Article
Biochemistry & Molecular Biology
Fangyuan Jia, Rui Ji, Gang Qiao, Zhigang Sun, Xiaosan Chen, Zhidong Zhang
Summary: Recent studies have shown that bitter taste receptors play a role in regulating various cellular processes. This study found that the bitter taste receptor activator amarogentin (AMA) can inhibit the proliferation and migration of vascular smooth muscle cells (VSMCs) by activating the AMPK signaling pathway, thereby attenuating neointimal hyperplasia. This highlights the potential of AMA as a new drug candidate for the treatment of neointimal hyperplasia.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Cell Biology
Tiantian Li, Hongchi Yu, Demao Zhang, Tang Feng, Michael Miao, Jianwei Li, Xiaoheng Liu
Summary: Vascular calcification is associated with increased risk of heart disease, stroke, and atherosclerotic plaque rupture. Extracellular vesicles, particularly matrix vesicles, play a crucial role in the early stages of vascular calcification. However, the underlying mechanism by which matrix vesicles drive vascular smooth muscle cells phenotype switching and calcification remains unclear.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Dan Shan, Ping Qu, Chao Zhong, Luling He, Qingshan Zhang, Guoyue Zhong, Wenhui Hu, Yulin Feng, Shilin Yang, Xiao-feng Yang, Jun Yu
Summary: This study identified Anemoside B4 as a potential therapeutic agent that regulates vascular smooth muscle cell plasticity and inhibits restenosis after vascular intervention.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Hematology
Chien-Jung Lin, Bridget M. Hunkins, Robyn A. Roth, Chieh-Yu Lin, Jessica E. Wagenseil, Robert P. Mecham
Summary: This study investigates the mechanism of neointima formation due to Eln insufficiency in a mouse model, showing that cells from the secondary heart field are significant contributors to intimal hyperplasia. Two unique SMC populations were identified in the neointima of SMC-Eln knockout mice, suggesting shared mechanisms with adult vessel injury models.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shunchi Zhang, Yanrou Bei, Yueling Huang, Yimin Huang, Lianjie Hou, Xi-Long Zheng, Yiming Xu, Shaoguo Wu, Xiaoyan Dai
Summary: Ferroptosis is positively associated with neointima formation. In vivo, the ferroptosis activator RSL3 exacerbated neointima formation, while the ferroptosis inhibitor Fer-1 had the opposite effect. In vitro, RSL3 promoted VSMC phenotypic conversion, which was abolished by Fer-1. The reactive oxygen species inhibitor NAC counteracted the effect of RSL3 on VSMC phenotypic conversion.
MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Dai Sik Ko, Junho Kang, Hye Jin Heo, Eun Kyoung Kim, Kihun Kim, Jin Mo Kang, YunJae Jung, Seung Eun Baek, Yun Hak Kim
Summary: Vascular smooth muscle cell (VSMC) proliferation plays a crucial role in atherosclerosis and restenosis. This study identified PCK2 as a key regulator of VSMC proliferation and suggested targeting PCK2 as a novel therapeutic approach for atherosclerosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Multidisciplinary Sciences
Yin Chen, Peng Gao, Lu Huang, Xing Tan, Ningling Zhou, Tong Yang, Hua Qiu, Xin Dai, Sean Michael, Qiufen Tu, Nan Huang, Zhihong Guo, Jianhua Zhou, Zhilu Yang, Hongkai Wu
Summary: Authors have developed a nitric oxide releasing hydrogel that promotes endothelialization of the stent surface and inhibits smooth muscle cell growth, reducing neointimal hyperplasia and thrombosis.
NATURE COMMUNICATIONS
(2021)
Article
Plant Sciences
Guanghong Chen, Honglin Xu, Yuting Wu, Xin Han, Lingpeng Xie, Guoyong Zhang, Bin Liu, YingChun Zhou
Summary: Myricetin inhibits neointimal hyperplasia and VSMC proliferation and migration by suppressing TGFBR1 signaling pathway. This study demonstrates the potential therapeutic value of myricetin for atherosclerosis and vascular restenosis.
Article
Biochemistry & Molecular Biology
Maria Francesca Greco, Alessandra Stefania Rizzuto, Marta Zara, Marco Cafora, Chiara Favero, Giulia Solazzo, Ilaria Giusti, Maria Pia Adorni, Francesca Zimetti, Vincenza Dolo, Cristina Banfi, Nicola Ferri, Cesare R. Sirtori, Alberto Corsini, Silvia Stella Barbieri, Anna Pistocchi, Valentina Bollati, Chiara Macchi, Massimiliano Ruscica
Summary: This study reveals that PCSK9 plays an inflammatory role through EVs released by vascular smooth muscle cells, affecting the function and content of neighboring cells, and may have a significant role in atherosclerosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xi-zhenzi Fan, Ying-Ying Wang, Zi-Yang Cui, Zi-Hao Cheng, Hai-Lin Zhang, Nikita Gamper, Fan Zhang, Mei Han
Summary: In this study, the researchers found that Kv7.4 channel is involved in vascular inflammation response, which affects neointimal hyperplasia and abdominal aortic aneurysm formation by regulating inflammation-related genes, matrix metalloproteinases, and intercellular adhesion molecules.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Tong Li, Baofu Wang, Hao Ding, Shiqi Chen, Weiting Cheng, Yang Li, Xiaoxiao Wu, Lei Wang, Yangyang Jiang, Ziwen Lu, Yu Teng, Sha Su, Xiaowan Han, Mingjing Zhao
Summary: Atherosclerosis (AS)-related diseases are the leading cause of death in clinical patients. Vascular smooth muscle cells (VSMCs) play a crucial role in AS, and intercellular communication through extracellular vesicles (EVs) is important in the pathophysiology of AS.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ya Zhang, Peidong Yuan, Xiaoping Ma, Qiming Deng, Jiangang Gao, Jianmin Yang, Tianran Zhang, Cheng Zhang, Wencheng Zhang
Summary: This study found that LGL1 inhibits VSMC proliferation and migration by promoting proteasomal degradation of STAT3, thereby suppressing neointimal hyperplasia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ya-Ning Shi, Le-Ping Liu, Chang-Feng Deng, Tan-Jun Zhao, Zhe Shi, Jian-Ye Yan, Yong-Zhen Gong, Duan-Fang Liao, Li Qin
Summary: The study found that celastrol effectively inhibited intimal hyperplasia and hyperproliferation of VSMCs by inducing autophagy, suggesting it may be a novel drug with great potential to prevent restenosis. The mechanism behind this effect involves lysosomal degradation of c-MYC and the Wnt5a/PKC/mTOR signaling pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shuai Wang, Xiaoning Liu, Zeqi Meng, Qi Feng, Yanling Lin, Honglin Niu, Chao Yu, Yanhong Zong, Lingling Guo, Weiwei Yang, Yuehua Ma, Wenjun Zhang, Chenyang Li, Yunran Yang, Wenjuan Wang, Xurui Gao, Yaxin Hu, Chao Liu, Lei Nie
Summary: DCBLD2 is a transmembrane protein that regulates PDGFR-beta endocytosis, and its inhibition of receptor endocytosis can regulate the phenotypic conversion of VSMCs and arterial wall proliferation, making it a potential therapeutic target for cardiovascular diseases.
Article
Chemistry, Multidisciplinary
Young Joo Lee, Miso Park, Hyun Young Kim, Jin-Ki Kim, Won-Ki Kim, Sung Chul Lim, Keon Wook Kang
Summary: The study investigates the role of circulating small extracellular vesicles (csEVs) in vascular smooth muscle cell (VSMC) functions and reveals that csEVs enhance cell proliferation and migration via the membrane phosphatidylserine (PS). Further experiments demonstrate the essential role of csEVs in neointima formation and uncover the involvement of AXL and MerTK pathways in mediating the effects of csEVs. Dual inhibition of AXL/MerTK effectively hinders csEV-mediated proliferation and migration of VSMCs, suggesting the potential of dual AXL/MerTK inhibitors in treating vascular diseases.
ACTA PHARMACOLOGICA SINICA
(2023)