Article
Psychology, Multidisciplinary
Ashley N. Clausen, Heather C. Bouchard, Kathleen A. Welsh-Bohmer, Rajendra A. Morey
Summary: This study compared the chronic effects of combat-related blast mTBI and subconcussive blast exposure on neuropsychological performance in Veterans. Results showed that Veterans with combat-related blast mTBI exhibited significantly slower processing speed compared to controls, even after controlling for PTSD and depressive symptoms. However, there were no significant differences in cognition between subconcussive and control groups, or between subconcussive and combat-related blast mTBI groups, suggesting that neurocognitive assessment may not be sensitive enough to detect the long-term effects of subconcussive blast exposure.
FRONTIERS IN PSYCHOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Charlotte Oris, Samy Kahouadji, Julie Durif, Damien Bouvier, Vincent Sapin
Summary: Mild traumatic brain injury (mTBI) is a growing burden worldwide, accounting for approximately 80% of all TBI cases. In recent years, candidate biomarkers have been investigated to improve the management of mTBI patients. Blood biomarker measurement in the acute phase after a traumatic event helps reduce unnecessary CT scans and hospitalizations. S100B protein has emerged as the most widely studied and used biomarker for clinical decision making in patients with mTBI. Besides its diagnostic use, S100B plays a role in the molecular pathogenic processes accompanying acute brain injury, making it a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Susanne M. van der Veen, Robert A. Perera, Laura Manning-Franke, Amma A. Agyemang, Karen Skop, Scott R. Sponheim, Elisabeth A. Wilde, Alexander Stamenkovic, James S. Thomas, William C. Walker
Summary: Among patients with mild traumatic brain injury (mTBI), postural instability often persists chronically. Reduced executive function (EF) may explain this phenomenon, as it affects the processing and interpretation of sensory information. Our study aimed to investigate if specific tests of EF could predict balance function in individuals with a history of chronic mTBI.
FRONTIERS IN NEUROLOGY
(2023)
Article
Immunology
Emer Ryan, Lynne Kelly, Catherine Stacey, Dean Huggard, Eimear Duff, Danielle McCollum, Ann Leonard, Gerard Boran, Dermot R. Doherty, Turlough Bolger, Eleanor J. Molloy
Summary: This study demonstrates altered cytokine profiles and endotoxin responses in children with traumatic brain injury (TBI), including mild TBI. Children with mild TBI showed decreased levels of IL-8, IL-10, IL-17A, and TNF-alpha compared to controls, along with increased levels of IFN-gamma. In severe TBI, there was no significant IL-6 response to endotoxin, but an increase in IL-17A. These findings suggest immune dysfunction following TBI, especially in mild cases.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Clinical Neurology
Henry W. Mahncke, Joseph DeGutis, Harvey Levin, Mary R. Newsome, Morris D. Bell, Chad Grills, Louis M. French, Katherine W. Sullivan, Sarah-Jane Kim, Annika Rose, Catherine Stasio, Michael M. Merzenich
Summary: This study evaluated the efficacy of self-administered plasticity-based cognitive training for individuals with a history of mild traumatic brain injury and cognitive impairment. The treatment group showed significant improvement in cognitive function compared to the active control group, with equivalent results in depressive and cognitive symptoms between the two groups.
Article
Rehabilitation
Eunkyung Kim, Han Gil Seo, Hyun Haeng Lee, Seung Hak Lee, Seung Hong Choi, Roh-Eul Yoo, Won-Sang Cho, Seo Jung Yun, Min-Gu Kang, Byung-Mo Oh
Summary: The study aimed to investigate changes in regional brain volume after mild traumatic brain injury and their relationship with cognitive deficits. The results showed that individuals with mild traumatic brain injury had reduced brainstem volume and this reduction was significantly associated with cognitive function, especially performance on tests like executive card sorting, forward digit span, and verbal learning.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Neurosciences
Rita Campos-Pires, Bee Eng Ong, Mariia Koziakova, Eszter Ujvari, Isobel Fuller, Charlotte Boyles, Valerie Sun, Andy Ko, Daniel Pap, Matthew Lee, Lauren Gomes, Kate Gallagher, Peter F. Mahoney, Robert Dickinson
Summary: This study investigates the effects of repeated mild blast traumatic brain injury (mbTBI) on rats and identifies specific brain regions that are particularly sensitive to repeated blast exposure. The findings suggest that repeated exposure to blast can lead to functional impairments and neuronal loss in certain brain regions. The reasons for this sensitivity may include exposure to stronger shockwaves or proximity to tissue density transitions. This study provides insights into the mechanisms of injury sensitization and potential new treatments.
Article
Medicine, General & Internal
Sophia Wagberg, Britt-Marie Stalnacke, Beatrice M. M. Magnusson
Summary: This study evaluates post-TBI symptoms and disabilities seven to eight years after mild TBI (mTBI), showing that women and individuals with repeated TBI experience more severe symptoms and functional decline. These findings have implications for clinical practice and research, and should be considered in rehabilitation and follow-up plans.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Emergency Medicine
Sean C. Rose, Deborah A. Levine, Junxin Shi, Krista Wheeler, Taylour Aungst, Rachel M. Stanley, Miriam H. Beauchamp
Summary: This study examined the incidence and healthcare utilization of mild traumatic brain injury (mTBI) in young children presenting to U.S. emergency departments. The findings showed that early childhood mTBI is prevalent and results in a significant financial burden. There is wide variation in diagnostic coding and treatment strategies among emergency departments, highlighting the need for further research.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Article
Behavioral Sciences
Fanny Degeilh, Tilmann von Soest, Lia Ferschmann, Joanne C. Beer, Malo Gaubert, Inga K. Koerte, Christian K. Tamnes
Summary: Childhood mTBI is associated with an increased risk of developing social problems, possibly due to changes in the structural development of the social brain. This study used data from the ABCD Study to examine the development of social problems and cortical thickness in social brain regions following childhood mTBI. The findings showed different developmental trajectories in social problems between children with and without mTBI, with the mTBI group showing higher levels of social problems. Both groups showed similar decreases in social brain cortical thickness.
Review
Psychiatry
Kathryn A. Ritchie, Beth S. Slomine
Summary: Mild traumatic brain injury (mTBI) is a significant public health concern for children. While most children recover within 1 month after mTBI, 10-30% experience lingering neuropsychiatric or neuropsychological symptoms. Factors associated with prolonged recovery include preinjury mental health concerns, female sex, and family characteristics. Early management includes reassurance and brief rest, while specialized evaluation and multimodal therapies are recommended for symptoms lasting more than 4 weeks.
CURRENT OPINION IN PSYCHIATRY
(2022)
Article
Clinical Neurology
Josh W. Faulkner, Alice Theadom, Deborah L. Snell, Matt N. Williams
Summary: This study applied network analysis to investigate post-concussion symptoms after mild traumatic brain injury (mTBI) and found that frustration, blurred vision, and concentration difficulties were central symptoms in two different mTBI samples. These symptoms may play an influential role in the experience and maintenance of post-concussion symptoms.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Sihong Huang, Chuxin Huang, Mengjun Li, Huiting Zhang, Jun Liu
Summary: This study used three diffusion models (DTI, DKI, NODDI) to investigate complex white matter changes in the acute stage after mTBI. The results showed that mTBI patients had white matter abnormalities and cognitive deficits, and these two changes were positively correlated.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Thorsten Rudroff, Craig D. Workman
Summary: Based on a review of the literature, there is limited evidence supporting the use of tDCS for improving cognitive and motor performance in mTBI patients, with only three studies meeting the inclusion criteria. This highlights the urgent need for further research to identify optimal therapeutic brain targets and stimulation parameters.
Article
Clinical Neurology
William C. Walker, Sarah W. Clark, Kaleb Eppich, Elisabeth A. Wilde, Aaron M. Martin, Chelsea M. Allen, Melissa M. Cortez, Mary Jo Pugh, Samuel R. Walton, Kimbra Kenney
Summary: This study analyzed the relationship between lifetime history of mild traumatic brain injury (mTBI) and other factors with headache prevalence and impact among combat-exposed current and former service members. The results showed that regardless of the remoteness of mTBI, participants with positive mTBI history had higher headache prevalence and impact. Blast-related mTBI posed the highest risk and was uniquely associated with elevated headache burden. Other demographic and potentially modifiable risk factors were also identified.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neuroimaging
Kathleen F. Pagulayan, Eric C. Petrie, David G. Cook, Rebecca C. Hendrickson, Holly Rau, Melissa Reilly, Cindy Mayer, James S. Meabon, Murray A. Raskind, Elaine R. Peskind, Natalia Kleinhans
BRAIN IMAGING AND BEHAVIOR
(2020)
Article
Clinical Neurology
James S. Meabon, David G. Cook, Mayumi Yagi, Garth E. Terry, Donna J. Cross, Mark Muzi, Kathleen F. Pagulayan, Aric F. Logsdon, Abigail G. Schindler, Vikas Ghai, Kai Wang, Shannon Fallen, Yong Zhou, Taek-Kyun Kim, Inyoul Lee, William A. Banks, Erik S. Carlson, Cynthia Mayer, Rebecca C. Hendrickson, Murray A. Raskind, Desiree A. Marshall, Daniel P. Perl, C. Dirk Keene, Elaine R. Peskind
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2020)
Article
Substance Abuse
Abigail G. Schindler, Britahny Baskin, Barbara Juarez, Suhjung Janet Lee, Rebecca Hendrickson, Kathleen Pagulayan, Larry S. Zweifel, Murray A. Raskind, Paul E. M. Phillips, Elaine R. Peskind, David G. Cook
Summary: Research showed that both single and repetitive blast-induced mild traumatic brain injury (mTBI) can affect ethanol-induced behavioral and physiological outcomes. Repetitive blast-induced mTBI may increase the risk of alcohol abuse.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Health Care Sciences & Services
Rebecca C. Hendrickson, Roisin A. Slevin, Katherine D. Hoerster, Bernard P. Chang, Ellen Sano, Catherine A. McCall, Gillian R. Monty, Ronald G. Thomas, Murray A. Raskind
Summary: The study shows a significant relationship between COVID-19 related occupational stressors and psychiatric symptoms and occupational outcomes among healthcare workers and first responders, with demoralization having the most prominent impact on mental health and work-related issues. Mitigating these stressors, especially by addressing factors causing demoralization, may lead to improvements in mental health, work functioning, and retention in this population.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2022)
Article
Behavioral Sciences
Britahny Baskin, Suhjung Janet Lee, Emma Skillen, Katrina Wong, Holly Rau, Rebecca C. Hendrickson, Kathleen Pagulayan, Murray A. Raskind, Elaine R. Peskind, Paul E. M. Phillips, David G. Cook, Abigail G. Schindler
Summary: Repetitive blast exposure in male mice was found to increase reward-seeking and goal-directed behavior while decreasing behavioral flexibility, with concurrent chronic adverse behavioral changes related to anxiety, compulsivity, and hyperarousal. These findings suggest that deficits in executive function post-blast mTBI may be linked to enhanced compulsivity/hyperreactivity and behavioral inflexibility.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Psychology, Clinical
David P. Sheppard, Holly K. Rau, Emily H. Trittschuh, Madeleine L. Werhane, Abigail G. Schindler, Rebecca C. Hendrickson, Elaine R. Peskind, Kathleen F. Pagulayan
Summary: This study found that Veterans with a history of mild traumatic brain injury (mTBI) demonstrated reduced time monitoring during a prospective memory (PM) task, which was associated with time-based PM performance.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Article
Psychology, Clinical
Katie Evans, Rebekah Barton, Rebecca Hendrickson, Laura Marie LaPlante
Summary: This paper presents a new virtual group intervention program, "Windows", for women Veterans who have experienced or are experiencing intimate partner violence (IPV). The program offers an eight-week therapeutic group curriculum, focusing on members' safety and flexible responses to their needs.
JOURNAL OF AGGRESSION MALTREATMENT & TRAUMA
(2023)
Article
Substance Abuse
Murray A. Raskind, Tammy Williams, Hollie Holmes, Kim Hart, Laura Crews, Eileen L. Poupore, Ronald G. Thomas, Jolee Darnell, Colin Daniels, Kevin Goke, Rebecca Hendrickson, Garth Terry, Cynthia Mayer, Tracy Simpson, Andrew Saxon, Dennis Rasmussen, Elaine R. Peskind
Summary: This study found that the use of the alpha-1 adrenergic receptor antagonist prazosin can reduce alcohol craving, drinking days, and heavy drinking days during alcohol withdrawal in soldiers. The effect is more significant in patients with comorbid PTSD. This finding can be helpful in preventing relapse in patients with alcohol use disorder.
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Meeting Abstract
Neurosciences
Ellen Lee, Jennifer Goldschmied, Kathleen Merikangas, Brant Hasler, Bryce Mander, Bengi Baran, Michael Irwin, Rebecca Hendrickson, A. J. Schwichtenberg, David Kupfer
NEUROPSYCHOPHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
Murray Raskind, Hollie Holmes, Tammy Williams, Ronald G. Thomas, Kim Hart, Rebecca Hendrickson, Garth Terry, Cynthia Mayer, Andrew Saxon, Tracy Simpson, Colin Daniels, Kevin Goke, Elaine Peskind
NEUROPSYCHOPHARMACOLOGY
(2021)
Meeting Abstract
Neurosciences
Rebecca Hendrickson, Roisin Slevin, Katherine Hoerster, Bernard Chang, Ellen Sano, Catherine McCalle, Gillian Monty, Ronald G. Thomas, Murray Raskind
NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Psychology, Clinical
Kyle J. Bourassa, Rebecca C. Hendrickson, Greg M. Reger, Aaron M. Norr
Summary: Research suggests that interventions for posttraumatic stress disorder (PTSD) may improve cardiovascular physiological outcomes, particularly cardiovascular reactions to trauma cues. However, current studies have limitations in terms of heterogeneity, small sample sizes, and lack of control conditions, highlighting the need for additional methodologically rigorous research.
JOURNAL OF TRAUMATIC STRESS
(2021)
Article
Health Care Sciences & Services
Rebecca C. Hendrickson, Ronald G. Thomas, Nicholas J. Schork, Murray A. Raskind
FRONTIERS IN DIGITAL HEALTH
(2020)
Meeting Abstract
Neurosciences
Rebecca Hendrickson, Murray Raskind, Elaine Peskind
NEUROPSYCHOPHARMACOLOGY
(2019)
