Article
Chemistry, Multidisciplinary
Tingxizi Liang, Di Wen, Guojun Chen, Amanda Chan, Zhaowei Chen, Hongjun Li, Zejun Wang, Xiao Han, Liping Jiang, Jun-Jie Zhu, Zhen Gu
Summary: The lipid droplets in adipocytes have been demonstrated to be a controllable and biocompatible vehicle for delivering anticancer drugs, enhancing the therapeutic effect of cancer photodynamic therapy through various pathways. Loading a lipid-conjugated photosensitizer into the lipid droplets reduces its IC50 value by 6.0-fold. In vivo results show that engineered lipid droplets effectively inhibit tumor growth with minimal side effects.
ADVANCED MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Puja Ghosh, Himja Tiwari, Jaya Lakkakula, Arpita Roy, Talha Bin Emran, Summya Rashid, Saad Alghamdi, Bodour S. Rajab, Mazen Almehmadi, Mamdouh Allahyani, Abdulelah Aljuaid, Ahad Amer Alsaiari, Rohit Sharma, Ahmad O. Babalghith
Summary: Despite advancements in the biomedical field, clinically approved cancer therapeutics are mostly limited to chemotherapy, surgery, and radiotherapy. There is a growing demand for targeted drug delivery using nanomaterials to mitigate the cardiotoxicity and side effects associated with current treatment strategies. In this review, the use of modified liposomes encapsulating the commonly used drug doxorubicin (DOX) is explored for the treatment of various types of cancer, showing potential for enhanced efficiency and site-specific drug delivery.
MATERIALS TODAY ADVANCES
(2022)
Article
Chemistry, Multidisciplinary
Fei Liu, Dmytro Danylchuk, Bohdan Andreiuk, Andrey S. Klymchenko
Summary: Organelle-specific targeting is crucial for enhancing the effectiveness of drugs and visualizing cellular processes. In this study, a novel concept of dynamic covalent targeting of organelles was proposed, where the molecule is conjugated with its ligand directly inside live cells through a dynamic covalent bond. Experimental results showed that this targeting method enabled fluorescence imaging in live cells and achieved preferential localization of drugs and dyes in specific organelles.
Article
Biochemistry & Molecular Biology
Klaudia Kwiecinska, Anna Stachowicz-Kusnierz, Beata Korchowiec, Maciej Roman, Wojciech M. Kwiatek, Anna Jagusiak, Irena Roterman, Jacek Korchowiec
Summary: The bioavailability of doxorubicin can be significantly enhanced by applying Congo red. Congo red particles act as molecular scissors to cut doxorubicin aggregates and incorporate them into small-sized Congo red clusters, promoting transfer through the membrane.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Fatemeh Abri-Mehraban, Seyed Jalal Zargar, Navvabeh Salarizadeh
Summary: The study investigated the structural changes of Hb induced by DOX in the presence of different concentrations of Glc using spectroscopic techniques. Results showed that the presence of Glc alleviated the hyperchromic effect of DOX on Hb, influenced the intrinsic fluorescence and alpha-helix structure of Hb.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Laszlo Smeller
Summary: Pressure is an important parameter in biology that is often overlooked. This review focuses on the application of high pressure in studying biological systems. It discusses the thermodynamic aspects of pressure, the technical aspects of high pressure production, and the spectroscopic techniques used in high pressure research. The review also explores the effects of pressure on biomolecules such as lipids, proteins, and nucleic acids, and highlights the potential of high pressure bioscience.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Mateusz Kciuk, Adrianna Gielecinska, Somdutt Mujwar, Damian Kolat, Zaneta Kaluzinska-Kolat, Ismail Celik, Renata Kontek
Summary: Doxorubicin (DOX) is a key component in current anti-cancer treatment regimens, but its precise mechanisms of action remain unclear. Recent evidence suggests that DOX exhibits pleiotropic anticancer activity, including DNA damage, reactive oxygen species (ROS) production, apoptosis, senescence, autophagy, ferroptosis, and pyroptosis induction, as well as immunomodulation. This review aims to gather information on the anticancer mechanisms of DOX and its impact on the anti-tumor immune response, providing a rationale for the importance of DOX in modern cancer therapy.
Article
Engineering, Biomedical
Sudipta Mallick, Ramadan Abouomar, David Rivas, Max Sokolich, Fatma Ceren Kirmizitas, Aditya Dutta, Sambeeta Das
Summary: Micro-sized magnetic particles, known as microrobots, have shown potential for biomedical applications such as drug delivery and cell manipulation. This study used microrobots to deliver anticancer drugs to cancer cells, resulting in cell death. The findings confirm the promise of microrobots as precise couriers for targeted delivery of therapeutic biomolecules for cancer therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Applied
Mohamed A. El-Bindary, Mohamed G. El-Desouky, Ashraf A. El-Bindary
Summary: Metal-organic framework (MOF) hybrid materials, specifically Zr-MOF with encapsulated doxorubicin (DOX@Zr-MOF), have shown promising results in pH-responsive drug release and enhanced cytotoxicity against cancer cells. This simple one-pot approach could potentially serve as a multifunctional drug delivery vehicle for various applications, including cancer treatment. Further studies are needed to explore the potential of DOX@Zr-MOF in targeting specific cancer types and antimicrobial activities.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Sijongesonke Peter, Sibusiso Alven, Rejoice Bethusile Maseko, Blessing Atim Aderibigbe
Summary: The scarcity of effective cancer therapeutics is a pressing issue. Doxorubicin, currently used in cancer treatment, is limited by drug resistance and toxicity. Combination with other chemotherapeutic agents is considered an effective treatment option.
Article
Oncology
Yi-Chun Chen, Chang-Jung Chang, Ging-Ho Hsiue, Yi-Ting Chiang
Summary: A stable and pH-responsive mixed micellar system was assembled with degradable copolymers to load the anticancer drug doxorubicin, showing high biosafety and effective drug release behavior in vitro and high tumor accumulation in vivo. This system increased cancer cells' sensitivity to doxorubicin and holds promise for clinical use in cancer therapy.
Review
Chemistry, Physical
Stephanie Andrade, Maria J. Ramalho, Joana A. Loureiro, Maria Carmo Pereira
Summary: Understanding how drugs interact with biological membranes is crucial for the pharmaceutical industry. In vitro lipid-based membrane models provide a simple alternative to study these interactions. Different lipid models and biophysical methodologies using liposomes are discussed for investigating drug-membrane interactions.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Radoslaw Starosta, Telma C. Santos, Andreia F. Dinis F. de Sousa, Maria Soledade Santos, M. Luisa Corvo, Ana Isabel Tomaz, Rodrigo F. M. de Almeida
Summary: This study investigates the possible role of the cell membrane in the mechanism of action of two ruthenium complexes against human tumor cells. The results show that these complexes increase the permeability of lipid vesicles and alter the biophysical properties of the membranes. Moreover, the effects of the complexes depend on changes in membrane lipid composition.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Katarzyna Krancewicz, Karolina Nowicka-Bauer, Katarzyna Fiedorowicz, Bronislaw Marciniak, Katarzyna Taras-Goslinska
Summary: In this study, a group of guanosine analogues containing an additional five-membered ring and a sulfur atom at the C-9 position were synthesized. The spectral, photophysical, and biological properties of the synthesized compounds were investigated. It was found that the combination of the thiocarbonyl chromophore and the tricyclic structure of guanine analogues allows for selective excitation above 350 nm, showing promising potential as anticancer agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Physical
Marjan Ghazimoradi, Aliakbar Tarlani, Abdolali Alemi, Hamed Hamishehkar, Marjan Ghorbani
Summary: In this study, a core/double shells magnetic-luminescent nanomaterial was developed and used as a nanocarrier for simultaneous delivery of methotrexate and doxorubicin as anti-cancer drugs. The nanocarrier demonstrated pH-sensitive controlled drug release and showed excellent biocompatibility. The in vitro cytotoxic studies exhibited significant tumor inhibition against MCF-7 cells compared to free drugs.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Correction
Chemistry, Physical
Li Fu, Shun-Li Chen, Hong-Fei Wang
JOURNAL OF PHYSICAL CHEMISTRY B
(2019)
Article
Nanoscience & Nanotechnology
Ye-Tao Chen, Xinyi Wen, Jiaxing He, Zhanhua Li, Sheng Zhu, Wenbin Chen, Jierong Yu, Yan Guo, Shaofei Ni, Shunli Chen, Li Dang, Ming-De Li
Summary: This study explores the intermolecular interactions of cocrystals in regulating photothermal conversion efficiency, demonstrating that pi-pi stacking and p-pi interactions play crucial roles in enhancing near-infrared light absorption. The findings offer a strategy to boost photothermal conversion efficiency by tuning the interactions between cocrystal materials.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Wenbin Chen, Li Dang, Zicong Situ, Shaofei Ni, Yetao Chen, Sheng Zhu, Hailin Li, Shun-Li Chen, David Lee Phillips, Ming-De Li
Summary: In this study, a system of molecularly tailored 1:1 donor-acceptor (D-A) charge-transfer (CT) cocrystals with ultrabroad absorption characteristics and fast self-assembly behaviors has been reported. One of these cocrystals can achieve high temperature through photothermal conversion and thermal polymerization reaction when irradiated with a low-power near-infrared laser, making it a potential compact, lightweight, and cost-effective near-infrared laser initiator.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Shun-Li Chen, Meng-Meng Zhang, Jiecheng Chen, Xinyi Wen, Wenbin Chen, Jiayu Li, Ye-Tao Chen, Yonghong Xiao, Huifen Liu, Qianqian Tan, Tangjun Zhu, Bowei Ye, Jiajun Yan, Yihang Huang, Jie Li, Shaofei Ni, Li Dang, Ming-De Li
Summary: Inspired by the concept of ionic charge-transfer complexes, integer-CT cocrystals were synthesized for NIR photo-thermal conversion. These cocrystals self-assembled through multiple D-A hydrogen bonds and exhibited strong charge-transfer interactions for efficient light-harvesting. Under 808 nm laser illumination, the cocrystals displayed excellent PTC efficiency. The results suggest that integer-CT cocrystals have potential as rapid, efficient, and scalable PTC platforms.
Article
Chemistry, Physical
Wei Zhang, Dengfeng Luo, Shao-Fei Ni, Shunli Chen, Limei Cha, Ming-De Li, Li Dang
Summary: The combination of inorganic perovskite and graphene oxide has been shown to be an effective method for achieving excellent optical and electrical properties. In this study, CsPbBr3 nanocrystals were loaded onto graphene oxide to form GO-CsPbBr3 nanocomposites. The results revealed that GO could significantly quench the luminescence of CsPbBr3 nanocrystals, potentially due to the fast separation and transfer of photogenerated charge carriers. Additionally, GO could greatly enhance the photocurrent intensity, making it a promising material for photocatalysis.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Chemistry, Physical
Chen Zhou, Guanheng Huang, Yaohui Liang, Bingjia Xu, Amjad Islam, Shunli Chen, Shaofei Ni, Li Dang, Ming-De Li
Summary: In a host-guest system, the space through charge transfer and long-range charge transport between α-cyclodextrin and diphenylacetylene and its derivatives induce ultralong room temperature phosphorescence and thermally activated delayed fluorescence emission. The charge transfer process plays a crucial role in regulating the lifetime and color of afterglow emission. The host-guest complexes, readily fabricated by self-assembly, show potential applications in rewritable ink, anti-counterfeiting, and information encryption due to their multiple color and lifetime as well as the switch property of afterglow emission control.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Biochemistry & Molecular Biology
Baomei Xu, Jianhui Li, Shuai Zhang, Johar Zeb, Shunli Chen, Qunhui Yuan, Wei Gan
Summary: Subtle variations in lipid membrane structure and composition can greatly affect the transport of functional molecules and cell functions. This study compares the permeability of bilayers made of three lipids and reveals that the structural mismatch between saturated and unsaturated alkane chains leads to looser packing in lipid bilayers and better permeability. It also shows that surface curvature in certain vesicles disturbs the bilayer structure. This information provides clues for drug development and other medical and biological studies.
Editorial Material
Chemistry, Multidisciplinary
Shun-Li Chen, Meng-Meng Zhang, Jiecheng Chen, Xinyi Wen, Wenbin Chen, Jiayu Li, Ye-Tao Chen, Yonghong Xiao, Huifen Liu, Qianqian Tan, Tangjun Zhu, Bowei Ye, Jiajun Yan, Yihang Huang, Jie Li, Shaofei Ni, Li Dang, Ming-De Li
Article
Chemistry, Physical
Qibin Huang, Xiaoting Ye, Wenbin Chen, Xinluo Song, Ye-tao Chen, Xinyi Wen, Mengmeng Zhang, Yingxian Wang, Shun-Li Chen, Li Dang, Ming-De Li
Summary: The first instance of photo-thermo-electric conversion based on the donor-acceptor organic cocrystal strategy has been demonstrated, showing excellent solar absorption and high near-infrared photothermal conversion efficiency. Combining organic cocrystals and thermoelectric devices results in exceptional voltage and output power density, offering a promising technology for outdoor portable power generation and remote rural areas.
ACS ENERGY LETTERS
(2023)
Article
Chemistry, Physical
Jiayu Li, Sirui Yang, Ziqi Deng, Shaofei Ni, Shunli Chen, Li Dang, Ming-De Li
Summary: Donor and acceptor compounds based on benzophenone and carbazole have been found to exhibit long afterglow phosphorescence in the solid state. However, the mechanism behind this phenomenon is still unclear. In this study, by designing new compounds and conducting experiments and theoretical calculations, researchers discovered that the excited-state evolution channels can be modified by tuning the substitution positions, which provides new insights for designing efficient luminescent materials.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Yi Hou, Baomei Xu, Shun-li Chen, Wei Gan, Qunhui Yuan, Xi Lin
Summary: This study presents a step forward in understanding the dynamic behavior of charged molecules on the lipid membrane surface using second harmonic generation and molecular dynamic simulation. The orientation flipping and cross-membrane transport of two charged molecules, MG and D289, on the DOPG lipid surface were investigated. The concentration dependent dynamics and the difference in transport rates between the two molecules were analyzed.
Article
Chemistry, Physical
Jianhui Li, Shun-Li Chen, Yi Hou, Qunhui Yuan, Wei Gan
Summary: The study used a surface-sensitive second harmonic generation technique to investigate the formation of micelles/vesicles in solutions of an anti-cancer drug and a surfactant. The results revealed the structural evolution of the aggregated micelles/vesicles and provided new insight into the formation mechanism of vesicles.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Physical
Shan Xue, Shun-Li Chen, Qing Ling, Qunhui Yuan, Wei Gan
Summary: This study demonstrates that the surface redox reaction of Ag nanoparticles in colloids can be investigated using second harmonic generation (SHG) and two-photon luminescence (TPL). The oxidation of silver on AgNPs was found to accelerate upon femtosecond laser excitation, leading to a decrease in SHG and TPL emissions. This work confirms that SHG and TPL are sensitive tools for probing subtle structural changes on the surface of AgNPs.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2021)
Article
Chemistry, Physical
Shan Xue, Xinxin Liu, Shun-Li Chen, Wei Gan, Qunhui Yuan
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2019)
Article
Chemistry, Physical
Shan Xue, Shun-Li Chen, Qunhui Yuan, Wei Gan
Summary: This study demonstrates that using second-harmonic generation and two-photon luminescence can detect active hydrides on the surface of metallic nanoparticles, revealing the origin of the induction time observed on AuNPs.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
