Article
Allergy
Meng Zhang, Qianying Yu, Wei Tang, Yujiao Wu, JiaJia Lv, Lin Sun, Guochao Shi, Min Wu, Jieming Qu, Caixia Di, Zhenwei Xia
Summary: The study revealed that HDM-AEC-EXOs facilitate recruitment, proliferation, migration, and activation of DCs, with CNTN1 playing a critical role. Notch2 receptor is necessary for relaying the CNTN1 signal to activate TH2 cell/TH17 cell immune response. Studies of patients with asthma support the existence of the CNTN1-Notch2 axis observed in cell and mouse models.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Microbiology
Ruyue Fan, Xiurui Han, Yanan Gong, Lihua He, Zhijing Xue, Yaming Yang, Lu Sun, Dongjie Fan, Yuanhai You, Fanliang Meng, Xiaomei Yan, Maojun Zhang, Jianzhong Zhang
Summary: The study investigated the expression of fucosylated glycans in gastric epithelial cells infected with H. pylori strains from patients with different diseases, and found that high levels of α 1,2-linked fucose synthesized by FUT1/2 may play a role in the preliminary stage of H. pylori infection.
Article
Chemistry, Multidisciplinary
Ignacio Sanz-Martinez, Ana Garcia-Garcia, Tomas Tejero, Ramon Hurtado-Guerrero, Pedro Merino
Summary: Protein O-fucosyltransferase 2 (PoFUT2) is an important glycosyltransferase that recognizes a diverse range of TSRs through water-mediated interactions. Water molecules not only play a role in ligand recognition but also in the catalytic mechanism of PoFUT2.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Biochemistry & Molecular Biology
Alice Coillard, Elodie Segura
Summary: This study reviews the research on mouse mo-DC, evaluates the in vivo evidence for monocyte-derived antigen-presenting cells, and proposes that mo-DC may present antigens to effector T cells locally in tissues, playing a complementary role to cDCs.
MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Teresa Pagano, Katia Fecchi, Marina Pierdominici, Elena Ortona, Daniela Peruzzu
Summary: Silibinin exhibits immunosuppressive activity by inhibiting the maturation and activation of human dendritic cells, suggesting its potential application as an adjuvant therapy for autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Nishan Deng, Xiaoshu Zuo, Qibin Lin, Tong Wang, Yun Li, Jieying Zhong, Haiyang Ni, Qianhui Chen, Xuhong Ding, Hongying Yu, Hanxiang Nie
Summary: Low-dose 5-FU treatment inhibits the development of asthma and improves Th2 cell response by inducing apoptotic cell death of moDCs.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Cell Biology
Frederic Coutant, Jean-Jacques Pin, Pierre Miossec
Summary: Inflammatory monocyte-derived dendritic cells exhibit a distinct phenotype with C-type lectin receptors and intracellular proteins. The interaction between infiltrating monocytes and local mesenchymal cells is crucial for the generation of Mo-DCs in rheumatoid arthritis patients.
Article
Biochemistry & Molecular Biology
Sara Monaci, Federica Coppola, Gaia Giuntini, Rossella Roncoroni, Francesco Acquati, Silvano Sozzani, Fabio Carraro, Antonella Naldini
Summary: Hypoxia enhances the expression and secretion of RNASET2 in dendritic cells, which is associated with survival, autophagy, and apoptosis in DCs. The expression of RNASET2 under hypoxia is regulated by the PI3K/AKT pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Katarina Kolostova, Eliska Pospisilova, Rafal Matkowski, Jolanta Szelachowska, Vladimir Bobek
Summary: By using the CliniMACS Prodigy (R) machine and CTC lysates, we successfully generated Mo-DCs and demonstrated their potential to activate NTBC in co-cultures.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Immunology
Haruhiko Kawaguchi, Takuya Sakamoto, Terutsugu Koya, Misa Togi, Ippei Date, Asuka Watanabe, Kenichi Yoshida, Tomohisa Kato, Yuka Nakamura, Yasuhito Ishigaki, Shigetaka Shimodaira
Summary: cc-IL-4-DCs generated through cluster control showed increased levels of CD80, CD86, and CD40 compared to la-IL-4-DCs, and induced antigen-specific CTLs with higher levels of IFN-gamma, along with upregulation of BCL2A1 for pro-survival effects. These findings suggest that cc-IL-4-DCs are useful for generating homogeneous and functional IL-4-DCs with long-lasting effects in DC vaccines.
Article
Immunology
Seul Hye Ryu, Hyun Soo Shin, Hye Hyeon Eum, Ji Soo Park, Wanho Choi, Hye Young Na, Hyunju In, Tae-Gyun Kim, Sejung Park, Soomin Hwang, Moah Sohn, Eun-Do Kim, Kyoung Yul Seo, Hae-Ock Lee, Min-Geol Lee, Min Kyung Chu, Chae Gyu Park
Summary: Dendritic cells (DCs) play a crucial role in initiating adaptive immunity. Injecting granulocyte macrophage-colony stimulating factor (GM-CSF) can generate a distinct subset of DCs called GMiDCs in the spleen, which have superior antigen-presenting ability and can activate CD4(+) T cells and polarize Th2 cells. The generation of GMiDCs depends on the expression of GM-CSF receptor, and they can also be found in other tissues and during chronic allergic inflammation. This study provides important insights into the development and immune regulation of DCs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Louis Hinkle, Yongbin Liu, Chaoyang Meng, Zhe Chen, Junhua Mai, Licheng Zhang, Yitian Xu, Ping-Ying Pan, Shu-Hsia Chen, Haifa Shen
Summary: The sympathetic nervous system plays a role in regulating immune cell function, particularly in tumor growth and antitumor immunity. Combining propranolol with a peptide cancer vaccine showed promising results in treating melanoma in mice by enhancing DC maturation and reducing the presence of myeloid-derived suppressor cells.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Wanjing Cen, Felix Umrath, Antonio Jose Salgado, Siegmar Reinert, Dorothea Alexander
Summary: The secretomes derived from osteogenically induced jaw periosteum-derived mesenchymal stem cells (JPCs) have inhibitory effects on the maturation of monocyte-derived dendritic cells (MoDCs), as they reduce the formation of MoDC clusters and down-regulate the expression of CD80, CD86, and CD197 on MoDCs. The secretomes also enhance the uptake capacity of MoDCs and promote the expansion of regulatory T cells. Furthermore, the secretomes affect the gene expression of MoDCs, up-regulating CD209, HLA-DRA, CSF3, IL10, and IL8, and down-regulating IFN gamma and IL12B.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Waqas Azeem, Ragnhild Maukon Bakke, Benjamin Gabriel, Silke Appel, Anne Margrete Oyan, Karl-Henning Kalland
Summary: Research indicates that axitinib and nitazoxanide did not significantly inhibit beta-catenin signaling in monocyte-derived dendritic cells, but exhibited lower cytotoxicity. Axitinib stimulated various aspects of dendritic cell function, such as IL12-p70 secretion, and countered IL-10 secretion.
Article
Dermatology
Lydia Bellmann, Claudia Zelle-Rieser, Paul Milne, Anastasia Resteu, Christoph H. Tripp, Natascha Hermann-Kleiter, Viktoria Zaderer, Doris Wilflingseder, Paul Hoertnagl, Maria Theochari, Jessica Schulze, Mareike Rentzsch, Barbara Del Frari, Matthew Collin, Christoph Rademacher, Nikolaus Romani, Patrizia Stoitzner
Summary: Langerhans cells in the skin, critical for immune response and skin homeostasis, can be generated from monocytes with specific cytokines and ligands. These monocyte-derived LCs show potential for vaccine testing and can be an effective tool for future research.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Chemistry, Analytical
Maki Sogabe, Shun Kojima, Takatoshi Kaya, Azusa Tomioka, Hiroyuki Kaji, Takashi Sato, Yasunori Chiba, Akira Shimizu, Nana Tanaka, Nao Suzuki, Io Hayashi, Mikio Mikami, Akira Togayachi, Hisashi Narimatsu
Summary: In this study, a new measurement system was developed to investigate the potential of Wisteria floribunda agglutinin-reactive ceruloplasmin as a serum marker for ovarian clear cell carcinoma (CCC). The specificity and sensitivity of the serum marker measurement were greatly improved, allowing for the accurate diagnosis of CCC. This method can be used for the serodiagnosis of early-stage CCC.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kiyohiko Angata, Takanori Wagatsuma, Akira Togayachi, Takashi Sato, Maki Sogabe, Kazuto Tajiri, Tatsuhiko Ozawa, Izuru Nagashima, Hiroki Shimizu, Sayuki Iijima, Masaaki Korenaga, Atsushi Kuno, Hiroyuki Kaji, Masashi Mizokami, Hisashi Narimatsu
Summary: The glycosylation patterns of different HBsAgs vary, with the newly developed Glyco-PS2 antibody targeting O-glycosylated M-HBsAg showing potential for inhibiting HBV infection.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)
Article
Rheumatology
Fumihiko Ando, Katsuhiko Takabayashi, Shinsuke Fujita, Hiroshi Nakajima, Hideki Hanaoka, Takahiro Suzuki
Summary: This study investigated the seasonal changes in the use of biological disease-modifying antirheumatic drugs (bDMARDs) and methotrexate (MTX), and found that their use was highest in spring and lowest in winter. These seasonal changes are often overlooked in daily practice.
MODERN RHEUMATOLOGY
(2023)
Article
Rheumatology
Junya Suzuki, Shunsuke Furuta, Takahiro Sugiyama, Taro Iwamoto, Kei Ikeda, Kotaro Suzuki, Hiroshi Nakajima
Summary: This study retrospectively assessed the proportion of aPL positivity and its association with thrombotic risk in Japanese patients with AAV. The results showed that 33.3% of the patients were aPL-positive, and aPL positivity was associated with a higher incidence of thrombotic events. Multivariate analyses confirmed aPL positivity as a risk factor for thrombosis.
MODERN RHEUMATOLOGY
(2023)
Article
Urology & Nephrology
Masayuki Tasaki, Hiroaki Tateno, Takashi Sato, Hisashi Narimatsu, Kazuhide Saito, Yuki Nakagawa, Toshinari Aoki, Masami Kamimura, Takashi Ushiki, Kota Takahashi, Yoshihiko Tomita
Summary: The study investigated the reactivity of anti-ABO antibodies detected after ABO-incompatible kidney transplantation with stable graft function to the renal graft endothelial cells, and found that the antibody reactivity was low.
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2023)
Letter
Infectious Diseases
Yoichi Mashimo, Keiko Yamazaki, Takahiro Kageyama, Shigeru Tanaka, Toshibumi Taniguchi, Kazuyuki Matsushita, Hidetoshi Igari, Hideki Hanaoka, Koutaro Yokote, Hiroshi Nakajima, Yoshihiro Onouchi
JOURNAL OF INFECTION
(2022)
Article
Biochemistry & Molecular Biology
Xia Zou, Jishun Lu, Yao Deng, Qiannan Liu, Xialin Yan, Yalu Cui, Xiao Xiao, Meng Fang, Fang Yang, Hiromichi Sawaki, Takashi Sato, Binbin Tan, Xiaoyan Lu, Bo Feng, Atsushi Kuno, Hisashi Narimatsu, Chunfang Gao, Yan Zhang
Summary: This study revealed that ST6GAL1 and alpha 2,6 sialylation are negatively correlated with HCC cell metastasis. ST6GAL1 overexpression inhibits HCC cell migration and invasion in vitro and suppresses HCC metastasis in vivo, possibly through regulating MCAM expression.
Review
Rheumatology
Ryohei Ono, Togo Iwahana, Shuji Toriumi, Kaoruko Aoki, Hirotoshi Kato, Kodai Kato, Masahiro Yasui, Yuzuho Nakagawa, Shunsuke Furuta, Hiroshi Nakajima, Yoshio Kobayashi
Summary: This study reports a rare case of a 43-year-old female with fulminant myocarditis with adult-onset Still's disease (AOSD). The patient had refractory AOSD and cardiogenic shock with significantly elevated ferritin levels. The case was successfully treated with canakinumab and mechanical circulatory support. A review of previous cases shows that myocarditis may be an early complication of AOSD, and the severity of AOSD may correlate with the severity of myocarditis.
CLINICAL RHEUMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Kensuke Suga, Akira Suto, Shigeru Tanaka, Yutaka Sugawara, Takahiro Kageyama, Junichi Ishikawa, Yoshie Sanayama, Kei Ikeda, Shunsuke Furuta, Shin-Ichiro Kagami, Arifumi Iwata, Koichi Hirose, Kotaro Suzuki, Osamu Ohara, Hiroshi Nakajima
Summary: Methotrexate (MTX) is a common treatment for rheumatoid arthritis (RA) but its precise mechanisms of action remain unclear. In this study, DNA microarray analyses of CD4+ T cells in RA patients revealed that TP63, specifically its isoform TAp63, was downregulated after MTX treatment. TAp63 was highly expressed in Th17 cells and suppressed by MTX in vitro. Knockdown of TAp63 in mouse Th17 cells improved arthritis symptoms. Furthermore, TAp63 knockdown in CD4+ T cells promoted Foxp3 expression and enhanced the suppressive function of induced Treg cells. In summary, TAp63 suppresses Foxp3 expression and worsens autoimmune arthritis.
Article
Rheumatology
Norihiro Mimura, Taro Iwamoto, Shunsuke Furuta, Kei Ikeda, Yoshihisa Kobayashi, Takayuki Nakamura, Aiko Saku, Shin-Ichiro Kagami, Ayako Matsuki, Kentaro Takahashi, Takeshi Umibe, Daiki Nakagomi, Yoshie Sanayama, Toyohiko Sugimoto, Masashi Fukuta, Masaki Hiraguri, Hirotoshi Kawashima, Koichi Hirose, Hiroaki Takatori, Kenichi Suehiro, Shigekazu Takahashi, Tomohiro Tamachi, Manami Kato, Fumiyoshi Takizawa, Yuya Kawarai, Shigeo Hagiwara, Junichi Nakamura, Seiji Ohtori, Hiroshi Nakajima
Summary: Objective: To determine the prevalence and risk factors for osteonecrosis of the femoral head (ONFH) in AAV patients. Methods: Assessment of 186 AAV patients for the presence of ONFH through radiographs and MRI screening. Results: 18% of AAV patients were diagnosed with ONFH, and 64% of them had bilateral ONFH. Prednisolone dose of >= 20 mg/day on day 90 of RIT was identified as an independent risk factor for ONFH. Conclusion: Early detection of precollapse ONFH by MRI and rapid reduction of glucocorticoids in RIT may help prevent the development of ONFH in AAV patients.
Article
Rheumatology
Kazuya Abe, Shunsuke Furuta, Yoshihisa Kobayashi, Takao Sugiyama, Shin-Ichiro Kagami, Daiki Nakagomi, Taro Iwamoto, Kei Ikeda, Hiroshi Nakajima
Summary: This study aimed to assess the association between spontaneous pneumomediastinum (SPNM) occurrence and mortality in myositis patients with interstitial lung disease (ILD) according to antimelanoma differentiation-associated gene 5 (MDA5) antibody status. The results showed that SPNM was more common in myositis patients who were anti-MDA5 antibody positive, and it was associated with a higher risk of mortality.
Article
Rheumatology
Koto Hattori, Shigeru Tanaka, Junichi Ishikawa, Yoko Yabe, Taro Iwamoto, Shunsuke Furuta, Kei Ikeda, Kotaro Suzuki, Hiroshi Nakajima
Summary: This case report describes a SLE patient who developed VD-VZV during hospitalization. The patient presented with vesicular eruption and subsequent testing confirmed VD-VZV infection.
MODERN RHEUMATOLOGY CASE REPORTS
(2023)
Article
Surgery
Masayuki Tasaki, Hiroaki Tateno, Takashi Sato, Azusa Tomioka, Hiroyuki Kaji, Hisashi Narimatsu, Kazuhide Saito, Yuki Nakagawa, Toshinari Aoki, Masami Kamimura, Takashi Ushiki, Manabu Okada, Yuko Miwa, Kiyohiko Hotta, Yutaka Yoshida, Kota Takahashi, Yoshihiko Tomita
Summary: In this study, a new method to measure antibody titer using a microarray of recombinant CD31 linked to ABO antigens was developed. The results showed that this method had higher sensitivity and specificity in predicting antibody-mediated rejection in kidney transplantation compared to traditional isohemagglutinin assays.
TRANSPLANT INTERNATIONAL
(2022)
Article
Rheumatology
Jumpei Shoda, Shigeru Tanaka, Keishi Etori, Koto Hattori, Tadamichi Kasuya, Kei Ikeda, Yuko Maezawa, Akira Suto, Kotaro Suzuki, Junichi Nakamura, Yoshiro Maezawa, Minoru Takemoto, Christer Betsholtz, Koutaro Yokote, Seiji Ohtori, Hiroshi Nakajima
Summary: The expression of semaphorin 3G in CD4(+) T cells is downregulated by MTX treatment in patients with RA, while upregulation of semaphorin 3G in the RA synovium exacerbates joint inflammation through the accumulation of macrophages.
ARTHRITIS RESEARCH & THERAPY
(2022)
Article
Rheumatology
Takahiro Sugiyama, Shunsuke Furuta, Masaki Hiraguri, Kei Ikeda, Yosuke Inaba, Shin-Ichiro Kagami, Yasuhiko Kita, Kei Kobayashi, Yoshihisa Kobayashi, Kazuhiro Kurasawa, Daiki Nakagomi, Yasushi Nawata, Yohei Kawasaki, Yuki Shiko, Takao Sugiyama, Hiroshi Nakajima
Summary: This study identified two subgroups of Adult-onset Still's disease (AOSD): the typical group and the elderly-onset group. Although the survival of AOSD patients was generally good, they often experienced relapses. Age >= 65 years at disease onset was identified as a risk factor for relapse.
ARTHRITIS RESEARCH & THERAPY
(2022)