High‐fat diet intake modulates maternal intestinal adaptations to pregnancy and results in placental hypoxia, as well as altered fetal gut barrier proteins and immune markers

Hypoxia regulates placental angiogenesis via alternatively activated macrophages

(2018) Hui Zhao et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression

(2018) Tovah N. Shaw et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MetaboAnalyst 4.0: towards more transparent and integrative metabolomics analysis

(2018) Jasmine Chong et al.   NUCLEIC ACIDS RESEARCH

Diet induced maternal obesity affects offspring gut microbiota, which persists into young adulthood.

(2018) Yanjie Guo et al.   Food & Function

Maternal omega-3 fatty acids regulate offspring obesity through persistent modulation of gut microbiota

(2018) Ruairi C. Robertson et al.   Microbiome

Distinct composition of gut microbiota during pregnancy in overweight and normal-weight women

(2018) Maria Carmen Collado et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Metagenomic analysis with strain-level resolution reveals fine-scale variation in the human pregnancy microbiome

(2018) Daniela S. Aliaga Goltsman et al.   GENOME RESEARCH

Metabolomics profiling reveals differential adaptation of major energy metabolism pathways associated with autophagy upon oxygen and glucose reduction

(2018) Katja Weckmann et al.   Scientific Reports

The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD

(2018) Taylor K. Soderborg et al.   Nature Communications

Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice

(2018) Umesh D. Wankhade et al.   Scientific Reports

Maternal High Fat Diet Alters Gut Microbiota of Offspring and Exacerbates DSS-Induced Colitis in Adulthood

(2018) Runxiang Xie et al.   Frontiers in Immunology

Effect of Maternal Obesity on Placental Lipid Metabolism

(2017) Virtu Calabuig-Navarro et al.   ENDOCRINOLOGY

The Sweat Metabolome of Screen-Positive Cystic Fibrosis Infants: Revealing Mechanisms beyond Impaired Chloride Transport

(2017) Adriana N. Macedo et al.   ACS Central Science

Exercise rescues obese mothers’ insulin sensitivity, placental hypoxia and male offspring insulin sensitivity

(2017) Denise S. Fernandez-Twinn et al.   Scientific Reports

Robust and High-Throughput Method for Anionic Metabolite Profiling: Preventing Polyimide Aminolysis and Capillary Breakages under Alkaline Conditions in Capillary Electrophoresis-Mass Spectrometry

(2016) Mai Yamamoto et al.   ANALYTICAL CHEMISTRY

The NF-κB family: Key players during embryonic development and HSC emergence

(2016) Raquel Espín-Palazón et al.   EXPERIMENTAL HEMATOLOGY

Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition and gene expression of suckling mouse pups

(2016) Wilma T. Steegenga et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Epithelial-mesenchymal transition during extravillous trophoblast differentiation

(2016) Jessica E. Davies et al.   Cell Adhesion & Migration

The early infant gut microbiome varies in association with a maternal high-fat diet

(2016) Derrick M. Chu et al.   Genome Medicine

Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut

(2016) Audrey Rivière et al.   Frontiers in Microbiology

Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88

(2015) Shuhong Guo et al.   JOURNAL OF IMMUNOLOGY

Principles and standards for reporting animal experiments inThe Journal of PhysiologyandExperimental Physiology

(2015) David Grundy   JOURNAL OF PHYSIOLOGY-LONDON

CD4 + T Cells Are Important Mediators of Oxidative Stress That Cause Hypertension in Response to Placental Ischemia

(2014) Kedra Wallace et al.   HYPERTENSION

Circulating Muramyl Dipeptide Is Negatively Associated with Interleukin-10 in the Frail Elderly

(2014) Chris P. Verschoor et al.   INFLAMMATION

Markers of endothelial cell dysfunction are increased in human omental adipose tissue from women with pre-existing maternal obesity and gestational diabetes

(2014) Martha Lappas   METABOLISM-CLINICAL AND EXPERIMENTAL

Regulation of Autophagy by Cytosolic Acetyl-Coenzyme A

(2014) Guillermo Mariño et al.   MOLECULAR CELL

Maternal obesity is associated with a lipotoxic placental environment

(2014) J. Saben et al.   PLACENTA

Maternal short-chain fatty acids are associated with metabolic parameters in mothers and newborns

(2014) Medha Priyadarshini et al.   Translational Research

High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model

(2014) Jun Ma et al.   Nature Communications

Impact of overweight and obesity on obstetric outcomes

(2014) S. Triunfo et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry: A High-Throughput Platform for Metabolomics with High Data Fidelity

(2013) Naomi L. Kuehnbaum et al.   ANALYTICAL CHEMISTRY

BMPR2 is required for postimplantation uterine function and pregnancy maintenance

(2013) Takashi Nagashima et al.   JOURNAL OF CLINICAL INVESTIGATION

The Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic Treg Cell Homeostasis

(2013) P. M. Smith et al.   SCIENCE

ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness through Activation of the Unfolded Protein Response

(2013) Jarom Heijmans et al.   Cell Reports

Host Remodeling of the Gut Microbiome and Metabolic Changes during Pregnancy

(2012) Omry Koren et al.   CELL

Gut Microbiota Composition and Activity in Relation to Host Metabolic Phenotype and Disease Risk

(2012) Elaine Holmes et al.   Cell Metabolism

Placental weight and efficiency in relation to maternal body mass index and the risk of pregnancy complications in women delivering singleton babies

(2012) J.M. Wallace et al.   PLACENTA

Adverse Fetal and Neonatal Outcomes Associated with a Life-Long High Fat Diet: Role of Altered Development of the Placental Vasculature

(2012) Emily K. Hayes et al.   PLoS One

Carnitine Deficiency in OCTN2−/− Newborn Mice Leads to a Severe Gut and Immune Phenotype with Widespread Atrophy, Apoptosis and a Pro-Inflammatory Response

(2012) Srinivas Sonne et al.   PLoS One

Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium

(2012) M. Good et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host-Gut Microbiota Metabolic Interactions

(2012) J. K. Nicholson et al.   SCIENCE

The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

(2012) Philipp Kimmig et al.   eLife

Occludin regulates macromolecule flux across the intestinal epithelial tight junction barrier

(2011) Rana Al-Sadi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Generation of Multimillion-Sequence 16S rRNA Gene Libraries from Complex Microbial Communities by Assembling Paired-End Illumina Reads

(2011) Andrea K. Bartram et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

Maternal High-Fat Diet Disturbs Uteroplacental Hemodynamics and Increases the Frequency of Stillbirth in a Nonhuman Primate Model of Excess Nutrition

(2011) Antonio E. Frias et al.   ENDOCRINOLOGY

Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation

(2011) Monica Guma et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Occludin: One Protein, Many Forms

(2011) P. M. Cummins   MOLECULAR AND CELLULAR BIOLOGY

Gut microbiota composition is associated with body weight, weight gain and biochemical parameters in pregnant women

(2010) A. Santacruz et al.   BRITISH JOURNAL OF NUTRITION

Hypoxia-Mediated Down-Regulation of OCTN2 and PPARα Expression in Human Placentas and in BeWo Cells

(2010) Ting-Ting Chang et al.   MOLECULAR PHARMACEUTICS

The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection

(2009) Nanda Burger-van Paassen et al.   BIOCHEMICAL JOURNAL

Long-term maternal high-fat feeding from weaning through pregnancy and lactation predisposes offspring to hypertension, raised plasma lipids and fatty liver in mice

(2009) Maqsood M. Elahi et al.   BRITISH JOURNAL OF NUTRITION

Feto-placental Adaptations to Maternal Obesity in the Baboon

(2009) D. Farley et al.   PLACENTA

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Established maternal obesity in the rat reprograms hypothalamic appetite regulators and leptin signaling at birth

(2008) M J Morris et al.   INTERNATIONAL JOURNAL OF OBESITY

Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet

(2008) G. J. Howie et al.   JOURNAL OF PHYSIOLOGY-LONDON

Obesity in Pregnancy Stimulates Macrophage Accumulation and Inflammation in the Placenta

(2008) J.C. Challier et al.   PLACENTA