Article
Chemistry, Organic
Plamen Angelov, Paraskeva Terziyska, Danail Georgiev
Summary: 3-(1-Ethylamino-ethylidene)-1-methyl-pyrrolidine-2,4-dione was obtained as an unexpected product in a three-step synthesis using o-nitrobenzoyl sarcosine, acetoacetanilide, and ethylamine. The compound exhibited moderate antibacterial activity against S. aureus and E. coli.
Article
Chemistry, Medicinal
Katarina Tomovic, Budimir S. Ilic, Andrija Smelcerovic
Summary: This study classifies approved and potent DPP-4 inhibitors with gliptin-like structures into three groups based on their structures and mechanisms of inhibition, showing different binding modes in various domains of the enzyme. The analysis of structure-activity relationship and protein-ligand interaction fingerprints provides insights for the design strategies of DPP-4 inhibitors.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Anis Ahamed, Ibrahim A. Arif, Radhakrishnan SurendraKumar, Idhayadhulla Akbar, Baji Shaik
Summary: This study aims to develop a new pyrimidine-2,4-dione hybrid with 2H-thiopyran molecules as potential antibacterial and antifungal agents. The synthesis of these compounds was carried out using water and an Mg(II) acetate catalyst. The antimicrobial and antifungal activities were tested, along with cytotoxic screening.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2023)
Article
Biology
Mohammed Al-Zharani, Mohammed S. Al-Eissa, Hassan A. Rudayni, Daoud Ali, Saud Alarifi, Radhakrishnan SurendraKumar, Akbar Idhayadhulla
Summary: A larvicidal test was conducted on Culex quinquefasciatus larvae using pyrrolidine-2,4-dione derivatives. The synthesized compounds showed significant larvicidal activities and high binding energy.
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sumeer Ahmed, Ajmal R. Bhat, Aziz Kalilur Rahiman, Rajendra S. Dongre, Aso Hameed Hasan, Vidya Niranjan, C. Lavanya, S. A. Sheikh, Joazaizulfazli Jamalis, Malika Berredjem, Sarkar M. A. Kawsar
Summary: In this study, a series of thiazolidine-2,4-dione derivatives were synthesized and evaluated for their antibacterial and antifungal activities. The results showed that these derivatives exhibited strong antimicrobial effects against a broad range of microorganisms, and molecular docking study revealed their strong interaction with the target enzyme. Pharmacokinetic studies also indicated the drug-like properties and non-toxic nature of these compounds.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Physical
Samet Poyraz, H. Ali Dondas, Jose M. Sansano, Samet Belveren, Cem Yamali, Mahmut Ulger, Naciye Yaktubay Dondas, Begum Nurpelin Saglik, Christopher M. Pask
Summary: A series of novel N-benzoylthiourea-pyrrolidine carboxylic acid derivatives with an imidazole moiety were synthesized and their various biological activities were evaluated. The molecules' ability to form intermolecular hydrogen bonds was studied to find the best antimicrobial activity. The compounds were tested for their enzyme inhibitory potency against AChE and BChE, which are the main targets for Alzheimer's disease. Additionally, the compounds were screened for antituberculosis and antibacterial activities, as well as antifungal activities against various strains of Candida.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Microbiology
Ashley L. Cunningham, Orhi Esarte Palomero, Bradley J. Voss, M. Stephen Trent, Bryan W. Davies
Summary: Otilonium bromide, a poorly absorbed oral medication used for irritable bowel syndrome, has been found to have broad-spectrum antibacterial and antifungal activity, including against multidrug-resistant strains. This suggests that otilonium bromide could be a new option for intestinal antimicrobial therapy targeting enteric pathogens.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Tianxi Li, Lulu Li, Fangyuan Du, Lei Sun, Jichao Shi, Miao Long, Zeliang Chen
Summary: This review focuses on antifungal peptides isolated from various microorganisms, outlining their antifungal activity, toxic effects, and mechanisms of action, as well as common solutions to mitigate their toxicity. This work serves as a useful reference for further clinical research and the development of safe antifungal drugs with high efficiencies and broad application spectra.
Article
Chemistry, Multidisciplinary
Min Chen, Chun-Wen Geng, Ling Han, Yu Liu, Yong-Kai Yu, Ai-Min Lu, Chun-Long Yang, Guo-Hua Li
Summary: Natural tetramic acids were used to design and synthesize new green herbicides with two different types of pyrrolidine-2,4-dione derivatives, which showed moderate to good inhibitory activities against plant growth in experiments. Compounds 10q and 10n exhibited the highest herbicidal activities among the tested derivatives.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Physical
Jia-long Tian, Hou-tian Yan, Qin Hu, Rui-xue Liu, Li-min Liu, Yan-cheng Liu
Summary: Enrofloxacin (EFX) was used to synthesize two transition metal complexes for the purpose of examining their crystal structures and antibacterial activities. The crystal structures of EFX-Mn and EFX-Co were found to belong to the same monoclinic crystal system with a six-coordinated octahedral configuration. In vitro antibacterial tests showed that both complexes exhibited significant growth inhibitory effects against pathogenic bacteria, particularly showing stronger bactericidal effects against E. coli and S. typhi compared to EFX itself.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Pharmacology & Pharmacy
Shabnam Yavari, Kayode Olaifa, Darya Shafiee, Reza Rasuli, Mehdi Shafiee
Summary: Microorganisms are emerging contaminants in the environment and pose significant risks to public health. Conventional disinfection methods are often ineffective and have drawbacks. This study presents a method to synthesize nanomaterials with antimicrobial properties and demonstrates their effectiveness against Escherichia coli and Candida albicans. The synthesized nanomaterials show potential for biomedical applications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Mauricio Osorio, Marcela Carvajal, Alejandra Vergara, Estefania Butassi, Susana Zacchino, Carolina Mascayano, Margarita Montoya, Sophia Mejias, Marcelo Cortez-San Martin, Yesseny Vasquez-Martinez
Summary: Prenylated flavonoids are important natural compounds with significant biological activity, particularly in antimicrobial functions. Compounds 11, 12, and 13 showed strong inhibitory activity against human pathogenic fungi and clinical isolated Staphylococcus aureus MRSA, indicating the key structural requirements for antibacterial activity. Additionally, the combination of prenylated flavonoids with commercial antibiotics significantly enhanced the antibacterial activity against drug-resistant bacteria.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Microbiology
Abdelmoneim K. Abdalla, Mutamed M. Ayyash, Amin N. Olaimat, Tareq M. Osaili, Anas A. Al-Nabulsi, Nagendra P. Shah, Richard Holley
Summary: Exopolysaccharides (EPSs) are metabolites synthesized and excreted by various microorganisms, playing important biological functions in interactions between bacteria and their environments, protection against hostile conditions, and evasion of immune responses. Numerous studies have shown the broad antimicrobial activities of EPS against pathogenic microbes. This review focuses on the in vitro and in vivo antimicrobial activities of different EPSs against foodborne bacterial, fungal, and viral pathogens, as well as the mechanisms of action and methods of measurement.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Chemistry, Medicinal
Yan-Yan Ding, Han Zhou, Bao-Qi Peng-Deng, Bao-Qi Zhang, Zhi-Jun Zhang, Guang-Han Wang, Shao-Yong Zhang, Zheng-Rong Wu, Yi-Rong Wang, Ying-Qian Liu
Summary: Since the isolation of the first natural carbazole alkaloid, murrayanine, from Mwraya Spreng, carbazole alkaloid derivatives have attracted wide attention for their anti-tumor, anti-viral, and anti-bacterial activities. Recent research has shown that carbazole alkaloids and their derivatives exhibit diverse biological activities. This study provides the first comprehensive description of the antifungal and antibacterial activities of carbazole alkaloids in the past decade (2012-2022), including both natural and partially synthesized compounds. The challenges and problems faced by this class of alkaloids are also summarized. This paper will facilitate further exploration of carbazole alkaloids.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Chemistry, Multidisciplinary
Varish Ahmad, Mohammad Omaish Ansari
Summary: Graphene and its nanocomposites have attracted significant interest due to their efficient antimicrobial properties. Graphene has found applications in tissue engineering and has been successfully conjugated with existing drugs to improve therapeutic efficacy. This review discusses the antimicrobial potential, synthesis, and toxicity of graphene-based nanomaterials in biological systems.
Article
Chemistry, Inorganic & Nuclear
Nikolia Lalioti, Vassilis Nastopoulos, Nikos Panagiotou, Anastasios Tasiopoulos, Nikolaos Ioannidis, Joris van Slageren, Peng Zhang, Gopalan Rajaraman, Abinash Swain, Vassilis Tangoulis
Summary: The reaction between Dy(O2CMe)(3)•4H(2)O and 1-acetyl-2-napthol (LH) in MeOH yielded the complex [Dy2L6(MeOH)]•MeOH (1•MeOH) with good success. Characterization was done through single-crystal X-ray crystallography, elemental analyses, IR spectra, and powder X-ray patterns. The complex showed slow magnetic relaxation with a single relaxation mechanism under a 0 Oe dc field and two relaxation processes under a 1500 G external magnetic field.
DALTON TRANSACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Panagiota Bika, Nikolaos Ioannidis, Maria-Anna Gatou, Yiannis Sanakis, Panagiotis Dallas
Summary: This study reveals the coordination of copper ions absorbed by a series of covalent organic frameworks. The copper retention capacity and efficiency of different morphologies and chemical structures were compared. SEM, XRD, and EPR spectroscopy were used to analyze the morphological changes and coordination structure of copper ions. The study also explores the influence of the environment on the coordination of copper ions.
Article
Biochemistry & Molecular Biology
Jennifer R. Baker, Peter J. Cossar, Mark A. T. Blaskovich, Alysha G. Elliott, Johannes Zuegg, Matthew A. Cooper, Peter J. Lewis, Adam McCluskey
Summary: Five focused compound libraries were synthesized and screened for antibiotic and anti-fungal activity. Modifications of the terminal aromatic moiety were explored, resulting in the discovery of compounds with improved activity.
Article
Chemistry, Physical
Pinelopi P. Falara, Adamantia Zourou, Konstantinos V. Kordatos
Summary: This critical review introduces the basic structure and properties of carbon dots, discusses their combination with 2-D nanomaterials, and explores their potential applications in various scientific and technological areas.
Article
Neurosciences
Barbara Mavroidi, Archontia Kaminari, Dimitris Matiadis, Dimitra Hadjipavlou-Litina, Maria Pelecanou, Athina Tzinia, Marina Sagnou
Summary: Alzheimer's disease involves the formation of Aβ oligomers, oxidative stress, inflammation and increased acetylcholinesterase activity. Synthetic isatin thiosemicarbazones have shown potential in preventing Aβ aggregation, protecting cells, and inhibiting Akt and GSK-3β phosphorylation.
Article
Chemistry, Inorganic & Nuclear
Valentina Stefanou, Dimitris Matiadis, Dimitrios Tsironis, Olga Igglessi-Markopoulou, Vickie Mckee, John Markopoulos
Summary: This study investigates the structure and assembly of four supramolecular coordination complexes, demonstrating the construction of metallosupramolecular architectures through self-assembly techniques. The findings provide valuable experimental data for the field of supramolecular chemistry.
JOURNAL OF COORDINATION CHEMISTRY
(2022)
Article
Chemistry, Physical
Alexandra Karagianni, Nikos G. Tsierkezos, Maurizio Prato, Mauricio Terrones, Konstantinos V. Kordatos
Summary: Photodynamic Therapy (PDT) is a non-invasive cancer treatment modality using photosensitizer drug, light, and oxygen. Conventional photosensitizers have limitations, which can be overcome by using nanomaterials such as Carbon Quantum Dots (CQDs) and Graphene Quantum Dots (GrQDs) due to their excellent photoluminescence properties, biocompatibility, and hydrophilicity. This review article summarizes the main features of PDT and carbon-based quantum dots and discusses their applications in cancer diagnosis and treatment.
Article
Biochemistry & Molecular Biology
Panagiota Pantiora, Veronika Furlan, Dimitris Matiadis, Barbara Mavroidi, Fereniki Perperopoulou, Anastassios C. Papageorgiou, Marina Sagnou, Urban Bren, Maria Pelecanou, Nikolaos E. Labrou
Summary: This study investigated the inhibitory effects of two curcuminoids and eleven monocarbonyl curcumin analogues against human glutathione transferase P1-1 (hGSTP1-1). The results showed that Demethoxycurcumin (Curcumin II) and three monocarbonyl curcumin analogues exhibited the highest inhibitory activity, with IC50 values ranging between 5.45 and 37.72 μM. The most potent inhibitors functioned as non-competitive/mixed-type inhibitors. Structural analysis revealed that the strongest hGSTP1-1 inhibitor, DM96, formed hydrophobic interactions and hydrogen bonds with specific residues, contributing to its superior inhibitory activity. The study highlights the potential of DM96 as a strong hGSTP1-1 inhibitor and its relevance for cancer chemosensitization.
Review
Chemistry, Multidisciplinary
Angelo Frei, Anthony D. D. Verderosa, Alysha G. G. Elliott, Johannes Zuegg, Mark A. T. Blaskovich
Summary: Metal ions have antimicrobial activity and are considered as potential new antibiotics. Metal complexes can also be used for antimicrobial photodynamic therapy and radionuclide diagnosis of bacterial infections.
NATURE REVIEWS CHEMISTRY
(2023)
Article
Biology
Bing Zhang, Wanida Phetsang, M. Rhia L. Stone, Sanjaya Kc, Mark S. S. Butler, Matthew A. A. Cooper, Alysha G. G. Elliott, Urszula Lapinska, Margaritis Voliotis, Krasimira Tsaneva-Atanasova, Stefano Pagliara, Mark A. T. Blaskovich
Summary: Antimicrobial resistance is a critical concern for human health, and this study presents the development of vancomycin fluorescent probes that can be used for detecting and visualizing Gram-positive bacteria as well as for measuring outer membrane permeabilization in Gram-negative bacteria. The probes were synthesized by modifying vancomycin with an azide substituent, enabling it to undergo copper-catalyzed azide-alkyne cycloaddition reactions. The probes exhibited similar antibacterial profiles to the parent vancomycin antibiotic and were versatile tools for various detection and imaging techniques.
COMMUNICATIONS BIOLOGY
(2023)
Article
Chemistry, Physical
Nikolaos D. Adamopoulos, Nikos G. Tsierkezos, Afroditi Ntziouni, Fu Zhang, Mauricio Terrones, Konstantinos V. Kordatos
Summary: This study synthesized and characterized three different nanocomposite materials, including silver and zinc oxide nanoparticles modified reduced graphene oxide (rGO), and rGO modified with both silver and zinc oxide nanoparticles. These materials were characterized using XRD, FTIR, TGA, Raman spectroscopy, SEM, and TEM techniques. The electrochemical responses of these materials towards the standard ferrocyanide/ferricyanide [Fe(CN)6]3-/4- redox system were investigated using CV and EIS techniques. The results showed that ZnO modified rGO exhibited excellent electrochemical performance, attributed to the high surface area of ZnO, providing a larger electrode/electrolyte interface and more sites at the electrolyte-ZnO interface.
Article
Biochemistry & Molecular Biology
Annick van Niekerk, M. Cassiem Joseph, Angela Kavanagh, Hue Dinh, Andrew J. Swarts, Selwyn F. Mapolie, Johannes Zuegg, Amy K. Cain, Alysha G. Elliott, Mark A. T. Blaskovich, Angelo Frei
Summary: Infections associated with antibiotic resistance (AMR) are projected to become the leading cause of death in the coming decades due to over-prescription of antibiotics and a lack of new drug development. A community-driven initiative, Community for Open Antimicrobial Drug Discovery (CO-ADD), has identified metal-based drugs as a potential and untapped source for combating AMR. Testing of 18 palladium (Pd) and ruthenium (Ru) complexes has revealed that Pd complexes, particularly Pd1, exhibit potent antifungal activity against Candida glabrata. Furthermore, in-vivo studies in Galleria mellonella larvae have demonstrated the non-toxic nature of these compounds.
Article
Chemistry, Multidisciplinary
Adamantia Zourou, Afroditi Ntziouni, Nikolaos D. Adamopoulos, Tiberiu Roman, Fu Zhang, Mauricio Terrones, Konstantinos Kordatos
Summary: The aim of this work is to synthesize and characterize a graphene oxide (GO)-MnFe2O4 nanohybrid material and study its effectiveness in removing Congo red (CR) dye from water. The GO-MnFe2O4 was prepared through a three-step method, including the production of GO using graphite powder and the decoration of GO with magnetic MnFe2O4 nanoparticles. The as-prepared GO-MnFe2O4 nanohybrid material was thoroughly characterized through various techniques. The adsorption performance of GO-MnFe2O4 in removing CR dye was evaluated, showing excellent reusability even after multiple cycles.
JOURNAL OF PHYSICS AND CHEMISTRY OF SOLIDS
(2023)
Article
Materials Science, Multidisciplinary
Adamantia Zourou, Afroditi Ntziouni, Nikolaos Adamopoulos, Tiberiu Roman, Fu Zhang, Mauricio Terrones, Konstantinos Kordatos
Summary: This study evaluates the performance of graphene oxide (GO) - copper ferrite (CuFe2O4) nanohybrid in removing Congo Red (CR) dye from aqueous solutions. The prepared adsorbent was characterized, and the results demonstrate that GO-CuFe2O4 is an attractive adsorbent for the efficient removal of CR dye from wastewater.
Article
Biochemistry & Molecular Biology
Michael Ramek, Jasmina Sabolovic
Summary: This paper investigates the geometries, energy landscapes, and magnetic parameters of copper(II) amino acid compounds using density functional theory calculations. The results show that certain conformers with histaminate-like and glycine-like modes have low Gibbs free energies and high metal-binding affinities. The predicted conformations reproduce the experimental electron paramagnetic resonance parameters.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Wei Tian, Wen Zhong, Zengyan Yang, Ling Chen, Shijie Lin, Yanping Li, Yuxing Wang, Peilin Yang, Xing Long
Summary: A series of novel dibutyltin complexes based on salen-like ligands were synthesized and characterized. Complex S03 showed excellent in vitro anticancer activity and induced cancer cell death through multiple mechanisms. This study reveals new mechanisms of organotin complexes and provides new insights into the development of organotin metal complexes as anticancer drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Natalie C. Korkola, Martin J. Stillman
Summary: Many proteins require a metal cofactor for their function, and these metals play a role in protein folding. The study found that the metallation rates of different metal binding pathways are influenced by pH, with the less cooperative pathway being more affected by low pH conditions. Specific mixtures of structures are formed in the initial steps of metallation, and unfolding the disordered apo-MT structure hinders the formation of these preliminary structures. The compact conformation of the native apo-MT allows for rapid formation of metal-thiolate structures with high affinity, providing protection from oxidation.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Boxuan Yang, Xitong Song, Binju Wang
Summary: The diiron active site plays a crucial role in catalytic transformations in both biological and chemical systems. Recent advancements in the field include the synthesis of biomimetic diiron catalysts inspired by the active structure of soluble methane monooxygenase (sMMO), which have been successfully applied to the dehydrogenation of indolines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Christina N. Banti, Angeliki A. Piperoudi, Catherine P. Raptopoulou, Vassilis Psycharis, Constantinos M. Athanassopoulos, Sotiris K. Hadjikakou
Summary: Two copper(I) polymorphs with mitochondria-targeting properties were successfully prepared via metal ion conjugation. These compounds showed promising activities in DNA binding, enzyme inhibition, and cancer cell inhibition. The molecular mechanisms of action were investigated.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2024)
