Article
Chemistry, Analytical
Oswaldo Hernandez-Gonzalez, Sergio Zarazua, Jose Ignacio Veytia-Bucheli, Marco Martin Gonzalez-Chavez, Cristian Jazmin Rodriguez-Pinal, Susanna Edith Medellin-Garibay, Edith Elena Uresti-Rivera, Francisco Javier Perez-Vazquez, Diana Patricia Portales-Perez, Silvia Romano-Moreno, Rosa del Carmen Milan-Segovia
Summary: This study developed and validated an alternative high-performance liquid chromatography method for simultaneous quantification of four antituberculosis drugs in plasma of patients. The method showed linearity, precision, and accuracy, and could be applied for therapeutic drug monitoring and pharmacokinetics studies throughout tuberculosis treatment.
JOURNAL OF SEPARATION SCIENCE
(2021)
Article
Polymer Science
Weinan Gu, Ranran Fan, Jingnan Quan, Yi Cheng, Shanshan Wang, Hui Zhang, Aiping Zheng, Shenghan Song
Summary: In this research, a thermosensitive polymer was used as a drug delivery system to form a drug-gel depot inside the resection cavity after surgical excision, effectively suppressing glioblastoma recurrence. The study successfully adjusted the gelation point by blending polymers and demonstrated excellent therapeutic efficacy in in vitro and in vivo experiments.
Article
Electrochemistry
Faezeh Zivari-Moshfegh, Fereshteh Javanmardi, Davood Nematollahi
Summary: The electrochemical behavior of rifampicin, an anti-tuberculosis drug, was studied in a water/ethanol mixture. The drug was found to undergo two-step oxidation, with the first step being a reversible oxidation of the hydroquinone moiety and the second step being an irreversible oxidation of the phenolic ring. The adsorption activity and diffusion coefficient of rifampicin were also determined, indicating that the first oxidation step is diffusion-controlled and the second step is a diffusion/adsorption control process. The oxidation of rifampicin was found to be complex and highly pH-dependent, with different rates of reaction observed for different drugs used in combination therapy.
ELECTROCHIMICA ACTA
(2023)
Article
Pharmacology & Pharmacy
Baoming Yuan, Yanfeng Zhang, Qian Wang, Guangkai Ren, Yanbing Wang, Shicheng Zhou, Qingyu Wang, Chuangang Peng, Xueliang Cheng
Summary: Osteomyelitis is a difficult-to-treat infectious disease. In this study, a thermosensitive hydrogel composed of vancomycin and hydroxyapatite was developed using PLGA-PEG-PLGA copolymer as a sustained-release drug carrier. The hydrogel demonstrated good sol-gel phase transition properties and sustained release of antibiotics. In vitro and in vivo experiments showed that the hydrogel had excellent anti-bacterial effects and promoted bone tissue repair. Therefore, this composite system has the potential for wide clinical applicability.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Zhimei Jiang, Liang Huang, Lingli Zhang, Qin Yu, Yunzhu Lin, Haotian Fei, Hongxin Shen, Hong Huang
Summary: In this study, a simple and sensitive method based on UPLC-UV was established for simultaneous quantification of INH, PZA, and RMP in human plasma. The method showed good accuracy and stability, making it suitable for monitoring the concentration changes of these drugs in anti-TB drug therapy.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Pharmacology & Pharmacy
Eva Snejdrova, Jan Loskot, Juraj Martiska, Tomas Soukup, Libor Prokes, Vladislav Frolov, Tomas Kucera
Summary: This study developed a nanosized drug delivery system for the treatment of orthopedic device-related infections. The formulation variables were adjusted to prepare rifampicin-loaded nanoparticles, which demonstrated effective drug release and antimicrobial effects for local treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Effat Sharafi, Susan Sadeghi
Summary: An ultrasensitive and disposable sensor based on modified SPCE was developed for rapid quantification of RIF and INZ in complex media using DPV. The sensor was characterized by AFM and CV, and it achieved individual and simultaneous detection of RIF and INZ with detection limits of 3.0 x 10(-9) mol L-1 and 5.0 x 10(-9) mol L-1, respectively, showing successful application for real sample analysis.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Mehdi Afrouz, Farnaz Ahmadi-Nouraldinvand, Amin Amani, Hoda Zahedian, Sabry G. Elias, Fatemeh Arabnejad, Hashem Yaghoubi, Omid Farshad, Neda Farazi, Atefeh Jalali, Hadi Eskanlou
Summary: This study evaluated the gene delivery capability of different micelles in MCF-7 cells and found that FePECLEFE/DNA micelles had higher gene transfer efficiency. Additionally, the ability of these micelles to neutralize the negative charge of DNA and protect it against restriction enzymes was investigated, and it was found that they have good biocompatibility and low cytotoxicity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Engineering, Biomedical
Paul Robert Neumann, Frank Erdmann, Joost Holthof, Gabriela Haedrich, Mark Green, Jianghong Rao, Lea Ann Dailey
Summary: This study investigated the use of PCPDTBT as a contrast agent for optical imaging, examining the impact of different encapsulation methods on imaging performance, biodistribution, and biocompatibility. Results showed that formulations have a significant impact on both imaging performance and biodistribution, indicating the importance of further exploration in this area.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Polymer Science
Elsa R. Arias, Vivian Angarita-Villamizar, Yolima Baena, Claudia Parra-Giraldo, Leon D. Perez
Summary: The research studied the effect of modifying polymer micelles with DSPE as carriers for AmB, finding that the modified copolymers self-assembled into particles with sizes below 100 nm and a lower critical micelle concentration. Furthermore, the presence of DSPE increased the loading capacity of AmB, reduced its aggregation, and decreased its toxicity towards red blood cells.
Article
Chemistry, Physical
Chufen Yang, Delin Wang, Wenyao Liu, Zexiong Yang, Teng He, Fang Chen, Wenjing Lin
Summary: In this study, folate (FA) modified dual pH/reduction-responsive mixed polymeric micelles were successfully assembled for high loading, controlled release, and active targeted delivery. The micelles showed excellent drug loading capacity and encapsulation efficiency, and demonstrated well-controlled release performance in neutral and acidic environments. Cytotoxicity assays further revealed the superior inhibitory effect of FA-modified micelles on cancer cells. These findings suggest that the developed micelles have great potential for anticancer drug delivery.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Pharmacology & Pharmacy
Roberto Oliva, Giovanna Ginestra, Anna Piperno, Antonino Mazzaglia, Antonia Nostro, Angela Scala
Summary: This study developed a novel PLA-PEG NPs for the delivery of Linezolid against MRSA. The encapsulation efficiency of LNZ in PLA-PEG NPs was 15% with a 10:3 polymer to drug mass ratio, and sustained release kinetics with 65% of the antibiotic released within 80 h. The NPs exhibited antimicrobial activity against various Gram-positive bacteria including MRSA, and showed inhibitory activity on both planktonic growth and preformed biofilm of MRSA.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Materials Science, Ceramics
Nehal Salahuddin, Ebtisam Ibrahim, Maged El-Kemary
Summary: The development of targeted drug delivery systems with controlled drug release and enhanced drug bioavailability has attracted increased attention in clinical applications. In this study, biocompatible citrate-functionalized hydroxyapatite nanorods loaded with artesunate were encapsulated into surfactant-free PLGA nanoparticles. The encapsulated nanoparticles demonstrated improved drug release and anti-cancer activity compared to free artesunate.
CERAMICS INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Kristen M. Manto, Prem Kumar Govindappa, Brandon Martinazzi, Aijie Han, John P. Hegarty, Zachary Koroneos, M. A. Hassan Talukder, John C. Elfar
Summary: This study synthesized an EPO-PLGA-PEG block copolymer formulation and found that it could release stable EPO and significantly improve functional recovery and neurovascular regeneration after nerve injury.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Anne-Sophie Vaillard, Alae El Haitami, Philippe Fontaine, Fabrice Cousin, Philipp Gutfreund, Michel Goldmann, Sophie Cantin
Summary: Binary blends of water-insoluble polymers are a versatile strategy to obtain nanostructured films at the air-water interface. The structural and thermodynamic properties of cellulose acetate (CA), deuterated and postoxidized polybutadiene (PBd), and their mixtures were investigated by surface pressure-area isotherms, Brewster angle microscopy (BAM), and neutron reflectometry. The study revealed varying film structures at different surface pressures depending on the composition of the films.
Article
Nanoscience & Nanotechnology
Mani Gajendiran, Heejung Jo, Kyobum Kim, Sengottuvelan Balasubramanian
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Article
Chemistry, Medicinal
Sundaram Bharathi, Dharmasivam Mahendiran, Raju Senthil Kumar, Young Guk Kim, Mani Gajendiran, Kyobum Kim, Aziz Kahlur Rahiman
CHEMICAL RESEARCH IN TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Heejung Jo, Mani Gajendiran, Kyobum Kim
MACROMOLECULAR BIOSCIENCE
(2019)
Article
Chemistry, Multidisciplinary
Heejung Jo, Mani Gajendiran, Kyobum Kim
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2020)
Review
Biochemistry & Molecular Biology
Heejung Jo, Minhyuk Yoon, Mani Gajendiran, Kyobum Kim
MACROMOLECULAR BIOSCIENCE
(2020)
Article
Green & Sustainable Science & Technology
Ravikumar Sankaralingam, Balasubramanian Sengottuvelan, Pranesh Venkat, Mahalingam Selvaraj, Velmurugan Arunachalam, Jeyakumaran Natarajan
Article
Chemistry, Multidisciplinary
Tamilselvan Abiraman, Kannan Rajavelu, Perumal Rajakumar, Sengottuvelan Balasubramanian
Article
Chemistry, Multidisciplinary
Mani Gajendiran, Sungjun Kim, Heejung Jo, Kyobum Kim
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
(2020)
Article
Chemistry, Multidisciplinary
Ramanjaneya Reddy Gontu, Chennakesavulu Kattela, Balasubramanian Sengottuvelan
Article
Biochemistry & Molecular Biology
Malathi Sampath, Arunkumar Pichaimani, Premkumar Kumpati, Balasubramanian Sengottuvelan
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Multidisciplinary
E. J. Padma Malar, Rebecca Jacob, S. Balasubramanian
JOURNAL OF CHEMICAL SCIENCES
(2019)
Article
Crystallography
Saleem Iqbal, Vijayan Viswanathan, Devadasan Velmurugan, Tamilselvan Abiraman, Sengottuvelan Balasubramanian, Krishnasamy Gunasekaran
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2019)
Article
Crystallography
S. Syed Abuthahir, M. NizamMohideen, V. Viswanathan, Tamilselvan Abiraman, Sengottuvelan Balasubramanian
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2019)
