Article
Cell Biology
Samar Sayedyahossein, Louise Thines, David B. Sacks
Summary: The Hippo signaling pathway regulates various cellular processes, including cell proliferation, differentiation, migration, and mechanosensation. Calcium ion (Ca2+) has been found to influence core components of the Hippo pathway. However, the crosstalk between Ca2+ signaling and the Hippo pathway is not fully understood.
CELLULAR SIGNALLING
(2023)
Review
Cell Biology
John A. P. Rostas, Kathryn A. Skelding
Summary: This review summarizes the structure and regulation of CaMKII, and explores how the molecular environment and interaction with binding partner proteins can lead to different populations of CaMKII in various cells or subcellular locations, resulting in diverse functional responses to activation by increased intracellular calcium concentration. It also proposes that identifying the molecular interactions responsible for the targeting of CaMKII in specific cells and determining the sites of interaction could lead to the development of highly selective inhibitors for specific CaMKII-mediated functional responses, with potential therapeutic implications.
Review
Plant Sciences
Houqing Zeng, Qiuqing Zhu, Peiguo Yuan, Yan Yan, Keke Yi, Liqun Du
Summary: Plants have developed mechanisms using calcium as signals to respond to biotic stresses, with calmodulins (CaMs) and calmodulin-like proteins (CMLs) acting as important calcium sensors. The coordination between calcium transients, CaMs/CMLs, and target proteins is crucial for plant responses. This review focuses on the involvement of CaMs/CMLs in plant responses to various biotic stresses and discusses future directions in understanding the signaling pathways. The application of this knowledge in crop cultivation can improve resistance to biotic stresses and ensure food production.
PLANT CELL AND ENVIRONMENT
(2023)
Article
Medicine, General & Internal
Juyi Li, Chunjia Kou, Tiantian Sun, Jia Liu, Haiqing Zhang
Summary: This study aimed to identify and validate the hub immune-related genes in nonalcoholic fatty liver disease (NAFLD). Five key genes, AQP9, BACH2, CD4, IL17RE, and S100A9, were identified and found to play important roles in immune-related pathways. Experimental evidence showed that inhibition of BACH2 and S100A9 could reduce lipid accumulation in NAFLD cells.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Chemistry, Multidisciplinary
Chengrui Zhong, Yi Niu, Wenwu Liu, Yichuan Yuan, Kai Li, Yunxing Shi, Zhiyu Qiu, Keren Li, Zhu Lin, Zhenkun Huang, Dinglan Zuo, Zhiwen Yang, Yadi Liao, Yuanping Zhang, Chenwei Wang, Jiliang Qiu, Wei He, Yunfei Yuan, Binkui Li
Summary: This study identifies S100A9 as a key driver for post-TACE HCC progression by promoting mitochondrial fission and reactive oxygen species production. Higher S100A9 levels are associated with worse prognosis in HCC patients.
Article
Nutrition & Dietetics
Guojun Wu, Hiba R. Tawfeeq, Atreju I. Lackey, Yinxiu Zhou, Zoe Sifnakis, Sophia M. Zacharisen, Heli Xu, Justine M. Doran, Harini Sampath, Liping Zhao, Yan Y. Lam, Judith Storch
Summary: This study investigated the effects of LFABP and IFABP deficiency on the gut microbiota in mice, and found that these changes were associated with phenotypic changes induced by a high-fat diet.
Review
Biochemistry & Molecular Biology
Sofia Beghi, Malgorzata Furmanik, Armand Jaminon, Rogier Veltrop, Nikolas Rapp, Kanin Wichapong, Elham Bidar, Annamaria Buschini, Leon J. Schurgers
Summary: Cardiovascular disease remains a major cause of death worldwide, despite advancements in medication and preventive measures. Calcium plays a vital role in the cardiovascular system, regulating events from action potentials to muscle contraction. Calcium calmodulin pathways are involved in the regulation of cardiac functions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Kristyna Vydra Bousova, Monika Zouharova, Katerina Jiraskova, Veronika Vetyskova
Summary: This article focuses on the interaction between TRPM channels and CaM, and summarizes the effects of CaM interactions and modulations on TRPM channels in cellular physiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Respiratory System
Jing Zhang, Cuifang Yuan, Enhong Li, Yiming Guo, Jie Cui, Heliang Liu, Xiaohui Hao, Lingli Guo
Summary: Elevated levels of S100A4 were found in patients with silicosis and were correlated with decreased lung function. The expression of S100A4 was also increased in the lung tissues and macrophages of silicotic mice. These findings suggest that S100A4 may play a role in the pathogenesis of silicosis.
BMC PULMONARY MEDICINE
(2022)
Article
Parasitology
Hai-Jun Gao, Xu-Dong Sun, Yan-Ping Luo, Hua-Sheng Pang, Xing-Ming Ma, Ting Zhang, Tao Jing, Wei Hu, Yu-Juan Shen, Jian-Ping Cao
Summary: The study demonstrated that verapamil has anti-parasitic effects against Echinococcus by downregulating the expression of Ca2+/CaM-CaMKII, indicating that Ca2+/CaM-CaMKII may be a novel drug target for the treatment of echinococcosis.
PARASITES & VECTORS
(2021)
Article
Plant Sciences
Tong Li, Zhi Liu, Tianxing Lv, Yaxiu Xu, Yun Wei, Weiting Liu, Yajing Wei, Li Liu, Aide Wang
Summary: A calcium module regulates the ethylene synthesis pathway during apple fruit ripening by controlling the phosphorylation and degradation of MdCYTOKININ RESPONSE FACTOR4. The study reveals that calcium ions suppress ethylene biosynthesis in apple fruit by promoting the phosphorylation and degradation of MdCRF4, leading to reduced expression of key genes involved in ethylene synthesis and delayed fruit ripening.
Article
Medicine, Research & Experimental
Hongli Yu, Wenli Yu, Min Zhu, Guicheng Zhang, Yiwei Shi, Ying Sun
Summary: The study found that parental donor liver transplantation may cause a certain degree of brain injury in pediatric patients with end-stage liver disease, as indicated by increased levels of serum NSE and S100 beta. Additionally, three months post-surgery, the mental development index and psychomotor development index of children showed a decrease.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Plant Sciences
Marco Pedretti, Filippo Favretto, Francesca Troilo, Moira Giovannoni, Carolina Conter, Benedetta Mattei, Paola Dominici, Carlo Travaglini-Allocatelli, Adele Di Matteo, Alessandra Astegno
Summary: The direct interaction between Arabidopsis PCaP1 and CaM1 was investigated, with the myristoylated peptide enhancing the binding and altering the structure of CaM1. These findings suggest that the biological function of PCaP1 is related to the balance between myristoylation, Ca2+ ions, and CaM1.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Oncology
Wenbing Hu, Zezhang Tao, Qiang Zhou, Deqing Zhao, Lei Gu, Sujin Zhu, Jun Chen
Summary: The study found that high expression of S100A8 and S100A9 may promote the expression of MMP7, MMP9, and MMP12, which are related to the invasion and metastasis of NPC cells.
TRANSLATIONAL CANCER RESEARCH
(2021)
Review
Oncology
Bi-Xia Liu, Chao-Tao Tang, Xi-Jian Dai, Ling Zeng, Fei Cheng, Youxiang Chen, Chunyan Zeng
Summary: S100P overexpression is associated with poor overall survival in patients with digestive system cancers, particularly as a prognostic indicator in non-gastrointestinal tract cancers.
FRONTIERS IN ONCOLOGY
(2021)