Flexible Prussian blue/Carbon dots nanocomposite modified exfoliated graphite paper based sensor for simultaneous monitoring of hypertension and Parkinson disease

Patients with hypertension are seriously affected by Parkinson's disease than patients with normal blood pressure. Thus, early detection of hypertension and Parkinson disease by monitoring subtle changes in specific biomarkers from body fluids can minimize the risk. This paper proposes a flexible, portable paper-based sensor for simultaneous electrochemical sensing of dopamine and uric acid, using differential pulse voltammetry and electrochemical impedance spectroscopy on electrodeposited Prussian blue on carbon dots@graphite paper. The characteristic peaks of dopamine and uric acid in the differential pulse voltammogram are well separated. Further surface characterization of Prussian blue/carbon dots@graphite paper was carried out by Raman Spectra and Scanning Electron Microscope (SEM). The proposed sensor promoted the fast electrochemical detection of dopamine and uric acid with the linear response for concentrations from 0.2-920.0 mu M with a limit of detection 0.015 mu M, respectively in an aqueous sample. Excellent flexing stability is demonstrated by the proposed sensor, which can maintain its initial current after being bent more than 300 times.

Automated summary

Early detection of hypertension and Parkinson's disease can be achieved by monitoring biomarkers in body fluids, reducing the risk for patients. A flexible and portable paper-based sensor is proposed for simultaneous electrochemical detection of dopamine and uric acid, showing excellent flexing stability.