Review
Pharmacology & Pharmacy
Haosheng Shen, Nikhil Aggarwal, Kwok Soon Wun, Yung Seng Lee, In Young Hwang, Matthew Wook Chang
Summary: This review highlights the use of engineered bacteria or bacteria-derived particles for targeted delivery of therapeutic agents. Complex genetic modifications in live bacteria and bacteria-derived particles simulate lipid-based vectors and enable the delivery of therapeutic molecules. The potential translation of these drug delivery systems into clinical therapies is discussed.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Review
Pharmacology & Pharmacy
Tong Gong, Jinhui Wu
Summary: This review discusses synthetic engineering methods for bacterial modifications and how these methods enhance the abilities of bacteria in cancer therapy. However, more research on safety concerns is needed to fulfill the potential of bacteriotherapy and move into clinical trials.
EXPERT OPINION ON DRUG DELIVERY
(2023)
Article
Multidisciplinary Sciences
Robert J. Nims, Lara Pferdehirt, Noelani B. Ho, Alireza Savadipour, Jeremiah Lorentz, Sima Sohi, Jordan Kassab, Alison K. Ross, Christopher J. O'Conor, Wolfgang B. Liedtke, Bo Zhang, Amy L. McNulty, Farshid Guilak
Summary: This study presents a novel approach using synthetic biology and tissue engineering to develop a mechanically responsive bioartificial tissue that produces therapeutic biologic drug in response to mechanical loading. By deconstructing signaling networks induced by TRPV4 activation, synthetic TRPV4-responsive genetic circuits were created in chondrocytes to produce anti-inflammatory drug in response to mechanical loading, protecting tissues from inflammatory degradation.
Article
Multidisciplinary Sciences
Shengwei Fu, Rongrong Zhang, Yanmei Gao, Jiarui Xiong, Ye Li, Lu Pu, Aiguo Xia, Fan Jin
Summary: Programming intratumoral bacterial lifestyle transitions allows precise control of multiple key steps throughout the bacteria-mediated cancer therapy process and therapeutic efficacy can be greatly improved by controlling the localization and dosage of therapeutic agents via optimizing the illumination scheme.
NATIONAL SCIENCE REVIEW
(2023)
Review
Biotechnology & Applied Microbiology
Mairead K. Heavey, Deniz Durmusoglu, Nathan Crook, Aaron C. Anselmo
Summary: In this article, the authors discuss the emerging class of therapeutics called live biotherapeutic products (LBPs) which involve genetically engineered microbes. They describe the discovery and delivery strategies of LBPs using omics-based methods and highlight the challenges these therapeutics face in the gut microenvironment. The authors also propose an integrated approach to tailor and optimize LBP efficacy.
TRENDS IN BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Kangsan Kim, Minjeong Kang, Byung-Kwan Cho
Summary: In recent years, there has been increasing interest in gut commensal engineering for therapeutic applications. Recent advancements in synthetic biology and systems biology have enabled effective utilization of gut commensals for therapy and diagnosis, including the rational design of synthetic microbial consortia and the construction of synthetic cells that can detect specific signals in the intestine and deliver therapeutic drugs in real-time.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Engineering, Biomedical
Yu Chen, Xiaoqing Liu, Yanxia Guo, Jianchuan Wang, Dingxiao Zhang, Yang Mei, Junfeng Shi, Wenzhi Tan, Jin Hai Zheng
Summary: Drug delivery systems based on genetically engineered oncolytic bacteria have unique properties that enable them to target tumor tissues and suppress tumor growth effectively, showing potential value for clinical applications. By integrating oncolytic bacteria into cancer therapies, novel strategies are being developed to improve and standardize current treatment regimens in the near future.
ACTA BIOMATERIALIA
(2021)
Review
Pharmacology & Pharmacy
Yong Liu, Wenqin Yu, Qian Wang, Zhenping Cao, Juanjuan Li
Summary: Therapeutics based on living organisms provide a roadmap for next-generation biomedicine, and bacteria play a crucial role in the development, regulation, and treatment of gastrointestinal disease and cancer through similar mechanisms. However, primitive bacteria lack stability to overcome complex drug delivery barriers and their multifunctionality is limited. Artificially engineered bacteria (ArtBac) with modified surfaces and genetic functions show promise in addressing these issues.
DRUG DISCOVERY TODAY
(2023)
Review
Biotechnology & Applied Microbiology
Jack W. Rutter, Linda Dekker, Kimberley A. Owen, Chris P. Barnes
Summary: The human microbiota is associated with many diseases, and microbiome engineering methods aim to modify the composition and function of the microbiota for therapeutic purposes. Clinical studies on engineered microorganisms have shown promising progress in recent years.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Chemistry, Multidisciplinary
Qiwen Wang, Zhehui Hu, Zhixuan Li, Tiangang Liu, Guangkai Bian
Summary: Engineered living materials (ELMs) represent a significant paradigm shift in material design, possessing unique living attributes and unprecedented potential in various fields. This review provides an overview of the latest research progress and design strategies for ELMs derived from bacteria, fungi, and plants, and offers valuable references for future ELM design and application. The investigation into synergistic application possibilities among different species of ELMs provides beneficial information for researchers and practitioners in this field.
ADVANCED MATERIALS
(2023)
Review
Biochemistry & Molecular Biology
Natallia V. Dubashynskaya, Anton N. Bokatyi, Yury A. Skorik
Summary: Dexamethasone, a commonly prescribed glucocorticoid, shows a wide spectrum of pharmacological activity. Conjugating it to polymeric carriers helps reduce side effects on non-target organs and achieve controlled release in various target organs, making it potentially effective for anti-tumor therapy.
Review
Chemistry, Physical
Yue Zhang, Yingjie Yu, Yannan Yang, Yue Wang, Chengzhong Yu
Summary: This review discusses the latest developments in designing SiNPs for nucleic acid delivery. The tailored design of SiNPs offers comprehensive functionalities for various nucleic acid applications. Insights for designing innovative delivery nanoplatforms are provided, which have the potential to revolutionize nucleic acid-based therapeutics.
Article
Chemistry, Multidisciplinary
Yixin Wang, Zhaoting Li, Fanyi Mo, Zhen Gu, Quanyin Hu
Summary: Platelets play crucial roles in blood circulation by mainly responsible for hemostasis, and are also involved in various physiological activities. By engineering platelets, they can be utilized as drug delivery carriers to enhance tumor immunotherapy.
Review
Oncology
Eric M. Bressler, Sarah Adams, Rong Liu, Yolonda L. Colson, Wilson W. Wong, Mark W. Grinstaff
Summary: The intersection of synthetic biology and biomaterials holds great promise for improving safety and efficacy in novel therapeutics. Recent research has shown that the use of Boolean logic in these fields can lead to the development of new and effective living therapeutics, such as stimuli-responsive drug delivery devices and logic-gated CAR T cells. Collaborations between synthetic biology and biomaterials have resulted in advancements in drug delivery and cell therapy, with potential benefits including enhanced safety and efficacy.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Engineering, Biomedical
Biaggio Uricoli, Lacey A. Birnbaum, Priscilla Do, James M. Kelvin, Juhi Jain, Emma Costanza, Andrew Chyong, Christopher C. Porter, Sarwish Rafiq, Erik C. Dreaden
Summary: Cytokine signaling plays a crucial role in biological processes such as cell development, tissue repair, and immunity, and can also be utilized as immunotherapies. However, challenges such as poor circulation limit their therapeutic potential. Recent advancements in engineering cytokines have focused on strategies across different size scales to enhance their effectiveness in treating diseases like cancer and autoimmune disorders.
ADVANCED HEALTHCARE MATERIALS
(2021)
