Article
Medical Laboratory Technology
Xinlei Zou, Ziyue Huang, Canghai Guan, Wujiang Shi, Jianjun Gao, Jiangang Wang, Yunfu Cui, Mei Wang, Yi Xu, Xiangyu Zhong
Summary: Pancreatic cancer (PC) is highly aggressive with a poor prognosis. The tumor microenvironment (TME) of PC is complex and diverse. Various cellular components in the microenvironment secrete different substances that promote tumor development. These substances can be released via exosomes, which are abundant extracellular vesicles (EVs) capable of carrying factors and enabling intercellular communication. MiRNAs are involved in regulating pathological and physiological processes and can be transported by exosomes to regulate the TME. Exosomal miRNAs hold promise as future targets for PC diagnosis and prognosis, offering potential new treatment strategies.
CLINICA CHIMICA ACTA
(2023)
Review
Biochemistry & Molecular Biology
Tahani Bakhsh, Safiah Alhazmi, Najla Ali Alburae, Ali Farsi, Faisal Alzahrani, Hani Choudhry, Ahmed Bahieldin
Summary: Colorectal cancer is a common type of cancer worldwide, and early diagnosis is crucial for effective treatment. Current blood biomarkers for CRC diagnosis are not accurate enough. Studies have found that specific miRNAs in extracellular vesicles can be used as noninvasive biomarkers for the screening and diagnosis of CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Ri Zhang, Yujia Wei, Tingmei Wang, Xiaoqi Nie, Zeqi Shi, Yunhua Deng, Dong Li
Summary: Exosomes, small vesicles coated with phospholipids, are released by cells and contain miRNA that plays a significant role in the pathogenesis of autoimmune skin diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Behnaz Bouzari, Shabahang Mohammadi, Dmitry Olegovich Bokov, Ivan Ivanovich Krasnyuk, Seyed Reza Hosseini-Fard, Marzieh Hajibaba, Rasoul Mirzaei, Sajad Karampoor
Summary: Glioblastoma is an aggressive cancer associated with angiogenesis. Recent research has discovered the critical role of microRNAs and exosomal miRNAs in the angiogenesis process of glioblastoma. This knowledge can lead to the development of potential new treatments.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Medicine, Research & Experimental
Chuanyun Li, Tong Zhou, Jing Chen, Rong Li, Huan Chen, Shumin Luo, Dexi Chen, Cao Cai, Weihua Li
Summary: Exosomal miRNAs play a critical role in regulating genes and their altered expression is associated with almost all human cancers. They modulate processes that interfere with cancer immunity and microenvironment, and significantly impact tumor growth, invasion, metastasis, angiogenesis, and drug resistance. Understanding the detailed mechanisms of miRNAs in cancer development could contribute to both cancer treatment and prevention of malignant diseases. This review highlights recent advances in cancer-derived exosomal miRNAs, including their sorting and delivery mechanisms, as well as their potential as diagnostic and prognostic markers and in detecting cancer resistance to therapeutic agents.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Kaylyn M. Bauer, June L. Round, Ryan M. O'Connell
Summary: Exosomal miRNAs play pivotal roles in extracellular communication, being produced by, trafficked between, and functioning in various immune cell types. Loss of these key communicators can impact cellular response to endotoxin, and loss of tumor cells' ability to secrete these vesicles can lead to effective immune suppression of tumor growth.
Review
Oncology
Xiaoyun He, Gaoyan Kuang, Yongrong Wu, Chunlin Ou
Summary: Exosomes are small vesicles secreted by cells and can carry various cargo including RNA, DNA, proteins, and metabolites. Studies have shown that exosomal microRNAs play a crucial role in the progression of diseases such as diabetes mellitus, affecting processes like pancreatic beta-cell injury and insulin resistance. Understanding the mechanisms of exosomal miRNAs in diabetes mellitus can provide valuable insights for identifying diagnostic biomarkers and drug targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Pinghua Yang, Fengliang Song, Xinwei Yang, Xingzhou Yan, Xinyu Huang, Zhengjun Qiu, Zhijian Wen, Chi Liang, Xianglei Xin, Zhengqin Lei, Kecheng Zhang, Jue Yang, Hu Liu, Hongcheng Wang, Shijun Xiang, Liang Li, Baohua Zhang, Hongyang Wang
Summary: Through biomarker discovery, training, and validation, we have identified a combination of miRNAs that can evaluate the risk of gallbladder carcinoma. This biomarker outperforms standard markers and can be used for early diagnosis. It is also associated with clinicopathological features and prognosis, and regulates cell functions and signaling pathways. This biomarker combination has potential for noninvasive diagnosis, screening, and prognosis prediction for gallbladder carcinoma.
Review
Pharmacology & Pharmacy
Jinxin Tang, Jieyu He, Chengyao Feng, Chao Tu
Summary: MiRNAs are non-coding RNA molecules that play important roles in cancer. Recent studies have shown that exosomal miRNAs play crucial roles in tumor initiation and progression, and have potential diagnostic and therapeutic functions.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biophysics
Yuan Wu, Ye Zhang, Xiaohe Zhang, Shihua Luo, Xiaohui Yan, Yurong Qiu, Lei Zheng, Ling Li
Summary: Exosomal miRNAs derived from cancer cells play a critical role in cancer development and diagnostic biomarkers. However, the lack of sensitive preparatory and analytical technologies hinders their clinical applications. Developing new biosensor strategies is essential for sensitive and reliable detection of exo-miRNAs.
BIOSENSORS & BIOELECTRONICS
(2021)
Review
Medicine, Research & Experimental
Xinyue Chen, Yuqiu Li, Miao Li, Yujie Xie, Keqin Wang, Lifang Zhang, Zhuoling Zou, Lixia Xiong
Summary: This article summarizes the role of exosomes as important mediators of intercellular communication in tumor progression. By studying the function of exosomal miRNAs, researchers have identified them as potential therapeutic tools and biomarkers for tumor progression. However, there is currently a lack of systematic review on the communication mechanisms of exosome-derived miRNAs between tumor cells and immune cells. This review provides a comprehensive summary of important miRNAs from tumor cells and immune cells based on the cell specificity of exosome-derived miRNAs, and elaborates on their potential clinical applications in tumor diagnostics and therapy.
Review
Biochemistry & Molecular Biology
Yongan Song, Leonardo Kelava, Istvan Kiss
Summary: Lung cancer, particularly lung adenocarcinoma (LUAD), is a major public health challenge and the leading cause of cancer-related deaths worldwide. MicroRNAs (miRNAs) have crucial roles in gene regulation and their involvement in cancer is extensively studied. However, there is a gap in the literature regarding the specific role of miRNAs in LUAD. This review provides an inclusive overview of the research conducted on miRNAs in the context of LUAD, highlighting their potential diagnostic, prognostic, and therapeutic implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Jia Feng, Yifan Zhang, Zhihan Zhu, Chenyang Gu, Ahmed Waqas, Lukui Chen
Summary: Exosomes, as intracellular mediators, have been implicated in the pathophysiological processes of various diseases, including spinal cord injury. They are considered to potentially play a significant role in the treatment of SCI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Ya-Ting Chuang, Jen-Yang Tang, Jun-Ping Shiau, Ching-Yu Yen, Fang-Rong Chang, Kun-Han Yang, Ming-Feng Hou, Ammad Ahmad Farooqi, Hsueh-Wei Chang
Summary: Cancer cells produce exosomes to regulate cell functions for tumor progression, and the modulation of exosome processing by natural products is not well understood. This review focuses on the organization of cancer-derived exosomal miRNAs and their processing and cell functions modulation by natural products. It provides a comprehensive understanding of the potential mechanisms and targets for exosome processing and cancer cell functions by natural products.
Review
Oncology
Yongzheng Li, Zhiyao Fan, Feifei Zhang, Jian Yang, Ming Shi, Shujie Liu, Yufan Meng, Hanxiang Zhan
Summary: Neoadjuvant therapies can decrease the tumor size and stage of some pNENs, providing some patients with the opportunity for radical resection. However, the optimal treatment regimen for neoadjuvant therapy in pNENs remains unknown based on current data.
FRONTIERS IN ONCOLOGY
(2022)
