期刊
IUBMB LIFE
卷 71, 期 6, 页码 749-759出版社
WILEY
DOI: 10.1002/iub.2040
关键词
secretory pathway; protein kinases; bacterial effectors; parasite kinases; Fam20C
资金
- NIH [R00DK099254]
- Welch Foundation [I-1911, I-1936]
- CPRIT Grant [RP170674]
- NSF [MCB1553334]
Previous decades have seen an explosion in our understanding of protein kinase function in human health and disease. Hundreds of unique kinase structures have been solved, allowing us to create generalized rules for catalysis, assign roles of communities within the catalytic core, and develop specific drugs for targeting various pathways. Although our understanding of intracellular kinases has developed at a fast rate, our exploration into extracellular kinases has just begun. In this review, we will cover the secreted protein kinase families found in humans, bacteria, and parasites. (c) 2019 IUBMB Life, 71(6):749-759, 2019
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