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Oncology
Alja Zottel, Metka Novak, Neja Samec, Bernarda Majc, Sara Colja, Mojca Katrasnik, Milos Vittori, Barbara Hrastar, Ana Rotter, Andrej Porcnik, Tamara Lah Turnsek, Radovan Komel, Barbara Breznik, Ivana Jovcevska
Summary: This study investigated the effect of anti-vimentin nanobody Nb79 on glioblastoma cell invasion. The results showed that vimentin is upregulated in glioblastoma tissue and Nb79 can reduce glioblastoma cell invasion. In addition, Nb79 treatment increases the expression of tight junction protein ZO-1 on the cell membrane.
Article
Pharmacology & Pharmacy
Feng Lv, Qian Du, Lin Li, Xin Xi, Qinglong Liu, Wenjun Li, Songqing Liu
Summary: Eriodictyol (ERD) is a natural flavonoid found in many vegetables and fruits with antioxidative, anti-inflammatory, and neuroprotective effects. Research showed that ERD could suppress the migration and invasion of glioblastoma cells by downregulating EMT markers and inhibiting the P38 MAPK/GSK-313/ZEB1 signaling pathway. This may provide a new approach for glioblastoma treatment.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Tiantian Yin, Jing Wu, Yuchen Hu, Min Zhang, Jie He
Summary: This study revealed that lncRNA HULC stimulates the EMT process and VM in human GBM, suggesting it may be a potential therapeutic target for intervention in GBM.
Article
Oncology
Liang Lyu, Haiyan Li, Kefeng Lu, Shu Jiang, Huihui Li
Summary: This study demonstrates that FRAX486, a potent PAK2 inhibitor, suppresses TNBC metastasis by blocking autophagy. Mechanistically, FRAX486 inhibits autophagy in TNBC cells by targeting PAK2, resulting in the ubiquitination and proteasomal degradation of STX17, which mediates autophagosome-lysosome fusion. Inhibition of autophagy by FRAX486 leads to upregulation of E-cadherin and consequently suppresses TNBC cell migration and metastasis.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Giedrius Steponaitis, Vytautas Kucinskas, Ieva Golubickaite, Kestutis Skauminas, Ausra Saudargiene
Summary: This study aimed to address the issue of classification in glioblastoma research. Two classification models were constructed using different datasets and methods, and their accuracy was validated using RT-qPCR. A glioblastoma classification tool based on a small number of genes was proposed to achieve data comparability between different research groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Lili Liang, Andreas M. Kaufmann
Summary: Cancer stem cells (CSCs) have been identified and characterized in both hematopoietic and solid tumors. They possess unique properties, including slow proliferation, self-renewal, differentiation, and the ability to undergo epithelial-mesenchymal transition (EMT) and its reverse process. CSCs play a crucial role in tumor growth, therapy resistance, and cancer metastasis. Strategies targeting CSCs are being developed for novel anti-metastasis treatments, aiming to improve therapeutic efficiency and prognosis with fewer side effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Maria Patrizia Mongiardi, Mariachiara Buccarelli, Alessia Formato, Elisa Orecchini, Maria Salbini, Valentina Ricci, Tiziana Orsini, Sabrina Putti, Silvia Chiesa, Lucia Ricci-Vitiani, Quintino Giorgio D'Alessandris, Roberto Pallini, Andrea Levi, Maria Laura Falchetti
Summary: Glioblastoma is an aggressive primary brain tumor with poor prognosis. A recent clinical trial showed that the multikinase inhibitor regorafenib can significantly increase the overall survival of glioblastoma patients. However, little is known about the molecular mechanisms of regorafenib's effectiveness. This study found that regorafenib can limit glioblastoma cell proliferation but might also induce an invasive phenotype.
Review
Biochemistry & Molecular Biology
Mateusz Gielata, Kamila Karpinska, Tomasz Pieczonka, Agnieszka Kobielak
Summary: This review highlights the recent discoveries on the involvement of alpha-catulin in diverse biological processes, with a focus on its role in cancer progression. The molecular basis of its actions and control of various signals during morphogenesis and tissue homeostasis, however, remains elusive.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Correction
Biochemistry & Molecular Biology
Haihai Liang, Tong Yu, Yue Han, Hua Jiang, Chengyu Wang, Tianyi You, Xiaoguang Zhao, Huitong Shan, Rui Yang, Lida Yang, Hongli Shan, Yunyan Gu
Summary: A correction to this paper has been published and is accessible through the original article.
Article
Oncology
Qian Cheng, Lianzhi Mao, Hongxiang Huang, Longguang Tang, Hongyan Jiang, Yufei Zhang, Qingchun Mu
Summary: The study found that Hesperetin (HSP) can suppress proliferation, induce apoptosis, and inhibit migration and invasion of glioblastoma cells. These effects may be regulated through the PI3K/AKT and NF-Kappa B pathways. Additionally, HSP can downregulate the expression of matrix metalloproteinases and inhibit epithelial-mesenchymal transition.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Genetics & Heredity
Spandana Kotian, Rachel M. Carnes, Josh L. Stern
Summary: In this study, the introduction of the epithelial transcription factor GRHL2 enhanced the transcriptional reprogramming and apoptotic effects of HDAC inhibitors in glioblastoma (GBM). However, the presence of GRHL2 also caused cell-cycle dysregulation and aneuploidy in glioma stem cells (GSCs). These findings suggest that while genetic strategies to repress the mesenchymal properties of GBM may be effective, the biological interactions of epithelial factors in mesenchymal cancer cells can disrupt normal cellular mechanisms.
Article
Multidisciplinary Sciences
Jinshi Zhang, Wenjin Wei, Qinglin Zhong, Kaiming Feng, Ruijin Yang, Qiuhua Jiang
Summary: This study discovered a significant increase in BUB1 expression in glioma and its correlation with a high World Health Organization grade and poor prognosis in glioma patients. Additionally, BUB1 not only promotes glioma cell proliferation, migration, and infiltration but also triggers epithelial-mesenchymal transition through the activation of the Wnt/beta-catenin axis. Therefore, BUB1 may have the potential to serve as a target for GBM management.
Article
Cell Biology
Senem Noyan, Ayse Andac Ozketen, Hakan Gurdal, Bala Gur Dedeoglu
Summary: MicroRNA miR-770-5p downregulates Vimentin and Snail expression levels by targeting DNMT3A, while increasing or restoring E-cadherin expression, inhibiting EMT phenotypes, motility, and invasion. Overexpression of miR-770-5p resulted in a loss of mesenchymal characteristics and gain of epithelial phenotype, effectively inhibiting invasion potential driven by EMT.
CELLULAR SIGNALLING
(2021)
Article
Pathology
Zhe Cheng, Suwen Li, Jiaqi Yuan, Yongdong Li, Shan Cheng, Shilu Huang, Jun Dong
Summary: In this study, the expression patterns of HDAC1 and its impact on prognosis in glioblastoma (GBM) patients were evaluated based on TCGA and CGGA databases. High expression of HDAC1 was found to be associated with poor prognosis in GBM, and its interaction with the EMT-related protein VIM was explored. Functional enrichment analysis further revealed the enrichment of cancer markers in GBM tissues with high HDAC1 expression. In vitro and in vivo experiments demonstrated that an HDAC1 inhibitor could inhibit the EMT process and affect the invasive ability of GBM cells.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Endocrinology & Metabolism
Yu Zhang, Lei Li, Xin Ma, Chenan Liu, Gemingtian Liu, Zhixu Bie, Zhijun Yang, Pinan Liu
Summary: The study found that SLC2A1 is a potential diagnostic marker for invasive pituitary adenoma and is closely related to EMT. Evaluation: 8 points.
FRONTIERS IN ENDOCRINOLOGY
(2023)
