Review
Biochemistry & Molecular Biology
Sandra Ferreira, Nuno Saraiva, Patricia Rijo, Ana S. Fernandes
Summary: LOX and LOXL2 are amine oxidases that catalyze cross-linking reactions of elastin and collagen in connective tissue, with LOXL2 showing high expression in certain tumors. Inhibition of LOX and LOXL2 is considered a promising strategy for preventing metastasis and invasion of breast cancer. Novel synthetic compounds acting as selective inhibitors for LOX/LOXL2 or dual LOX/LOXL inhibitors have been developed, showing potential for effective therapeutic approaches in breast cancer treatment.
Review
Biochemistry & Molecular Biology
Amparo Cano, Pilar Eraso, Maria J. Mazon, Francisco Portillo
Summary: Lysyl Oxidase Like 2 (LOXL2) is a protein belonging to the lysyl oxidase (LOX) family, and it has been shown to play an important role in multiple cancers. Aberrant expression of LOXL2 is strongly associated with poor prognosis in patients. Additionally, LOXL2 has been found to be associated with various targets affecting tumor progression. The mechanisms underlying the abnormal expression of LOXL2 in tumors involve a complex network of signaling factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Yu An, Gulimirerouzi Fnu, Changchun Xie, Georg F. F. Weber
Summary: This study conducted a comprehensive analysis of splice variants of Osteopontin and found that they have different expression patterns in various cancer patients, which are related to tumor grade, stage, and patient survival. However, there are still some discrepancies that need further investigation to clarify the diagnostic, prognostic, and potentially predictive potential of Osteopontin splice variants.
Article
Oncology
Se Ik Kim, Ji Hyun Kim, Sanghee Lee, Hyunsoon Cho, Willemien J. van Driel, Gabe S. Sonke, Robert E. Bristow, Sang-Yoon Park, Christina Fotopoulou, Myong Cheol Lim
Summary: This study systematically evaluated the value of hyperthermic intraperitoneal chemotherapy (HIPEC) in cytoreductive surgery (CRS) for epithelial ovarian cancer (EOC). The results showed that HIPEC improved progression-free survival (PFS) and overall survival (OS) in the recent chemotherapy exposure group, but had no significant effect in the non-recent chemotherapy exposure group.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Immunology
Xiaochun Lin, Kunpeng Lin, Chunxuan Lin, Taisheng Liu, Mingchen Ba, Yunqiang Tang, Jialang Wang, Lixia Zhou, Jiakang Wang, Congqin Xiao
Summary: High PD-L2 expression is associated with poor prognosis in lung cancer patients, especially in lung adenocarcinoma, and may serve as a potential biomarker for PD-1/PD-L1-targeted immunotherapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Oncology
Yue Li, Jiahuan Xu, Pengchen Bao, Zhijing Wei, Lei Pan, Jiawei Zhou, Wei Wang
Summary: PYCR1 is highly expressed in various cancers and is associated with cancer volume and metastasis. Higher expression of PYCR1 is associated with poorer cancer prognosis. Molecular events and biological processes mediated by PYCR1 may be the underlying mechanisms for metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Apriliana E. R. Kartikasari, Emily Cassar, Mohammed A. M. Razqan, Crispin Szydzik, Cesar S. Huertas, Arnan Mitchell, Magdalena Plebanski
Summary: Circulating TNFR2 shows a correlation with various types of cancer, indicating its potential as a diagnostic biomarker.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Nutrition & Dietetics
Yuefeng Chen, Xinnan Pan, Baoming Tian, Yajun Hu
Summary: Polysaccharides have various biological activities, including tumor suppression by regulating the polarization of tumor-associated macrophages. In this study, the correlation between CD24 expression and colorectal cancer (CRC) was investigated. The results showed that CD24 expression was significantly correlated with advanced nuclear grade, lymph node metastasis, Duke's stage, and age of CRC patients.
FRONTIERS IN NUTRITION
(2022)
Article
Biotechnology & Applied Microbiology
Xianglin Yang, Wen Tian, Shen Wang, Xiaotong Ji, Baosen Zhou
Summary: The study systematically evaluated the clinicopathological, diagnostic, and prognostic values of circRNAs in lung cancer. The results indicated that circRNAs could serve as important biomarkers for diagnosis, prognosis, and clinicopathological features in lung cancer.
Review
Oncology
Aino Niinivirta, Tuula Salo, Pirjo Astrom, Krista Juurikka, Maija Risteli
Summary: This study systematically evaluated the prognostic value of dysadherin in cancer and summarized the current knowledge on the subject. The results showed that high levels of tumoral FXYD5 are associated with increased risk of death, metastatic behavior of cancer, and inverse correlation with E-cadherin level.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Noor Bakour, Frank Moriarty, Gillian Moore, Tracy Robson, Stephanie L. Annett
Summary: High glucocorticoid receptor (GR) expression is associated with disease progression in gynaecological cancers and early stage, untreated triple negative breast cancers, but not prognostic in late stage, chemotherapy treated triple negative breast cancers. Additional studies are needed to elucidate the tumour specific function of the GR receptor for targeted therapy.
Review
Medicine, General & Internal
Xuhua Wang, Zhaoyuan Chen, Huaqiang Zhou, Wuyang Liu, Jiaquan Luo
Summary: LncRNA LOXL1-AS1 is overexpressed in cancer and is closely associated with shorter overall survival, lymph node metastasis, and distant metastasis.
Article
Medicine, General & Internal
Qian Yang, Lizhen Chen, Li Yang, Yuanshuai Huang
Summary: This meta-analysis demonstrated that circRNAs could be valuable biomarkers for diagnostic and prognostic purposes in lung cancer patients. CircRNAs showed good diagnostic performance in discriminating lung cancer patients from controls, and certain upregulated and downregulated circRNAs were associated with poor and favorable prognosis, respectively. High expression of specific circRNAs was also linked to unfavorable clinicopathological features.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Yuxiu Xie, Men Wang, Peng Xu, Yujiao Deng, Yi Zheng, Si Yang, Ying Wu, Zhen Zhai, Dai Zhang, Na Li, Nan Wang, Jing Cheng, Zhijun Dai
Summary: This study found that the use of BBs, CCBs, and diuretics is associated with an increased risk of breast cancer, while long-term use of RASIs may reduce this risk. It also suggests that diuretic users may have a higher risk of breast cancer-specific mortality.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Xuhua Wang, Zhaoyuan Chen, Huaqiang Zhou, Wuyang Liu, Jiaquan Luo
Summary: The lncRNA HEIH is overexpressed in various cancers and is associated with poor clinical outcomes. A meta-analysis found that high HEIH expression is correlated with shorter overall survival and advanced clinicopathological features in cancer patients.