Article
Clinical Neurology
Luiz Ricardo C. Vasconcellos, Leticia Martimiano, Danillo Pereira Dantas, Filipe Mota Fonseca, Hilton Mata-Santos, Leonardo Travassos, Rosalia Mendez-Otero, Marcelo Torres Bozza, Pedro Moreno Pimentel-Coelho
Summary: The study established a model in mice for intrastriatal heme injection, causing lipid peroxidation, neuroinflammation, and sensorimotor deficits. Heme induced brain damage and reactive astrogliosis, along with behavior deficits. NLRP3 was found to play a role in heme-induced behavior deficits in this model.
Article
Biochemistry & Molecular Biology
Dominic Robles, De-Huang Guo, Noah Watson, Diana Asante, Sangeetha Sukumari-Ramesh
Summary: Stroke is a common disease that often leads to brain injury and mortality, with intracerebral hemorrhage (ICH) being the most severe subtype. However, the effect of aging on ICH pathophysiology is not well studied, and there is no effective treatment for ICH. Recent studies have shown that circulating microRNAs can be potential diagnostic and prognostic biomarkers in various conditions, but their functions in ICH are not well understood. This study aims to identify potential blood biomarkers for acute ICH in the elderly by analyzing dysregulated microRNAs in aged mice.
Article
Biochemistry & Molecular Biology
Tsai-Wei Hung, Kuo-Jen Wu, Yu-Syuan Wang, Eun-Kyung Bae, YoungHa Song, JongWon Yoon, Seong-Jin Yu
Summary: This study investigated the protective effect of 2-Fucosyllactose (2FL) in cellular and rodent models of Intracerebral hemorrhage (ICH). Results showed that 2FL has neuroprotective effects against ICH by inhibiting neuroinflammation and ER stress, indicating its potential clinical implications for ICH treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Yu-Xin Ding, Gao-Wa Eerduna, Si-Jin Duan, Ting Li, Rong-Xia Liu, Lei-Ming Zhang, Tian Wang, Feng-Hua Fu
Summary: The study demonstrates that escin improves neurological function in ICH mice by ameliorating systemic inflammation instead of directly targeting the brain, notably by inhibiting the IL-1 beta/RhoA/NF-kappa B signaling pathway in the blood-brain barrier. This suggests a potential therapeutic approach for brain injury post-ICH.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Clinical Neurology
Marc Durocher, Bodie Knepp, Alan Yee, Glen Jickling, Fernando Rodriguez, Kwan Ng, Xinhua Zhan, Farah Hamade, Eva Ferino, Hajar Amini, Paulina Carmona-Mora, Heather Hull, Bradley P. Ander, Frank R. Sharp, Boryana Stamova
Summary: This study identified peripheral blood genes and pathways associated with ICH and PHE volumes in human ICH patients. The inflammatory pathways, immune system genes, and hub genes enriched in neutrophil and T cell-specific genes may represent potential therapeutic targets for ICH outcomes.
TRANSLATIONAL STROKE RESEARCH
(2021)
Article
Clinical Neurology
Xiaohong Wang, Yin Hong, Lei Wu, Xiaochun Duan, Yue Hu, Yongan Sun, Yanqiu Wei, Zhen Dong, Chenghao Wu, Duonan Yu, Jun Xu
Summary: The study revealed that miR-144/451 might protect mice with ICH against neuroinflammation and oxidative stress by targeting the pathway of miR-451-14-3-3 zeta-FoxO3.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Jatinder S. Minhas, Tom J. Moullaali, Gabriel J. E. Rinkel, Craig S. Anderson
Summary: Blood pressure is an important factor in managing intracerebral hemorrhage and aneurysmal subarachnoid hemorrhage. However, there are controversies surrounding the management of blood pressure for these conditions. Current research involves analyzing patient data to determine the strength and direction of blood pressure changes and provide recommendations for clinical practice and future research.
Article
Clinical Neurology
Laurent Puy, Antoine Rauch, Vincent Deramecourt, Charlotte Cordonnier, Vincent Berezowski
Summary: This study conducted a postmortem examination to investigate acute microvascular lesions (microbleeds and microinfarcts) in the perihematomal area of patients with spontaneous intracerebral hemorrhage (ICH). It was found that these lesions may contribute to secondary brain tissue damage.
Article
Clinical Neurology
Kristin Tveitan Larsen, Maiken Nordahl Selseth, Silje Holt Jahr, Vigdis Hillestad, Nojoud Koubaa, Else Charlotte Sandset, Ole Morten Ronning, Espen Saxhaug Kristoffersen
Summary: This study investigated the relationship between prehospital blood pressure (BP) and clinical and radiological outcomes in acute intracerebral hemorrhage patients. The results showed that elevated prehospital BP parameters were associated with in-hospital death and hematoma expansion. Changes in prehospital BP were not consistently associated with outcome. A possible U-shaped association between prehospital BP and in-hospital death needs further investigation.
Article
Clinical Neurology
Xianping Zhou, Yaqiang Li, Zhongbo Sun, Li Mu, Yaoyao Ma
Summary: This study aimed to evaluate the impact of red blood cell distribution width (RDW) on depression after intracerebral hemorrhage (ICH). The results showed that patients with depression after ICH had higher RDW levels, and RDW independently predicted post-ICH depression. RDW has a good accuracy as a predictor for depression after ICH.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Edward R. Bader, Tiberiu A. Pana, Raphae S. Barlas, Anthony K. Metcalf, John F. Potter, Phyo K. Myint
Summary: This study investigates the association between admission inflammatory biomarkers and adverse outcomes in spontaneous intracerebral hemorrhage (ICH) using a stroke register in the United Kingdom. The results show that elevated inflammatory biomarkers are associated with poor outcomes in ICH, highlighting the importance of inflammation in this condition.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Ronda Lun, Vignan Yogendrakumar, Greg Walker, Michel Shamy, Robert Fahed, Adnan Qureshi, Dar Dowlatshahi
Summary: The study validates revised definitions of hematoma expansion incorporating intraventricular hemorrhage expansion for predicting poor outcome, outperforming conventional definitions even after accounting for care limitations.
INTERNATIONAL JOURNAL OF STROKE
(2021)
Article
Clinical Neurology
Joseph P. Broderick, James C. Grotta, Andrew M. Naidech, Thorsten Steiner, Nikola Sprigg, Kazunori Toyoda, Dar Dowlatshahi, Andrew M. Demchuk, Magdy Selim, J. Mocco, Stephan Mayer
Summary: Research in the acute management of intracerebral hemorrhage (ICH) over the past 35 years has shown that early treatment to control bleeding and minimize brain injury is crucial. However, current medical and surgical interventions have not yet shown significant benefits in large-scale trials, emphasizing the need for further research and improvement in the delivery of ICH therapies for better outcomes.
Article
Medicine, Research & Experimental
Haipeng Song, Na Xu, Shan Jin
Summary: The present study aimed to investigate the function of miR-30e-5p in rats with intracerebral hemorrhage (ICH), and found that overexpression of miR-30e-5p exerted a protective role against neuronal deficit and inflammation caused by ICH in rats by targeting Toll-like receptor (TLR)4 and inactivating TLR4/MyD88/TRIF signaling.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Review
Immunology
Yuanyuan Li, Chenxi Tao, Na An, Haoqi Liu, Zhenhong Liu, Hongrui Zhang, Yikun Sun, Yanwei Xing, Yonghong Gao
Summary: Intracerebral hemorrhage (ICH) is a stroke subtype characterized by non-traumatic rupture of blood vessels in the brain, resulting in blood pooling in the brain parenchyma. ICH remains a significant contributor to stroke-related mortality and has various complex pathological damage including mechanical damage, inflammatory response, and complement activation. This review summarizes the pathological mechanisms of brain injury after ICH, particularly focusing on the role of complement and its related mechanisms, as well as provides an overview of complement-targeted therapies for ICH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Kaylynn Purdy, Rebecca Long, Glen Jickling
Summary: This article reports a case of COVID-19 infection-induced vertebral artery dissection and lateral medullary stroke, highlighting the potential role of infection in contributing to certain cases of CeAD. COVID-19 infection can cause endothelial dysfunction and inflammatory response, leading to vascular damage.
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2022)
Meeting Abstract
Clinical Neurology
Paulina Carmona-Mora, Bodie Knepp, Glen Jickling, Xinhua Zhan, Marisa Hakoupian, Heather Hull, Noor Alomar, Hajar Amini, Frank R. Sharp, Boryana Stamova, Bradley Ander
Editorial Material
Clinical Neurology
Sarina R. Falcione, Glen C. Jickling
Meeting Abstract
Clinical Neurology
Anas Alrohimi, Laura C. Gioia, Mahesh P. Kate, Kelvin Ng, Dar Dowlatshahi, Thalia S. Field, Shelagh B. Coutts, Muzzafar Siddiqui, Michael D. Hill, Jodi Miller, Robert G. Hart, Glen Jickling, Ashfaq Shuaib, Brian H. Buck, Mukul A. Sharma, Ken Butcher
Article
Clinical Neurology
Laura Ibanez, Laura Heitsch, Caty Carrera, Fabiana H. G. Farias, Jorge L. Del Aguila, Rajat Dhar, John Budde, Kristy Bergmann, Joseph Bradley, Oscar Harari, Chia Ling Phuah, Robin Lemmens, Alessandro A. Viana Oliveira Souza, Francisco Moniche, Antonio Cabezas-Juan, Juan Francisco Arenillas, Jerzy Krupinksi, Natalia Cullell, Nuria Torres-Aguila, Elena Muino, Jara Carcel-Marquez, Joan Marti-Fabregas, Raquel Delgado-Mederos, Rebeca Marin-Bueno, Alejandro Hornick, Cristofol Vives-Bauza, Rosa Diaz Navarro, Silvia Tur, Carmen Jimenez, Victor Obach, Tomas Segura, Gemma Serrano-Heras, Jong Won Chung, Jaume Roquer, Carol Soriano-Tarraga, Eva Giralt-Steinhauer, Marina Mola-Caminal, Joanna Pera, Katarzyna Lapicka-Bodzioch, Justyna Derbisz, Antoni Davalos, Elena Lopez-Cancio, Lucia Munoz, Turgut Tatlisumak, Carlos Molina, Marc Ribo, Alejandro Bustamante, Tomas Sobrino, Jose Castillo-Sanchez, Francisco Campos, Emilio Rodriguez-Castro, Susana Arias-Rivas, Manuel Rodriguez-Yanez, Christina Herbosa, Andria L. Ford, Alonso Gutierrez-Romero, Rodrigo Uribe-Pacheco, Antonio Arauz, Iscia Lopes-Cendes, Theodore Lowenkopf, Miguel A. Barboza, Hajar Amini, Boryana Stamova, Bradley P. Ander, Frank R. Sharp, Gyeong Moon Kim, Oh Young Bang, Jordi Jimenez-Conde, Agnieszka Slowik, Daniel Stribian, Ellen A. Tsai, Linda C. Burkly, Joan Montaner, Israel Fernandez-Cadenas, Jin Moo Lee, Carlos Cruchaga
Summary: This study aimed to determine the genetic architecture of early neurological instability after stroke. It identified eight significant loci that are associated with neurological instability, suggesting that excitotoxicity may contribute to this instability.
Article
Clinical Neurology
Glen C. Jickling, Bradley P. Ander, Xinhua Zhan, Boryana Stamova, Heather Hull, Charles DeCarli, Frank R. Sharp
Summary: Cerebral white matter hyperintensities are associated with aging brain pathology, cognitive decline, and gait impairment. The interaction between the immune system and cerebral vessels and tissue may contribute to the progression of white matter hyperintensities. Understanding the relationship between blood leucocyte gene expression and white matter hyperintensity progression can provide insights into pathogenesis and potential treatment targets. Genes associated with endothelial dysfunction, extracellular matrix remodeling, altered remyelination, inflammation, and response to ischemia play a role in the progression of white matter hyperintensities. Further research is needed to evaluate the role of peripheral inflammation in relation to cognitive decline and the rate of white matter hyperintensity progression.
Article
Clinical Neurology
Ali Z. Nomani, Jeremy L. Rempel, Khurshid A. Khan, Ashfaq Shuaib, Glen C. Jickling
Summary: This study evaluated the variable rate of infarct progression in acute ischemic stroke using different thresholds. It found that a substantial proportion of patients were excluded when assessed by various time or core constraints. However, the hypoperfusion index (HI) showed comprehensive evaluation of the fast and slow rate of infarct progression and provided indications for reperfusion and clinical outcomes assessment.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Andrew E. Beaudin, Cheryl R. McCreary, Erin L. Mazerolle, Myrlene Gee, Breni Sharma, Arsenije Subotic, Angela M. Zwiers, Emily Cox, Krista Nelles, Anna Charlton, Richard Frayne, Zahinoor Ismail, Christian Beaulieu, Glen C. Jickling, Richard M. Camicioli, G. Bruce Pike, Eric E. Smith
Summary: This study found that reduced cerebrovascular reactivity is a core feature of cerebral amyloid angiopathy (CAA), and it is associated with white matter hyperintensity volume and cognitive function. This finding could provide additional biomarkers for assessing the severity of the disease and cognitive impairment.
Review
Clinical Neurology
Anas Alrohimi, Glen Jickling, Brian Buck, Ken S. Butcher
Summary: Patients with atrial fibrillation and ischemic stroke are at high risk for stroke recurrence. Early anticoagulation may reduce the risk of recurrent events but is usually avoided due to the risk of hemorrhagic transformation. Direct oral anticoagulants have demonstrated lower risk of intracranial hemorrhage compared to older anticoagulants. However, the optimal timing of DOAC initiation after AF-related ischemic stroke is still unclear.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Joseph Kamtchum-Tatuene, Luca Saba, Mirjam R. Heldner, Michiel H. F. Poorthuis, Gert J. de Borst, Tatjana Rundek, Stavros K. Kakkos, Seemant Chaturvedi, Raffi Topakian, Joseph F. Polak, Glen C. Jickling
Summary: This study demonstrates that circulating IL-6 levels predict carotid plaque severity, vulnerability, and progression. A cutoff of 2.0 pg/mL for IL-6 levels could facilitate the selection of individuals that would benefit from anti-IL-6 drugs for stroke prevention.
CIRCULATION RESEARCH
(2022)
Article
Immunology
Hajar Amini, Bodie Knepp, Fernando Rodriguez, Glen C. Jickling, Heather Hull, Paulina Carmona-Mora, Cheryl Bushnell, Bradley P. Ander, Frank R. Sharp, Boryana Stamova
Summary: This study identified early immune gene responses in peripheral blood associated with 90-day ischemic stroke (IS) outcomes. Whole-transcriptome analyses revealed genes and networks associated with poor and good 90-day outcomes. The study suggests that the immune response after stroke may impact functional outcomes and some early post-stroke gene expression markers could be used for predicting outcomes and improving outcomes.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Biochemistry & Molecular Biology
Raluca Todoran, Sarina R. Falcione, Michael Clarke, Twinkle Joy, Roobina Boghozian, Glen C. Jickling
Summary: microRNA (miRNA) regulates gene expression and has the potential to be used as a treatment for ischemic stroke. This review focuses on the role of miRNA in reducing thrombosis, blood brain barrier disruption, hemorrhagic transformation, inflammation, and angiogenesis. Although no miRNA has been approved for human use yet, clinical trials have shown promising results in treating conditions such as hepatitis C. The benefits, barriers, and future directions of using miRNA as a treatment for ischemic stroke are also discussed.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Medicine, General & Internal
Paulina Carmona-Mora, Bodie Knepp, Glen C. Jickling, Xinhua Zhan, Marisa Hakoupian, Heather Hull, Noor Alomar, Hajar Amini, Frank R. Sharp, Boryana Stamova, Bradley P. Ander
Summary: After ischemic stroke, peripheral leukocytes infiltrate the damaged region and modulate the response to injury. Peripheral blood cells display distinctive gene expression signatures post-stroke, reflecting changes in immune responses to stroke. Analyzing the temporal dynamics of gene expression after stroke can improve our understanding of immune and clotting responses at the molecular and cellular level, and may assist with time-targeted, cell-specific therapy.
Article
Clinical Neurology
Anas Alrohimi, David Z. Rose, W. Scott Burgin, Swetha Renati, Nicholas Corbin Hilker, Wei Deng, Guilherme H. Oliveira, Theresa M. Beckie, Arthur J. Labovitz, Michael G. Fradley, Nhi Tran, Laura C. Gioia, Mahesh Kate, Kelvin Ng, Dar Dowlatshahi, Thalia S. Field, Shelagh B. Coutts, Muzzafar Siddiqui, Michael D. Hill, Jodi Miller, Glen Jickling, Ashfaq Shuaib, Brian Buck, Mike Sharma, Ken S. Butcher
Summary: This study aimed to assess the risk of hemorrhagic transformation (HT) in acute ischemic stroke (AIS) associated with the initiation of direct oral anticoagulant (DOAC). The results showed that initiating DOAC within 48 hours post-stroke was not associated with an increased risk of HT, and no patients developed symptomatic HT. However, early DOAC use was not significant in reducing the risk of recurrent ischemic events.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Editorial Material
Clinical Neurology
Roobina Boghozian, Sarina Falcione, Glen C. Jickling
