期刊
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
卷 19, 期 5, 页码 3031-3034出版社
AMER SCIENTIFIC PUBLISHERS
DOI: 10.1166/jnn.2019.15876
关键词
Glibenclamide; Nanoparticles; Solubility; Carboxymethyl Dextran Sodium Salt; Dynamic Light Scattering; Infrared Spectroscopy; Scanning Electron Microscopy
类别
资金
- Ministry of Education, Youth and Sports of the Czech Republic from the National Programme of Sustainability (NPU II) project IT4Innovations Excellence in Science [LQ1602]
- VEGA [1/0298/16]
- Slovak Research and Development Agency [APVV-0516-12]
- CEBV project [ITMS 26240120034]
Glibenclamide, a drug used for the treatment of type 2 diabetes, belongs to Class II of Biopharmaceutical Classification System. It is a highly permeable, but poorly water-soluble drug. Nanoparticles of glibenclamide were prepared by an emulsion solvent evaporation method using dichloromethane as a solvent of glibenclamide and 3% (w/w) aqueous solution of carboxymethyl dextran sodium salt as a stabilizer, which was found as optimal. A solubility test comparing the water solubility of glibenclamide bulk and nanoparticles confirmed the improved (2-fold higher) solubility of glibenclamide nanoparticles (0.045 mu g/ml) compared with bulk (0.024 mu g/ml).
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