Review
Chemistry, Multidisciplinary
Seokhwan Chung, Richard A. Revia, Miqin Zhang
Summary: Graphene quantum dots (GQDs) have excellent properties for various applications in nanomedicine. Recent research focuses on their physicochemical, electronic, magnetic, and biological properties, discussing their use in bioimaging and therapy, as well as technical progress in GQDs synthesis.
ADVANCED MATERIALS
(2021)
Article
Engineering, Chemical
You-Sheng Lin, Kuen-Song Lin, Yun Chen, Ndumiso Vukile Mdlovu
Summary: In this study, nitrogen-doped graphene quantum dots were synthesized and coated with polyethylene glycol and branched polyethylenimine to enhance their imaging performance. The resulting fluorescent markers successfully targeted neuroblastoma by binding with an anti-GD2 antibody and showed potential as gene carriers.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2022)
Article
Biochemical Research Methods
Yuan Zhao, Ying Zhang, Huilin Liu, Baoguo Sun
Summary: A chiroptical system based on chiral assembly graphene quantum dots was developed for visual testing of D-phenylalanine, and successfully applied to intracellular chiroptical imaging.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Article
Nanoscience & Nanotechnology
Lin Gong, Ji Sun, Peng Zheng, Yousong Liu, Guangcheng Yang
Summary: A new method was developed for the efficient synthesis of N and Br co-doped GQDs, exhibiting excitation-independent emission properties and high quantum yields, along with excellent cytotoxicity and biological labeling potential.
ACS APPLIED NANO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Fariba Mohebichamkhorami, Mehrdad Faizi, Matin Mahmoudifard, Arman Hajikarim-Hamedani, Seyedeh Sarvenaz Mohseni, Amirhossein Heidari, Yekta Ghane, Mona Khoramjouy, Maryam Khayati, Rasoul Ghasemi, Hakimeh Zali, Simzar Hosseinzadeh, Ebrahim Mostafavi
Summary: The combination of chitosan nanoparticles (CS NPs) and graphene quantum dots (GQDs) in ultrasmall NP form shows promising potential as theranostic agents for Alzheimer's disease. The CS/GQD NPs, synthesized through microfluidics, can be efficiently delivered to the brain and enter glioma cells in vitro. In vivo bioimaging confirms their localization in the brain and their noncytotoxicity. However, further research is needed to understand the mechanism behind their positive effects on memory recovery in AD rats.
Review
Pharmacology & Pharmacy
Sopan Nangare, Sachin Chandankar, Pravin Patil
Summary: This review discusses the applications of carbon-based fluorescent nanomaterials in early detection and treatment of GBM. Surface modifications, integration with anticancer agents, and receptor-based targeting systems have shown excellent biocompatibility and selectivity of GQDs and CQDs, expanding the possibilities for GBM management. The photo-physical attributes of GQDs and CQDs make them suitable for advanced anticancer therapies. Research has validated the bioimaging capabilities of these nanomaterials in GBM-associated cell lines and animal models, highlighting their potential for real-time detection.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Energy & Fuels
Norazuwana Shaari, Siti Kartom Kamarudin, Raihana Bahru
Summary: Carbon quantum dots (CQDs) and graphene quantum dots (GQDs) are frequently mentioned in recent studies for their unique potential in electrical, optical, and optoelectrical properties. They are highly stable due to their carbon material and environmentally friendly nature. Various production methods and additive materials can enhance their performance, with shapes and sizes influenced by different parameters. Applications in fuel cell technology have shown improved performance.
INTERNATIONAL JOURNAL OF ENERGY RESEARCH
(2021)
Article
Materials Science, Multidisciplinary
Yu Ma, Yan Liu, Yurui Wang, Yanzhu Guo, Yuanyuan Li, Ruizhi Li, Xinzi Kong, Qize Han, Rong Wei, Jing Wang
Summary: The study utilized graphene quantum dots as a vehicle to deliver evodiamine, which significantly inhibited the growth of oral squamous cell carcinoma cells in nude mice, providing a new approach for the treatment of OSCC.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Physical
Bing Liu, Xingjian Lu, Xiaokun Liao, Hao Zou, Junting Tao, Chuyao Ni, Jiaqi Pan, Chaorong Li, Yingying Zheng
Summary: A-GQDs demonstrate excellent potential in bioimaging due to their hydrophilic and lipophilic properties, and show enhanced imaging effects when combined with WP5, providing a promising candidate for visualization of cell membrane and bioimaging.
APPLIED SURFACE SCIENCE
(2021)
Article
Chemistry, Physical
Salar Khaledian, Farhad Nalaini, Mahmood Mehrbakhsh, Mohadese Abdoli, Saleh Salehi Zahabi
Summary: Quantum dots, as a type of zero dimensional nanostructure, play an important role in the field of bioimaging due to their unique optical properties and wide applications. Recently, quantum dots derived from two-dimensional nanostructures have received more attention for their more stable fluorescence, less toxicity, and eco-friendly properties.
Article
Materials Science, Biomaterials
Mounika Choppadandi, Aditya Teja Guduru, Piyush Gondaliya, Neha Arya, Kiran Kalia, Hemant Kumar, Govinda Kapusetti
Summary: Through investigating the structural features of CQDs and GQDs, it was found that GQDs exhibit higher fluorescence intensity compared to CQDs, which may be attributed to the quantum confinement effect, crystallinity, and surface edge effects.
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Microbiology
Yeshen Luo, Fei Liu, Jianhua Song, Qian Luo, Yonggang Yang, Chengfang Mei, Meiying Xu, Bing Liao
Summary: Functional microorganisms play a crucial role in removing environmental pollutants due to their diverse metabolic capability. A fluorescence resonance energy transfer-based graphene quantum dots probe was developed for the specific identification and sorting of azo-degrading bacteria in environmental samples. Bioimaging confirmed the probe's specific recognition capability, and the strategy showed high accuracy in single-cell sorting of target bacteria with azo degradation function.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tatsiana Kulahava, Nikita Belko, Marina Parkhats, Anastasiya Bahdanava, Sergei Lepeshkevich, Vyacheslav Chizhevsky, Dmitri Mogilevtsev
Summary: In this paper, we discuss the interaction between fluorescent graphene quantum dots (GQDs) and red blood cell membranes, and describe two observed phenomena: photodegradation of GQDs and their accumulation in red blood cell membranes. The findings are important for the application of GQDs as fluorescent labels and drug delivery agents.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Yongsheng Yang, Bingli Gu, Zhiduo Liu, Da Chen, Yun Zhao, Qinglei Guo, Gang Wang
Summary: Doped carbon-based materials have unique optical, thermal, and electronic properties, and a facile method involving hydrothermal treatment of citric acid and phosphonitrilic chloride trimer was demonstrated for the synthesis of nitrogen and phosphorus co-doped graphene quantum dots. The obtained N, P-GQDs show bright yellow fluorescence, good solubility, and can be selectively quenched by Fe3+ ions, leading to the fabrication of high-performance Fe3+ sensors with ultra-sensitive detection limit. The fluorescence intensity of N, P-GQDs is minimally affected by high ionic strength, mild acids, and alkaline conditions, making them suitable for bioimaging applications.
JOURNAL OF NANOPARTICLE RESEARCH
(2021)
Article
Engineering, Environmental
Libin Huang, Chaoran Xie, Zixia Wu, Man Ji, Jia Shan, Pei Cheng, Jianming Liu, Luya Chen, Benqing Zhou, Wenjie Sun
Summary: In this study, a dopant controllable mechanochemical procedure for potassium doped graphene quantum dots (K-GQDs) synthesis was proposed, and it was found that potassium doping could enhance the long wavelength fluorescence intensity. This finding is important for the application of graphene quantum dots in bioimaging.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Cen Gao, Xingxing Zhang, Jian Chen, Jiayuan Zhao, Yanmei Liu, Jue Zhang, Jing Wang
MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL
(2018)
Article
Biotechnology & Applied Microbiology
Qi Guo, Yanmei Liu, Jiayuan Zhao, Jing Wang, Yue Li, Yunqing Pang, Jian Chen, Jing Wang
ONCOTARGETS AND THERAPY
(2019)
Article
Biochemistry & Molecular Biology
Yuyan Wu, Jing Wang, Jiayuan Zhao, Yunxia Zhang, Yunjie Sun, Jian Chen, Jing Wang
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Bei Wang, Jiayuan Zhao, Wenxin Lu, Yuanya Ma, Xusen Wang, Xiaoli An, Zengjie Fan
Summary: The development of a novel wound dressing with highly effective antibacterial and wound healing properties has been the focus of this study. Through a simple electrostatic interaction method, a novel and injectable hydrogel composed of lactoferrin and lithium magnesium silicate was synthesized. The physical and biological properties of the hydrogel were characterized and it was found to have good antibacterial properties and biocompatibility. The hydrogel was able to effectively promote wound healing in a rat skin wound model, achieving a much higher healing rate compared to other groups.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Health Care Sciences & Services
Jiayuan Zhao, Majing Su, Qian Zhao, Jiajie Liu, Junbin Wang, Junjie Wang, Xiaoli An
Summary: This study aimed to investigate the effect of the physiological anchorage control concept on anchorage molars in lingual and labial orthodontic techniques. The results showed that the physiological anchorage control concept in lingual orthodontics provides better sagittal anchorage control than in labial orthodontics. However, attention should be given to the control of torsion, torque, and arch width.
JOURNAL OF HEALTHCARE ENGINEERING
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)