期刊
BIOMACROMOLECULES
卷 16, 期 8, 页码 2412-2417出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.5b00653
关键词
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资金
- Multidisciplinary University Research Initiative of the Department of Defense
- Army Research Office [W911NF-10-1-0518]
- DOD [W81XWH-11-1-0111]
- EU [310445]
- United States National Institutes of Health [R01CA170198]
- NATIONAL CANCER INSTITUTE [R01CA170198] Funding Source: NIH RePORTER
CXCR4 is a cell membrane receptor that is overexpressed in triple-negative breast cancers and implicated in growth and metastasis of this disease. Using electrohydrodynamic cojetting, we prepared multicompartmental drug delivery carriers for CXCR4 targeting. The particles are comprised of a novel poly(lactide-co-glycolide) derivative that allows for straightforward immobilization of 1,1'[1,4-phenylenebis(methylene)This[1,4,8,11-tetraazacyclotetradecane] (Plerixafor), a small molecule with affinity for CXCR4. Targeted nanocarriers are selectively taken up by CXCR4-expressing cells and effectively block CXCR4 signaling. This study suggests that CXCR4 may be an effective target for nanocarrier-based therapies.
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