期刊
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
卷 97, 期 -, 页码 827-832出版社
ELSEVIER
DOI: 10.1016/j.msec.2018.12.009
关键词
CuO NPs; Coleus aromaticus; in-vitro cytotoxicity; A549 cells; miRNA; Drug delivery
资金
- National Natural Science Foundation of China [81372567]
- Key Laboratory of Malignant Tumor Molecular Mechanisms, and the Translational Medicine of Guangzhou Bureau of Science and Information Technology [20131163]
- Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong Higher Education Institutes [KLB09001]
Copper oxide nanoparticles (CuO NPs) are fabricated using Coleus aromaticus leaf extract with an environmental friendly method and studied using various microscopic and spectroscopic techniques. Also, a new aptamer-conjugated hybrid delivery system using green synthesized CuO NPs is developed to deliver miRNA-29b to A549 cells. This delivery system can effectively deliver miRNAs to cancer cells, with superior performance compared to traditionally available transfection agents, thus acting as an efficient platform for intracellular miRNA delivery and improving therapeutic outcomes for lung cancer.
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