Article
Biochemistry & Molecular Biology
Soheyla Karimi, Hossein Rasuli, Reza Mohammadi
Summary: In this study, a pH-sensitive drug delivery system using Alginate beads impregnated with Al-Cu layered double hydroxides supported copper metal-organic framework was prepared for controlled release of doxorubicin to breast cancer cells. The physicochemical properties of the beads were analyzed, and in vitro release studies showed controlled drug release with pH-response. Cytotoxicity tests showed that the Alg-DOX-Cu MOF-LDH beads had higher cytotoxicity effects on breast cancer cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Vahid Mohammadzadeh, Amin Norouzi, Marjan Ghorbani
Summary: Developing pH-sensitive multifunctional nanocomposites for drug targeted delivery and controlled release is a promising approach for cancer treatment. In this study, a nanocomposite of doxorubicin/Lactose@layered double hydroxide-hydroxyapatite was designed and thoroughly analyzed. The nanocomposite showed high encapsulation efficiency, controlled drug release behavior, and strong cytotoxicity against liver cancer cells. These results suggest that the designed nanocomposite could be used for targeted and controlled delivery of anti-cancer drugs and other biomedical applications.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Engineering, Environmental
Chunyan Li, Xin Li, Huiqin Wang, Pengwei Huo, Yan Yan, Xinkun Wang
Summary: By inducing partial phosphating on NiGa-LDH, the derived Ni2P/NiGa2O4/NiGa-LDH structure effectively improves the capacitance and charge/discharge speed of supercapacitors, while preserving the layered structure of LDHs and reducing the charge transfer impedance. Additionally, the hybrid supercapacitor (HSCs) composed of Co3O4-C negative electrode and Ni2P/NiGa2O4/NiGa-LDH positive electrode demonstrates excellent energy density and long-term stability under high power density.
CHEMICAL ENGINEERING JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
V. K. Ameena Shirin, Renu Sankar, Asha P. Johnson, H. V. Gangadharappa, K. Pramod
Summary: Layered double hydroxides (LDHs) are nanomaterials with high surface-to-volume ratio, suitable for drug delivery applications. Interlayered drugs can be released in a sustained manner, reducing drug administration frequency.
JOURNAL OF CONTROLLED RELEASE
(2021)
Editorial Material
Biotechnology & Applied Microbiology
Parteek Prasher, Mousmee Sharma
Summary: Layered double hydroxide nanocarriers can enhance the pharmacokinetics and bioavailability of hydrophobic NSAIDs, such as mefenamic acid.
Article
Chemistry, Analytical
Yuhui Wei, Yanxing Hui, Xinjiao Lu, Chengzhou Liu, Youlin Zhang, Youjun Fan, Wei Chen
Summary: Rationally designing and constructing electrocatalytic nanomaterials is crucial for enhancing the sensitivity and selectivity of non-enzyme-based electrochemical sensors. In this study, a NiMn layered double hydroxide (LDH)-based MOF material was synthesized and used as an electrochemical electrode for highly sensitive detection of glucose. The NiMn-LDH-MOF exhibited excellent electrocatalytic activity for glucose oxidation, and the NiMn-LDH-MOF/GCE sensor showed a wide linear detection range, low detection limit, and high sensitivity. Additionally, the sensor demonstrated good selectivity and reliability for glucose detection in actual serum samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Physical
Elaheh Ranjbar, Hassan Namazi
Summary: In this study, a biocompatible pH-sensitive system was designed for targeted anticancer drug delivery using a nano-composition of layered double hydroxide@hydroxyapatite-doxorubicin coated magnetic Fe3O4-polyethylene glycol. The nanocomposites showed controlled drug release behavior and high cytotoxicity, making them a promising candidate for targeted drug delivery.
Review
Chemistry, Physical
Joonghak Lee, Hee Seung Seo, Wooram Park, Chun Gwon Park, Yukwon Jeon, Dae-Hwan Park
Summary: This review summarizes the recent advances in LDH nanohybrids for cancer therapeutic strategies, including gene therapy, chemotherapy, immunotherapy, and combination therapy. LDH hybridized with therapeutic agents plays a significant role in cancer imaging and therapy.
Article
Agricultural Engineering
Linhan He, Ruiqing Ren, Liuliu Wang, Jingxuan Zhou, Kaili Ling, Jing Li, Songwu Chen, Yao Chen
Summary: In this study, a metal-organic framework (MOF) was grown on a wood surface to generate a nanoscale layered double hydroxide (LDH) for wood dyeing. The LDH formation was achieved through a hydrolytically induced exchange process between the MOF and hydroxide ions. The modified wood surface exhibited a uniform light green color and excellent UV light aging and water resistances. This method is mild, environmentally friendly, and can be applied to other types of wood.
INDUSTRIAL CROPS AND PRODUCTS
(2023)
Article
Biochemistry & Molecular Biology
Zhaoyun Liu, Xi Wang, Chen Zhang, Kui Lin, Jian Yang, Yi Zhang, Jia Hao, Fei Tian
Summary: The development of multifunctional magnetic nanocomposites for cancer therapy is highly desirable in nanomedicine. In this study, a novel nanocomposite FA-BSA/Fe3O4@LDH was developed for the delivery of 5-Fluorouracil. The nanocomposite showed good dispersibility, magnetic property, and pH-responsive drug release. It exhibited excellent anti-cancer cell activity and specific targeting ability.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Pharmacology & Pharmacy
Tae-Hyun Kim, Jun Young Lee, Jing Xie, Jeong Hoon Park, Jae-Min Oh
Summary: Layered double hydroxide is a versatile two-dimensional material that has attracted attention in biomedical applications for drug delivery systems and nanodiagnostics. Its different components, including interlayer space, outer surface, and lattice points, can be utilized for various biomedical approaches, such as drug stabilization, sustained release, and cellular delivery.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Polymer Science
S. Barkhordari, A. Alizadeh
Summary: Nanocomposite hydrogels based on chitosan, magnetic nanoparticles, and Mg-Al double-layered hydroxides were prepared for pH-sensitive drug delivery systems. The drug release and swelling behavior were influenced by pH and external magnetic field, with Fe3O4 NPs content affecting the rate of diclofenac release. By increasing Fe3O4 NPs content, the drug release became more targeted and release percentages varied under different pH values and EMF conditions.
Article
Chemistry, Physical
Antonio J. S. Fernandes Junior, Welton C. Sodre, Barbara E. C. F. Soares, Cicero W. B. Bezerra, Alex Rojas, Javier Perez-Carvajal, Ana C. S. Alcantara
Summary: Global concerns over the future consequences of uncontrolled industrial development have led to the emergence of sustainable materials composed of earth abundant elements. A new type of heterostructured material has been synthesized by assembling inexpensive metals on synthetic silicates, showing promising performance in catalytic reactions. The study indicates that the presence of particular metal-oxide nanoparticles supported on specific materials can enhance photocatalytic activity and stability.
APPLIED SURFACE SCIENCE
(2021)
Review
Chemistry, Multidisciplinary
Seungjin Yu, Goeun Choi, Jin-Ho Choy
Summary: Two-dimensional nanomaterials, especially layered double hydroxides (LDHs), have found extensive applications in biomedical field due to their biocompatibility, biodegradability, controllable drug release/loading ability, and enhanced cellular permeability. This review summarizes the synthetic strategies and therapeutic actions of single-function LDH-based nanohybrids, as well as the recently developed multifunctional systems for drug delivery and bio-imaging (from 2019 to 2023).
Article
Chemistry, Multidisciplinary
Wenhui Wang, Hongwei Yan, Utkarsh Anand, Utkur Mirsaidov
Summary: The study reveals the process of MOF nanoparticles converting into LDH nanostructures using liquid-phase transmission electron microscopy. The findings show that maintaining comparable etching and growth rates is crucial for forming hollow nanostructures with the shape of underlying MOF NP template.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Toxicology
Jalil Mehrzad, Taghi Zahraei Salehi, Alireza Khosravi, Saman Hosseinkhani, Yaser Tahamtani, Ensiyeh Hajizadeh-Saffar, Maedeh Moazenchi, Amir Mohammad Malvandi
Summary: This study analyzed the effects of aflatoxins on rat pancreatic islet cells, finding that these environmental toxins can impair the quality and function of the cells, potentially leading to endocrine disorders such as type-2 diabetes.
Article
Chemistry, Multidisciplinary
Nazanin Amareh, Yadollah Yamini, Mahboubeh Saeidi, Mostafa Ghaemmaghami
Summary: Zeolitic imidazole framework-67 was synthesized using a simple and low-cost method and used as a solid-phase microextraction coating for extracting alcohols from the headspace of an aqueous solution. The coating material was characterized using various techniques, and the extraction parameters were optimized. The method showed good performance in terms of linearity, limits of quantification and detection, repeatability, and reproducibility.
Article
Chemistry, Analytical
Seyedeh Sara Nasrollahi, Yadollah Yamini
Summary: A green approach for dispersive solid phase microextraction was developed using a water-insoluble adsorbent made from cross-linked β-cyclodextrin and citric acid to extract and determine melamine in various matrices. The extraction efficiency of melamine was optimized by evaluating different parameters, such as ion strength, extraction time, sample volume, absorbent amount, pH, desorption solvent type, desorption time, and desorption solvent volume. The method showed a good linear dynamic range, with a coefficient of determination of 0.9985, and a low limit of detection of 0.3 μg/L. The technique was successfully applied to extract and determine melamine in a melamine bowl and infant formula.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Analytical
Kobra Zavar Mousavi, Yadollah Yamini, Babak Karimi, Fariborz Mansouri
Summary: A magnetic N,S-codoped ordered mesoporous carbon (Fe-GIOMC) was synthesized and applied for microextraction of triazine herbicides. The Fe-GIOMC showed high hydrophilicity, low detection limits, and wide linear ranges. It also exhibited good reusability, making it a promising sorbent for the determination of triazine herbicides.
MICROCHEMICAL JOURNAL
(2023)
Review
Chemistry, Analytical
Raheleh Ahmadi, Ebaa Adnan Azooz, Yadollah Yamini, Amir M. Ramezani
Summary: Deep eutectic solvents (DESs) are gaining attention as green alternatives to traditional ionic liquids and hazardous organic solvents due to their low toxicity, easy synthesis procedures, low cost, and high biodegradability. These solvents, which are a mixture of two or more green components with a high capability to form hydrogen bonds, are being rapidly applied in various extraction approaches in the field of analytical chemistry. The facile synthesis procedures of DESs based on hydrogen bonding have led to the development of innovative liquid-liquid microextraction (LLME) strategies involving the in-situ formation or decomposition of these solvents. This review provides a summary of literature on LLME approaches based on the in-situ formation/decomposition of DESs to offer up-to-date information in this field.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Review
Biochemical Research Methods
Mahsa Samadifar, Yadollah Yamini, Mohammad Mahdi Khataei, Mahboue Shirani
Summary: This study reviews the packed sorbent solid phase (micro) extraction methods from manual to automated modes. The automated methods offer remarkable advantages such as high sample throughput, reproducibility, sensitivity, and extraction efficiency. Various methods including solid-phase extraction, pipette tip micro-solid phase extraction, microextraction by packed sorbent, in-tip solid phase microextraction, in-tube solid phase microextraction, lab-on-a-chip, and lab-on-a-valve are discussed, along with their recent applications for the extraction of organic and inorganic compounds. The combination of novel technologies like 3D printing and robotic platforms with (semi)automated methods are also investigated as the future trend.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Biochemical Research Methods
Negar Sabahi Moosavi, Yadollah Yamini, Mostafa Ghaemmaghami
Summary: The use of electrospinning has gained attention for producing nanofiber webs due to its flexibility and simplicity. By directly electrospinning nanofibers in aligned or twisted forms and producing nanofiber yarns, the diversity in nanofiber applications is increased and their possibilities expanded. In this study, a successful nanofiber yarn spinning system was developed using a rotating funnel and a composited PAN/MXene polymer solution. The application of this system in the solid-phase microextraction of ss-blocker drugs from biofluids was demonstrated.
JOURNAL OF CHROMATOGRAPHY A
(2023)
Article
Chemistry, Analytical
Negar Sabahi Moosavi, Yadollah Yamini
Summary: In this study, a composited bimetallic organic framework-polyacrylonitrile was used for thin-film solid phase microextraction of tricyclic antidepressant drugs from biological samples. The method showed wide linear range, low limits of detection, and good repeatability and reproducibility. The results demonstrate the effectiveness of this technique for the extraction and measurement of the target analytes.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Article
Chemistry, Analytical
Payam Osooli, Yadollah Yamini, Mahmoud Tabibpour, Seyedeh Sara Nasrollahi, Nasser Nikfarjam
Summary: A novel solid-phase microextraction method on a screw was developed to extract cationic dyes from food samples and fish breeding pool water. The extracted dyes were analyzed using high-performance liquid chromatography with an ultraviolet/visible detector. The method showed good efficiency and precision, with low limits of detection and acceptable relative recoveries for the determination of cationic dyes in various samples.
JOURNAL OF SEPARATION SCIENCE
(2023)
Article
Chemistry, Analytical
Mohammad Mahdi Khataei, Yadollah Yamini, Monireh Karami, Alireza Badiei, Fernando Maya, Michael Breadmore
Summary: A smartphone-assisted method for determining copper ions using a down-scaled microfluidic mixer is introduced. The system includes a micro-column packed with a periodic mesoporous organosilica (PMO) material for preconcentration of copper ions. The method utilizes an Android-based software to analyze RGB components of images from the packed PMO material to determine the color change of the adsorbent. The method shows higher sensitivity and precision than ICP-AES for determination of copper ions.
Review
Chemistry, Analytical
Seyedeh Sara Nasrollahi, Negar Sabahi Moosavi, Yadollah Yamini
Summary: Due to concern about health and the environment, green, eco, and environment-friendly practices have been established in different research areas. This has motivated the analytical chemistry community to improve methods that align with the principles of green analytical chemistry. Microextraction techniques, such as sorbent microextraction and liquid-phase microextraction, are of great importance as alternative methods. Parabens, synthetic preservatives widely used in cosmetics, pharmaceuticals, and beverages, are known as endocrine-disrupting chemicals. This review discusses the definition and principles of green chemistry, summarizes the development of green analytical chemistry, and focuses on recent applications for the determination of parabens in different samples.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Fatemeh Zanganeh, Yadollah Yamini, Mohammad Mahdi Khataei, Mahboube Shirani
Summary: This study developed a microextraction in a packed syringe (MEPS) method for the determination of three opiates in urine samples. A COF-PPy-CTAB nanocomposite as an efficient adsorbent was synthesized and applied to the MEPS process. The analytes were separated and extracted on the adsorbent surface through π stacking, hydrophobic, and host-guest interaction, and then eluted with a desorbing solvent. The method showed good linearity, with a wide concentration range and low limits of detection and quantification. The precision and recovery of the method were also satisfactory.
Article
Chemistry, Analytical
Nazanin Amareh, Yadollah Yamini, Mahboubeh Saeidi, Zeinab Dinmohammadpour, Mahsa Nazraz
Summary: The ZIF-7@ZIF-67/PES composite was synthesized and applied for efficient dispersive solid-phase extraction of bisphenol A (BPA) and 2-phenyl phenol (BPh) from real samples. The composite structure was examined through various techniques and satisfactory results were obtained in the application process.
Article
Chemistry, Analytical
Payam Osooli, Yadollah Yamini, Mahmoud Tabibpour, Negar Sabahi Moosavi
Summary: A novel and efficient online microextraction method coupled with high-performance liquid chromatography and UV-visible detection was developed for the extraction and determination of trace amounts of opium alkaloids. The method was simple, reproducible, and showed acceptable recovery rates for opium alkaloids in water and urine samples.
Article
Chemistry, Analytical
Mohsen Aghaziarati, Yadollah Yamini, Maryam Shamsayei
Summary: A novel adsorbent consisting of carbon dots, CuCr-layered double hydroxides, and L-histidine was successfully applied for in-tube solid-phase microextraction of chlorophenols. Through optimization of various parameters, good separation and measurement results were achieved, enabling accurate detection of chlorophenols in water samples.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)