Butein provides neuroprotective and anti-neuroinflammatory effects through Nrf2/ARE-dependent haem oxygenase 1 expression by activating the PI3K/Akt pathway

(2016) Dong-Sung Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

Lycopene modulates cholinergic dysfunction, Bcl-2/Bax balance, and antioxidant enzymes gene transcripts in monosodium glutamate (E621) induced neurotoxicity in a rat model

(2016) Kadry Sadek et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

α-Lipoic acid inhibits sevoflurane-induced neuronal apoptosis through PI3K/Akt signalling pathway

(2016) Rong Ma et al.   CELL BIOCHEMISTRY AND FUNCTION

Reversal of Beta-Amyloid-Induced Neurotoxicity in PC12 Cells by Curcumin, the Important Role of ROS-Mediated Signaling and ERK Pathway

(2016) Cun-dong Fan et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Lycopene protects human SH-SY5Y neuroblastoma cells against hydrogen peroxide-induced death via inhibition of oxidative stress and mitochondria-associated apoptotic pathways

(2016) CHUNSHENG FENG et al.   Molecular Medicine Reports

Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology

(2016) Stephen W. Scheff et al.   NEUROBIOLOGY OF AGING

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

Lycopene abrogates Aβ(1–42)-mediated neuroinflammatory cascade in an experimental model of Alzheimer’s disease

(2015) Anand Kamal Sachdeva et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Decreased Poly(ADP-Ribose) Polymerase 1 Expression Attenuates Glucose Oxidase-Induced Damage in Rat Cochlear Marginal Strial Cells

(2015) Yuanyuan Zhang et al.   MOLECULAR NEUROBIOLOGY

Neuroprotective effect of lycopene against MPTP induced experimental Parkinson’s disease in mice

(2015) Asokan Prema et al.   NEUROSCIENCE LETTERS

Lycopene attenuates Aβ1–42 secretion and its toxicity in human cell and Caenorhabditis elegans models of Alzheimer disease

(2015) Wei Chen et al.   NEUROSCIENCE LETTERS

Implicating the role of lycopene in restoration of mitochondrial enzymes and BDNF levels in β-amyloid induced Alzheimer׳s disease

(2014) Atish Prakash et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Protective effects of lycopene against methylmercury-induced neurotoxicity in cultured rat cerebellar granule neurons

(2013) Mingyue Qu et al.   BRAIN RESEARCH

Serum Lycopene, Lutein and Zeaxanthin, and the Risk of Alzheimer's Disease Mortality in Older Adults

(2013) Jin-young Min et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Lycopene Protects Against MPP+-Induced Cytotoxicity by Maintaining Mitochondrial Function in SH-SY5Y Cells

(2013) Fang Yi et al.   NEUROCHEMICAL RESEARCH

Protective Effect of Extract of Astragalus on Learning and Memory Impairments and Neurons Apoptosis Induced by Glucocorticoids in 12-Month Male Mice

(2011) Wei-Zu Li et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Mitochondria in Apoptosis: Bcl-2 Family Members and Mitochondrial Dynamics

(2011) Jean-Claude Martinou et al.   DEVELOPMENTAL CELL

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Protective Effect of Lycopene on Oxidative Stress and Cognitive Decline in Rotenone Induced Model of Parkinson’s Disease

(2011) Harpreet Kaur et al.   NEUROCHEMICAL RESEARCH

Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway

(2011) Mingyue Qu et al.   NEUROCHEMISTRY INTERNATIONAL

Bcl-2 inhibits apoptosis by increasing the time-to-death and intrinsic cell-to-cell variations in the mitochondrial pathway of cell death

(2010) Joanna Skommer et al.   APOPTOSIS

Helicobacter hepaticusCytolethal Distending Toxin Causes Cell Death in Intestinal Epithelial Cells via Mitochondrial Apoptotic Pathway

(2010) Namal P. M. Liyanage et al.   HELICOBACTER

Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system

(2010) Rajat Sandhir et al.   NEUROCHEMISTRY INTERNATIONAL

Characterization of Age-Dependent and Progressive Cortical Neuronal Degeneration in Presenilin Conditional Mutant Mice

(2010) Mary Wines-Samuelson et al.   PLoS One

Accumulation of pyrethroid compounds in primary cultures from rat cortex

(2010) Timothy J. Shafer et al.   TOXICOLOGY IN VITRO

Enterovirus-related activation of the cardiomyocyte mitochondrial apoptotic pathway in patients with acute myocarditis

(2009) L. Venteo et al.   EUROPEAN HEART JOURNAL

Low Density Lipoprotein Receptor-related Protein 1 Promotes Anti-apoptotic Signaling in Neurons by Activating Akt Survival Pathway

(2009) Rodrigo A. Fuentealba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages☆

(2009) Paola Palozza et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY