Review
Immunology
Dandan Song, Yan Lian, Lin Zhang
Summary: AP-1 is a transcription factor involved in cell proliferation, migration, and invasion. Dysfunctional AP-1 activity is associated with cancer initiation, development, invasion, migration, and drug resistance. Small molecule inhibitors targeting AP-1 have shown some anticancer effects, but more research is needed to understand the specific mechanisms and select appropriate inhibitors and treatment strategies. Ultimately, this review summarizes the potential of combination therapy for cancer.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Nataliia Sergeevna Karpova, Olga Pavlovna Dmitrenko, Tatyana Sergeevna Budykina
Summary: One of the main causes of maternal and neonatal morbidity and mortality is pre-eclampsia, characterized by a high sFlt1/PlGF ratio. Pregestational diseases in mothers may increase the risk, but few studies have looked at the connection between maternal comorbidities and the sFlt1/PlGF ratio. This review summarizes the latest information on the association between maternal pregestational diseases and the ratio of sFlt1/PlGF, as well as the link between changes in pregnancy hormones/metabolites and a high sFlt1/PlGF ratio. Debate remains on the association between the ratio and maternal disorders, calling for further research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Tianxiang Yu, Xiangwei Xu, Jiajia Wei, Jiachen Xu, Wu Luo, Ankang Li, Guang Liang, Mengyang Wang
Summary: This study evaluated the effects of ginsenoside Rg5 on Ang II-induced cardiac remodeling and heart failure. It was found that Rg5 inhibited cardiac inflammation, myocardial fibrosis, and hypertrophy, and prevented cardiac malfunction in mice challenged with Ang II, through the JNK/AP-1 signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Isidoro Cobo, Anyan Cheng, Jessica Murillo-Saich, Roxana Coras, Alyssa Torres, Yohei Abe, Addison J. Lana, Johannes Schlachetzki, Ru Liu-Bryan, Robert Terkeltaub, Elsa Sanchez-Lopez, Christopher K. Glass, Monica Guma
Summary: MSUc induces a metabolic-inflammatory response in non-primed macrophages, leading to metabolic rewiring in gouty arthritis patients and mice. This response is regulated by JUN and JNK signaling and is independent of LPS stimulation and inflammasome activation.
Article
Medicine, Research & Experimental
Yuliu Zhang, Jianping Du, Xiaofan Duan, Wei Peng, Lei Lv, Zhiyu Chen, Yumei Zhang
Summary: In this study, RIPK1 expression was found to significantly contribute to cisplatin-induced apoptosis in human ESCC cells. Reduced RIPK1 expression promoted cell proliferation, while overexpressed RIPK1 facilitated apoptosis. Mechanistic investigations revealed that inhibition of RIPK1 proliferation in ESCC cells was regulated through activation of the c-Jun NH2-terminal kinase signaling pathway, leading to mitochondrial damage, ATP depletion, and increased reactive oxygen species generation.
Article
Oncology
Kristin Frensemeier, Angela Holzer, Karin Hoppe-Seyler, Felix Hoppe-Seyler
Summary: This study reveals that the expression of tumor suppressor protein Dkk1 is strongly restrained in HPV-positive cervical cancer cells through the continuous expression of the viral E6 oncogene, leading to increased resistance to Cisplatin-induced apoptosis. The repression of Dkk1 is not linked to Wnt pathway activation but rather the diminished stimulation of JNK signaling, which is required for efficient apoptosis induction by Cisplatin.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Jiao Luo, Xiujun Tan, Ling Ye, Chenglin Wang
Summary: The study reveals that the JNK signaling pathway plays a positive role in the formation of dental papilla cell polarity, as indicated by the up-regulation of polarity-related genes and rescue effects of RhoA Q63L mutant. JNK activation is linked to polarization, migration, and differentiation of dental papilla cells, highlighting its importance in tooth development.
Article
Oncology
Milad Soleimani, Alexander Somma, Tamer Kaoud, Ria Goyal, Jorge Bustamante, Dennis C. Wylie, Nisha Holay, Agnieszka Looney, Uma Giri, Todd Triplett, Kevin Dalby, Jeanne Kowalski, S. Gail Eckhardt, Carla Van Den Berg
Summary: JNK-IN-8, a covalent JNK inhibitor, suppresses the growth of triple-negative breast cancer (TNBC) by activating TFEB/TFE3 and inducing lysosome biogenesis and autophagy via mTOR inhibition independently of JNK.
MOLECULAR CANCER THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Fang Liu, Yan Liu, Qifeng Peng, Guodong Wang, Qing Tan, Zhongyue Ou, Qishan Xu, Chixiang Liu, Daming Zuo, Jianbo Zhao
Summary: This study revealed that creatinine is closely related to drug-induced liver injury and exacerbates APAP-induced hepatocyte death by promoting the production and activation of reactive oxygen species and c-Jun N-terminal kinase.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Tianxiang Yu, Jiachen Xu, Qinyan Wang, Xue Han, Yu Tu, Yi Wang, Wu Luo, Mengyang Wang, Guang Liang
Summary: This study found that 20(S)-Rh2 alleviates cardiac damage induced by Ang-II through inhibition of the JNK/AP-1 pathway, reducing myocardial fibrosis, hypertrophy, and inflammation. These findings provide evidence for the use of 20(S)-Rh2 as an effective regimen for HHF.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Lesley Jia Wei Pua, Chun-Wai Mai, Felicia Fei-Lei Chung, Alan Soo-Beng Khoo, Chee-Onn Leong, Wei-Meng Lim, Ling-Wei Hii
Summary: JNK and p38 MAPK signaling pathways play important roles in nasopharyngeal carcinoma (NPC), promoting tumor processes such as cell proliferation, apoptosis, inflammation, metastasis, and angiogenesis. Although the underlying mechanisms are not fully understood, further research on JNK and p38 MAPK could provide important insights for diagnosis, prognosis, and treatment decision-making in NPC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Yizhen Sang, Kenji Tsuji, Kazuhiko Fukushima, Kensaku Takahashi, Shinji Kitamura, Jun Wada
Summary: Renal fibrosis, a common pathological process in renal diseases, was studied using a UUO mouse model, revealing increased SEMA3A signaling and its inhibition ameliorating fibrosis through JNK regulation. This study suggests SEMA3A inhibitor as a potential therapeutic option for renal fibrosis.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Cell Biology
Michael Keith Kullmann, Fragka Pegka, Christian Ploner, Ludger Hengst
Summary: In addition to serving as a CDK inhibitor and tumor suppressor, p57 may also promote tumor growth by activating the proto-oncoprotein c-Jun.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Acoustics
K. Lau, A. Wright, M. Sarno, N. A. Kametas, K. H. Nicolaides
Summary: This study compared the predictive performance of serum placental growth factor (PlGF) and soluble fms-like tyrosine kinase-1 (sFlt-1)/PlGF ratio with the competing-risks model utilizing maternal risk factors, mean arterial pressure (MAP), and ophthalmic artery peak systolic velocity (PSV) ratio for predicting pre-eclampsia (PE) delivery. The results showed that ophthalmic artery Doppler combined with maternal risk factors and blood pressure could potentially replace the measurement of PlGF and sFlt-1/PlGF ratio in predicting imminent PE.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Woo Yeon Hwang, Wook Ha Park, Dong Hoon Suh, Kidong Kim, Yong Beom Kim, Jae Hong No
Summary: DFMO significantly reduces cell viability in ovarian cancer cells through polyamine depletion and apoptosis pathways, as well as by mediating through AP-1, activating JNK, and enhancing the effect of cisplatin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)