Efficacy and Pharmacodynamic Modeling of the BTK Inhibitor Evobrutinib in Autoimmune Disease Models

Bruton’s Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages

(2018) Lindsay E. Nyhoff et al.   JOURNAL OF IMMUNOLOGY

Discovery of GDC-0853: A Potent, Selective, and Noncovalent Bruton’s Tyrosine Kinase Inhibitor in Early Clinical Development

(2018) James J. Crawford et al.   JOURNAL OF MEDICINAL CHEMISTRY

ABBV-105, a selective and irreversible inhibitor of Bruton’s Tyrosine Kinase (BTK), is efficacious in multiple preclinical models of inflammation

(2018) Christian Goess et al.   Modern Rheumatology

Bruton's tyrosine kinase inhibitor BMS-986142 in experimental models of rheumatoid arthritis enhances efficacy of agents representing clinical standard-of-care

(2017) Kathleen M. Gillooly et al.   PLoS One

Mediation of transitional B cell maturation in the absence of functional Bruton’s tyrosine kinase

(2017) Shalini Tanwar et al.   Scientific Reports

Btk inhibition treats TLR7/IFN driven murine lupus

(2016) Andrew T. Bender et al.   CLINICAL IMMUNOLOGY

The role of Bruton’s tyrosine kinase in autoimmunity and implications for therapy

(2016) Leslie J. Crofford et al.   Expert Review of Clinical Immunology

Bruton's Tyrosine Kinase Deficiency Inhibits Autoimmune Arthritis in Mice but Fails to Block Immune Complex-Mediated Inflammatory Arthritis

(2016) Lindsay E. Nyhoff et al.   Arthritis & Rheumatology

K/BxN Serum-Transfer Arthritis as a Model for Human Inflammatory Arthritis

(2016) Anne D. Christensen et al.   Frontiers in Immunology

Partial reconstitution of humoral immunity and fewer infections in patients with chronic lymphocytic leukemia treated with ibrutinib

(2015) C. Sun et al.   BLOOD

Self-reactive IgE exacerbates interferon responses associated with autoimmunity

(2015) Jill Henault et al.   NATURE IMMUNOLOGY

Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK

(2015) Idit Sagiv-Barfi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ibrutinib rash in a patient with 17p del chronic lymphocytic leukemia

(2014) Gabriel Mannis et al.   AMERICAN JOURNAL OF HEMATOLOGY

Bruton's tyrosine kinase inhibitors for the treatment of rheumatoid arthritis

(2014) Jennifer A. Whang et al.   DRUG DISCOVERY TODAY

Update on B-cell targeted therapies for systemic lupus erythematosus

(2014) Chi Chiu Mok   EXPERT OPINION ON BIOLOGICAL THERAPY

Btk Regulates B Cell Receptor-Mediated Antigen Processing and Presentation by Controlling Actin Cytoskeleton Dynamics in B Cells

(2014) S. Sharma et al.   JOURNAL OF IMMUNOLOGY

Bruton's Tyrosine Kinase Promotes Persistence of Mature Anti-Insulin B Cells

(2014) R. H. Bonami et al.   JOURNAL OF IMMUNOLOGY

Resistance Mechanisms for the Bruton's Tyrosine Kinase Inhibitor Ibrutinib

(2014) Jennifer A. Woyach et al.   NEW ENGLAND JOURNAL OF MEDICINE

Ibrutinib Resistance in Chronic Lymphocytic Leukemia

(2014) Richard R. Furman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Characterization of Novel PI3Kδ Inhibitors as Potential Therapeutics for SLE and Lupus Nephritis in Pre-Clinical Studies

(2014) Philipp Haselmayer et al.   Frontiers in Immunology

Suppression of Glomerulonephritis in Lupus-Prone NZB × NZW Mice by RN486, a Selective Inhibitor of Bruton's Tyrosine Kinase

(2013) Paola Mina-Osorio et al.   ARTHRITIS AND RHEUMATISM

B-Cell Targeted Therapies in Systemic Lupus Erythematosus

(2013) Philip R. Harvey et al.   BIODRUGS

Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes

(2013) J. A. Dubovsky et al.   BLOOD

The orally available Btk inhibitor ibrutinib (PCI-32765) protects against osteoclast-mediated bone loss

(2013) Masahiro Shinohara et al.   BONE

B-cell-targeted therapies in systemic lupus erythematosus

(2013) Vera Sau-Fong Chan et al.   Cellular & Molecular Immunology

Developing Irreversible Inhibitors of the Protein Kinase Cysteinome

(2013) Qingsong Liu et al.   CHEMISTRY & BIOLOGY

The deleterious role of basophils in systemic lupus erythematosus

(2013) Christophe Pellefigues et al.   CURRENT OPINION IN IMMUNOLOGY

Selective Inhibition of BTK Prevents Murine Lupus and Antibody-Mediated Glomerulonephritis

(2013) A. L. Rankin et al.   JOURNAL OF IMMUNOLOGY

Brutonˈs tyrosine kinase-an integral protein of B cell development that also has an essential role in the innate immune system

(2013) Gabriela López-Herrera et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Skin Rash could Predict the Response to EGFR Tyrosine Kinase Inhibitor and the Prognosis for Patients with Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis

(2013) Hong-bing Liu et al.   PLoS One

Bruton Tyrosine Kinase Inhibitor Ibrutinib (PCI-32765) Has Significant Activity in Patients With Relapsed/Refractory B-Cell Malignancies

(2012) Ranjana H. Advani et al.   JOURNAL OF CLINICAL ONCOLOGY

Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment

(2012) Georg Schett et al.   Nature Reviews Rheumatology

Modulating proximal cell signaling by targeting Btk ameliorates humoral autoimmunity and end-organ disease in murine lupus

(2012) Jack Hutcheson et al.   ARTHRITIS RESEARCH & THERAPY

B cell biomarkers of rituximab responses in systemic lupus erythematosus

(2011) Edward M. Vital et al.   ARTHRITIS AND RHEUMATISM

Basophils and Autoreactive IgE in the Pathogenesis of Systemic Lupus Erythematosus

(2011) Nicolas Charles et al.   CURRENT ALLERGY AND ASTHMA REPORTS

The Tyrosine Kinase BMX Is an Essential Mediator of Inflammatory Arthritis in a Kinase-Independent Manner

(2011) M. Gottar-Guillier et al.   JOURNAL OF IMMUNOLOGY

Antiarthritis Effect of a Novel Bruton's Tyrosine Kinase (BTK) Inhibitor in Rat Collagen-Induced Arthritis and Mechanism-Based Pharmacokinetic/Pharmacodynamic Modeling: Relationships between Inhibition of BTK Phosphorylation and Efficacy

(2011) L. Liu et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

(2011) Falk Hiepe et al.   Nature Reviews Rheumatology

Cellular and molecular pathogenesis of systemic lupus erythematosus: lessons from animal models

(2011) Simanta Pathak et al.   ARTHRITIS RESEARCH & THERAPY

The Bruton tyrosine kinase inhibitor PCI-32765 ameliorates autoimmune arthritis by inhibition of multiple effector cells

(2011) Betty Y Chang et al.   ARTHRITIS RESEARCH & THERAPY

The Src, Syk, and Tec family kinases: Distinct types of molecular switches

(2010) J. Michael Bradshaw   CELLULAR SIGNALLING

Specific Btk inhibition suppresses B cell– and myeloid cell–mediated arthritis

(2010) Julie A Di Paolo et al.   Nature Chemical Biology

The Bruton tyrosine kinase inhibitor PCI-32765 blocks B-cell activation and is efficacious in models of autoimmune disease and B-cell malignancy

(2010) L. A. Honigberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The efficacy and safety of rituximab for the treatment of active rheumatoid arthritis: a systematic review and meta-analysis of randomized controlled trials

(2010) Young Ho Lee et al.   RHEUMATOLOGY INTERNATIONAL

MANAGEMENT OF SKIN RASH DURING EGFR-TARGETED MONOCLONAL ANTIBODY TREATMENT FOR GASTRO INTESTINAL MALIGNANCIES: CANADIAN RECOMMENDATIONS

(2009) Barb Melosky et al.   Current Oncology

Reduced Diabetes in btk-Deficient Nonobese Diabetic Mice and Restoration of Diabetes with Provision of an Anti-Insulin IgH Chain Transgene

(2009) P. L. Kendall et al.   JOURNAL OF IMMUNOLOGY

Chemical target and pathway toxicity mechanisms defined in primary human cell systems

(2009) Ellen L. Berg et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Tyrosine Kinases Btk and Tec Regulate Osteoclast Differentiation by Linking RANK and ITAM Signals

(2008) Masahiro Shinohara et al.   CELL

The Tec Family Tyrosine Kinase Btk Regulates RANKL-induced Osteoclast Maturation

(2008) Seoung Hoon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Btk regulates localization, in vivo activation, and class switching of anti-DNA B cells

(2008) Kristina E. Halcomb et al.   MOLECULAR IMMUNOLOGY