The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy

Final results of a phase I dose-escalation, dose-expansion study of adding disulfiram with or without copper to adjuvant temozolomide for newly diagnosed glioblastoma

(2018) Jiayi Huang et al.   JOURNAL OF NEURO-ONCOLOGY

Patterns of Invasive Growth in Malignant Gliomas—The Hippocampus Emerges as an Invasion-Spared Brain Region

(2018) Awais A. Mughal et al.   NEOPLASIA

Phenotypic and Expressional Heterogeneity in the Invasive Glioma Cells

(2018) Artem Fayzullin et al.   Translational Oncology

Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4

(2017) Zdenek Skrott et al.   NATURE

Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy

(2017) Xiaoyang Lan et al.   NATURE

EXTH-79. INITIAL EXPERIENCES WITH COMPASSIONATE-USE CUSP9v3/v4 FOR RECURRENT GLIOBLASTOMA

(2017) Marc-Eric Halatsch et al.   NEURO-ONCOLOGY

The clinical value of patient-derived glioblastoma tumorspheres in predicting treatment response

(2017) Quintino Giorgio D’Alessandris et al.   NEURO-ONCOLOGY

Promoting oligodendroglial-oriented differentiation of glioma stem cell: a repurposing of quetiapine for the treatment of malignant glioma

(2017) Yun Wang et al.   Oncotarget

Disulfiram when Combined with Copper Enhances the Therapeutic Effects of Temozolomide for the Treatment of Glioblastoma

(2016) X. Lun et al.   CLINICAL CANCER RESEARCH

Wnt inhibition is dysregulated in gliomas and its re-establishment inhibits proliferation and tumor sphere formation

(2016) Kirsten Strømme Kierulf-Vieira et al.   EXPERIMENTAL CELL RESEARCH

Multi-omics analysis of primary glioblastoma cell lines shows recapitulation of pivotal molecular features of parental tumors

(2016) Shai Rosenberg et al.   NEURO-ONCOLOGY

Development of Resistance to EGFR-Targeted Therapy in Malignant Glioma Can Occur through EGFR-Dependent and -Independent Mechanisms

(2015) S. Klingler et al.   CANCER RESEARCH

Pitfalls of the MTT assay: Direct and off-target effects of inhibitors can result in over/underestimation of cell viability

(2015) A.A. Stepanenko et al.   GENE

Targeting PBK/TOPK decreases growth and survival of glioma initiating cells in vitro and attenuates tumor growth in vivo

(2015) Mrinal Joel et al.   Molecular Cancer

Drug repurposing in oncology—patient and health systems opportunities

(2015) Francesco Bertolini et al.   Nature Reviews Clinical Oncology

Comparative genomic and genetic analysis of glioblastoma-derived brain tumor-initiating cells and their parent tumors

(2015) Brad Davis et al.   NEURO-ONCOLOGY

Toward precision medicine in glioblastoma: the promise and the challenges

(2015) Michael D. Prados et al.   NEURO-ONCOLOGY

A conceptually new treatment approach for relapsed glioblastoma: Coordinated undermining of survival paths with nine repurposed drugs (CUSP9) by the International Initiative for Accelerated Improvement of Glioblastoma Care.

(2015) Richard E. Kast et al.   Oncotarget

CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide

(2015) Richard E. Kast et al.   Oncotarget

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

A Proposal Regarding Reporting of In Vitro Testing Results

(2013) M. A. Smith et al.   CLINICAL CANCER RESEARCH

Comparison of glioma stem cells to neural stem cells from the adult human brain identifies dysregulated Wnt- signaling and a fingerprint associated with clinical outcome

(2013) Cecilie Jonsgar Sandberg et al.   EXPERIMENTAL CELL RESEARCH

Nonsteroidal Anti-inflammatory Drugs Diclofenac and Celecoxib Attenuates Wnt/β-Catenin/Tcf Signaling Pathway in Human Glioblastoma Cells

(2013) Gangadhara Reddy Sareddy et al.   NEUROCHEMICAL RESEARCH

Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics

(2013) A. Sottoriva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Raise standards for preclinical cancer research

(2012) C. Glenn Begley et al.   NATURE

Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response

(2012) N. J. Szerlip et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tissue concentration of systemically administered antineoplastic agents in human brain tumors

(2011) Marshall W. Pitz et al.   JOURNAL OF NEURO-ONCOLOGY

Brain tumor stem cells maintain overall phenotype and tumorigenicity after in vitro culturing in serum-free conditions

(2010) Einar Osland Vik-Mo et al.   NEURO-ONCOLOGY

MTT assays cannot be utilized to study the effects of STI571/Gleevec on the viability of solid tumor cell lines

(2009) Jonathan T. Sims et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Neurosphere Formation Is an Independent Predictor of Clinical Outcome in Malignant Glioma

(2009) Dan R. Laks et al.   STEM CELLS

A COMPARISON BETWEEN STEM CELLS FROM THE ADULT HUMAN BRAIN AND FROM BRAIN TUMORS

(2008) Mercy Varghese et al.   NEUROSURGERY