Article
Biology
Rabih Roufayel, Khaled Younes, Ahmed Al-Sabi, Nimer Murshid
Summary: Apoptosis is a crucial pathway for maintaining homeostasis, with BH3-only proteins Noxa and Puma playing important roles. These proteins are involved in physiological and pathological processes, such as immunity, cancer, and neurodegenerative diseases. Future research should focus on the impact of hyperthermia on Noxa and other BH3-only proteins, as well as the post-transcriptional mechanisms controlling the translation of Puma and Noxa mRNA.
Article
Biochemistry & Molecular Biology
Chang Woo Han, Han Na Lee, Mi Suk Jeong, So Young Park, Se Bok Jang
Summary: PUMA is a direct target in p53-mediated apoptosis and can trigger mitochondrial apoptosis through transcription-dependent and independent mechanisms. Experimental results demonstrate the interaction between PUMA peptide and the DNA binding domain of p53 inhibits the growth of a lung cancer cell line. These findings contribute to understanding the mechanism responsible for p53-mediated apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Wanxiao Sun, Qiting Qing, Xu Cheng, Jing Chen, Ningning Yu, Liyuan Zhu, Mei Zhao
Summary: This study found that folate deficiency only led to depression-like behavior in female mice, while no similar effects were observed in male mice. This may be associated with reduced estrogen levels, inhibition of the PI3K/AKT pathway, and upregulation of the expression of cleaved caspase-3.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
James M. Pemberton, Justin P. Pogmore, David W. Andrews
Summary: Axonal degeneration and neuronal cell death are regulated by BCL-2 family proteins, with potential influences from other cell death pathways. Deciphering the subsets of proteins required and separately regulating these outcomes is essential for future research and pharmacological interventions.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Yu Feng, Hantao Wang, Zhi Chen, Bin Chen
Summary: Research suggests that high glucose levels in T2D-IDD patients lead to overactivation of glucose transporters and subsequent gene dysregulation, resulting in apoptosis and IDD development. Inhibiting GLUTs can reverse IDD defects caused by high glucose levels.
Article
Biochemistry & Molecular Biology
Vera Belousova, Oxana Svitich, Elena Timokhina, Irina Ignatko, Irina Bogomazova, Svetlana Pesegova, Tatiana Silaeva, Tatiana Kuzmina, Oxana Skorobogatova
Summary: This article presents the hypothesis that premature placenta apoptosis could be a potential cause of preterm birth, supported by evaluating gene expression. The study found that during pregnancy, the expression of apoptosis-related genes in the placenta is low, but the expression of the apoptosis inhibitor XIAP is high. However, at the onset of preterm labor, the expression of apoptosis-related genes increases significantly, potentially initiating preterm birth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Hong-Chieh Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Chiung-Yin Huang, Ko-Ting Chen, Ya-Jui Lin, Hsiao-Wei Cheng, Yi-Rou Chen, Hsiang-Tsui Wang
Summary: Combination treatment of TMZ and VPA in GBM patients can be beneficial for survival, depending on the p53 gene status. In cellular experiments, VPA enhances the antineoplastic effect of TMZ by promoting p53 activation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiaozhi Li, Longyu Jin, Yuchao Ma, Zhibin Jiang, Hao Tang, Xiyuan Tong
Summary: Xanthohumol exhibits anti-tumor activity in non-small cell lung cancer cells by activating mitochondrial apoptosis pathway.
Article
Multidisciplinary Sciences
Asal Moradi, Mohammadreza Abdihaji, Sara Barari Kouchaksaraie, Tabarek Abdulrazaq Alkinani, Aida Mahmoudi, Arash Davoudi, William Dashtmiani, Somayeh Mikaeili Ghezeljeh, Shahrzad Aghajani, Reza Ghasemian, Somayeh Maghsoomi Taramsari, Amitis Majlesi, Zahra Mahdavi Niyaki, Ali Salehzadeh
Summary: The study aimed to fabricate Bi2O3/Gln-TSC nanoparticles and investigate their anticancer mechanism. The results showed that Bi2O3/Gln-TSC had significant cytotoxicity against prostate cancer cells and induced apoptosis.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Rosa Manca, Monia Delia, Marianna Abate, Silvia Zappavigna, Sergio Papa, Chester Glomski, Alessandra Pica
Summary: Apoptosis, programmed cell death, plays a central role in haematopoiesis. This study investigates the expression and subcellular distribution of Bcl-2, Bcl-X-L, and Bax proteins in nucleated erythrocytes and the effect of X-ray irradiation on these cells. The results demonstrate the role of these proteins in the maturation of erythrocytes.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Matthias Kist, Domagoj Vucic
Summary: In recent years, research has identified various forms of cell death, each relying on different proteins for activation. Many pathways share components and signaling principles, working together rather than independently. Several cell death regulators are linked to human diseases and may be potential therapeutic targets.
Article
Medicine, General & Internal
Aleksandra Mielczarek-Palacz, Sylwia Jasinska, Anna Strzelec
Summary: Ovarian cancer is a major issue in gynecological oncology, and research on diagnostic markers like caspase-3, -8, and -9 is ongoing. This study found significantly decreased levels of these caspases in ovarian cancer patients compared to healthy controls, suggesting a link to immune system disturbances and potential for future diagnostic use, pending further research.
Article
Neurosciences
Qi Wang, Yuan Li, Hong Tan, Yingwei Wang
Summary: The study found that sevoflurane-induced apoptosis in the primary somatosensory cortex of mice increased without interfering with the developmental patterns of physiological apoptosis. The age-dependent differences in the magnitude and cell-type specificity of sevoflurane-induced apoptosis were observed.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Biology
Sanna Huda, Bethany Chau, Chuanqi Chen, Herman Somal, Neiloy Chowdhury, Nicola Cirillo
Summary: The study indicates that caspase activation plays a significant role in the pathogenesis of pemphigus vulgaris, but most in vivo studies assessing caspase inhibition in PV models have a high risk of bias. Further research is needed to confirm the efficacy of caspase inhibitors in preventing PV-induced blistering in vivo.
Article
Endocrinology & Metabolism
Ariane Lalonde-Larue, Alexandre Boyer, Esdras Correa Dos Santos, Derek Boerboom, Daniel J. Bernard, Gustavo Zamberlam
Summary: The study shows that YAP and TAZ play critical roles in gonadotropin synthesis and secretion. Deletion of Yap and Taz genes resulted in increased levels of FSH and LH in male mice, as well as increased testosterone levels and testis weight. Female mice had increased levels of LH and exhibited a hyperfertility phenotype. Loss of YAP/TAZ did not affect the expression of gonadotropin subunit genes, but increased LH secretion. Furthermore, pharmacologic inhibition of YAP binding to TEAD transcription factors increased LH secretion without affecting Lhb gene expression. The study suggests that YAP/TAZ may regulate LH secretion by modulating the expression of secretory granule cargo proteins.
Article
Genetics & Heredity
Julia Koch, Valerio Marques Portela, Esdras Correa dos Santos, Daniele Missio, Leonardo Guedes de Andrade, Zigomar da Silva, Bernardo Garziera Gasperin, Alfredo Quites Antoniazzi, Paulo Bayard Dias Goncalves, Gustavo Zamberlam
Summary: This study found that the inhibition of the interaction between the Hippo effector YAP or its transcriptional co-activator TAZ with the TEAD family of transcription factors is critical for the cumulus expansion-related events induced by the EGF network in cumulus-oocyte complexes (COCs). These findings provide important insights into the functional relevance of cumulus expansion and oocyte maturation in monovulatory species, and may serve as potential targets to improve the efficiency of in vitro maturation (IVM) systems.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Essa Dirandeh, Zarbakht Ansari-Pirsaraei, William Thatcher
Summary: The study aimed to examine the role of melatonin and its pathways in the maintenance of pregnancy in lactating dairy cows. The results showed that melatonin concentrations were closely related to pregnancy maintenance and played a regulatory role in the well-being of embryos.
Article
Agriculture, Dairy & Animal Science
Ning Liu, Shiyou Wang, Qichun Yao, Yuanyou Li, Hai Hu, Xiaorong Tang, Haohan Ran, Christopher A. Price, Zhongliang Jiang
Summary: Research shows that in atretic follicles, ACT-A helps reduce apoptosis of BGC, while also promoting autophagy through increased ER beta. This provides important insights for further understanding ovarian function.
REPRODUCTION IN DOMESTIC ANIMALS
(2022)
Article
Environmental Sciences
Evelyn Winter, Julia Cisilotto, Andre L. F. Goetten, Angela Veiga, Adriano T. Ramos, Francielli C. Zimermann, Carolina Reck, Tania B. Creczynski-Pasa
Summary: This study analyzed miRNA profiling to identify potential diagnostic biomarkers for Senecio brasiliensis poisoning in cattle. The high expression of miR-21, miR-885, and miR-122 was found to be associated with the poisoning, and these miRNAs demonstrated high sensitivity and specificity, making them potential candidates for detecting the poisoning.
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
(2022)
Review
Developmental Biology
Mathilde Daudon, Yves Bigot, Joelle Dupont, Christopher A. Price
Summary: Dietary stress, such as obesity and changes in energy balance, can disrupt ovarian function and lead to infertility. FNDC proteins, particularly FNDC5 and FNDC4, play important roles in energy homeostasis and may have potential impacts on female fertility.
Article
Obstetrics & Gynecology
Lauriane Relav, Esdras Correa Dos Santos, Gustavo Zamberlam, Christopher A. Price
Summary: Ovulatory disorders are a significant cause of infertility in both humans and economically important species. This study reveals that LH and the Hippo pathway regulate the expression of DUSP1 and DUSP6 genes in bovine pre-ovulatory granulosa cells, suggesting a complex control of MAPK signaling during ovulation.
REPRODUCTIVE SCIENCES
(2023)
Article
Food Science & Technology
Raziyeh Mokhtari, Mansour Rezaei, Mohammad Kazemi Fard, Essa Dirandeh
Summary: In this study, bioactive peptides were produced by enzymatic hydrolysis of casein protein. The hydrolysates were analyzed for the degree of hydrolysis and antioxidant activities. The antimicrobial activity of the peptides was also evaluated. The results showed that the casein-derived peptides had antioxidant and antibacterial properties.
JOURNAL OF FOOD QUALITY
(2023)
Article
Reproductive Biology
Andre Lucio Fontana Goetten, Julia Koch, Cecilia Constantino Rocha, Alceu Mezzalira, Christopher Allan Price, Valerio Marques Portela, Marcos Henrique Barreta
Summary: This study characterized the transcript expression profile of genes involved in DNA repair mechanisms in bovine cumulus cells cultured in serum-free medium. The results showed higher mRNA expression of TP53BP1 and BRCA1 genes and lower mRNA expression of TNFAIP6 gene in cumulus cells cultured with BSA. This suggests increased apoptosis rate and DNA damage, which may explain the reduced developmental potential of bovine oocytes in serum-free medium.
REPRODUCTIVE BIOLOGY
(2022)
Article
Food Science & Technology
Angelica D. Reyes-Perea, Hilda M. Guerrero-Netro, Europa Meza-Serrano, Anthony Estienne, Christopher A. Price
Summary: This study found that deoxynivalenol (DON), a major mycotoxin in animal feed, negatively affects the growth and reproduction of farm animals. The study determined that in bovine theca cells, the metabolite of DON, de-epoxy-DON (DOM-1), activates endoplasmic stress pathways. However, DON only partially activates these pathways in granulosa cells.
Article
Pharmacology & Pharmacy
Rafael Chitolina, Patricia Nicola, Adrieli Sachett, Fernanda Bevilaqua, Lemen Cunico, Alissara Reginatto, Kanandra Bertoncello, Katiuska Marins, Ana Paula Zanatta, Marta Medeiros, Acauane S. Lima, Cristiane Parisotto, Jean Carlo O. Menegatt, Andre F. Goetten, Francielli C. Zimermann, Adriano T. Ramos, Valerio M. Portela, Marcos H. Barreta, Greicy Michelle M. Conterato, Leila Zanatta
Summary: Studies have shown that glyphosate can disrupt the endocrine system and have negative effects on male reproductive system. However, its effects on ovarian function are not well understood, calling for further studies on the toxicity of glyphosate in the female reproductive system.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Esdras Correa Dos Santos, Alexandre Boyer, Guillaume St-Jean, Natalia Jakuc, Nicolas Gevry, Christopher A. Price, Gustavo Zamberlam
Summary: This study provides the first evidence that the deregulation of Hippo pathway effector yes-associated protein (YAP) may play a potential role in the pathogenesis of cystic ovarian disease. This finding suggests that Hippo pathway could serve as a potential therapeutic target for the treatment of this major ovarian disorder in cattle.
Article
Endocrinology & Metabolism
Nour Abou Nader, Etienne Blais, Guillaume St-Jean, Derek Boerboom, Gustavo Zamberlam, Alexandre Boyer
Summary: Recent research has shown that the Hippo signaling pathway is crucial for the development and maintenance of the adrenal cortex. The upstream kinases MST1 and MST2 are expressed in the mouse adrenal cortex, with MST2 specifically expressed in the zona glomerulosa. Conditional deletion of Mst1/2 in steroidogenic cells led to the accumulation of adrenal gonadal primordium-like progenitor cells, without affecting hormone secretion. Gene expression analysis revealed overexpression of downstream target genes of YAP, the main effector of Hippo signaling, and underexpression of genes normally specific to or overexpressed in the zona glomerulosa.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Article
Veterinary Sciences
Aline Cristine de Moraes Muhlbauer, Iggor Frederico Ortlieb, Grasiela de Bastiani, Andre Lucio Fontana Goetten, Adriano Tony Ramos
Summary: This study reports a rare case of equine lacrimal gland adenocarcinoma and its treatment by surgical excision and intralesional chemotherapy. The efficacy of this treatment method was relatively effective. The study highlights the importance of accurate diagnosis and differentiation of lacrimal gland adenocarcinoma from other orbital neoplasms in horses.
ACTA SCIENTIAE VETERINARIAE
(2022)