Review
Engineering, Biomedical
Welson Cunha, Oscar Carvalho, Bruno Henriques, Filipe S. Silva, Mutlu Ozcan, Julio C. M. Souza
Summary: The aim of this integrative literature review was to examine the effects of laser irradiation on zirconia implants' surface topography and biological response for osseointegration. The results showed that laser irradiation could induce changes in zirconia surfaces, resulting in increased roughness and wettability, and enhanced biological response. In vivo studies in dogs demonstrated similar bone-to-implant contact percentages between zirconia and standard titanium surfaces. Laser irradiation parameters, such as intensity, time, and frequency, can be optimized and controlled to achieve desired surface morphologic aspects and biological response in the osseointegration process.
LASERS IN MEDICAL SCIENCE
(2022)
Review
Engineering, Biomedical
Siyi Wang, Xiao Zhao, Yuchien Hsu, Yunjiao He, Feilong Wang, Fan Yang, Fanyu Yan, Dandan Xia, Yunsong Liu
Summary: Titanium and titanium alloys are commonly used in dental implants, but their inert surface leads to delayed osseointegration. Magnesium ions, known for promoting bone regeneration, have been extensively studied for surface modification of titanium implants. This systematic review summarizes the methods, effects, and clinical applications of magnesium-containing coatings for titanium implant surface modification.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Ernesto B. Benalcazar Jalkh, Marcelo Parra, Andrea Torroni, Vasudev Vivekanand Nayak, Nick Tovar, Arthur Castellano, Rafael M. Badalov, Estevam A. Bonfante, Paulo G. Coelho, Lukasz Witek
Summary: The study evaluated the effect of two surface modifications on early osseointegration parameters of conical implants. Supplemental acid etching significantly increased roughness parameters and improved bone-implant contact, leading to higher values in bone to implant contact and torque-out resistance. However, there were no significant differences between the two surfaces in histological features.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Xiao Wang, Jingshu Guo, Jin Wen, Xiangkai Zhang, Lingyan Cao, Deliang Zeng, Xuanyong Liu, Xinquan Jiang
Summary: The study successfully enhanced the bioactivity of PEEK implants by applying dual Sr/Si ion modification, promoting osseointegration and accelerating bone formation. This has the potential to be widely adopted in the dental field under osteoporotic conditions.
MATERIALS & DESIGN
(2021)
Review
Biotechnology & Applied Microbiology
Zhenshi Wang, Jiaolong Wang, Runfa Wu, Junchao Wei
Summary: This article provides a brief introduction to the challenges and healing process of dental implant operations, and comprehensively summarizes various surface modification methods and emerging biomaterials used to tune the properties of dental implants.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Engineering, Multidisciplinary
Ehsan Anbarzadeh, Bijan Mohammadi
Summary: This study investigated the best sandblasting conditions for dental implant fixtures by examining 18 different sandblasting conditions. The parameters included particle size, blasting pressure, and blasting angle. Surface treatment was performed using the SLA + Anodizing method, and AFM testing was conducted to compare surface roughness. State No. 4, prepared using the SLA + Anodizing method with a surface roughness of 1.989 μm, showed the best sandblasting conditions with high cell viability and accelerated bone formation.
JOURNAL OF BIONIC ENGINEERING
(2023)
Review
Chemistry, Multidisciplinary
Yifan Zhang, Karan Gulati, Ze Li, Ping Di, Yan Liu
Summary: Titanium and its alloys are ideal materials for dental implants, but long-term success may be hindered by implant-related infections and inadequate osseointegration. Recent development in nanotechnology has focused on nanoscale modifications and application of nanomaterials for improving dental implant performance.
Article
Materials Science, Multidisciplinary
Wiktor Luczak, Ciril Reiner-Rozman, Martina Muck, Johannes Heitz, Gergo Mitov, Florian Pfaffeneder, Constantin von See, Achim Walter Hassel, Christoph Kleber
Summary: Surface modifications of dental implants are crucial for material stability, durability, and patient contentment. This study investigated the surface roughness and topography of dental implant screws after polishing, sandblasting, and laser treatment using tapping-mode atomic force microscopy. Differences in roughness at different topological sites were described, highlighting the need for more precise treatment to optimize the roughness.
PHYSICA STATUS SOLIDI A-APPLICATIONS AND MATERIALS SCIENCE
(2023)
Article
Multidisciplinary Sciences
Kristian Kniha, Benita Hermanns-Sachweh, Faruk Al-Sibai, Reinhold Kneer, Stephan Christian Moehlhenrich, Marius Heitzer, Frank Hoelzle, Ali Modabber
Summary: The purpose of this rat study was to investigate the feasibility of temperature thresholds affecting bone contact at the surface of implants in vivo. The results showed that thermal necrosis should be used for implant removal in subsequent in vivo studies. The study found that temperatures ranging from 48°C to 50°C led to a decrease in the BIC ratio, with significant differences observed between the 50°C group and the control group. However, there were no significant variations within the cold temperatures.
SCIENTIFIC REPORTS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alessandra Julie Schuster, Joao Luiz Bittencourt de Abreu, Natalia Marcumini Pola, Lukasz Witek, Paulo G. Coelho, Fernanda Faot
Summary: This study evaluated peri-implant bone formation of titanium implants using an in vivo rat model with and without uncontrolled diabetes mellitus. The results showed that the hydrophilic surface was able to counteract the adverse effects of diabetes at early osseointegration periods, but the metabolic systemic impairment caused by diabetes overcame the surface treatment effect after 28 days, leading to impaired osseointegration in both hydrophilic and hydrophobic implants.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Jinmeng Li, Abeer Ahmed, Tanika Degrande, Jeremie De Baerdemaeker, Abdulaziz Al-Rasheed, Jeroen Jjp van den Beucken, John A. Jansen, Hamdan S. Alghamdi, X. Frank Walboomers
Summary: The study showed that the application of a flexible titanium fiber mesh can promote new bone formation within the pores of the implant, increasing bone-to-implant contact and bone area percentage.
Article
Dentistry, Oral Surgery & Medicine
Bruno Luis Graciliano Silva, Julio Cesar Sanchez-Puetate, Felipe Eduardo Pinotti, Camila Chierici Marcantonio, Gabriel Gimenez Pedroso, Elcio Marcantonio Junior, Rosemary Adriana Chierici Marcantonio
Summary: The aim of this study was to evaluate the effect of obesity on the osseointegration of implants with hydrophobic and hydrophilic surfaces. The results showed that obesity does not interfere with the osseointegration of hydrophobic and hydrophilic implants.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Viktoria Hoppe, Patrycja Szymczyk-Ziolkowska, Malgorzata Rusinska, Dominik Poradowski, Maciej Janeczek, Grzegorz Ziolkowski, Bogdan Dybala
Summary: Research has shown that surfaces formed by the treatment enabling the formation of titanium oxide and zirconium oxide exhibit the lowest cytotoxicity, which could be a significant innovation in implantology.
JOURNAL OF MATERIALS SCIENCE
(2021)
Article
Dentistry, Oral Surgery & Medicine
Ingemar Abrahamsson, Ahmed Almohandes, Carlotta Dionigi, Tord Berglundh
Summary: This study aimed to investigate early bone healing around implants with non-modified and modified surfaces. Four different surface characteristics were tested in the mandibles of 6 dogs. The results showed that implants with surface modifications had higher bone-to-implant contact and more newly formed bone within the defect area compared to implants with non-modified surfaces. Acid-etching in oxalic and hydrofluoric acid was found to promote early formation of bone-to-implant contact.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Gabrielle Alencar Ferreira Silva, Fernanda Faot, Wander Jose da Silva, Altair Antoninha Del Bel Cury
Summary: The study evaluated the influence of hydrophilicity on the surface integrity of implants after insertion in low-density artificial bone. It was found that implants with hydrophilic surface treatment resulted in more titanium particle release into the bone bed. Surface damage was observed after insertion, mainly in the apical region of the implants.
Article
Anatomy & Morphology
Furqan A. Shah, Krisztina Ruscsak, Anders Palmquist
Summary: The surface of bone serves as a historical record of osteogenesis, providing key insights into bone quality. Chemical analysis of bone is crucial for various fields such as human health, cell biology, anthropology/archaeology, and biomedical engineering.
CELLS TISSUES ORGANS
(2021)
Article
Endocrinology & Metabolism
John-Olov Jansson, Adria Dalmau Gasull, Erik Schele, Suzanne L. Dickson, Vilborg Palsdottir, Anders Palmquist, Ferran Font Girones, Jakob Bellman, Fredrik Anesten, Daniel Hagg, Claes Ohlsson
Summary: The study found that increased artificial loading affects the growth and development of animals, and this effect is related to body weight sensing mechanisms, which may regulate the somatotropic axis to maintain the individual specific growth channel.
Article
Engineering, Aerospace
Niklas Anthony, Jan Frostevarg, Heikki Suhonen, Christina Wanhainen, Mikael Granvik
Summary: The researchers conducted experiments on olivine, pyroxene, and serpentine using different power densities of laser for spallation, finding that pyroxene and serpentine could be spalled at certain power levels while olivine would melt at higher power levels. Laser-induced spallation of pyroxene and serpentine is found to be more energy-efficient and effective compared to laser-induced splattering.
Review
Immunology
Martin L. Johansson, Tim G. A. Calon, Omar Omar, Furqan A. Shah, Margarita Trobos, Peter Thomsen, Robert J. Stokroos, Anders Palmquist
Summary: Osseointegration is a well-established concept in applications like the BAHS. While few retrieved implants have been described, cases of patients needing abutment removal after BAHS treatment are not uncommon.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Engineering, Biomedical
Dario Farina, Ivan Vujaklija, Rickard Branemark, Anthony M. J. Bull, Hans Dietl, Bernhard Graimann, Levi J. Hargrove, Klaus-Peter Hoffmann, He (Helen) Huang, Thorvaldur Ingvarsson, Hilmar Bragi Janusson, Kristleifur Kristjansson, Todd Kuiken, Silvestro Micera, Thomas Stieglitz, Agnes Sturma, Dustin Tyler, Richard F. Ff Weir, Oskar C. Aszmann
Summary: This Perspective discusses the development and clinical application of high-performance bionic limbs, emphasizing the use of different technologies, such as osseointegration, neural signal amplification, and muscle sensors, to create better performing bionic limbs.
NATURE BIOMEDICAL ENGINEERING
(2023)
Article
Engineering, Aerospace
Niklas Anthony, Jan Frostevarg, Heikki Suhonen, Mikael Granvik
Summary: The results of two experiments show that laser melting of metal and bonding it to rock can form a strong physico-mechanical bond, suitable for manipulating small boulders on asteroid surfaces, redirecting small monolithic asteroids, or space debris removal.
Article
Engineering, Biomedical
Alexander Thesleff, Max Ortiz-Catalan, Rickard Branemark
Summary: This article investigates the effect of a surface enhancement method (LPB) on the fretting fatigue resistance of bone-anchored implants. The results show that the LPB treatment significantly improves the implant's ability to resist fretting fatigue and reduces wear at the modular interface.
MEDICAL ENGINEERING & PHYSICS
(2022)
Review
Engineering, Biomedical
Chiara Micheletti, Ariana Hurley, Aurelien Gourrier, Anders Palmquist, Tengteng Tang, Furqan A. Shah, Kathryn Grandfield
Summary: This article provides a new perspective on bone structure, highlighting the ubiquitous presence of mineral ellipsoids in bones and their importance in terms of toughness and strength.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Alexander Thesleff, Max Ortiz-Catalan, Rickard Branemark
Summary: This study investigates the structural interplay of a bone-anchored implant system under different loads using parametric finite element analysis. The results show that cortical thickness has the largest effect on the stress and strain in the implant and the cortical bone.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Adrien Da Silva, Filippo Belelli, Giorgia Lupi, Francesco Bruzzo, Benedikt Brandau, Lukas Maier, Alexander Pesl, Jan Frostevarg, Riccardo Casati, Elena Lopez, Alexander F. H. Kaplan
Summary: The use of aluminium alloys for Additive Manufacturing is highly interesting, but aging of the powder feedstock remains challenging due to the sensitivity of aluminium alloys to oxidation and porosity. Aging introduces oxygen and hydrogen into the powder, resulting in reduced laser beam absorbance, increased wetting of the melt pool, and higher porosity in the deposited material. Parts built with aged powder exhibit lower yield and ultimate strength, as well as higher elongation, attributed to coarser microstructure and increased porosity.
MATERIALS & DESIGN
(2022)
Review
Engineering, Biomedical
Anders Palmquist, Martina Jolic, Eduard Hryha, Furqan A. Shah
Summary: In the past decade, additive manufacturing technologies, particularly electron beam melting (EBM), have revolutionized the production of biomedical implants. EBM offers faster build rates and a high vacuum environment, making it advantageous for materials susceptible to oxidation and nitrogen pick-up. EBM manufactured implants have shown great potential in skeletal reconstruction, with anatomical mimickry and macro-porous architecture. The personalized design and diverse clinical applications of EBM in skeletal repair and prosthetic rehabilitation are discussed in this review.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Furqan A. Shah, Martina Jolic, Chiara Micheletti, Omar Omar, Birgitta Norlindh, Lena Emanuelsson, Hakan Engqvist, Thomas Engstrand, Anders Palmquist, Peter Thomsen
Summary: Calcium phosphates (CaP) are important biomaterials for bone regeneration. This study demonstrates how a multi-component CaP formulation can guide bone formation beyond the normal physiological range. The study shows successful bone formation and remodeling in sheep models using this CaP formulation, and the presence of woven bone and vascularized lamellar bone in the pores of the CaP material.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Tatiana Fedina, Frank Brueckner, Alexander F. H. Kaplan, Christoph Wilsnack
Summary: This study investigates the possibility of using Al powder as a reducing agent for iron ore waste through laser-assisted reduction. The reaction between Fe2O3 and Al powder proceeded in an intense and uncontrolled manner, resulting in the formation of Fe-rich domains and alumina as separate phases. The reduced iron droplets were mainly concentrated near the surface of the alumina melt or at the interface with the iron oxide. Various analyses and imaging techniques were employed to study the chemical composition, microstructure, and morphological appearances of the reaction products. X-ray computed microtomography revealed that approximately 2.4% of iron was reduced, possibly due to insufficient reaction time or inappropriate equivalence ratio.
JOURNAL OF LASER APPLICATIONS
(2023)
Article
Engineering, Biomedical
Heithem Ben Amara, Diana C. Martinez, Furqan A. Shah, Anna Johansson Loo, Lena Emanuelsson, Birgitta Norlindh, Regine Willumeit-Romer, Tomasz Plocinski, Wojciech Swieszkowski, Anders Palmquist, Omar Omar, Peter Thomsen
Summary: Using a rat soft tissue model, the researchers found that magnesium (Mg) implants exacerbated initial inflammation but also initiated chemotaxis and upregulated immunomodulatory markers, leading to tissue repair. The understanding of the relationship between Mg material properties and cellular processes provides a basis for interpretation of clinical observations and future improvements in Mg implants.
BIOACTIVE MATERIALS
(2023)
Article
Medicine, General & Internal
Emir Benca, Beatrice Ferrante, Ewald Unger, Andreas Strassl, Lena Hirtler, Rickard Branemark, Reinhard Windhager, Gerhard M. Hobusch
Summary: This study investigated the accuracy and precision in implant positioning using case-specific positioning guides and found that it is feasible to achieve accurate and precise positioning of the implants compared to the preoperative plan with the use of these guides.
MEDICINA-LITHUANIA
(2023)
