标题
A review of the molecular design and biological activities of RXR agonists
作者
关键词
-
出版物
MEDICINAL RESEARCH REVIEWS
Volume -, Issue -, Pages -
出版商
Wiley
发表日期
2019-04-03
DOI
10.1002/med.21578
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Emerging roles of bexarotene in the prevention, treatment and anti-drug resistance of cancers
- (2018) Danyang Shen et al. Expert Review of Anticancer Therapy
- Computer-Assisted Discovery of Retinoid X Receptor Modulating Natural Products and Isofunctional Mimetics
- (2018) Daniel Merk et al. JOURNAL OF MEDICINAL CHEMISTRY
- Structural Basis for the Enhanced Anti-Diabetic Efficacy of Lobeglitazone on PPARγ
- (2018) Jun Young Jang et al. Scientific Reports
- Overview of the structure-based non-genomic effects of the nuclear receptor RXRα
- (2018) Liqun Chen et al. CELLULAR & MOLECULAR BIOLOGY LETTERS
- Molecular dynamics simulations and molecular flooding studies of the retinoid X-receptor ligand binding domain
- (2017) Geoffrey M. Gray et al. JOURNAL OF MOLECULAR MODELING
- Clinical and pharmacologic evaluation of two dosing schedules of indotecan (LMP400), a novel indenoisoquinoline, in patients with advanced solid tumors
- (2016) Shivaani Kummar et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR)-Selective Agonists: Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and 6-(Ethyl(5,5,8,8-tetrahydronaphthalen-2-yl)amino)nicotinic Acid (NEt-TMN)
- (2016) Michael C. Heck et al. JOURNAL OF MEDICINAL CHEMISTRY
- Chiral Dihydrobenzofuran Acids Show Potent Retinoid X Receptor–Nuclear Receptor Related 1 Protein Dimer Activation
- (2016) Henrik Sundén et al. JOURNAL OF MEDICINAL CHEMISTRY
- Conformationally Defined Rexinoids and Their Efficacy in the Prevention of Mammary Cancers
- (2015) Venkatram R. Atigadda et al. JOURNAL OF MEDICINAL CHEMISTRY
- Nuclear receptor full-length architectures: confronting myth and illusion with high resolution
- (2015) Fraydoon Rastinejad et al. TRENDS IN BIOCHEMICAL SCIENCES
- Positron Emission Tomography to Elucidate Pharmacokinetic Differences of Regioisomeric Retinoid X Receptor Agonists
- (2015) Toshiki Kobayashi et al. ACS Medicinal Chemistry Letters
- 9-cis-13,14-Dihydroretinoic Acid Is an Endogenous Retinoid Acting as RXR Ligand in Mice
- (2015) Ralph Rühl et al. PLoS Genetics
- Regulation of the nongenomic actions of retinoid X receptor-α by targeting the coregulator-binding sites
- (2014) Xiao-kun Zhang et al. ACTA PHARMACOLOGICA SINICA
- Diarylamines Incorporating Hexahydrophenalene or Octahydrobenzoheptalene as Retinoid X Receptor (RXR)-Specific Agonists
- (2014) Yohei Amano et al. CHEMICAL & PHARMACEUTICAL BULLETIN
- Methyl Substitution of a Rexinoid Agonist Improves Potency and Reveals Site of Lipid Toxicity
- (2014) Venkatram R. Atigadda et al. JOURNAL OF MEDICINAL CHEMISTRY
- RXR Partial Agonist Produced by Side Chain Repositioning of Alkoxy RXR Full Agonist Retains Antitype 2 Diabetes Activity without the Adverse Effects
- (2014) Kohei Kawata et al. JOURNAL OF MEDICINAL CHEMISTRY
- Rexinoids Isolated from Sophora tonkinensis with a Gene Expression Profile Distinct from the Synthetic Rexinoid Bexarotene
- (2014) Makoto Inoue et al. JOURNAL OF NATURAL PRODUCTS
- Dual RXR Agonists and RAR Antagonists Based on the Stilbene Retinoid Scaffold
- (2014) Claudio Martínez et al. ACS Medicinal Chemistry Letters
- Low Dose Bexarotene Treatment Rescues Dopamine Neurons and Restores Behavioral Function in Models of Parkinson’s Disease
- (2013) Krista McFarland et al. ACS Chemical Neuroscience
- Design, synthesis and evaluation of retinoids with novel bulky hydrophobic partial structures
- (2013) Yohei Amano et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Methyl-substituted conformationally constrained rexinoid agonists for the retinoid X receptors demonstrate improved efficacy for cancer therapy and prevention
- (2013) Anil Desphande et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Regulation of proteolytic cleavage of retinoid X receptor- by GSK-3
- (2013) W. Gao et al. CARCINOGENESIS
- Retinoic Acid Actions through Mammalian Nuclear Receptors
- (2013) Pengxiang Huang et al. CHEMICAL REVIEWS
- Molecular Pathways: Current Role and Future Directions of the Retinoic Acid Pathway in Cancer Prevention and Treatment
- (2013) R. M. Connolly et al. CLINICAL CANCER RESEARCH
- Modeling, Synthesis, and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene) and (E)-3-(3-(1,2,3,4-tetrahydro-1,1,4,4,6-pentamethylnaphthalen-7-yl)-4-hydroxyphenyl)acrylic Acid (CD3254)
- (2013) Peter W. Jurutka et al. JOURNAL OF MEDICINAL CHEMISTRY
- Signaling by Nuclear Receptors
- (2013) R. Sever et al. Cold Spring Harbor Perspectives in Biology
- A Naturally Occurring Rexinoid, Honokiol, Can Serve as a Regulator of Various Retinoid X Receptor Heterodimers
- (2012) Hitoshi Kotani et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor-Selective Agonists: Novel Halogenated Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene)
- (2012) Julie K. Furmick et al. ChemMedChem
- General Molecular Biology and Architecture of Nuclear Receptors
- (2012) Michal Pawlak et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Identification, Synthesis, and Biological Evaluation of the Metabolites of 3-Amino-6-(3′-aminopropyl)-5H-indeno[1,2-c]isoquinoline-5,11-(6H)dione (AM6–36), a Promising Rexinoid Lead Compound for the Development of Cancer Chemotherapeutic and Chemopreventive Agents
- (2012) Lian Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- RXR Partial Agonist CBt-PMN Exerts Therapeutic Effects on Type 2 Diabetes without the Side Effects of RXR Full Agonists
- (2012) Hiroki Kakuta et al. ACS Medicinal Chemistry Letters
- Modulation of RXR function through ligand design
- (2011) Efrén Pérez et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- The retinoid X receptors and their ligands
- (2011) Marcia I. Dawson et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
- Retinoid X Receptor Gamma Is Implicated in Docosahexaenoic Acid Modulation of Despair Behaviors and Working Memory in Mice
- (2011) Marta Wietrzych-Schindler et al. BIOLOGICAL PSYCHIATRY
- Induction of Retinoid X Receptor Activity and Consequent Upregulation of p21WAF1/CIP1 by Indenoisoquinolines in MCF7 Cells
- (2011) E.-J. Park et al. Cancer Prevention Research
- Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA
- (2011) Igor Orlov et al. EMBO JOURNAL
- Structure Basis of Bigelovin as a Selective RXR Agonist with a Distinct Binding Mode
- (2011) Haitao Zhang et al. JOURNAL OF MOLECULAR BIOLOGY
- Induction of Apoptosis by 3-Amino-6-(3-aminopropyl)-5,6-dihydro-5,11-dioxo-11H-indeno[1,2-c]isoquinoline via Modulation of MAPKs (p38 and c-Jun N-terminal Kinase) and c-Myc in HL-60 Human Leukemia Cells
- (2011) Eun-Jung Park et al. JOURNAL OF NATURAL PRODUCTS
- Honokiol Increases ABCA1 Expression Level by Activating Retinoid X Receptor Beta
- (2010) Cha-Gyun Jung et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Modification at the acidic domain of RXR agonists has little effect on permissive RXR-heterodimer activation
- (2010) Shuji Fujii et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- NSAID Sulindac and Its Analog Bind RXRα and Inhibit RXRα-Dependent AKT Signaling
- (2010) Hu Zhou et al. CANCER CELL
- A Pilot, First-in-Human, Pharmacokinetic Study of 9cUAB30 in Healthy Volunteers
- (2010) J. M. Kolesar et al. Cancer Prevention Research
- Identification of a Naturally Occurring Rexinoid, Honokiol, That Activates the Retinoid X Receptor
- (2010) Hitoshi Kotani et al. JOURNAL OF NATURAL PRODUCTS
- Research Resource: Transcriptome Profiling of Genes Regulated by RXR and Its Permissive and Nonpermissive Partners in Differentiating Monocyte-Derived Dendritic Cells
- (2010) Lajos Széles et al. MOLECULAR ENDOCRINOLOGY
- Retinoid X receptor gamma signaling accelerates CNS remyelination
- (2010) Jeffrey K Huang et al. NATURE NEUROSCIENCE
- Modification at the Lipophilic Domain of RXR Agonists Differentially Influences Activation of RXR Heterodimers
- (2010) Fuminori Ohsawa et al. ACS Medicinal Chemistry Letters
- Bexarotene: a promising anticancer agent
- (2009) Liyan Qu et al. CANCER CHEMOTHERAPY AND PHARMACOLOGY
- Bexarotene as Add-On to Antipsychotic Treatment in Schizophrenia Patients
- (2009) Vladimir Lerner et al. CLINICAL NEUROPHARMACOLOGY
- Modulating Retinoid X Receptor with a Series of (E)-3-[4-Hydroxy-3-(3-alkoxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)phenyl]acrylic Acids and Their 4-Alkoxy Isomers†
- (2009) Efrén Pérez Santín et al. JOURNAL OF MEDICINAL CHEMISTRY
- Modeling, Synthesis and Biological Evaluation of Potential Retinoid X Receptor (RXR) Selective Agonists: Novel Analogues of 4-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-2-naphthyl)ethynyl]benzoic Acid (Bexarotene)
- (2009) Carl E. Wagner et al. JOURNAL OF MEDICINAL CHEMISTRY
- Cross-Talk between PPARs and the Partners of RXR: A Molecular Perspective
- (2009) Lap Shu Alan Chan et al. PPAR Research
- Corepressor interaction differentiates the permissive and non-permissive retinoid X receptor heterodimers
- (2008) Johanna Lammi et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- The RXR agonists PA024 and HX630 have different abilities to activate LXR/RXR and to induce ABCA1 expression in macrophage cell lines
- (2008) Tomoko Nishimaki-Mogami et al. BIOCHEMICAL PHARMACOLOGY
- The First Potent Subtype-Selective Retinoid X Receptor (RXR) Agonist Possessing a 3-Isopropoxy-4-isopropylphenylamino Moiety, NEt-3IP (RXRα/β-dual agonist)
- (2008) Kayo Takamatsu et al. ChemMedChem
- Expanding the Use of Retinoids in Acute Myeloid Leukemia: Spotlight on Bexarotene
- (2008) S. McNamara et al. CLINICAL CANCER RESEARCH
- Nuclear receptor signalling in dendritic cells connects lipids, the genome and immune function
- (2008) Istvan Szatmari et al. EMBO JOURNAL
- Alitretinoin: a comprehensive review
- (2008) Caleb Cheng et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA
- (2008) Vikas Chandra et al. NATURE
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now