Article
Biochemical Research Methods
Ann Morgell, Julie A. Reisz, Zeeshan Ateeb, Haleh Davanian, Susanne E. Reinsbach, Asif Halimi, Rogier Gaiser, Roberto Valente, Urban Arnelo, Marco Del Chiaro, Margaret Sallberg Chen, Angelo D'Alessandro
Summary: Pancreatic cancer is the seventh leading cause of cancer-related death worldwide, with a low 5-year survival rate. Lack of reliable tools for early diagnosis complicates its management. Research has identified novel metabolic markers that can help determine the progression of pancreatic cysts and pancreatic cancer. These findings suggest a potential role of bacterial infections in the development and severity of pancreatic cancer, similar to other cancers like Helicobacter pylori and gastric cancer.
JOURNAL OF PROTEOME RESEARCH
(2021)
Review
Oncology
Kylie E. Shockley, Briana To, Wei Chen, Gerard Lozanski, Zobeida Cruz-Monserrate, Somashekar G. Krishna
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are benign pancreatic cysts with the potential to become pancreatic cancer. Identifying high-risk IPMNs and potential biomarkers can help prevent unnecessary surgery. This review summarizes the changes within IPMNs that promote their progression to pancreatic adenocarcinoma and highlights potential biomarkers for identifying high-risk IPMNs.
Article
Oncology
Masahiro Tsujimae, Atsuhiro Masuda, Takuya Ikegawa, Takeshi Tanaka, Jun Inoue, Hirochika Toyama, Keitaro Sofue, Hisahiro Uemura, Shinya Kohashi, Noriko Inomata, Kae Nagao, Shigeto Masuda, Shohei Abe, Masanori Gonda, Kohei Yamakawa, Shigeto Ashina, Yasutaka Yamada, Shunta Tanaka, Ryota Nakano, Arata Sakai, Takashi Kobayashi, Hideyuki Shiomi, Maki Kanzawa, Tomoo Itoh, Takumi Fukumoto, Yoshihide Ueda, Yuzo Kodama
Summary: This study found that PDAC concomitant with IPMN has tumor characteristics similar to those of conventional PDAC in terms of major driver gene alterations, tumor microenvironment, and prognosis.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Carl-Stephan Leonhardt, Ulf Hinz, Jorg Kaiser, Thomas Hank, Christine Tjaden, Frank Bergmann, Thilo Hackert, Markus W. Buechler, Oliver Strobel
Summary: The impact of IPMN dysplasia at the pancreatic transection margin on the prognosis of IPMN-associated carcinoma (IPMN-Ca) is unclear, leading to varying institutional practices on additional resections. However, low-grade IPMN at the transection margin is not associated with shorter overall survival after partial pancreatectomy for IPMN-Ca. Therefore, additional resections for low-grade dysplasia, up to total pancreatectomy, do not result in a survival benefit and should be omitted.
Article
Gastroenterology & Hepatology
Marcus Holmberg, Stefan Linder, Maximilian Kordes, Maria Liljefors, Poya Ghorbani, J-Matthias Lohr, Ernesto Sparrelid
Summary: This study investigates the recurrence pattern and impact of adjuvant chemotherapy on overall survival for inv-IPMN compared with PDAC. The results show that resected inv-IPMN has a less aggressive recurrence pattern and a more favorable overall survival compared to PDAC. The effect of adjuvant chemotherapy is similar in the two groups.
Review
Gastroenterology & Hepatology
Michael Johannes Pflueger, Kevin Tony Jamouss, Elham Afghani, Su Jin Lim, Salvador Rodriguez Franco, Harrison Mayo, Marcus Spann, Hao Wang, Aatur Singhi, Anne Marie Lennon, Laura D. Wood
Summary: Analysis of cyst fluid biomarkers showed that mutations in KRAS and/or GNAS can efficiently identify mucinous cysts, while mutations in VHL are specific for serous cystadenomas. DNA-based cyst fluid biomarkers are crucial for accurately distinguishing pancreatic cyst types.
Review
Medicine, General & Internal
Ronald C. Turner, Jared T. Melnychuk, Wei Chen, Daniel Jones, Somashekar G. Krishna
Summary: Early detection and diagnosis of precursor lesions for pancreatic malignancy is crucial. Current diagnostic tools for cystic precursor lesions, such as CEA levels and cytology, have limitations. Molecular analysis of cystic fluid can improve the diagnosis and risk stratification of pancreatic malignancy precursor lesions.
Article
Gastroenterology & Hepatology
Asif Halimi, Giorgio Gabarrini, Michal Jacek Sobkowiak, Zeeshan Ateeb, Haleh Davanian, Rogier Aaron Gaiser, Urban Arnelo, Roberto Valente, Alicia Y. W. Wong, Carlos Fernandez Moro, Marco Del Chiaro, Volkan Ozenci, Margaret Sallberg Chen
Summary: The study reveals a potential link between pancreatic cystic lesions and cancer, with cultivated bacteria demonstrating pathogenic properties such as intracellular survival capability, cell death induction, and causing DNA double-strand breaks in surviving cells.
Article
Surgery
Yoshinori Takeda, Hiroshi Imamura, Jiro Yoshimoto, Yuki Fukumura, Ryuji Yoshioka, Yoshihiro Mise, Seiji Kawasaki, Akio Saiura
Summary: The study highlights the clinical entity of T1a invasive intraductal papillary mucinous carcinoma specifically observed in patients with intraductal papillary mucinous carcinoma, associated with excellent postoperative survival outcomes. The survival advantage of invasive intraductal papillary mucinous carcinoma over pancreatic ductal adenocarcinoma is attributed to intrinsic indolent biological behavior, especially in patients without lymphatic invasion or lymph node metastasis.
Article
Surgery
Brett L. Ecker, Shannan M. Dickinson, Lily V. Saadat, Alice J. Tao, Alessandra Pulvirenti, Vinod P. Balachandran, Michael I. D'Angelica, Jeffrey A. Drebin, T. P. Kingham, William R. Jarnagin, Alice C. Wei, Mithat Gonen, Kevin C. Soares
Summary: This study aimed to determine if the morphologic features of the main pancreatic duct (MPD) have implications for the risk of malignancy and extent of resection in main-duct-involved-intraductal papillary mucinous neoplasm (IPMN) patients. The results showed that for most patients with segmental main-duct-involved-IPMN, the MPD morphology conferred malignancy risk. However, duct morphology was not predictive for the development of HGD/PDAC in the pancreatic remnant.
Review
Oncology
Joanna Jiang, Wei-Lun Chao, Stacey Culp, Somashekar G. Krishna
Summary: Pancreatic cancer is projected to become the second leading cause of cancer-related mortality. Artificial intelligence is being used to improve the screening and prognostication of precancerous lesions in the pancreas. This review summarizes the current literature on the application of AI in the diagnosis and management of premalignant lesions that may progress to pancreatic cancer.
Review
Medicine, General & Internal
Elit Quingalahua, Mahmoud M. Al-Hawary, Jorge D. Machicado
Summary: Pancreatic cystic lesions (PCLs) are commonly found incidental findings on cross-sectional imaging. Magnetic resonance imaging (MRI) has become the preferred non-invasive method for predicting cyst type, stratifying risk of neoplasia, and monitoring changes in PCLs. In some cases, additional diagnostic approaches such as endoscopic ultrasound (EUS) and molecular analysis may be necessary for treatment decisions. The use of radiomics and artificial intelligence in MRI could enhance the stratification of PCLs and improve treatment guidance.
Article
Gastroenterology & Hepatology
Francesca Gavazzi, Giovanni Capretti, Laura Giordano, Cristina Ridolfi, Paola Spaggiari, Mauro Sollai, Silvia Carrara, Gennaro Nappo, Silvia Bozzarelli, Alessandro Zerbi
Summary: Invasive intraductal papillary mucinous neoplasm (IPMN) has better overall survival and prognosis compared to pancreatic ductal adenocarcinoma (PDAC).
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Medicine, General & Internal
Yohei Shirakami, Takuji Iwashita, Shinya Uemura, Hisashi Imai, Katsutoshi Murase, Masahito Shimizu
Summary: This study investigated the use of miRNA in pancreatic cyst fluid as a marker for evaluating malignant alternation of IPMN. Six miRNAs were found to be significantly enriched in IPMC compared to IPMA. Further evaluation with larger cohorts is needed to confirm the efficacy of cyst fluid miRNA analysis for diagnosing malignant alteration of IPMN.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Sarah Borsekofsky, Shlomo Tsuriel, Rami R. Hagege, Dov Hershkovitz
Summary: The study aimed to develop a PNI detection algorithm to improve accuracy and efficiency in identifying PNI in PDAC specimens. The algorithm accurately identifies PNI in PDAC by imitating pathologist thought processes, even with a small training cohort.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Kristin Stendahl, Syed M. Gilani, Olca Basturk, Pei Hui, Carlie Sigel, Guoping Cai
Summary: Our study analyzed cytomorphologic and molecular features of intraductal papillary neoplasm of the bile duct (IPNB) cases. The cytomorphologic features of IPNB included papillary/complex papillary architecture, columnar cells with vacuolated cytoplasm, enlarged nuclei, and fine granular chromatin. Most cases had adenocarcinoma or high-grade dysplasia, and KRAS mutations were found in a significant number of cases, which may have diagnostic and therapeutic implications.
CANCER CYTOPATHOLOGY
(2023)
Article
Pathology
Claudio Luchini, Paola Mattiolo, Olca Basturk, Andrea Mafficini, Kerem Ozcan, Rita T. Lawlor, Seung-Mo Hong, Lodewijk A. Brosens, Giovanni Marchegiani, Antonio Pea, Erminia Manfrin, Giuseppe Sciacca, Federica Zampieri, Rita Polati, Riccardo De Robertis, Michele Milella, Mirko D'Onofrio, Giuseppe Malleo, Roberto Salvia, Volkan Adsay, Aldo Scarpa
Summary: Acinar cystic transformation (ACT) of the pancreas is a poorly understood and rare entity among pancreatic cystic lesions. This study aims to clarify its real nature by describing the clinicopathological features and molecular profile of a cohort of 25 patients with pancreatic ACT. The findings suggest that ACT is a benign entity potentially arising from diverse conditions/backgrounds, but the presence of driver mutations raises the possibility of long-term surveillance for these patients.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2023)
Editorial Material
Surgery
Jamie S. Pak, Wei Phin Tan
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2023)
Editorial Material
Urology & Nephrology
Wei Phin Tan, James S. Wysock, Herbert Lepor
Summary: The treatment landscape for localized prostate cancer is rapidly evolving to achieve disease control and preserve the function of the gastrointestinal and genitourinary systems. Focal cryoablation therapy for prostate cancer has shown promising results in terms of both oncological and functional outcomes based on short-term and intermediate-term clinical data.
NATURE REVIEWS UROLOGY
(2023)
Editorial Material
Urology & Nephrology
Wei Phin Tan
Article
Multidisciplinary Sciences
Luis A. Rojas, Zachary Sethna, Kevin C. Soares, Cristina Olcese, Nan Pang, Erin Patterson, Jayon Lihm, Nicholas Ceglia, Pablo Guasp, Alexander Chu, Rebecca Yu, Adrienne Kaya Chandra, Theresa Waters, Jennifer Ruan, Masataka Amisaki, Abderezak Zebboudj, Zagaa Odgerel, George Payne, Evelyna Derhovanessian, Felicitas Mueller, Ina Rhee, Mahesh Yadav, Anton Dobrin, Michel Sadelain, Marta Luksza, Noah Cohen, Laura Tang, Olca Basturk, Mithat Goenen, Seth Katz, Richard Kinh Do, Andrew S. Epstein, Parisa Momtaz, Wungki Park, Ryan Sugarman, Anna M. Varghese, Elizabeth Won, Avni Desai, Alice C. Wei, Michael I. D'Angelica, T. Peter Kingham, Ira Mellman, Taha Merghoub, Jedd D. Wolchok, Ugur Sahin, Oezlem Tuereci, Benjamin D. Greenbaum, William R. Jarnagin, Jeffrey Drebin, Eileen M. O'Reilly, Vinod P. Balachandran
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease with a high mortality rate, but it can be targeted using mutation-derived T cell neoantigens as vaccines. In this phase I trial, researchers synthesized individualized mRNA neoantigen vaccines from PDAC tumors and administered them to patients along with atezolizumab, autogene cevumeran, and mFOLFIRINOX chemotherapy. The results showed that the autogene cevumeran vaccine induced neoantigen-specific T cells in patients, and those with vaccine-expanded T cells had a longer recurrence-free survival.
Editorial Material
Urology & Nephrology
Wei Phin Tan
Article
Oncology
Zhi Ven Fong, Jonathan Teinor, Theresa P. Yeo, Dee Rinaldi, Jonathan B. Greer, Harish Lavu, Motaz Qadan, Fabian M. Johnston, Cristina R. Ferrone, David C. Chang, Charles J. Yeo, Christopher L. Wolfgang, Andrew L. Warshaw, Keith D. Lillemoe, Carlos Fernandez-del Castillo, Jennifer L. Wolff, Albert W. Wu, Matthew J. Weiss
Summary: People with pancreatic and periampullary cancers often rely on family and unpaid caregivers for assistance after surgery, but little is known about the nature and difficulty of the assistance they provide. This study aimed to assess the frequency and difficulty of specific assistance caregivers provide and identify potential interventions to alleviate their caregiving demands.
JCO ONCOLOGY PRACTICE
(2023)
Review
Gastroenterology & Hepatology
Zhi Ven Fong, Yasmin G. G. Hernandez-Barco, Carlos Fernandez-del Castillo
Summary: Intraductal papillary mucinous neoplasms (IPMNs) are commonly diagnosed and range from benign to malignant lesions. Current prediction of high-grade dysplasia and invasive cancer relies on clinical and radiographic features to guide treatment decisions. However, the natural history of IPMNs is not completely understood and guidelines from different societies provide conflicting recommendations, making it challenging to balance the risk of missing cancer with surveillance and surgical resection morbidity. This review aims to reconcile guideline differences, provide a clinical framework for IPMN management, and highlight advances to minimize missed cancers and unnecessary operations.
JOURNAL OF GASTROINTESTINAL SURGERY
(2023)
Review
Gastroenterology & Hepatology
Laura D. Wood, N. Volkan Adsay, Olca Basturk, Lodewijk A. A. Brosens, Noriyoshi Fukushima, Seung-Mo Hong, Sung-Joo Kim, Jae W. Lee, Claudio Luchini, Michael Noe, Martha B. Pitman, Aldo Scarpa, Aatur D. Singhi, Mariko Tanaka, Toru Furukawa
Summary: This review presents updated perspectives on key issues in the examination of pathological specimens in patients with intraductal papillary mucinous neoplasms (IPMN), providing a foundation for data-driven approaches.
Meeting Abstract
Medicine, Research & Experimental
Kerem Ozcan, Hulya Sahin Ozkan, Pietro Antonini, Claudio Luchini, Burcu Saka, Yue Xue, Michelle Reid, Aldo Scarpa, N. Volkan Adsay, Olca Basturk
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Kerem Ozcan, Hulya Sahin Ozkan, Laura Tang, Bahar Memis, Grace Kim, Sui Zee, Guoli Chen, Zhaohai Yang, David Klimstra, N. Volkan Adsay, Olca Basturk
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Hulya Sahin Ozkan, Kerem Ozcan, Bahar Memis, Burcin Pehlivanoglu, Gokce Askan, Pelin Bagci, N. Volkan Adsay, David Klimstra, Olca Basturk
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Zeynep Tarcan, Rohat Esmer, Kadriye Akar, Pelin Bagci, Emine Bozkurtlar, Burcu Saka, Ayse Armutlu, Hulya Sahin Ozkan, Kerem Ozcan, Orhun Taskin, Yersu Kapran, Makbule Aydin Mericoz, Serdar Balci, Serpil Yilmaz, Duygu Cengiz, Bengi Gurses, Emrah Alper, Gurkan Tellioglu, Emre Bozkurt, Orhan Bilge, Olca Basturk, N. Volkan Adsay
LABORATORY INVESTIGATION
(2023)
Meeting Abstract
Medicine, Research & Experimental
Nuray Tezcan, Duygu Cengiz, Rohat Esmer, Berk Kaan Aktas, Ayse Armutlu, Burcu Saka, Ozgur Kurt, Orhun Taskin, Yersu Kapran, Hatice Goksu Kayim, Afak Durur Karakaya, Emre Bozkurt, Gurkan Tellioglu, Orhan Bilge, Emrah Alper, Olca Basturk, Bengi Gurses, N. Volkan Adsay
LABORATORY INVESTIGATION
(2023)