期刊
JOURNAL OF INFECTIOUS DISEASES
卷 220, 期 4, 页码 589-593出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiz166
关键词
bocavirus; parvovirus; nasopharynx; tonsil; serology; diagnosis; detection
资金
- Turku University Hospital Foundation, Turku in Finland
- Turku University Foundation, Turku in Finland
- Sigrid Juselius Foundation, Helsinki in Finland
- Life and Health Medical Association, Helsinki in Finland
Human bocavirus 1 (HBoV1) can persist in nasopharynx and tonsils. Using HBoV1 serology, reverse-transcription polymerase chain reaction (PCR) for detecting messenger RNA (mRNA) and quantitative PCR for HBoV1 genome load count, we studied to what extent the HBoV1 DNA loads in nasopharynx correlate with acute infection markers. Tonsillar tissue, nasopharyngeal aspirate, and serum were obtained from 188 elective adeno-/tonsillectomy patients. Relatively high loads of HBoV1 DNA were detected in the nasopharynx of 14 (7%) primarily asymptomatic subjects with negative mRNA and/or serodiagnostic results. Quantitative HBoV1 DNA PCR may have lower specificity than HBoV1 mRNA detection for diagnosing symptomatic infection.
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