Article
Medicine, General & Internal
Eriseld Krasniqi, Laura Pizzuti, Maria Rosaria Valerio, Elisabetta Capomolla, Claudio Botti, Giuseppe Sanguineti, Paolo Marchetti, Elisabetta Anselmi, Silverio Tomao, Antonio Giordano, Corrado Ficorella, Katia Cannita, Lorenzo Livi, Icro Meattini, Maria Mauri, Filippo Greco, Enzo Maria Veltri, Andrea Michelotti, Luca Moscetti, Francesco Giotta, Vito Lorusso, Ida Paris, Federica Tomao, Daniele Santini, Giuseppe Tonini, Alice Villa, Vittorio Gebbia, Teresa Gamucci, Gennaro Ciliberto, Isabella Sperduti, Marco Mazzotta, Maddalena Barba, Patrizia Vici
Summary: The use of eribulin mesylate in second line treatment of mTNBC patients showed efficacy in terms of overall survival and progression free survival, with good tolerability. Longer PFS on previous first line treatment may predict better outcomes on second line treatment, and prior adjuvant chemotherapy may also positively influence the PFS on eribulin treatment.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Letter
Medicine, General & Internal
Shuvadeep Ganguly, Ajay Gogia
Summary: In the KEYNOTE-522 trial, the addition of Pembrolizumab to neoadjuvant chemotherapy improved pathological complete response rate in early triple-negative breast cancer patients and also improved event-free survival. However, this improvement was predominantly observed in patients who did not achieve a pathological complete response.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Oncology
Felipe Batalini, Niya Xiong, Nabihah Tayob, Madeline Polak, Julia Eismann, Lewis C. Cantley, Geoffrey Shapiro, Viktor Adalsteinsson, Eric P. Winer, Panagiotis A. Konstantinopoulos, Alan D'Andrea, Elizabeth M. Swisher, Ursula A. Matulonis, Gerburg M. Wulf, Erica L. Mayer
Summary: This study aimed to evaluate the safety and recommended dose of olaparib in combination with alpelisib in patients with breast cancer, and explore its effects on different subtypes. The results showed that this combination therapy was tolerable for pre-treated TNBC patients and demonstrated activity in non-BRCA mutant patients. Analysis of circulating-free DNA also provided important prognostic information.
CLINICAL CANCER RESEARCH
(2022)
Article
Medicine, General & Internal
A. Bardia, S. A. Hurvitz, S. M. Tolaney, D. Loirat, K. Punie, M. Oliveira, A. Brufsky, S. D. Sardesai, K. Kalinsky, A. B. Zelnak, R. Weaver, T. Traina, F. Dalenc, P. Aftimos, F. Lynce, S. Diab, J. Cortes, J. O'Shaughnessy, V Dieras, C. Ferrario, P. Schmid, L. A. Carey, L. Gianni, M. J. Piccart, S. Loibl, D. M. Goldenberg, Q. Hong, M. S. Olivo, L. M. Itri, H. S. Rugo
Summary: Patients with metastatic triple-negative breast cancer treated with Sacituzumab govitecan had significantly longer progression-free and overall survival compared to standard chemotherapy, but experienced more frequent myelosuppression and diarrhea as adverse events.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Oncology
Sara M. Tolaney, Kevin Kalinsky, Virginia G. Kaklamani, David R. D'Adamo, Gursel Aktan, Michaela L. Tsai, Ruth M. O'Regan, Peter A. Kaufman, Sharon T. Wilks, Eleni Andreopoulou, Debra A. Patt, Yuan Yuan, Grace Wang, Claudio Savulsky, Dongyuan Xing, Ella Kleynerman, Vassiliki Karantza, Sami Diab
Summary: The study investigated the efficacy and safety of combination therapy with eribulin and pembrolizumab in mTNBC, showing promising antitumor activity in this population. Efficacy outcomes appeared to be influenced by the line of therapy and PD-L1 status.
CLINICAL CANCER RESEARCH
(2021)
Article
Medicine, General & Internal
J. Cortes, H. S. Rugo, D. W. Cescon, S-A Im, M. M. Yusof, C. Gallardo, O. Lipatov, C. H. Barrios, J. Perez-Garcia, H. Iwata, N. Masuda, M. Torregroza Otero, E. Gokmen, S. Loi, Z. Guo, X. Zhou, V Karantza, W. Pan, P. Schmid
Summary: The addition of pembrolizumab to chemotherapy significantly improves overall survival in patients with advanced triple-negative breast cancer whose tumors express PD-L1 with a CPS of 10 or more.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Endocrinology & Metabolism
Xiangdi Meng, Yuanyuan Cai, Xiaolong Chang, Yinghua Guo
Summary: This study aimed to estimate conditional survival (CS) and develop a novel CS-nomogram for non-metastatic triple-negative breast cancer patients. The CS analysis showed an improvement in survival over time since diagnosis and the CS-nomogram included predictors such as age, marriage, race, tumor and lymph node status, chemotherapy, surgery, and radiotherapy. The model had satisfactory predictive performance and could aid clinical decision-making and reduce patient anxiety.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Renfei Wu, Koukou Li, Mingheng Yuan, Kathy Qian Luo
Summary: NGFR was identified as a novel driver for transforming TNBC into higher grade metastatic tumors, with its high expression associated with tumor malignancy and negative correlation with TNBC patient survival. The study provides the basis for developing NGFR as a diagnostic, prognostic marker, and therapeutic target for TNBC patients in the future.
Article
Multidisciplinary Sciences
Chitra Thakur, Yiran Qiu, Qian Zhang, Nicholas J. Carruthers, Miaomiao Yu, Zhuoyue Bi, Yao Fu, Priya Wadgaonkar, Bandar Almutairy, Akimasa Seno, Paul M. Stemmer, Fei Chen
Summary: This report provides evidence of diminished expression of the mineral dust-induced gene (mdig) in human triple negative breast cancer (TNBC). The study demonstrates that mdig promotes the growth of primary tumors but inhibits metastasis of TNBC cells. The findings also suggest a potential role of mdig in regulating genes related to cell motility, invasion, and metastasis.
Article
Oncology
Jose P. Leone, Noah Graham, Julieta Leone, Sara M. Tolaney, Bernardo A. Leone, Rachel A. Freedman, Michael J. Hassett, Carlos T. Vallejo, Eric P. Winer, Nancy U. Lin, Nabihah Tayob
Summary: This study developed a tool called "ESTIMATE-TN" to assess the risk of breast cancer-specific mortality (BCSM), non-BCSM, and all-cause mortality in non-metastatic triple-negative breast cancer (TNBC) patients. The tool allows input of patient and tumor characteristics and provides a nonparametric estimate of cumulative risks using Gray's subdistribution method.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Multidisciplinary Sciences
Jieqiong Liu, Ying Wang, Zhenluan Tian, Ying Lin, Hengyu Li, Zhaowen Zhu, Qiang Liu, Shicheng Su, Yinduo Zeng, Weijuan Jia, Yaping Yang, Shengqiang Xu, Herui Yao, Wen Jiang, Erwei Song
Summary: This multicentered phase II trial evaluated the efficacy and safety of camrelizumab in combination with apatinib and eribulin for heavily pre-treated advanced TNBC patients. The results showed that this combination therapy showed promising efficacy and an acceptable safety profile in this population.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Martina Dameri, Lorenzo Ferrando, Gabriella Cirmena, Claudio Vernieri, Giancarlo Pruneri, Alberto Ballestrero, Gabriele Zoppoli
Summary: This review discusses the clinical applications of multi-gene testing in breast cancer, especially in metastatic triple-negative breast cancer (mTNBC), and briefly touches on the emerging role of immunotherapy in mTNBC. The potential predictive utility of homologous recombination repair deficiency (HRD) and tumor mutational burden (TMB) in mTNBC treatment is also highlighted, with the use of NGS platforms in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yin Liu, Xiu-Zhi Zhu, Yi Xiao, Song-Yang Wu, Wen-Jia Zuo, Qiang Yu, A-Yong Cao, Jun-Jie Li, Ke-Da Yu, Guang-Yu Liu, Jiong Wu, Tao Sun, Jiu-Wei Cui, Zheng Lv, Hui-Ping Li, Xiao-Yu Zhu, Yi-Zhou Jiang, Zhong-Hua Wang, Zhi-Ming Shao
Summary: Triple-negative breast cancer is a heterogeneous disease with limited treatment options. The results of the FUTURE trial show that subtype-based therapy may improve outcomes in metastatic TNBC patients, with objective responses achieved in nearly 30% of patients. This study also provides insights into the association between genomic and clinicopathological parameters and treatment efficacy.
Article
Oncology
Juan Luis Gomez Marti, Colin H. Beckwitt, Amanda M. Clark, Alan Wells
Summary: The study examined the effects of atorvastatin on chemotherapy for mTNBC through animal models and clinical correlations. Atorvastatin was found to have additive effects with doxorubicin targeting liver metastases, and the combination of atorvastatin and chemotherapy led to increased cell death in dormant cancer cells.
BRITISH JOURNAL OF CANCER
(2021)
Article
Oncology
David B. Page, Joanna Pucilowska, Brie Chun, Isaac Kim, Katherine Sanchez, Nicole Moxon, Staci Mellinger, Yaping Wu, Yoshinobu Koguchi, Valerie Conrad, William L. Redmond, Maritza Martel, Zhaoyu Sun, Mary B. Campbell, Alison Conlin, Anupama Acheson, Reva Basho, Philomena McAndrew, Mary El-Masry, Dorothy Park, Laura Bennetts, Robert S. Seitz, Tyler J. Nielsen, Kimberly McGregor, Venkatesh Rajamanickam, Brady Bernard, Walter J. Urba, Heather L. McArthur
Summary: Chemoimmunotherapy with anti-PD-1/L1 and cytotoxic chemotherapy is a promising treatment for triple-negative breast cancer, but further research is needed to determine the optimal chemotherapy regimen and biomarkers for patient selection. This study investigated the safety and efficacy of pembrolizumab in combination with paclitaxel or capecitabine, and found that both regimens were safe and clinically active.
Article
Oncology
Fabian Grass, David Martin, Michael Montemurro, Patrice Mathevet, Anita Wolfer, George Coukos, Nicolas Demartines, Martin Hubner
Meeting Abstract
Oncology
Y. Drew, M. de Jonge, S. H. Hong, Y. H. Park, A. Wolfer, J. Brown, M. Ferguson, M. E. Gore, R. H. Alvarez, C. Gresty, H. Angell, K. Meyer, M. Learoyd, M. Tang, M. Lanasa, P. Herbolsheimer, S. M. Domchek
GYNECOLOGIC ONCOLOGY
(2018)
Meeting Abstract
Oncology
Sana Intidhar Labidi-Galy, Thibault De La Motte Rouge, Olfa Derbel, Elsa Kalbacher, Anita Wolfer, Timothee Olivier, Ketty Hu, Olivier Tredan, Hemerson Guevara, Fernando Bazan, Victoire De Castelbajac, Jean-Damien Combes, Pauline Vaflard, Louise Crivelli, Valerie Bonadona, Valeria Viassolo, Lisa Golmard, Adrien Buisson, Manuel Rodrigues, Isabelle Laure Ray-Coquard
JOURNAL OF CLINICAL ONCOLOGY
(2018)
Article
Oncology
S. Intidhar Labidi-Galy, Thibault de La Motte Rouge, Olfa Derbel, Anita Wolfer, Elsa Kalbacher, Timothee Olivier, Jean-Damien Combes, Ketty Heimgartner-Hu, Olivier Tredan, Hemerson Guevara, Pierre-Etienne Heudel, Thibaut Reverdy, Fernando Bazan, Viola Heinzelmann-Schwarz, Mathias Fehr, Victoire de Castelbajac, Pauline Vaflard, Louise Crivelli, Valerie Bonadona, Valeria Viassolo, Adrien Buisson, Lisa Golmard, Manuel Rodrigues, Isabelle Ray-Coquard
GYNECOLOGIC ONCOLOGY
(2019)
Meeting Abstract
Oncology
R. E. O'Cearbhaill, K. Homicsko, A. Wolfer, P. A. DiSilvestro, D. M. O'Malley, P. Sabbatini, A. Orcurto, D. Barras, L. Shohara, T. Ricciardi, M. Macri, A. Ryan, R. R. Venhaus, B. J. Monk, G. Coukos
GYNECOLOGIC ONCOLOGY
(2020)
Meeting Abstract
Oncology
S. Banerjee, P. B. Ottevanger, A. Sarivalasis, R. Le Scodan, A. Montes, J. R. Kroep, M. Romeo Marin, A. Casado Herraez, M. Auvray-Kuentz, A. M. Westermann, B. Lucas, D. Dangaj, F. Herrera, A. Wolfer, C. Coens, M. B. Vanlancker, L. Kandalaft, G. Coukos
ANNALS OF ONCOLOGY
(2021)
Article
Oncology
Sandro Anchisi, Anita Wolfer, Bettina Bisig, Edoardo Missiglia, Amine Tiab, Ehab Mohamed Kamel, Olivier Michielin, George Coukos, Krisztian Homicsko
Summary: The treatment of BRAFV600E mutant melanoma has been revolutionized by BRAF inhibitors, and BRAF/MEK combination has shown further improvements. BRAF inhibitor use has also been proposed in low-grade ovarian tumors.
CANCER BIOLOGY & THERAPY
(2023)
Article
Medicine, Research & Experimental
Ulrich-P. Rohr, Mario Iovino, Leonie Rudofsky, Qiyu Li, Stephanie Juritz, Arunas Gircys, Oliver Wildner, Magda Bujar, Claus Bolte, Simon Dalla Torre di Sanguinetto, Anita Wolfer
Summary: Consensus among regulatory agencies is crucial for stakeholders. This study analyzed regulatory decision patterns from Swissmedic (SMC), FDA, and EMA for hemato-oncology products (OP) and non-oncology products (NOP). The study found differences in approval rates, consensus, and divergent decisions among the agencies, with the main driver for divergent decisions in OP being nonrandomized trial design and low patient numbers.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Editorial Material
Oncology
Matea Pavic, Anita Wolfer, Qiyu Li, Arunas Gircys, Stephanie Juritz, Andreas Wicki, Thomas Cerny, Ulrich-Peter Rohr
Summary: The Swiss regulator emphasizes the insufficiency of relying solely on surrogate endpoints in (neo)adjuvant trials, highlighting the need for a more comprehensive evaluation.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
U-P. Rohr, M. Iovino, L. Rudofsky, Q. Li, S. Juritz, A. Gircys, O. Wildner, M. Bujar, S. Dalla-Torre, A. Wolfer
ANNALS OF ONCOLOGY
(2022)
Meeting Abstract
Oncology
S. I. Labidi-Galy, T. deLa Motte Rouge, O. Derbel, A. Wolfer, E. Kalbacher, T. Olivier, J-D. Combes, K. Hu-Heimgartner, O. Tredan, H. Guevara, V. Heinzelmann-Schwarz, M. Fehr, V. de Castelbajac, P. Vaflard, L. Crivelli, V. Bonadona, V. Viassolo, F. Bazan, M. Rodrigues, I. L. Ray-Coquard
ANNALS OF ONCOLOGY
(2019)
Meeting Abstract
Oncology
Apostolos Sarivalasis, Anita Wolfer, Maria Teresa Alvarez Flores, Fernanda Herrera, Mariangela Costanza, Patrice Mathevet
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2018)
Meeting Abstract
Oncology
R. E. O'Cearbhaill, A. Wolfer, P. Disilvestro, D. M. O'Malley, P. Sabbatini, L. Shohara, P. O. Schwarzenberger, T. Ricciardi, M. Macri, A. Ryan, R. R. Venhaus, J. K. Bryan, P. Wong, K. Homicsko, L. Kandalaft, S. Rusakiewicz, A. Harari, B. J. Monk, G. Coukos
ANNALS OF ONCOLOGY
(2018)
Meeting Abstract
Oncology
R. T. Penson, Y. Drew, M. J. A. de Jonge, S-H. Hong, Y. H. Park, A. Wolfer, J. Brown, M. Ferguson, M. E. Gore, R. H. Alvarez, B. Kaufman, C. Gresty, H. K. Angell, K. Meyer, M. Lanasa, P. Herbolsheimer, S. Domchek
ANNALS OF ONCOLOGY
(2018)
Article
Hematology
Frederica Schyrr, Anita Wolfer, Jerome Pasquier, Anne-Laure Nicoulaz, Olivier Lamy, Olaia Naveiras
ANNALS OF HEMATOLOGY
(2018)