期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 141, 期 19, 页码 7680-7686出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.9b02312
关键词
-
资金
- National Natural Science Foundation [21772125, 21602145]
- Sichuan University
We demonstrate that readily available and bench-stable alpha-oxo-vinylsulfones are competent electrophiles in Ni-catalyzed Suzuki-Miyaura cross-coupling reactions. The C-sulfone bond in the alpha-oxo-vinylsulfone motif is cleaved chemoselectively in these reactions, furnishing C-aryl glycals or acyclic vinyl ethers in high yields. These reactions proceed under mild conditions and tolerate a remarkable scope of heterocycles and functional groups. Preliminary mechanistic studies revealed the importance of an alpha-heteroatom in facilitating these transformations.
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