Article
Clinical Neurology
Simone Braca, Angelo Miele, Antonio Stornaiuolo, Gennaro Cretella, Roberto De Simone, Cinzia Valeria Russo
Summary: Anti-CGRP monoclonal antibodies are highly effective in preventing migraine with aura, leading to significant reduction in mean monthly aura days and mean monthly headache days, without causing adverse events.
NEUROLOGICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Aqfan Jamaluddin, Chia-Lin Chuang, Elyse T. Williams, Andrew Siow, Sung Hyun Yang, Paul W. R. Harris, Jakeb S. S. M. Petersen, Rebekah L. Bower, Shanan Chand, Margaret A. Brimble, Christopher S. Walker, Debbie L. Hay, Kerry M. Loomes
Summary: This study explores the feasibility of developing lipidated CGRP peptide antagonists and demonstrates that selected lipidated peptide antagonists can retain potent antagonist activity at the CGRP receptor and inhibit endogenous CGRP action in vivo.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Tessa de Vries, Deirdre M. Boucherie, Antoon van den Bogaerdt, A. H. Jan Danser, Antoinette Maassen VanDenBrink
Summary: This study investigated the effect of the CGRP receptor antagonist zavegepant on CGRP-induced relaxation in human coronary arteries and compared its potency with other drugs. Zavegepant showed similar potency in coronary arteries and no difference in potency between coronary arteries and middle meningeal arteries was observed.
Article
Clinical Neurology
Stefan Evers, Dagny Holle-Lee, Christoph J. Schankin, Pia Kull, Bianca Raffaelli
Summary: Visual snow syndrome is not related to calcitonin gene related peptide and its receptor, and the antibody treatment is ineffective for this syndrome.
Article
Pharmacology & Pharmacy
Chia Lin Chang, Zheqing Cai, Sheau Yu Teddy Hsu
Summary: The chimeric adrenomedullin/adrenomedullin 2 peptide ADE651 and its analogs could potentially be promising candidates for targeting headaches in migraine patients, as they form gels that allow direct and sustained access to target cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Clinical Neurology
Byung-Kun Kim, Soohyun Cho, Ha Yan Kim, Min Kyung Chu
Summary: The study investigated the validity and reliability of the self-administered Visual Aura Rating Scale (VARS) questionnaire in screening visual aura in patients with migraine. The conclusion demonstrated that the questionnaire is a valid and reliable instrument for this purpose.
Article
Clinical Neurology
Claudia Altamura, Giovanna Viticchi, Adriana Fallacara, Carmelina Maria Costa, Nicoletta Brunelli, Chiara Fiori, Mauro Silvestrini, Fabrizio Vernieri
Summary: The study found that erenumab preserves cerebral vasomotor reactivity and flow-mediated dilation in migraineurs without aura, with no significant differences compared to the control group. There was no significant correlation between responder status, treatment time, chronic conditions, and these variables.
Article
Oncology
Tian Fang, Zhihao Zhang, Huijie Zhou, Wanchun Wu, Fuqing Ji, Liqun Zou
Summary: This study used Mendelian randomization analysis to assess the association between migraine and breast cancer risk. The results suggested that migraines, particularly those without aura, may increase the risk of overall breast cancer and estrogen receptor-negative breast cancer.
Article
Biochemistry & Molecular Biology
Mamoru Shibata, Satoshi Kitagawa, Miyuki Unekawa, Tsubasa Takizawa, Jin Nakahara
Summary: Migraine is a debilitating neurovascular disorder characterized by recurrent headache attacks. Calcitonin gene-related peptide (CGRP) plays a crucial role in migraine pathogenesis. In a CSD-based mouse migraine model, CSD did not significantly change the density of CGRP mRNA-synthesizing neurons in the trigeminal ganglion (TG), but it did cause an increase in cell sizes of CGRP mRNA-synthesizing TG neurons. The findings suggest that the increase in cell size may contribute to increased disease activity and reduced responsiveness to CGRP-based therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Iris E. Verhagen, Simone de Vries Lentsch, Britt W. H. van Der Arend, Saskia le Cessie, Antoinette MaassenVanDenBrink, Gisela M. Terwindt
Summary: This study compared the treatment effect on perimenstrual and nonperimenstrual migraine days and found that anti-CGRP antibodies have a similar reduction effect on both types of migraine days.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Mira P. Fitzek, Elisabeth Storch, Lucas H. Overeem, Pia Kull, Maria Terhart, Kristin S. Lange, Uwe Reuter, Bianca Raffaelli
Summary: Hormonal contraception (HC) should be considered in the management of women with migraine. A survey in Germany revealed that gynecologists take into account the presence of migraine and limiting factors when prescribing combined oral contraception (COC), while they seem to be less concerned with migraine when prescribing progestogen monotherapy (PM).
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Lars Edvinsson
Summary: Migraine is a common neurovascular disorder, affecting over 15% of the global population. Women are three times more likely to suffer from migraine compared to men. The underlying mechanisms of migraine are still largely unknown, but molecules such as CGRP play a crucial role in its pathophysiology.
JOURNAL OF INTERNAL MEDICINE
(2022)
Review
Clinical Neurology
Crystal J. J. Jicha, Ashley Alex, Steven Herskovitz, Sheryl R. R. Haut, Richard Lipton
Summary: This study demonstrates that a known CACNA1A variant is associated with a phenotype of prolonged aphasic aura without hemiparesis. The findings expand the phenotypic spectrum of the CACNA1A mutation and FHM to include this specific phenotype.
Review
Pediatrics
Hannah F. J. Shapiro, Alyssa Lebel
Summary: Migraine headache is a common cause of pain and disability in children and adolescents, with approximately one-third having migraine with aura. Despite MA being considered similar to MO, treatment recommendations are usually analogous, with a few notable exceptions.
Review
Clinical Neurology
Monica E. Maher, William Kingston
Summary: This review summarizes the literature and case reports on retinal migraine over the past 15 years, finding it to be a rare and predominantly female migraine variant possibly related to retinal vessel constriction. Diagnosis of retinal migraine should be exclusionary, and patients with this condition seem to respond well to typical migraine treatments.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Neurosciences
Rami Burstein, Rodrigo Noseda, David Borsook
JOURNAL OF NEUROSCIENCE
(2015)
Article
Neurosciences
Duncan J. Hodkinson, Sophie L. Wilcox, Rosanna Veggeberg, Rodrigo Noseda, Rami Burstein, David Borsook, Lino Becerra
JOURNAL OF NEUROSCIENCE
(2016)
Article
Neurosciences
Agustin Melo-Carrillo, Andrew M. Strassman, Rony-Reuven Nir, Aaron J. Schain, Rodrigo Noseda, Jennifer Stratton, Rami Burstein
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Agustin Melo-Carrillo, Rodrigo Noseda, Rony Nir, Aaron J. Schain, Jennifer Stratton, Andrew M. Strassman, Rami Burstein
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Aaron J. Schain, Agustin Melo-Carrillo, Andrew M. Strassman, Rami Burstein
JOURNAL OF NEUROSCIENCE
(2017)
Article
Neurosciences
Rodrigo Noseda, Agustin Melo-Carrillo, Rony-Reuven Nir, Andrew M. Strassman, Rami Burstein
JOURNAL OF NEUROSCIENCE
(2019)
Article
Neurosciences
Agustin Melo-Carrillo, Aaron J. Schain, Andrew M. Strassman, Rami Burstein
JOURNAL OF NEUROSCIENCE
(2020)
Article
Clinical Neurology
Lisa Gfrerer, L. Wenjie Xu, William Austen, W. Sait Ashina, Agustin Melo-Carrillo, Maria Serena Longhi, Aubrey Manack Adams, Timothy Houle, Mitchell F. Brin, Rami Burstein
Summary: The study investigated the anti-inflammatory effects of onabotulinumtoxinA in occipital headache, finding significant anti-inflammatory effects in the periosteum of historical responders but not in muscles and fascia, suggesting the reduction in immune cells may play a role in migraine prevention through localized interaction.
Article
Clinical Neurology
Sait Ashina, Lars Bendtsen, Rami Burstein, Afrim Iljazi, Rigmor Hoejland Jensen, Richard B. Lipton
Summary: This study investigated whether coexistent self-reported neck pain influences pain sensitivity in individuals with migraine and tension-type headache. The results showed that individuals with chronic headache had higher pericranial tenderness than controls, and this difference was more significant in individuals with neck pain. Coexistent neck pain was associated with greater pericranial tenderness in individuals with chronic headache and to a lesser degree in those with episodic headache.
SCANDINAVIAN JOURNAL OF PAIN
(2023)
Article
Neurosciences
Duncan J. Hodkinson, Rosanna Veggeberg, Aaron Kucyi, Koene R. A. van Dijk, Sophie L. Wilcox, Steven J. Scrivani, Rami Burstein, Lino Becerra, David Borsook