Article
Medicine, General & Internal
Mariano Provencio, Ernest Nadal, Jose L. Gonzalez-Larriba, Alex Martinez-Marti, Reyes Bernabe, Joaquim Bosch-Barrera, Joaquin Casal-Rubio, Virginia Calvo, Amelia Insa, Santiago Ponce, Noemi Reguart, Javier de Castro, Joaquin Mosquera, Manuel Cobo, Andres Aguilar, Guillermo Lopez Vivanco, Carlos Camps, Rafael Lopez-Castro, Teresa Moran, Isidoro Barneto, Delvys Rodriguez-Abreu, Roberto Serna-Blasco, Raquel Benitez, Carlos Aguado de la Rosa, Ramon Palmero, Florentino Hernando-Trancho, Javier Martin-Lopez, Alberto Cruz-Bermudez, Bartomeu Massuti, Atocha Romero
Summary: This study evaluated the efficacy of the neoadjuvant nivolumab plus chemotherapy regimen on operable stage III non-small-cell lung cancer (NSCLC) patients. The results showed that patients receiving the combination therapy had a higher rate of pathological complete response and longer survival, indicating the effectiveness of this treatment approach in this patient population.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Joe Y. Chang, Reza J. Mehran, Lei Feng, Vivek Verma, Zhongxing Liao, James W. Welsh, Steven H. Lin, Michael S. O'Reilly, Melenda D. Jeter, Peter A. Balter, Stephen E. McRae, Donald Berry, John Heymach, Jack A. Roth
Summary: Long-term results from the revised STARS trial showed that survival after SABR is non-inferior to VATS L-MLND for operable stage IA NSCLC. SABR remains promising for such cases, with multidisciplinary management strongly recommended.
Article
Oncology
Yuhei Miyasaka, Shuichiro Komatsu, Takanori Abe, Nobuteru Kubo, Naoko Okano, Kei Shibuya, Katsuyuki Shirai, Hidemasa Kawamura, Jun-ichi Saitoh, Takeshi Ebara, Tatsuya Ohno
Summary: The study compared oncologic outcomes after CIRT and SBRT for early-stage NSCLC and found that CIRT showed superior overall survival and local control compared to SBRT. These results were validated by propensity score-adjusted analyses, demonstrating a positive efficacy profile of CIRT in the management of early-stage NSCLC.
Article
Oncology
Mary Katherine Anastasio, Anjali Gupta, Tomi F. Akinyemiju, Rebecca A. Previs
Summary: Disparities exist for Black patients with uterine cancer in terms of diagnosis, treatment, and survival. Black patients are more likely to have aggressive disease, receive less treatment, and have worse survival regardless of cancer subtype.
FRONTIERS IN ONCOLOGY
(2023)
Article
Surgery
Chan Y. Pu, Sarah Rodwin, Bre Nelson, Najya Fayyaz, Nicholas Scott, Rene J. Bouchard, Adrienne Groman, Mark Hennon, Sai Yendamuri
Summary: In patients with clinical N1 NSCLC, minimally invasive surgery (MIS) does not compromise oncological quality or overall survival compared to open thoracotomy. Overall survival is improved in patients treated with chemotherapy, with no difference between neoadjuvant and adjuvant chemotherapy.
JOURNAL OF SURGICAL RESEARCH
(2021)
Review
Oncology
Xiaoli Liu, Alexander Chi
Summary: Immunotherapy has revolutionized the treatment of metastatic NSCLC. Combining SBRT with immunotherapy is recognized as a promising treatment option. However, the most optimal approach for this combination remains controversial, and further exploration is needed.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Shuri Aoki, Hiroshi Onishi, Masataka Karube, Naoyoshi Yamamoto, Hideomi Yamashita, Yoshiyuki Shioyama, Yasuo Matsumoto, Yukinori Matsuo, Akifumi Miyakawa, Haruo Matsushita, Hitoshi Ishikawa
Summary: This retrospective study aimed to assess the efficacy and safety of stereotactic body radiotherapy (SBRT) and carbon ion radiotherapy (CIRT) in elderly patients with non-small-cell lung cancer (NSCLC) using Japanese multicenter data. The study found that SBRT and CIRT showed similar survival and local control rates in elderly patients, but CIRT was associated with a lower incidence of radiation pneumonitis.
Article
Oncology
Sivesh K. Kamarajah, Filip Bednar, Clifford S. Cho, Hari Nathan
Summary: Adjuvant radiotherapy after resection of distal cholangiocarcinoma was associated with a survival benefit in patients, even in patients with margin-negative or node-negative resections. Adjuvant radiotherapy should be considered routinely irrespective of margin and nodal status after resection of distal cholangiocarcinoma.
Review
Oncology
Olwen Leaman Alcibar, Ernest Nadal, Inmaculada Romero Palomar, Arturo Navarro-Martin
Summary: Despite the high locoregional relapse rate in stage III NSCLC patients, adding SBRT to conventional treatment regimens shows promise in improving local control. Prospective and retrospective studies have demonstrated the potential benefit of SBRT in reducing local failure rates, leading to ongoing phase II and III trials to further evaluate its efficacy in clinical scenarios.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Fei Li, Hairong Jiang, Mingwei Bu, Xin Mu, Hongfu Zhao
Summary: Through literature analysis, it was found that the effectiveness of stereotactic body radiation therapy (SBRT) for early non-small cell lung cancer (NSCLC) is related to the central dose and average dose, while it is not significantly related to the nominal dose and peripheral dose. Therefore, more attention should be paid to the prescription of the central dose and average dose in the treatment.
RADIATION ONCOLOGY
(2022)
Review
Oncology
Megan E. Daly
Summary: Stereotactic ablative radiotherapy (SABR) is the standard treatment for medically inoperable, early-stage non-small-cell lung cancer. However, regional and distant failures remain a challenge, especially in larger and more biologically aggressive tumors. Use of cytotoxic chemotherapy is limited in this patient population, prompting the investigation of alternative systemic therapy options with fewer side effects, such as immune checkpoint inhibitors.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kimihiro Shimizu, Yoichi Ohtaki, Kenji Suzuki, Hiroshi Date, Motohiro Yamashita, Toshihiko Iizasa, Hiroyuki Ito, Kenichi Yoshimura, Morihito Okada, Masayuki Chida
Summary: The study found that pathological nodal stage was an independent prognosticator in the chemoradiotherapy or conventional external beam group, while age 70 years and greater was the only independent prognosticator in the stereotactic body radiotherapy or ion beam radiotherapy group. Overall, patients undergoing salvage surgery can have reasonable outcomes.
ANNALS OF THORACIC SURGERY
(2021)
Article
Multidisciplinary Sciences
Esengul Kocak Uzel, Melisa Bagci Kilic, Hasan Morcali, Omer Uzel
Summary: This study retrospectively analyzed the outcomes of operable patients with early-stage NSCLC who underwent SBRT after refusing surgery. The results suggest that SBRT can be an effective and well-tolerated alternative for operable early-stage NSCLC patients.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Ravi Shridhar, Paige Blinn, Jamie Huston, Kenneth L. Meredith
Summary: This study is the first to show that adjuvant radiation therapy after chemotherapy can significantly improve overall survival in resected high-risk extrahepatic cholangiocarcinoma patients. Further clinical trials are needed to investigate the role of radiation therapy in this population.
Review
Oncology
Nicola Martucci, Alessandro Morabito, Antonello La Rocca, Giuseppe De Luca, Rossella De Cecio, Gerardo Botti, Giuseppe Totaro, Paolo Muto, Carmine Picone, Giovanna Esposito, Nicola Normanno, Carmine La Manna
Summary: Small-cell lung cancer (SCLC) is an aggressive tumor with limited response to chemotherapy and radiotherapy, but surgery may benefit selected early-stage patients. International guidelines recommend surgical intervention in selected stage I SCLC patients after proper evaluation.
Article
Oncology
T. Y. Seiwert, C. C. Foster, E. A. Blair, T. G. Karrison, N. Agrawal, J. M. Melotek, L. Portugal, R. J. Brisson, A. Dekker, S. Kochanny, Z. Gooi, M. W. Lingen, V. M. Villaflor, D. T. Ginat, D. J. Haraf, E. E. Vokes
ANNALS OF ONCOLOGY
(2019)
Review
Oncology
Corey C. Foster, Ralph R. Weichselbaum, Sean P. Pitroda
Article
Oncology
Corey C. Foster, David J. Sher, Chad G. Rusthoven, Vivek Verma, Michael T. Spiotto, Ralph R. Weichselbaum, Matthew Koshy
RADIATION ONCOLOGY
(2019)
Article
Oncology
Benjamin Foster, William Jackson, Corey Foster, Robert Dess, Eyad Abu-Isa, Patrick William McLaughlin, Gregory Merrick, Jason Hearn, Daniel Spratt, Stanley Liauw, Daniel Hamstra
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2019)
Editorial Material
Oncology
Corey C. Foster, Sean P. Pitroda, Ralph R. Weichselbaum
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Editorial Material
Oncology
Corey C. Foster, Sean P. Pitroda, Ralph R. Weichselbaum
JOURNAL OF THORACIC ONCOLOGY
(2019)
Correction
Oncology
Corey C. Foster, Chad G. Rusthoven, David J. Sher, Lawrence Feldman, Mary Pasquinelli, Michael T. Spiotto, Matthew Koshy
Editorial Material
Oncology
Corey C. Foster, Yasmin Hasan, Christina H. Son, Anne R. McCall
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Article
Oncology
Bin Liu, Julio Ricarte Filho, Apurva Mallisetty, Cassandra Villani, Anastasia Kottorou, Kristen Rodgers, Chen Chen, Tomoaki Ito, Kyla Holmes, Nicole Gastala, Klara Valyi-Nagy, Odile David, Ron C. Gaba, Christian Ascoli, Mary Pasquinelli, Lawrence E. Feldman, Malek G. Massad, Tza-Huei Wang, Ignacio Jusue-Torres, Enrico Benedetti, Robert A. Winn, Malcolm V. Brock, James G. Herman, Alicia Hulbert
CLINICAL CANCER RESEARCH
(2020)
Article
Medicine, General & Internal
Nicole M. Kuderer, Toni K. Choueiri, Dimpy P. Shah, Yu Shyr, Samuel M. Rubinstein, Donna R. Rivera, Sanjay Shete, Chih-Yuan Hsu, Aakash Desai, Gilberto de Lima Lopes, Petros Grivas, Corrie A. Painter, Solange Peters, Michael A. Thompson, Ziad Bakouny, Gerald Batist, Tanios Bekaii-Saab, Mehmet A. Bilen, Nathaniel Bouganim, Mateo Bover Larroya, Daniel Castellano, Salvatore A. Del Prete, Deborah B. Doroshow, Pamela C. Egan, Arielle Elkrief, Dimitrios Farmakiotis, Daniel Flora, Matthew D. Galsky, Michael J. Glover, Elizabeth A. Griffiths, Anthony P. Gulati, Shilpa Gupta, Navid Hafez, Thorvardur R. Halfdanarson, Jessica E. Hawley, Emily Hsu, Anup Kasi, Ali R. Khaki, Christopher A. Lemmon, Colleen Lewis, Barbara Logan, Tyler Masters, Rana R. McKay, Ruben A. Mesa, Alicia K. Morgans, Mary F. Mulcahy, Orestis A. Panagiotou, Prakash Peddi, Nathan A. Pennell, Kerry Reynolds, Lane R. Rosen, Rachel Rosovsky, Mary Salazar, Andrew Schmidt, Sumit A. Shah, Justin A. Shaya, John Steinharter, Keith E. Stockerl-Goldstein, Suki Subbiah, Donald C. Vinh, Firas H. Wehbe, Lisa B. Weissmann, Julie Tsu-Yu Wu, Elizabeth Wulff-Burchfield, Zhuoer Xie, Albert Yeh, Peter P. Yu, Alice Y. Zhou, Leyre Zubiri, Sanjay Mishra, Gary H. Lyman, Brian Rini, Jeremy L. Warner
Editorial Material
Oncology
Article
Multidisciplinary Sciences
Alexandre F. Aissa, Abul B. M. M. K. Islam, Majd M. Ariss, Cammille C. Go, Alexandra E. Rader, Ryan D. Conrardy, Alexa M. Gajda, Carlota Rubio-Perez, Klara Valyi-Nagy, Mary Pasquinelli, Lawrence E. Feldman, Stefan J. Green, Nuria Lopez-Bigas, Maxim Frolov, Elizaveta Benevolenskaya
Summary: Tyrosine kinase inhibitors have clinical effectiveness in treating certain subsets of cancers with receptor tyrosine kinase somatic mutations, but limited duration of response and development of drug resistance are common issues. Single-cell RNA sequencing revealed multiple cancer cell subpopulations with epigenetic changes and variable therapeutic sensitivity. Overrepresented gene ontologies associated with drug tolerance include epithelial-to-mesenchymal transition, drug metabolism, and vesicle transport. Combination therapy targeting specific drug tolerant cell subpopulations shows promise in inhibiting drug resistance.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Mary M. Pasquinelli, Martin C. Tammemagi, Kevin L. Kovitz, Marianne L. Durham, Zane Deliu, Kayleigh Rygalski, Li Liu, Matthew Koshy, Patricia Finn, Lawrence E. Feldman
JOURNAL OF THORACIC ONCOLOGY
(2020)