Article
Immunology
Abbas Hatim Rupawala, Darrel Gachette, Mena Bakhit, Lanre Jimoh, Colleen R. Kelly
Summary: The study found that serial fecal microbiota transplant may not always be effective in patients with severe or complicated Clostridoides difficile infection unresponsive to standard antibiotic therapy, and may lead to serious adverse events.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Gastroenterology & Hepatology
Kelly Suchman, Yuying Luo, Ari Grinspan
Summary: This study supports the efficacy and safety of fecal microbiota transplant (FMT) for Clostridioides difficile infection (CDI) in immunocompromised patients. The primary cure rate was 85.1% and the overall cure rate was 86.5%. Serious adverse events were experienced by 11.7% of patients following FMT.
DIGESTIVE DISEASES AND SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Tanveer Singh, Prabhjot Bedi, Karandeep Bumrah, Darshan Gandhi, Tanureet Arora, Nikita Verma, Mary Schleicher, Manoj P. Rai, Rajat Garg, Beni Verma, Madhusudhan R. Sanaka
Summary: Fecal microbiota transplantation (FMT) is effective in the treatment of recurrent Clostridium difficile infection (CDI), but not significant in primary CDI.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2022)
Article
Microbiology
Fahimeh Sadat Gholam-Mostafaei, Masoumeh Azimirad, Kaveh Naseri, Ali Nabavi-Rad, Hamid Asadzadeh Aghdaei, Shabnam Shahrokh, Nasser Ebrahimi Daryani, Abbas Yadegar, Mohammad Reza Zali
Summary: This study aimed to investigate the impact of fecal microbiota transplantation (FMT) on intestinal microbiota alterations in Iranian rCDI patients with underlying IBD. The results showed that the fecal microbiota profile of recipients became more similar to donor samples after the transplantation, with a significant increase in the relative abundance of Bacteroidetes. This study demonstrates that FMT is a safe and effective approach to restore the indigenous composition of the intestinal microbiota in rCDI patients and ultimately results in the treatment of concurrent IBD.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Krishna Vedala, Philip Sobash, Parth Shah, Gilbert-Roy Kamoga
Summary: Clostridioides difficile infection imposes a significant economic burden in inpatient and rural settings. Fecal Microbiota Transplant, although limited by guidelines and resources, has been shown to save an average of $11,603.49 per patient after the first recurrence of CDI. Our study suggests that utilizing FMT in rural hospitals for recurrent CDI treatment could be economically beneficial.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Cell Biology
Camilla Kara Svensson, Frederik Cold, Iben Ribberholt, Mike Zangenberg, Hengameh Chloe Mirsepasi-Lauridsen, Andreas Munk Petersen, Morten Helms
Summary: This retrospective cohort study found that FMT capsules were more effective than FMT enema and RBT in treating recurrent CDI, and reduced the risk of further recurrences.
Article
Gastroenterology & Hepatology
Christian Bestfater, Maria J. G. T. Vehreschild, Andreas Stallmach, Kester Tueffers, Andreas Erhardt, Thorsten Frank, Thomas Glueck, Felix Goeser, Gernot Sellge, Philipp Solbach, Herbert Eisenlohr, Martin Storr
Summary: Simultaneous bidirectional FMT showed superior primary cure rates compared to standard unidirectional approaches for recurrent Clostridioides difficile infection, highlighting the importance of treatment route in optimizing patient outcomes. Further prospective studies are needed to confirm these findings.
DIGESTIVE AND LIVER DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Andrea Piccioni, Federico Rosa, Federica Manca, Giulia Pignataro, Christian Zanza, Gabriele Savioli, Marcello Covino, Veronica Ojetti, Antonio Gasbarrini, Francesco Franceschi, Marcello Candelli
Summary: The composition of the human microbiome plays a crucial role in health, and alterations in the microbiota can lead to Clostridium difficile infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, General & Internal
Teena Chopra, Gail Hecht, Glenn Tillotson
Summary: Clostridioides difficile infection poses challenges due to its recurrent nature, and current antibiotic management does not address the underlying issue of dysbiosis. Restoring the microbiome through therapies like live biotherapeutics can lead to positive clinical outcomes. Several such therapies are currently being investigated.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Daniel Popa, Bogdan Neamtu, Manuela Mihalache, Adrian Boicean, Adela Banciu, Daniel Dumitru Banciu, Doru Florian Cornel Moga, Victoria Birlutiu
Summary: Faecal microbiota transplant (FMT) is highly effective for recurrent Clostridioides difficile infection (rCDI) with a cure rate of 85-92%, but its role in primary CDI is still uncertain. This study shows FMT's effectiveness in primary severe CDI and the risk of recurrence is related to the number of CDI episodes. Further research on larger cohorts is needed.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Pei-Chang Lee, Tien-En Chang, Yen-Po Wang, Kuei-Chuan Lee, Yi-Tsung Lin, Jen-Jie Chiou, Chi-Wei Huang, Ueng-Cheng Yang, Fen-Yau Li, Hui-Chun Huang, Chun-Ying Wu, Yi-Hsiang Huang, Ming-Chih Hou
Summary: This study aimed to investigate the efficacy of FMT for treating rCDI and its association with microbial changes. The research found that successful FMT was related to treatment outcomes and led to dynamic changes in fecal microbial composition.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Immunology
Elizabeth S. Aby, Byron P. Vaughn, Eva A. Enns, Radha Rajasingham
Summary: This study assessed the cost-effectiveness of fecal microbiota transplantation (FMT) for first recurrent Clostridioides difficile infection (CDI). The findings indicate that FMT is a cost-effective treatment strategy for first recurrent CDI.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Surgery
Emmanuel Nwachuku, Yizhi Shan, Prabhu Senthil-Kumar, Todd Braun, Ryan Shadis, Orlando Kirton, Thai Q. Vu
Summary: This case series reports 9 surgical patients with CDI who did not experience diarrhea prior to diagnosis. While all patients tested positive for C. difficile toxin, some presented with minimal bowel movements or constipation instead. These findings highlight the importance of considering CDI as a potential diagnosis in patients with atypical gastrointestinal symptoms even in the absence of diarrhea.
AMERICAN JOURNAL OF SURGERY
(2021)
Article
Infectious Diseases
Fanni Dembrovszky, Noemi Gede, Zsolt Szakacs, Peter Hegyi, Szabolcs Kiss, Nelli Farkas, Zsolt Molnar, Marcell Imrei, Dora Dohos, Zoltan Peterfi
Summary: This network meta-analysis found that vancomycin + FMT may be the most effective option for the treatment and prevention of multiple recurrent CDI, while tolevamer and vancomycin + FMT seemed to be the most effective in preventing recurrence.
INFECTIOUS DISEASES AND THERAPY
(2021)
Article
Gastroenterology & Hepatology
Maribeth R. Nicholson, Suchitra K. Hourigan, Maire Conrad, Alka Goyal, Kyle Jensen, Judith Kelsen, Melissa Kennedy, Madison Weatherly, Stacy A. Kahn
Summary: The impact of the 2019 US FDA safety alert and the COVID-19 pandemic on the use of FMT in children has led to changes in practices for many pediatric gastroenterologists, with a majority of programs being halted as a result.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Pippa Storey, Oded Gonen, Andrew B. Rosenkrantz, Kiranpreet K. Khurana, Tiejun Zhao, Rajesh Bhatta, Joseph P. Alukal
INVESTIGATIVE RADIOLOGY
(2018)
Review
Gastroenterology & Hepatology
Sudhir K. Dutta, Sandeep Verma, Vardhmaan Jain, Balaram K. Surapaneni, Rakesh Vinayek, Laila Phillips, Padmanabhan P. Nair
JOURNAL OF NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Article
Urology & Nephrology
Wen Liu, Michael L. Schulster, Joseph P. Alukal, Bobby B. Najari
UROLOGIC CLINICS OF NORTH AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Bo Xia, Yun Yan, Maayan Baron, Florian Wagner, Dalia Barkley, Marta Chiodin, Sang Y. Kim, David L. Keefe, Joseph P. Alukal, Jef D. Boeke, Itai Yanai
Article
Obstetrics & Gynecology
Feng Pan, Xingyuan Xiao, Jingtao Guo, Yarong Song, Honggang Li, Darshan P. Patel, Adam M. Spivak, Joseph P. Alukal, Xiaoping Zhang, Chengliang Xiong, Philip S. Li, James M. Hotaling
FERTILITY AND STERILITY
(2020)
Article
Medical Laboratory Technology
Laila E. Phillips, Sandeep Verma, Balarama K. Surapaneni, Sudhir K. Dutta
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2020)
Letter
Urology & Nephrology
Nahid Punjani, Philip S. Li, Joseph P. Alukal
UROLOGIA INTERNATIONALIS
(2020)
Article
Obstetrics & Gynecology
Darshan P. Patel, Nahid Punjani, Jingtao Guo, Joseph P. Alukal, Philip S. Li, James M. Hotaling
Summary: Many couples initially delayed fertility care due to COVID-19 concerns, but later resumed services despite uncertainties related to male reproductive health. Ongoing research on COVID-19 and male sexual and reproductive health has limited definitive evidence, making it challenging for patients and physicians to provide the best clinical care.
FERTILITY AND STERILITY
(2021)
Review
Andrology
Nahid Punjani, Spyridon P. Basourakos, Quincy G. Nang, Richard K. Lee, Marc Goldstein, Joseph P. Alukal, Philip S. Li
Summary: Male circumcision is a longstanding surgical procedure used to treat foreskin-related conditions and prevent infections. Existing data suggest that male circumcision may play a significant role in preventing genitourinary infections and safeguarding male fertility.
WORLD JOURNAL OF MENS HEALTH
(2022)
Article
Oncology
Balarama K. Surapaneni, Pragnan Kancharla, R. Vinayek, Sudhir K. Dutta, Mendel Goldfinger
CASE REPORTS IN ONCOLOGY
(2019)
Article
Gastroenterology & Hepatology
Michelle Le, Balarama Krishna Surapaneni, Vardhmaan Jain, Rakesh Vinayek, Sudhir K. Dutta
CLINICAL MEDICINE INSIGHTS-GASTROENTEROLOGY
(2018)
Article
Gastroenterology & Hepatology
Samiksha Gupta, Balaram Krishna Surapaneni, Rakesh Vinayek, Sudhir K. Dutta
CASE REPORTS IN GASTROINTESTINAL MEDICINE
(2018)