Article
Radiology, Nuclear Medicine & Medical Imaging
Chumin Zhao, Magdalena Herbst, Thomas Weber, Christoph Luckner, Sebastian Vogt, Ludwig Ritschl, Steffen Kappler, Jeffrey H. Siewerdsen, Wojciech Zbijewski
Summary: The study investigated the feasibility of slot-scan dual-energy bone densitometry on motorized radiographic equipment for fast quantitative measurements of areal bone mineral density. Results showed accurate and reproducible aBMD measurements across different body sizes and positioning with small errors. Empirical evaluations confirmed the reduction in aBMD errors with proposed procedures on robotic x-ray systems.
Article
Clinical Neurology
Wentao Lin, Chaoqin He, Faqin Xie, Tao Chen, Guanghao Zheng, Houjie Yin, Haixiong Chen, Zhiyun Wang
Summary: This study compared the diagnostic accuracy of quantitative computed tomography (QCT) and dual-energy X-ray absorptiometry (DXA) in detecting lumbar osteoporosis, and found that QCT provided more accurate evaluation of bone density than DXA. QCT measurements at specific vertebral levels showed high diagnostic performance for osteoporotic vertebral compression fractures (OVCF).
Review
Clinical Neurology
Zach Pennington, Jeff Ehresman, Daniel Lubelski, Ethan Cottrill, Andrew Schilling, A. Karim Ahmed, James Feghali, Timothy F. Witham, Daniel M. Sciubba
Summary: Poor bone quality and low bone mineral density have been associated with higher rates of mechanical complications after spinal fusion surgery. Accurate assessment of bone quality is crucial for all elective procedures. While DXA is considered the gold standard for assessing BMD, there are limitations in its accuracy according to growing research.
Article
Endocrinology & Metabolism
William D. Leslie, Heenam Goel, Neil Binkley, Eugene McCloskey, Didier Hans
Summary: Lumbar spine trabecular bone score (TBS) is a bone mineral density (BMD)-independent risk factor for fracture, but its sensitivity to technical factors and oral antiresorptive therapies is limited. This study analyzed TBS changes over time and in response to osteoporosis treatment, and found that TBS is strongly affected by technical factors and has little effect on monitoring response to antiresorptive treatment. Therefore, the current version of the TBS algorithm has limited usefulness in untreated individuals or routine clinical practice.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huan-Hua Wu, Biao Wu, Shao-Juan Zhang, Zi-Qing Zhou, Jing-Jie Shang, Yong Cheng, Jin-Ci Mai, Jian Gong, Hao Xu
Summary: This study provides normative reference ranges for TBS in Chinese men and women. Chinese men with a TBS score <1.31 and Chinese women with a TBS score <1.27 can be considered to have reduced bone microarchitecture and may be at higher risk of osteoporosis fractures.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Medicine, General & Internal
Fabio Massimo Ulivieri, Luca Rinaudo
Summary: A proper assessment of osteoporotic fragility fracture prediction requires consideration of factors like bone density, texture, geometry, and strength, obtained through methods like dual X-ray absorptiometry (DXA). The Bone Strain Index (BSI) is a new DXA-derived index designed to evaluate bone resistance to strain by incorporating information on density distribution, bone geometry, and loadings.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Leith Al-Hashimi, Jens Klotsche, Sarah Ohrndorf, Timo Gaber, Paula Hoff
Summary: The trabecular bone score (TBS) is a useful addition to DXA for diagnosing and evaluating bone loss, especially in patients with secondary osteoporosis. In this study, TBS measurement influenced treatment decisions for approximately 40% of patients with a treatment indication for anti-osteoporotic drugs. It was found that 21-25.5% of patients had unremarkable BMD measurements but showed poor bone quality in TBS measurements, indicating the importance of using TBS in assessing fracture risk and initiating timely therapy for osteoporosis in patients with secondary osteoporosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Katherine N. Haseltine, Tariq Chukir, Pinar J. Smith, Justin T. Jacob, John P. Bilezikian, Azeez Farooki
Summary: Bone mineral density measurement and FRAX assessment tools can help evaluate fracture risk and guide decisions for osteoporosis pharmacologic treatment. Specific populations like postmenopausal women and men over 50 should receive pharmacologic treatment according to guidelines. Monitoring BMD regularly and considering secondary causes or non-compliance is important during treatment.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Kathleen T. Nevola, Douglas P. Kiel, Andrew R. Zullo, Stefan Weiss, Georg Homuth, Ines Foessl, Barbara Obermayer-Pietsch, Katherine J. Motyl, Christine W. Lary
Summary: Osteoporosis is a common disease, and recent studies have found that individuals using beta blockers have higher bone density and lower fracture risk. Certain miRNAs have been associated with adrenergic signaling and bone density. This study investigates the potential role of miRNAs in the association between beta blocker use and bone density.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Lismeri Wuicik Merfort, Mateus de Oliveira Lisboa, Luciane Regina Cavalli, Carmem Maria Sales Bonfim
Summary: Fanconi Anemia is a genomic instability disease characterized by sensitivity to DNA cross-linking agents and chromosomal abnormalities. Diagnosis relies on cytogenetic analysis, which reveals chromosomal breaks induced by cross-linking agents. Understanding the genetic abnormalities and monitoring patients' prognosis is important for clinical management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Guangyue Yang, Hansong Wang, Zhufeng Wu, Yinyu Shi, Yongfang Zhao
Summary: This study investigated the use of Hounsfield units (HU) from different regions of interest (ROI) in opportunistic lumbar computed tomography (CT) to predict osteoporosis. The HU values of different ROI were compared to bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA). The results showed a strong correlation between CT HU and BMD, suggesting that HU measurements can be used to predict osteoporosis.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Article
Orthopedics
Elena Boehm, Eduard Kraft, Johanna Theresia Biebl, Bernd Wegener, Robert Stahl, Isa Feist-Pagenstert
Summary: This study compared the sensitivity and discriminatory power of DXA and QCT in detecting osteoporosis and predicting fractures. The results indicate that QCT is more sensitive than DXA in predicting osteoporosis and fractures.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Endocrinology & Metabolism
M. M. Delsmann, A. Strahl, M. Muhlenfeld, N. M. Jandl, F. T. Beil, C. Ries, T. Rolvien
Summary: The study found a high prevalence of low bone mineral density in elderly patients with end-stage osteoarthritis scheduled for total hip arthroplasty. Routine DXA measurements should be considered in these patients to prevent undiagnosed and untreated osteoporosis, which could impact the success of osseointegration and other clinical outcomes.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Endocrinology & Metabolism
Mahshid Mohseni, Pooya Hosseinzadeh, Roberto Civitelli, Seth Eisen
Summary: While limited studies show no significant impact of neuropathy on bone density, more research is needed to confirm the relationship. The results of the study should be interpreted with caution, and future studies require more advanced assessment measures and imaging technologies.
Article
Chemistry, Inorganic & Nuclear
M. M. Al-Bogami, O. A. Akanle, S. Aldawood, M. Alkhorayef, A. Sulieman, A. S. Jawad, R. A. Mageed
Summary: The goal of this research was to study the impact of individual characteristics and gender on the response of osteoporosis patients to bisphosphonate medication. The results showed that male patients experienced a significant increase in bone mineral density after two years of therapy, while female patients had smaller changes. This difference was attributed to ovarian failure and estrogen loss in male patients.
APPLIED RADIATION AND ISOTOPES
(2023)
Article
Hematology
Anna Hecht, Julia A. Meyer, Astrid Behnert, Eric Wong, Farid Chehab, Adam Olshen, Aaron Hechmer, Catherine Aftandilian, Rukhmi Bhat, Sung Won Choi, Satheesh Chonat, Jason E. Farrar, Mark Fluchel, Haydar Frangoul, Jennifer H. Han, Edward A. Kolb, Dennis J. Kuo, Margaret L. MacMillan, Luke Maese, Kelly W. Maloney, Aru Narendran, Benjamin Oshrine, Kirk R. Schultz, Maria L. Sulis, David Van Mater, Sarah K. Tasian, Wolf-Karsten Hofmann, Mignon L. Loh, Elliot Stieglitz
Summary: Mutations in the CBL gene can lead to various myeloid malignancies, with some pediatric patients with JMML carrying CBL mutations but having milder disease courses. The majority of CBL mutations in JMML patients are germline, not somatic mutations. The disease presentation and overall outcome of JMML patients with CBL mutations are highly diverse, and some patients have more aggressive disease with somatically acquired CBL mutations. Clinical features and methylation profiling cannot accurately distinguish patients with different types of CBL mutations, highlighting the need for germline testing.
Article
Hematology
Asim Saha, Sharon Hyzy, Tahirih Lamothe, Katelyn Hammond, Nicholas Clark, Leanne Lanieri, Prashant Bhattarai, Rahul Palchaudhuri, Geoffrey O. Gillard, Jennifer Proctor, Megan J. Riddle, Angela Panoskaltsis-Mortari, Margaret L. MacMillan, John E. Wagner, Hans-Peter Kiem, Lisa M. Olson, Bruce R. Blazar
Summary: Allo-HSCT is a potential curative treatment for blood disorders, but graft-versus-host disease (GVHD) limits its success. CD45-ADC, an antibody-drug-conjugate, facilitates stable donor cell engraftment and provides a new approach to reduce treatment toxicity.
Letter
Biophysics
Gabrielle Meyers, Mehdi Hamadani, Michael Martens, Haris Ali, Hannah Choe, Peter Dawson, Andrew C. Harris, Eric van Hooren, Willem Klaassen, Eric Leifer, Margaret L. MacMillan, Ypke van Oosterhout, Lia Perez, Iskra Pusic, Phuong Vo, John E. Levine
BONE MARROW TRANSPLANTATION
(2022)
Review
Hematology
Tewodros Mamo, Keli L. Hippen, Margaret L. MacMillan, Claudio G. Brunstein, Jeffrey S. Miller, John E. Wagner, Bruce R. Blazar, David H. McKenna
Article
Biophysics
Najla El Jurdi, Grigori Okoev, Todd E. DeFor, Shernan G. Holtan, Brian C. Betts, Bruce R. Blazar, Claudio G. Brunstein, Margaret L. MacMillan, Daniel J. Weisdorf, Mukta Arora
Summary: This study found that patients with chronic graft-versus-host disease (cGVHD) may experience flares during immunosuppressive therapy (IST), and implementing appropriate treatment measures may reduce disease progression and treatment duration.
BONE MARROW TRANSPLANTATION
(2022)
Article
Dermatology
Brittney Schultz, Daniel D. Miller, Todd DeFor, Bruce R. Blazar, Angela Panoskaltsis-Mortari, Brian C. Betts, Margaret L. MacMillan, Daniel J. Weisdorf, Shernan G. Holtan
Summary: This study found that high skin AREG immunohistochemical expression is associated with high clinical grade aGVHD, poor overall survival (OS), and increased non-relapse mortality (NRM).
JOURNAL OF CUTANEOUS PATHOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Sanket S. Dhruva, Emily P. Zeitler, Daniel Canos, Hetal Odobasic, Jacqueline M. Major, Li Wang, Steven Mullane, Yelena Nabutovsky, Valerie Smith, Lei Zhang, Kimberly A. Selzman
Summary: Post-market evaluation is crucial for ensuring the ongoing safety and effectiveness of cardiovascular implantable electronic device leads. The EP PASSION project utilizes real-world data for longitudinal evaluation, providing support for regulatory, clinical, and manufacturer decision-making.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2023)
Article
Hematology
Phuong Vo, Ted A. Gooley, Paul A. Carpenter, Mohamed L. Sorror, Margaret L. MacMillan, Todd E. DeFor, Paul J. Martin
Summary: This study examined the long-term outcomes of patients who received second-line treatment for acute GVHD after HCT. Serum albumin and total bilirubin concentrations, patient age, and the severity of abdominal pain/gut involvement were identified as important predictors of treatment outcomes. The estimated overall survival (OS) and failure-free survival (FFS) at 6 and 12 months were calculated, and predictive models for 6- and 12-month mortality were proposed.
Letter
Biophysics
Gabrielle Meyers, Mehdi Hamadani, Michael Martens, Haris Ali, Patrice Chevallier, Hannah Choe, Andrew C. Harris, Ernst Holler, Eric van Hooren, Willem Klaassen, Eric Leifer, Ypke van Oosterhout, Lia Perez, Iskra Pusic, Matthias Stelljes, Walter van der Velden, Emanuele Ammatuna, David Beauvais, Jerome Cornillon, Richard T. Maziarz, Johannes Schetelig, Jennifer Romeril, Margaret L. MacMillan, John E. Levine, Gerard Socie
BONE MARROW TRANSPLANTATION
(2023)
Article
Hematology
Nancy Gillis, Eric Padron, Tao Wang, Karen Chen, Jakob D. Devos, Stephen R. Spellman, Stephanie J. Lee, Carrie L. Kitko, Margaret L. Macmillan, Jeffrey West, Yi -Han Tang, Mingxiang Teng, Samantha Mcnulty, Todd E. Druley, Joseph A. Pidala, Aleksandr Lazaryan
Summary: Improved treatment options enable older patients to receive potentially curative allogeneic hematopoietic cell transplantation. An unintended risk associated with older donors is the transplantation of donor cells with clonal hematopoiesis, which may affect transplantation outcomes.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Hematology
Rima M. Salibaaw, Amin M. Alousia, Joseph Pidala, Mukta Arora, Stephen R. Spellman, Michael T. Hemmer, Tao Wang, Camille Abboudg, Sairah Ahmed, Joseph H. Antin, Amer Beitinjanehi, David K. Buchbinder, Michael Byrne, Jean-Yves Cahn, Hannah Choen, Rabi Hanna, Peiman HemattiP, Rammurti T. Kamble, Carrie L. Kitkor, Mary Laughlin, Lazaros Lekakis, Margaret L. MacMillan, Rodrigo Martino, Parinda A. Mehta, Taiga Nishihori, Sagar S. Patel, Miguel-Angel Perales, Hemalatha G. Rangarajan, Olov Ringden, Joseph Rosenthal, Bipin N. Savani, Kirk R. Schultz, Sachiko Seo, Takanori Teshimaag, Marjolein van der Poela, Leo F. Verdonck, Daniel Weisdorf, Baldeep Wirk, Jean A. Yared, Jeffrey Schriber, Richard E. Champlin, Stefan O. Ciurea
Summary: This retrospective registry study compared the distribution, severity, and outcomes of graft-versus-host disease (GvHD) in patients receiving haploidentical (Haplo) transplantation with post-transplantation cyclophosphamide (PTCy) prophylaxis and HLA-matched unrelated donor transplantation with conventional prophylaxis. The study found that Haplo/PTCy transplantation was associated with reduced rates of severe acute GvHD and chronic GvHD, particularly in the gastrointestinal (GI) tract.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Hematology
Catherine J. Lee, Tao Wang, Karen Chen, Mukta Arora, Ruta Brazauskas, Stephen R. Spellman, Carrie Kitko, Margaret L. MacMillan, Joseph A. Pidala, Jeffery J. Auletta, Sherif M. Badawy, Neel Bhatt, Vijaya R. Bhatt, Jean-Yves Cahn, Zachariah DeFilipp, Miguel A. Diaz, Nosha Farhadfar, Shahinaz Gadalla, Robert P. Gale, Hasan Hashem, Shahrukh Hashmi, Peiman Hematti, Sanghee Hong, Nasheed M. Hossain, Yoshihiro Inamoto, Lazaros J. Lekakis, Dipenkumar Modi, Sager Patel, Akshay Sharma, Scott Solomon, Daniel R. Couriel
Summary: Chronic graft-versus-host disease (cGVHD) is a common complication following allogeneic hematopoietic cell transplantation (HCT) in children, and it significantly affects the quality of life of long-term survivors. This study aimed to analyze the occurrence of late effects (LEs) in pediatric HCT survivors and investigate the correlation between cGVHD and subsequent neoplasms (SNs) and nonmalignant LEs (NM-LEs). The findings suggest that patients with cGVHD have a higher cumulative incidence of LEs within 10 years after HCT, and cGVHD-related features are closely associated with the occurrence of NM-LEs.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Hematology
Jo-Anne H. Young, Najla El Jurdi, Ahmad Rayes, Margaret L. MacMillan, Shernan G. Holtan, Qing Cao, Judith Witte, Mukta Arora, Daniel J. Weisdorf
Summary: This study retrospectively analyzed the infectious complications in patients with acute graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). The results showed that patients with steroid-sensitive GVHD had fewer bacterial and viral infections compared to patients with steroid-resistant GVHD. The study suggests that anti-infective therapy should be guided by infection density during active GVHD treatment.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Hematology
Abdelrahman Saqr, Brooke Carlson, Christopher Staley, Armin Rashidi, Mahmoud Al-Kofahi, Thomas Kaiser, Shernan Holtan, Margaret MacMillan, Jo-Anne Young, Najla El Jurdi, Daniel Weisdorf, Alexander Khoruts, Pamala A. Jacobson
Summary: Mycophenolate mofetil (MMF) is an important immunosuppressant used after allogeneic hematopoietic cell transplantation (HCT). This study found that blood concentrations of MMF were highly variable, with low concentrations associated with the risk of graft-versus-host disease (GVHD) and high concentrations associated with toxicity. The presence of beta-glucuronidase-producing bacteria in the gastrointestinal tract may enhance the enterohepatic recirculation (EHR) of MMF, leading to higher concentrations. Individuals with high EHR had a greater abundance of certain Bacteroides species in their stool and higher exposure to MMF.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Hematology
Vijaya Raj Bhatt, Tao Wang, Karen Chen, Carrie L. Kitko, Margaret L. MacMillan, Joseph A. Pidala, Monzr M. Al Malki, Sherif M. Badawy, Amer Beitinjaneh, Siddhartha Ganguly, Betty Hamilton, Gerhard C. Hildebrandt, Lazaros J. Lekakis, Hongtao Liu, Richard T. Maziarz, Dipenkumar Modi, Hemant S. Murthy, Jaime M. Preussler, Akshay Sharma, Stephen R. Spellman, Mukta Arora, Stephanie J. Lee
Summary: In this study, the effect of chronic graft-versus-host disease (cGVHD) on nonrelapse mortality (NRM) and relapse risk was investigated in older adults undergoing allogeneic hematopoietic cell transplantation. The results revealed that cGVHD significantly increased the risk of NRM and decreased the risk of relapse, regardless of age. Older adults had a higher risk of NRM, but the impact of cGVHD on NRM did not differ based on age.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
