Article
Oncology
Clement T. Narh, Charles P. Dzamalala, Blandina T. Mmbaga, Diana Menya, Yohannie Mlombe, Peter Finch, Gissela Nyakunga, Joachim Schuz, Valerie McCormack
Summary: The study revealed that geophagia is more common in women in Africa, but is not a significant contributor to esophageal cancer risk in men. While the practice is common in women, there is currently no consistent evidence linking it to esophageal squamous cell carcinoma.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Nutrition & Dietetics
Shanshan Li, Joshua Ye, Zheng Lin, Zhifeng Lin, Xuwei Tang, Wenqing Rao, Zhijian Hu
Summary: This study investigated the independent and interactive effects of dietary nutrients on the risk of Esophageal Squamous Cell Carcinoma (ESCC) in Chinese adults. The results showed that fat, carbohydrate, and fiber intake significantly increased ESCC risk, while fiber and riboflavin intake significantly reduced the risk.
Article
Oncology
Elia J. Mmbaga, Beatrice P. Mushi, Katrina Deardorff, William Mgisha, Larry O. Akoko, Alan Paciorek, Robert A. Hiatt, Geoffrey C. Buckle, Julius Mwaiselage, Li Zhang, Katherine Van Loon
Summary: In Tanzania, low International Wealth Index, smoking, household second-hand smoke exposure, daily intake of spicy chilies and salted foods were associated with an increased risk of ESCC, while daily consumption of raw greens, fruit, and smoked fish was protective. Permanent residence in the Central, Northern-Lake, or Southern Highlands zones of Tanzania compared with the Eastern zone was associated with an increased risk of ESCC.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2021)
Review
Oncology
Munir Tarazi, Swathikan Chidambaram, Sheraz R. Markar
Summary: Esophageal squamous cell carcinoma (ESCC) is the sixth most common cause of death worldwide, with varying incidence rates internationally. This review aims to summarize the role of risk factors in ESCC development and propose future research directions. Risk factors were categorized into seven groups, including genetic, dietary, infection, and other potential risk factors yet to be fully explored. Further research on the validation of these results and their impact on tumor biology is crucial.
Article
Oncology
Chang Kyun Choi, Jungho Yang, Sun-Seog Kweon, Sang-Hee Cho, Hye-Yeon Kim, Eun Myung, Min-Ho Shin
Summary: In Eastern Asians, ALDH2 rs671 polymorphisms are associated with esophageal cancer, which may be linked to acetaldehyde accumulation. The study found that in men, the risk of esophageal cancer was higher with GA and AA genotypes, while in women, the risk was higher with GA and AA genotypes as well. Additionally, in men, the association between ALDH2 polymorphisms and esophageal cancer was influenced by alcohol consumption.
Article
Multidisciplinary Sciences
Fumisato Sasaki, Shuji Kanmura, Kohei Oda, Hidehito Maeda, Masayuki Kabayama, Hiromichi Iwaya, Yuga Komaki, Shiho Arima, Shiroh Tanoue, Shinichi Hashimoto, Hiroshi Fujita, Akio Ido
Summary: Patients with inactive ALDH2 have a higher risk of ESCC and HPSCC. The ABT can be a potential screening tool for detecting at-risk individuals. Inactive ALDH2 and A/E ratio were significantly higher in the SCC group compared to the control group, especially in the multiple subgroup.
Article
Oncology
Chikatoshi Katada, Tetsuji Yokoyama, Kanae Mure, Hisashi Doyama, Hiroyoshi Nakanishi, Yuichi Shimizu, Keiko Yamamoto, Yasuaki Furue, Masashi Tamaoki, Tomoyuki Koike, Yoshiro Kawahara, Hirofumi Kiyokawa, Maki Konno, Akira Yokoyama, Shinya Ohashi, Hideki Ishikawa, Akira Yokoyama, Manabu Muto
Summary: This study investigated the association between genetic polymorphisms related to alcohol and nicotine metabolism and the development of second primary esophageal squamous-cell carcinoma after endoscopic resection. The results showed that slow-metabolizing alcohol dehydrogenase 1B may be a significant risk factor for the development of second primary esophageal squamous-cell carcinoma. In addition, inactive aldehyde dehydrogenase 2 and poorly-metabolizing cytochrome P450 2A6 may be important factors.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Manning Zhu, Xiaoying Li, Yanan Feng, Tianshuang Jia, Songxue Li, Liping Gong, Shuang Dong, Xianchao Kong, Litao Sun
Summary: This study investigated the correlation between single nucleotide polymorphisms (SNPs) of the CD40 gene and susceptibility to cervical squamous cell carcinoma (CSCC) in a population from the northeastern Han Chinese population. The results showed that two SNPs of the CD40 gene were significantly associated with the risk of CSCC.
Article
Oncology
Mengjie Yu, Wei Wen, Xin Yi, Wei Zhu, Jiye Aa, Guangji Wang
Summary: This study found impaired oxidative stress function in ESCC patients and identified risk metabolites associated with the development of ESCC. The levels of alpha-tocopherol and cysteine decreased progressively, while the levels of aminomalonic acid increased progressively. A high level of aminomalonic acid was a risk factor for the development of ESD to ESCC and for lymphatic metastasis in ESCC patients. A low level of alpha-tocopherol was an independent risk factor for ESCC. The panel constructed by glycolic acid, oxalic acid, glyceric acid, malate, and alpha-tocopherol performed well in distinguishing ESD/ESCC from healthy controls.
FRONTIERS IN ONCOLOGY
(2022)
Article
Nutrition & Dietetics
Liping Sun, Wenjing Zhao, Jun Li, Lap Ah Tse, Xiangbin Xing, Sihao Lin, Jin Zhao, Zefang Ren, Cai-Xia Zhang, Xudong Liu
Summary: The study found that increased dietary intake of isoflavones and moderate consumption of anthocyanidins were associated with a decreased risk of esophageal squamous cell carcinoma.
Review
Medicine, Research & Experimental
Tao Yang, Ruting Hui, Jessica Nouws, Maor Sauler, Tianyang Zeng, Qingchen Wu
Summary: This study identified that glycerophospholipid metabolism is associated with the tumorigenesis and progression of esophageal squamous cell carcinoma (ESCC), and could be a potential therapeutic target for ESCC progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Jingbing Zhang, Geng Wang, Anyan Huang, Kexin Cao, Wei Tan, Hui Geng, Xiaosheng Lin, Fulan Zhan, Kusheng Wu, Shukai Zheng, Caixia Liu
Summary: The study found a negative trend with risk for esophageal squamous cell carcinoma (ESCC) for zinc, selenium, and strontium, and a significant overall effect of the mixture of multiple trace elements on ESCC.
Article
Oncology
Xiaorong Yang, Chen Suo, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Ziyu Yuan, Hui Chen, Jingru Yu, Li Jin, Xingdong Chen, Ming Lu, Weimin Ye
Summary: This study identified that most ESCC cases were usually exposed to 4 to 6 risk factors, while most controls were usually exposed to 3 to 5 risk factors. The AUCs of predictive nomograms for males and females were 0.75 and 0.76, respectively. By incorporating age into the predictive model, the AUC improved to 0.81 for men and 0.88 for women.
Article
Oncology
Dongxian Jiang, Haixing Wang, Minying Deng, Qi Song, Yufeng Liu, Rui Peng, Lei Xu, Jieakesu Su, Chen Xu, Yingyong Hou
Summary: The number of diagnosed esophageal basaloid squamous cell carcinoma (EBSCC) has been increasing recently, but available data on EBSCC are limited. A retrospective analysis of 165 EBSCC and 515 conventional esophageal squamous cell carcinoma (ESCC) showed that EBSCC had similar prognosis to ESCC in pIA-B stage, pIIA-B stage, pIIIA-B stage, and pIVA-B stage. Pure EBSCC did not have poorer survival compared to mixed EBSCC with concomitant ESCC or other components.
Letter
Medicine, General & Internal
Muhammet Ozer, Ilyas Sahin, Hassan Abushukair, Aya Abushukair, Anwaar Saeed
Summary: The results of the CheckMate 648 trial demonstrate that nivolumab plus chemotherapy or nivolumab plus ipilimumab can prolong overall survival in patients with advanced esophageal squamous-cell carcinoma compared to chemotherapy alone. This survival benefit is significant among patients with tumor-cell programmed death ligand 1 (PD-L1) expression of 1% or greater.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Yuan Fang, Zhen Li, Hui Chen, Tongchao Zhang, Xiaolin Yin, Jinyu Man, Xiaorong Yang, Ming Lu
Summary: The incidence, mortality, and burden of lung cancer in China have been increasing over the past three decades, with a more noticeable increase in incidence among females. Smoking remains the leading cause of lung cancer burden, but the contribution of ambient particulate matter pollution has also been increasing.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Letter
Biochemistry & Molecular Biology
Shixiong Tian, Ziqi Wang, Liting Liu, Yiling Zhou, Yue Lv, Dongdong Tang, Jiaxiong Wang, Jing Jiang, Huan Wu, Shuyan Tang, Guanxiong Wang, Hao Geng, Fangbiao Tao, Hongbin Liu, Xiaojin He, Feng Zhang, Jinsong Li, Li Jin, Tao Huang, Chunyu Liu, Yunxia Cao
JOURNAL OF GENETICS AND GENOMICS
(2023)
Article
Dermatology
Qianqian Peng, Yu Liu, Anke Huels, Canfeng Zhang, Yao Yu, Wenqing Qiu, Xiyang Cai, Yuepu Zhao, Tamara Schikowski, Katja Merches, Yun Liu, Yajun Yang, Jiucun Wang, Yong Zhao, Li Jin, Liang Zhang, Jean Krutmann, Sijia Wang
Summary: Solar lentigines (SLs) are a common sign of aging skin caused by chronic exposure to sunlight and environmental stressors. Recent studies have suggested a possible genetic component, but the findings are inconsistent. Through a multi-trait analysis, researchers discovered that genetic variants in the telomerase reverse transcriptase gene are significantly associated with non-facial SLs in East Asian and Caucasian populations. These variants are also related to facial SLs but not other skin aging or pigmentation traits, highlighting a previously unrecognized role of telomerase reverse transcriptase in lentigines formation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Genetics & Heredity
Shixiong Tian, Chaofeng Tu, Xiaojin He, Lanlan Meng, Jiaxiong Wang, Shuyan Tang, Yang Gao, Chunyu Liu, Huan Wu, Yiling Zhou, Mingrong Lv, Ge Lin, Li Jin, Yunxia Cao, Dongdong Tang, Feng Zhang, Yue-Qiu Tan
Summary: This study identified biallelic deleterious mutations of CFAP54 in three unrelated men with severe MMAF or NOA. These mutations were associated with abnormal sperm morphology, reduced sperm concentration and motility. Immunofluorescence assays showed reduced staining of four flagellar assembly-associated proteins in the spermatozoa of CFAP54-deficient men.
JOURNAL OF MEDICAL GENETICS
(2023)
Letter
Plant Sciences
Xiao-Min Yang, Hai-Liang Meng, Jian-Lin Zhang, Yao Yu, Edward Allen, Zi-Yang Xia, Kong-Yang Zhu, Pan-Xin Du, Xiao-Ying Ren, Jian-Xue Xiong, Xiao-Yu Lu, Yi Ding, Sheng Han, Wei-Peng Liu, Li Jin, Chuan-Chao Wang, Shao-Qing Wen
JOURNAL OF SYSTEMATICS AND EVOLUTION
(2023)
Article
Medicine, General & Internal
Xiaorong Yang, Shaohua Zhao, Shaohua Wang, Xuelei Cao, Yue Xu, Meichen Yan, Mingmin Pang, Fan Yi, Hao Wang
Summary: This study aimed to comprehensively assess the association between systemic inflammatory indicators and atrial fibrillation/flutter (AF), ventricular arrhythmia (VA), and bradyarrhythmia. The results showed that multiple systemic inflammatory indicators were positively correlated with the risk of arrhythmia, with the strongest association found in VA, followed by AF and bradyarrhythmia.
Article
Environmental Sciences
Tongchao Zhang, Xiaolin Yin, Xiaorong Yang, Ziyu Yuan, Qiyun Wu, Li Jin, Xingdong Chen, Ming Lu, Weimin Ye
Summary: This study investigated the association between 12 trace elements and gastroesophageal cancers (GOC) using hair and fingernail samples collected from GOC cases and controls in Taixing, China. The results showed that higher levels of Ca, Zn, Fe, Al, Cr, Pb, Se, and V were positively associated with increased GOC, while higher levels of Mg, Mn, Sr, and As were inversely associated with GOC. Interaction effects between hair level of Cr and smoking or alcohol drinking were also observed.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Biochemical Research Methods
Hongwei Guo, Jinlong Zhao, Xinjun Li, Feifei Sun, Yiming Qin, Xiaorong Yang, Xueting Xiong, Qianshuo Yin, Xueli Wang, Lin Gao, Meng Jiao, Jing Hu, Bo Han
Summary: miR-1-3p, miR-143-3p, and miR-145-5p are associated with bone metastasis in Gleason 3 + 4 prostate cancer. Functional experiments showed that these miRNAs promote proliferation and migration of prostate cancer in vitro. LASP1 was identified as their common target and may activate the Wnt signaling pathway through interaction with I3-β-catenin.
MOLECULAR AND CELLULAR PROBES
(2023)
Article
Multidisciplinary Sciences
Yang Gao, Xiaofei Yang, Hao Chen, Xinjiang Tan, Zhaoqing Yang, Lian Deng, Baonan Wang, Shuang Kong, Songyang Li, Yuhang Cui, Chang Lei, Yimin Wang, Yuwen Pan, Sen Ma, Hao Sun, Xiaohan Zhao, Yingbing Shi, Ziyi Yang, Dongdong Wu, Shaoyuan Wu, Xingming Zhao, Binyin Shi, Li Jin, Zhibin Hu, Yan Lu, Jiayou Chu, Kai Ye, Shuhua Xu
Summary: The data from the Chinese Pangenome Consortium's first phase reveals a substantial increase in the discovery of novel and missing sequences when individuals from underrepresented minority ethnic groups are included. The missing reference sequences contain archaic-derived alleles and genes related to keratinization, response to ultraviolet radiation, DNA repair, immunological responses, and lifespan, suggesting great potential for understanding human evolution and filling in missing heritability in complex diseases.
Article
Neurosciences
Jincheng Li, Sibo Zhu, Yingzhe Wang, Min Fan, Jiacheng Dai, Chengkai Zhu, Kelin Xu, Mei Cui, Chen Suo, Li Jin, Yanfeng Jiang, Xingdong Chen
Summary: By comparing the gut microbiota in a community-based cohort, it was found that bacteria capable of producing SCFAs were positively associated with better cognitive performance. In addition, specific bacterial strains were more abundant in individuals with MCI or CN groups and were correlated with cognitive performance.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Chemistry, Applied
Junyu Luo, Qili Qian, Wenxin Zheng, Ieva Gripkauskaite, Sijie Wu, Min Zhang, Jinxi Li, Bingfei Fu, Ranjit Bhogal, Peter Murray, Matthew Rowson, Bin Li, Xiangyang Xue, Xuelan Gu, Yajun Yang, Li Jin, David Andrew Gunn, Sijia Wang
Summary: This study investigated the extent to which scalp hair parameters change with age in Chinese men and women. The number of hairs per follicular unit was found to have a negative correlation with age in both men and women. Men had a greater number of hairs and follicular units than women on average, but experienced a greater decrease in the number of hairs per follicular unit with age, particularly in multi-hair follicular units. Hair loss was not random across follicular units, and a higher number of hairs per follicular unit increased the risk of hair loss. The results suggest that the presence of multi-hair follicular units on the scalp contributes to the greater susceptibility of scalp hair to hair loss compared to other body sites.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Qianqian Xu, Tingxiao Zhang, Tong Xia, Bin Jin, Hui Chen, Xiaorong Yang
Summary: Over the past 30 years, the burden of kidney cancer in China has gradually increased and is expected to continue rising in the next decade, highlighting the need for more targeted intervention measures.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Tian Ma, Meng Wan, Guanqun Liu, Xiuli Zuo, Xiaorong Yang, Xiaoyun Yang
Summary: This study aims to analyze and predict the epidemiological burden and trends of inflammatory bowel disease (IBD) in China and compare them globally. The findings show that the incidence and prevalence of IBD in China have increased over the years, leading to an increased burden in terms of years of life lost and years lived with disability, while the mortality rate and burden of disability-adjusted life-years have decreased.
CLINICAL EPIDEMIOLOGY
(2023)
Article
Reproductive Biology
Yana Ma, Jiale Liu, Ning Li, Hualei Bu, Yongwen Huang, Chengjuan Jin, Hao Wen, Shuai Feng, Hui Zhang, Xiaorong Yang, Beihua Kong, Lingying Wu, Kun Song
Summary: There is no significant difference in therapeutic effect between PARPi monotherapy and platinum-based chemotherapy for BRCA1/2-mutated ovarian cancer patients with secondary platinum-sensitive relapse, and PARPi could improve prognosis.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Genetics & Heredity
Shichao Liu, Shoucai Zhang, Yingjie Liu, XiaoRong Yang, Guixi Zheng
Summary: This study identified copper-related lncRNAs (CRLs) as prognostic and diagnostic markers in colon adenocarcinoma and provided guidance for individualized immunotherapy.
