期刊
JOURNAL OF ENVIRONMENTAL MANAGEMENT
卷 237, 期 -, 页码 519-525出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jenvman.2019.02.102
关键词
POPs; EDCs; C. elegans; Different exposures; Toxicity assessments; Toxicological mechanisms
资金
- National Key Research and Development Plan [2016YFC0206200]
- National Natural Science Foundation of China [41877377]
- Program of Shanghai Academic/Technology Research Leader [18XD1424100]
- Open Foundation of State Key Laboratory of Environmental Criteria and Risk Assessment Chinese Research Academy of Environmental Sciences [SKLECRA2016OFP19]
Persistent organic pollutants (POPs) and endocrine disrupting compounds (EDCs) are almost ubiquitous in synthetic and natural sources; however these contaminants adversely impact ecosystems and humans. Owing to their potential toxicity, concerns have been raised about the effects of POPs and EDCs on ecological and human health. Therefore, toxicity evaluation and mechanisms actions of these contaminants are of great interest. The nematode Caenorhabditis elegans (C. elegans), an excellent model animal for environmental toxicology research, has been used widely for toxicity studies of POPs or EDCs from the whole-animal level to the single-cell level. In this review, we have discussed the toxicity of specific POPs or EDCs after acute, chronic, and multigenerational exposure in C. elegans. We have also introduced a discussion of the toxicological mechanisms of these compounds in C. elegans, with respect to oxidative stress, cell apoptosis, and the insulin/IGF-1 signaling pathway. Finally, we raised considered the perspectives and challenges of the toxicity assessments, multigenerational toxicity, and toxicological mechanisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据