TLR2 Plays a Pivotal Role in Mediating Mucosal Serotonin Production in the Gut

A Map of Toll-like Receptor Expression in the Intestinal Epithelium Reveals Distinct Spatial, Cell Type-Specific, and Temporal Patterns

(2018) April E. Price et al.   IMMUNITY

Serotonin disturbs colon epithelial tolerance of commensal E. coli by increasing NOX2-derived superoxide

(2017) Suhrid Banskota et al.   FREE RADICAL BIOLOGY AND MEDICINE

A comprehensive evaluation of the sl1p pipeline for 16S rRNA gene sequencing analysis

(2017) Fiona J. Whelan et al.   Microbiome

Intestinal Serotonin Transporter Inhibition by Toll-Like Receptor 2 Activation. A Feedback Modulation

(2017) Eva Latorre et al.   PLoS One

Systemic TLR2 agonist exposure regulates hematopoietic stem cells via cell-autonomous and cell-non-autonomous mechanisms

(2016) A C Herman et al.   Blood Cancer Journal

Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical- and infection-induced intestinal inflammation

(2015) Janice J. Kim et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis

(2015) Jessica M. Yano et al.   CELL

Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells

(2015) Christopher S. Reigstad et al.   FASEB JOURNAL

New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection

(2015) Huaqing Wang et al.   INFECTION AND IMMUNITY

Chronic Trichuris muris Infection in C57BL/6 Mice Causes Significant Changes in Host Microbiota and Metabolome: Effects Reversed by Pathogen Clearance

(2015) Ashley Houlden et al.   PLoS One

Targeting TLR2 Attenuates Pulmonary Inflammation and Fibrosis by Reversion of Suppressive Immune Microenvironment

(2014) H.-Z. Yang et al.   JOURNAL OF IMMUNOLOGY

Mycobacterium tuberculosis Subverts the TLR-2 - MyD88 Pathway to Facilitate Its Translocation into the Cytosol

(2014) Md. Aejazur Rahman et al.   PLoS One

Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets

(2013) Gary M. Mawe et al.   Nature Reviews Gastroenterology & Hepatology

TLR2 Mediates Helicobacter pylori–Induced Tolerogenic Immune Response in Mice

(2013) Xia Sun et al.   PLoS One

Simultaneous TLR2 inhibition and TLR9 activation synergistically suppress tumor metastasis in mice

(2012) Jun Yan et al.   ACTA PHARMACOLOGICA SINICA

Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells

(2012) Barbara Drobits et al.   JOURNAL OF CLINICAL INVESTIGATION

Tryptophan hydroxylase-1 regulates immune tolerance and inflammation

(2012) Elizabeth C. Nowak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-13-mediated immunological control of enterochromaffin cell hyperplasia and serotonin production in the gut

(2012) M Manocha et al.   Mucosal Immunology

Trichuris muris: a model of gastrointestinal parasite infection

(2012) Joanna E. Klementowicz et al.   Seminars in Immunopathology

Life on the edge: the balance between macrofauna, microflora and host immunity

(2012) Allison J. Bancroft et al.   TRENDS IN PARASITOLOGY

Serotonin and GI Disorders: An Update on Clinical and Experimental Studies

(2012) Marcus Manocha et al.   Clinical and Translational Gastroenterology

Serotonin Activates Dendritic Cell Function in the Context of Gut Inflammation

(2011) Nan Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Generation of Multimillion-Sequence 16S rRNA Gene Libraries from Complex Microbial Communities by Assembling Paired-End Illumina Reads

(2011) Andrea K. Bartram et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Deficiency in TLR2 but not in TLR4 impairs dendritic cells derived IL-10 responses to schistosome antigens

(2011) Y. Gao et al.   CELLULAR IMMUNOLOGY

Toll-like receptor 2 monoclonal antibody or/and Toll-like receptor 4 monoclonal antibody increase counts of Lactobacilli and Bifidobacteria in dextran sulfate sodium-induced colitis in mice

(2011) Le Dong et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Exploitation of the Intestinal Microflora by the Parasitic Nematode Trichuris muris

(2010) K. S. Hayes et al.   SCIENCE

Normalizing genes for real-time polymerase chain reaction in epithelial and nonepithelial cells of mouse small intestine

(2009) Fengchao Wang et al.   ANALYTICAL BIOCHEMISTRY

Serotonin release and uptake in the gastrointestinal tract

(2009) Paul P. Bertrand et al.   AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL

Myocardial Ischemia/Reperfusion Injury Is Mediated by Leukocytic Toll-Like Receptor-2 and Reduced by Systemic Administration of a Novel Anti–Toll-Like Receptor-2 Antibody

(2009) Fatih Arslan et al.   CIRCULATION

Serotonin Has a Key Role in Pathogenesis of Experimental Colitis

(2009) Jean–Eric Ghia et al.   GASTROENTEROLOGY