Article
Medicine, Research & Experimental
Le Lv, Ziyang Chen, Wenhui Bai, Jiahui Hao, Zhengang Heng, Caijin Meng, Lin Wang, Xianglan Luo, Xinmiao Wang, Yanjun Cao, Jiao He
Summary: This study aimed to explore the efficacy of THDCA on ulcerative colitis and to reveal its mechanisms of action. The results showed that THDCA can significantly alleviate colitis and exert its effects by regulating the Th1/Th2 and Th17/Treg balance.
Article
Immunology
Mengxian Zhou, Ruyi Qu, Xuewei Yin, Yan Qiu, Yuan Peng, Bin Liu, Yane Gao, Hongsheng Bi, Dadong Guo
Summary: In this study, the regulatory effects of prednisone acetate (PA) on the Th1/Th2 and Th17/Treg balance in experimental autoimmune uveitis (EAU) through modulating the Notch signaling pathway were investigated. The results showed that activation of the Notch signaling pathway resulted in a severe imbalance of the Th17/Treg and Th1/Th2 ratios, while PA treatment significantly alleviated ocular inflammation, inhibited activation of the Notch signaling pathway, and restored the Th1/Th2 and Th17/Treg balance.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Juliana Dias Lourenco, Juliana Tiyaki Ito, Milton de Arruda Martins, Iolanda de Fatima Lopes Calvo Tiberio, Fernanda Degobbi Tenorio Quirino dos Santos Lopes
Summary: The imbalance between pro-inflammatory Th17 and anti-inflammatory Treg cells plays a crucial role in the development and progression of inflammation in COPD. Studies evaluating treatments targeting Th17/Treg cells have shown conflicting results, which vary based on lung compartments, COPD stages, or local and systemic markers. Careful examination of the data is necessary.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Environmental Sciences
Mingcui Ding, Chengpeng Zhang, Wei Wang, Pengpeng Wang, Yangqing Pei, Na Wang, Shan Huang, Changfu Hao, Wu Yao
Summary: Exosomal miR-125a-5p promotes the development of silicosis by targeting TRAF6 to regulate T cell differentiation.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Ophthalmology
Xingyi Guo, Weiyu Dang, Na Li, Ying Wang, Deming Sun, Hong Nian, Ruihua Wei
Summary: Fenofibrate can effectively alleviate inflammation in lacrimal glands in a model of autoimmune dry eye, potentially making it a novel therapeutic agent for SS-associated dacryoadenitis by activating the PPAR-alpha/LXR-beta signaling pathway.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Environmental Sciences
Yongcan Wu, Caixia Pei, Xiaomin Wang, Yilan Wang, Demei Huang, Shihua Shi, Zherui Shen, Shuiqin Li, Yacong He, Zhenxing Wang, Jianwei Wang
Summary: This study found that probiotic intervention can prevent lung damage caused by PM2.5, and the mechanisms mainly include inhibiting inflammatory response, regulating Th17/Treg balance, and maintaining intestinal environment stability.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Biochemistry & Molecular Biology
Miner Yuan, Xiaobing Qian, Yanqiao Huang, Xinqi Ma, Fang Duan, Yao Yang, Bingsheng Lou, Xiaofeng Lin
Summary: Th17 activation and Th17/Treg imbalance contribute to prolonged anterior intraocular inflammation after OAB.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Wenjing Chen, Yuxue Cao, Yuanyuan Zhong, Jing Sun, Jingcheng Dong
Summary: CD4(+) helper T cell subsets play a critical role in the pathogenesis of asthma. Different subsets of Th cells differentiate under the stimulation of different cytokines and are driven by lineage-specific transcription factors. The balance between effector Th cell response and Treg cell immunosuppression is essential for maintaining immune homeostasis and understanding the immunopathological mechanism of asthma. Recent studies have found that certain factors involved in effector Th cell response also contribute to the development and function of Treg cells. This review aims to summarize the role of these factors in Treg cell development and function to gain new insights into the immunopathological mechanism and potential therapy strategies of asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Microbiology
Ekaterina Martynova, Albert Rizvanov, Richard A. Urbanowicz, Svetlana Khaiboullina
Summary: This review focuses on the mechanisms of inflammasome activation and their role in the development of Th1, Th2, and Th17 lymphocytes. The contribution of cytokines released from activated inflammasomes to the immune response is summarized, along with the discussion of the role of cytokines released from tissue cells in promoting lymphocyte differentiation.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Immunology
Weihang Luo, Jindong Hu, Weifang Xu, Jingcheng Dong
Summary: The immune response in the asthmatic respiratory tract is driven by CD4(+) T helper cells, especially Th2 cells. Asthma is a heterogeneous and progressive disease, with different stages of the disease course showing different immune responses. The complex immune networks in the inflammatory airway make it challenging to find a universal treatment for all asthmatics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Mingxia Zhou, Xiaoman Liu, Jing He, Xinyu Xu, Chenxi Ju, Shangjian Luo, Xiajuan Lu, Peng Du, Yingwei Chen
Summary: Dietary fructose, widely used in processed foods, has been linked to increased prevalence of multiple diseases, including inflammatory bowel disease. This study reveals that high-fructose corn syrup exacerbates intestinal inflammation and disrupts barrier integrity, and elucidates the involvement of gut microbiota and immune cells in this process. Furthermore, it highlights the role of bile acids imbalance in the modulation of Th17/Treg cells equilibrium and subsequent promotion of intestinal inflammation, providing potential strategies for precise treatment of IBD.
Article
Immunology
Xia Ke, Ziqi Chen, Xiaoqiang Wang, Houyong Kang, Suling Hong
Summary: In this study, the effects of quercetin on the balance of Th1/Th2 and Treg/Th17 ratios in allergic rhinitis were explored. By orally administering different doses of quercetin to mice, nasal symptoms were observed and immunoglobulin levels, Treg/Th17-related factors, and pro-inflammatory factors were examined. The results showed that quercetin alleviated allergic rhinitis symptoms by balancing the Th1/Th2 and Treg/Th17 ratios and inhibiting the NF-kappa B pathway.
Article
Mathematics, Interdisciplinary Applications
Qiantong Liang, Wing-Cheong Lo
Summary: This paper investigated a mathematical model of the interactions between Th1 and Th2 cells with Treg cell inhibition and stochastic effects to study the preference of outcomes and noise-induced hopping among different states. The results showed that under small noise effects, the high-Th2-low-Th1 state is more attractive due to the stronger inhibitory effect of Treg cells on Th1 cell development, with the attractiveness of states mainly affected by extrinsic noise in Th2 cell signaling.
CHAOS SOLITONS & FRACTALS
(2021)
Article
Immunology
Xin Lv, Jian Wang, Li Zhang, Xian Shao, Yao Lin, Hongyan Liu, Guangyang Ma, Jing Li, Saijun Zhou, Pei Yu
Summary: This study investigated the mechanism by which the SGLT2 inhibitor canagliflozin attenuates podocyte injury in rats with idiopathic membranous nephropathy (MN). The results showed that canagliflozin improved kidney function, reduced proteinuria, and had a more pronounced protective effect on the kidneys compared to losartan. The mechanism involved reversing the imbalance in Th1/Th2 cells and restoring podocyte autophagy inhibited by abnormal immunoglobulin G secretion from B-cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Toxicology
Jing Cheng, Sheng Wang, Shi-Qin Lv, Yuan Song, Ning-Hong Guo
Summary: This study aimed to explore the inhibitory effect of resveratrol ultrafine nanoemulsion (Res-mNE) in treating immune thrombocytopenia and found that Res-mNE reversed the imbalance of T helper 17/regulatory T (Th17/Treg) by activating Foxp3 via the AhR/Notch signaling pathway.
TOXICOLOGY RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Mengmeng Zhao, Jishou Zhang, Hanli Li, Zhen Luo, Jing Ye, Yao Xu, Zhen Wang, Di Ye, Jianfang Liu, Dan Li, Menglong Wang, Jun Wan
Summary: The COVID-19 pandemic has led to antiviral treatments becoming mainstream therapeutic approaches, but the efficacy of these treatments remains controversial. High-quality randomized clinical trials are needed to demonstrate the safety and efficacy of these antiviral drugs for COVID-19 treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Xingcheng Xiong, Juanli Xi, Qian Liu, Cixiao Wang, Zeyou Jiang, Su-Yang Yue, Lei Shi, Yuping Rong
Summary: Co-expression of IL-7 and PH20 significantly enhances the proliferation of G3CAR-7 x 20 in vitro and in vivo, reduces apoptosis levels after stimulation by tumour cells, and increases the ability of CAR-T cells to infiltrate tumour tissue.
LIVER INTERNATIONAL
(2021)
Correction
Biochemistry & Molecular Biology
Jing Ye, Yuan Wang, Yao Xu, Zhen Wang, Ling Liu, Menglong Wang, Di Ye, Jishou Zhang, Zicong Yang, Yingzhong Lin, Qingwei Ji, Jun Wan
Review
Immunology
Shuwan Xu, Jishou Zhang, Jianfang Liu, Jing Ye, Yao Xu, Zhen Wang, Junping Yu, Di Ye, Mengmeng Zhao, Yongqi Feng, Wei Pan, Menglong Wang, Jun Wan
Summary: Members of the IL-10 cytokine family, such as IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29, play critical roles in regulating inflammation, which is closely associated with the occurrence and progression of cardiovascular diseases. Studies have focused on the relationship between the IL-10 cytokine family and cardiovascular diseases, aiming to determine their contribution to disease regulation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Jianwei Zhang, Zicong Yang, Zhishan Liang, Mengjie Wang, Changxing Hu, Chao Chang, Lei Shi, Qingwei Ji, Ling Liu
Summary: This study found that DOX increased the expression of IL-16 in cardiac macrophages. The anti-IL-16 nAb significantly reduced serum LDH, myocardial CK-MB, and cardiac cTnT levels in DOX-induced mice, while also improving cardiac function. Additionally, the anti-IL-16 nAb reduced M1 macrophage-related markers and cytokine expression, and protected against cardiomyocyte apoptosis in DOX-induced mice.
MEDIATORS OF INFLAMMATION
(2021)
Article
Pharmacology & Pharmacy
Zhen Wang, Menglin Liu, Di Ye, Jing Ye, Menglong Wang, Jianfang Liu, Yao Xu, Jishou Zhang, Mengmeng Zhao, Yongqi Feng, Shuwan Xu, Wei Pan, Zhen Luo, Dan Li, Jun Wan
Summary: The study revealed an upregulation of Il12a in septic patients, while Il12a deletion exacerbated sepsis-induced cardiac dysfunction and injury mainly by affecting macrophage activity and the NF-κB signaling pathway. The findings suggest Il12a as a potential target for treating sepsis-induced cardiac dysfunction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, General & Internal
Mengmeng Zhao, Zhen Luo, Hua He, Bo Shen, Jinjun Liang, Jishou Zhang, Jing Ye, Yao Xu, Zhen Wang, Di Ye, Menglong Wang, Jun Wan
Summary: The study revealed that COVID-19 patients have lower levels of low-density lipoprotein cholesterol (LDL-C), which may indicate a poor prognosis for severe and critical cases. Patients with lower LDL-C levels were more likely to exhibit complications upon admission compared to those with higher levels.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Mengmeng Zhao, Jishou Zhang, Yao Xu, Jianfang Liu, Jing Ye, Zhen Wang, Di Ye, Yongqi Feng, Shuwan Xu, Wei Pan, Menglong Wang, Jun Wan
Summary: The study revealed that the NLRP3 inhibitor MCC950 could reverse cardiac remodeling induced by transverse aortic constriction (TAC), improving cardiac dysfunction, reducing cardiac hypertrophy and fibrosis, and decreasing inflammation and macrophage infiltration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Menglong Wang, Jishou Zhang, Mengmeng Zhao, Jianfang Liu, Jing Ye, Yao Xu, Zhen Wang, Di Ye, Dan Li, Jun Wan
Summary: This study demonstrates that RvD1 attenuates Dox-induced cardiac injury through improving cardiac function, reducing apoptosis and oxidative stress, and inhibiting inflammation and endoplasmic reticulum stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Xiyi Lu, Zhen Wang, Di Ye, Yongqi Feng, Menglin Liu, Yao Xu, Menglong Wang, Jishou Zhang, Jianfang Liu, Mengmeng Zhao, Shuwan Xu, Jing Ye, Jun Wan
Summary: Cardiovascular disease incidence is increasing annually and closely related to inflammation, immunity, injury, and repair. CXC chemokines play a crucial role in various cardiovascular diseases, such as atherosclerosis and myocardial infarction.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Menglong Wang, Mengmeng Zhao, Junping Yu, Yao Xu, Jishou Zhang, Jianfang Liu, Zihui Zheng, Jing Ye, Zhen Wang, Di Ye, Yongqi Feng, Shuwan Xu, Wei Pan, Cheng Wei, Jun Wan
Summary: This study investigated the effects of the selective NLRP3 inhibitor MCC950 on heart failure (HF) induced by pressure overload in obese mice and its metabolic mechanism. The results showed that MCC950 improved cardiac hypertrophy, fibrosis, and inflammation in obese mice. It also promoted M2 macrophage infiltration and regulated fatty acid and glucose uptake and utilization. Additionally, MCC950 affected the phosphorylation of AKT and AMPK in obese mice with HF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Yongqi Feng, Di Ye, Zhen Wang, Heng Pan, Xiyi Lu, Menglong Wang, Yao Xu, Junping Yu, Jishou Zhang, Mengmeng Zhao, Shuwan Xu, Wei Pan, Zheng Yin, Jing Ye, Jun Wan
Summary: This review discusses the role of IL-6 family members in cardiovascular disease, providing relevant information for identifying intervention targets for cardiovascular disease prevention and treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Menglin Liu, Zhen Wang, Jishou Zhang, Di Ye, Menglong Wang, Yao Xu, Mengmeng Zhao, Yongqi Feng, Xiyi Lu, Heng Pan, Wei Pan, Cheng Wei, Dan Tian, Wenqiang Li, Jingjun Lyu, Jing Ye, Jun Wan
Summary: This study investigated the role of IL-12p40 in LPS-induced cardiac dysfunction and its mechanisms. The findings showed that IL-12p40 deletion exacerbated LPS-induced cardiac injury and dysfunction by regulating the NF-kappa B and MAPK signaling pathways and involving monocytes. Moreover, adoptive transfer of IL-12p40-positive monocytes alleviated LPS-induced cardiac dysfunction. Therefore, IL-12p40 plays a protective role in sepsis-induced cardiac dysfunction.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Shiying Li, Lingyun Fang, Wenqian Wu, Ziming Zhang, Li Ji, Zhenxing Sun, Lin He, Zhen Wang, Wenpei Fu, Fangya Li, Mingxing Xie, Yali Yang
Summary: This study explored the value of echocardiography in diagnosing papillary muscle rupture (PMR) of the mitral valve and summarized the characteristic echocardiographic features of different types. The results showed that combining preoperative transthoracic echocardiography (TTE) and intraoperative transesophageal echocardiography (TEE) accurately identified the features of PMR, including leaflet prolapse, high-echoic mass, massive eccentricity, and lateral regurgitation.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2023)
Article
Medicine, General & Internal
Jishou Zhang, Yao Xu, Bo Shen, Hua He, Mingxiao Liu, Mengmeng Zhao, Jianfang Liu, Shuwan Xu, Wei Pan, Jing Ye, Zhen Wang, Di Ye, Menglin Liu, Dan Li, Zhen Luo, Yongqi Feng, Menglong Wang, Jun Wan
Summary: Obesity may increase the risk of developing severity in patients with COVID-19, as evidenced by abnormal physiological indicators, higher rates of hypertension, and more severe illness.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
