期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 93, 期 -, 页码 213-221出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmbbm.2019.02.007
关键词
Biomechanics; Electrophysiology; H-H model; Cable Theory; Neuron diseases
资金
- National Natural Science Foundation of China [11522219, 11532009, 11602191]
- Projects of International (Regional) Cooperation and Exchanges of NSFC [11761161004]
- Natural Science Basic Research Plan in Shaanxi Province of China [2017JM1026]
- China Postdoctoral Science Foundation [2018M631173]
Neurons are situated in a microenvironment composed of various mechanical cues, where stretching is thought to have a major impact on neurons, resulting in microstructural changes in neural tissue and further leading to abnormal electrophysiological function. In spite of significant experimental efforts, the underlying mechanism remains elusive, more works are needed to provide a detailed description of the process that leads to the observed phenomena. Here, we developed a mechanoelectrical coupling model of central neurons under stretching and specially considered the plastic deformation of neurons. With the model, we showed that the increasing axial strain induces a decreased membrane action potential and a more frequent neuronal firing, which agree well with experimental observations reported in the literature. The simulation results also showed a faster electrophysiological signal conduction. Our model provides a reference for the prediction and regulation of neuronal function under simplified conditions of mechanical loadings.
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