期刊
JOURNAL OF INORGANIC BIOCHEMISTRY
卷 194, 期 -, 页码 1-6出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2019.02.005
关键词
Vanadium; Diindolylmethane; Anticancer drugs; Reactive oxygen species; DNA binding
资金
- Deutsche Forschungsgemeinschaft [Scho 402/12-1]
In order to identify new active drug candidates against cancer diseases we investigated the tumor cell growth inhibition, formation of reactive oxygen species, mitochondrial membrane damage, cell cycle arrest and DNA binding activity of a new bis(triethylammonium) tris[1,1-bis(indol-3-yl)-1-(3,4-catecholate)methane]vanadate (IV) complex. It exhibited significant antiproliferative activity against various cancer cell lines, showed a stronger DNA binding than cisplatin and led to mitochondria] damage, a formation of reactive oxygen species, and a cell cycle arrest in the G2/M phase of cancer cells.
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