期刊
METABOLIC ENGINEERING
卷 58, 期 -, 页码 17-34出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.ymben.2019.03.008
关键词
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资金
- ERACoBiotech via grant INDIE [BMEL 22023517]
- ERACoBiotech via grant C1Pro [BMEL 22023617]
- Indo-German project BIOCON [BMBF 01DQ17009]
- state of North Rhine-Westphalia (NRW)
- European Regional Development Fund (EFRE), Project Cluster Industrial Biotechnology (CLIB) Kompetenzzentrum Biotechnologie (CKB) [34.EFRE-0300095/1703FI04]
Amino acid fermentation is one of the major pillars of industrial biotechnology. The multi-billion USD amino acid market is rising steadily and is diversifying. Metabolic engineering is no longer focused solely on strain development for the bulk amino acids L-glutamate and L-lysine that are produced at the million-ton scale, but targets specialty amino acids. These demands are met by the development and application of new metabolic engineering tools including CRISPR and biosensor technologies as well as production processes by enabling a flexible feedstock concept, co-production and co-cultivation schemes. Metabolic engineering advances are exemplified for specialty proteinogenic amino acids, cyclic amino acids, omega-amino acids, and amino acids functionalized by hydroxylation, halogenation and N-methylation.
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