Article
Gastroenterology & Hepatology
Sudiksha Rathan-Kumar, Joseph T. Roland, Michael Momoh, Anna Goldstein, Lynne A. Lapierre, Elizabeth Manning, Louise Mitchell, Jim Norman, Izumi Kaji, James R. Goldenring
Summary: This study demonstrates the importance of Rab11FIP1 in maintaining mucosal integrity in the colon. Deficiency of Rab11FIP1 leads to mistrafficking of Rab14 and MUC13, as well as a decrease in colonic goblet cells, resulting in impaired mucosal integrity.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Birgitte Villadsen, Camilla Thygesen, Manuela Grebing, Stefan J. Kempf, Marie B. Sandberg, Pia Jensen, Stefanie H. Kolstrup, Helle H. Nielsen, Martin R. Larsen, Bente Finsen
Summary: Ceruloplasmin (Cp) is a multicopper oxidase with important roles in iron and copper regulation. Cp deficiency can lead to aceruloplasminemia, which is characterized by neurological symptoms. This study compared the brain proteome in Cp-deficient and wild-type mice, revealing that Cp deficiency affects proteins involved in neuronal projections, synaptic signaling, cellular mRNA processing, and neurodegenerative disease and diabetes. Cp deficiency also affects iron concentration and transferrin saturation, potentially impacting protein and lipid synthesis.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Cell Biology
Wenbo Zhao, Philip Wiedemann, Eva Maria Woelfel, Mona Neven, Stephanie Peters, Thomas Imhof, Manuel Koch, Bjoern Busse, Michael Amling, Thorsten Schinke, Timur Alexander Yorgan
Summary: Col22a1, predominantly expressed in bone, deficiency may result in trabecular osteopenia and increased osteoclast numbers.
Article
Geriatrics & Gerontology
Sigrid Nilsson, Mats Hammar, Janne West, Magnus Borga, Sofia Thorell, Anna -Clara Spetz Holm
Summary: This study aimed to investigate the changes of abdominal adipose tissue volumes and ratios after a 15-week structured resistance training intervention. Sixty-five postmenopausal women with vasomotor symptoms and low physical activity were randomly assigned to either a supervised resistance training group or a control group. The study found that women who participated in the resistance training had significantly different reductions in subcutaneous adipose tissue, visceral adipose tissue, total abdominal adipose tissue, and fat ratio compared to the control group.
Article
Nutrition & Dietetics
Takumi Komaru, Noriyuki Yanaka, Thanutchaporn Kumrungsee
Summary: Research indicates that vitamin B6 deficiency reduces the number of dormant satellite cells in mouse muscles, inhibiting satellite cell proliferation and self-renewal during myogenesis.
Article
Biochemistry & Molecular Biology
Zhengye Liu, Thomas Chaillou, Estela Santos Alves, Theresa Mader, Baptiste Jude, Duarte M. S. Ferreira, Heidi Hynynen, Arthur J. Cheng, William O. Jonsson, Gianluigi Pironti, Daniel C. Andersson, Ellinor Kenne, Jorge L. Ruas, Pasi Tavi, Johanna T. Lanner
Summary: The study demonstrates that NDUFA4L2 regulates skeletal muscle mass and force by decreasing mitochondrial activity and production of reactive oxygen species, leading to muscle atrophy. Overexpression of NDUFA4L2 reduces mitochondrial respiration and antioxidant capacity, lowering levels of important intramuscular metabolites, ultimately affecting muscle function.
Article
Nutrition & Dietetics
Lana Schumann, Annett Wilken-Schmitz, Sandra Trautmann, Alexandra Vogel, Yannick Schreiber, Lisa Hahnefeld, Robert Gurke, Gerd Geisslinger, Irmgard Tegeder
Summary: Progranulin deficiency in mice leads to a stronger preference for fatty taste and an increase in body weight, potentially due to reduced CD36 expression in the tongue.
Article
Geriatrics & Gerontology
Thomas A. Paul, Peter C. Macpherson, Tara L. Janetzke, Carol S. Davis, Malcolm J. Jackson, Anne McArdle, Susan V. Brooks
Summary: The regenerative ability of neuromuscular junctions (NMJ) in old mice is diminished, which may contribute to the impaired recovery of skeletal muscle following injury. This decreased ability to regenerate NMJs could be a triggering factor for degenerative changes at the NMJ, leading to muscle weakness and loss in old age.
Article
Biochemistry & Molecular Biology
Natalie R. Janzen, Jamie Whitfield, Lisa Murray-Segal, Bruce E. Kemp, John A. Hawley, Nolan J. Hoffman
Summary: By studying AMPK beta double knock-in mice, it was found that DKI mice displayed increased whole-body fat mass and glucose intolerance, along with reduced fat oxidation compared to wild-type. DKI mice had reduced liver glycogen content in the fed state, increased utilization of skeletal muscle glycogen in response to fasting but no repletion during refeeding, and also showed reductions in AMPK protein content in liver and skeletal muscle compared to WT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Muhammad O. Chohan, Hannah Yueh, Halli Fein, Jared M. Kopelman, Susanne E. Ahmari, Jeremy Veenstra-VanderWeele
Summary: Repeated amphetamine use leads to locomotor sensitization, which may be related to the development of psychosis and addiction. The interaction between dopaminergic and glutamatergic systems plays a significant role in amphetamine sensitization. However, the impact of chronic alterations in the expression of the excitatory amino acid transporter (EAAT3) on this phenomenon is still uncertain.
NEUROCHEMISTRY INTERNATIONAL
(2022)
Article
Cell Biology
Michael A. Lopez, Sherina Bontiff, Mary Adeyeye, Aziz Shaibani, Matthew S. Alexander, Shari Wynd, Aladin M. Boriek
Summary: The MDX mouse model was used to study the role of dystrophin in skeletal muscle mechanics, finding that muscle extensibility and compliance were increased in MDX mice, as well as a higher relaxed elastic modulus in dystrophin-deficient diaphragms. Additionally, age was found to impact the passive mechanics of the diaphragm, with older MDX mice showing decreased compliance and extensibility compared to younger mice.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Physiology
David A. Reiter, Moriah P. Bellissimo, Lei Zhou, Scott Boebinger, Greg D. Wells, Dean P. Jones, Thomas R. Ziegler, Jessica A. Alvarez, Candace C. Fleischer
Summary: This study aimed to investigate the relationship between skeletal muscle energy metabolism and body composition in healthy adults. The results suggest that increased adiposity is associated with reduced muscle energetic efficiency and more reliance on glycolysis.
JOURNAL OF APPLIED PHYSIOLOGY
(2023)
Article
Clinical Neurology
Benjamin B. Tournier, Silvia Sorce, Antoine Marteyn, Roberta Ghidoni, Luisa Benussi, Giuliano Binetti, Francois R. Herrmann, Karl-Heinz Krause, Dina Zekry
Summary: This study investigates the links between CCR5 deficiency, neuronal sensitivity to oxidative stress, and the development of dementia. The results show that CCR5-& UDelta;32 allele, when combined with ApoE & epsilon;4, increases the risk for dementia, particularly vascular dementia. Additionally, Ccr5 deficiency in mice neurons leads to increased vulnerability to oxidative stress-induced cell death, suggesting a possible mechanism contributing to dementia.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Maria Elena Klibo Lie, Christina Birkedahl Falk-Petersen, Louise Piilgaard, Nane Griem-Krey, Petrine Wellendorph, Birgitte Rahbek Kornum
Summary: This study reveals that the GABA(A) receptor beta(1)-subunit does not play a crucial role in sleep initiation or maintenance, but instead regulates the power spectrum and expression of theta rhythm. Functional beta(1)-subunit-containing GABA(A) receptors exhibit highest binding levels in the hippocampus and frontal cortex, indicating their significance in modulating sleep patterns.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Hematology
Alexandra Mazharian, Blandine Maitre, Alicia Bornert, Desline Hennequin, Marc Lourenco-Rodrigues, Mitchell J. Geer, Christopher W. Smith, Silke Heising, Michaela Walter, Florian Montel, Lucy S. K. Walker, Henri de la Salle, Steve P. Watson, Christian Gachet, Yotis A. Senis
Summary: Mice lacking the G6b-B receptor exhibit a range of platelet abnormalities, including macrothrombocytopenia and reduced collagen receptor expression. Treatment with romiplostim, a thrombopoietin mimetic, showed promising results in rescuing platelet counts and function in G6b KO mice. However, inhibitors targeting Syk and Src kinases had limited effects on platelet abnormalities. These findings suggest that romiplostim may be a potential therapeutic option for patients lacking functional G6b-B.
Article
Biochemistry & Molecular Biology
Ara Yoo, Hyeonhee Lee, Jinyoung Jung, Sang Seok Koh, Soojin Lee
Summary: The study identified MCT9 as a novel gene highly downregulated in renal cell cancer, with its overexpression clearly attenuating RCC cell proliferation. Functional analysis of MCT9 may help in deciphering kidney-specific energy metabolism during renal tumor progression.
Article
Nutrition & Dietetics
Abdulkadir Yusif Maigoro, Soojin Lee
Summary: Research has found that individuals with ASD have more bacteria in their gut microbiome that produce enzymes involved in synthesizing lipid A endotoxin, which may lead to an increased rate of synthesis of immunogenic LPS products, possibly related to their gastrointestinal symptoms and inflammatory conditions.
Article
Chemistry, Medicinal
Abdulkadir Yusif Maigoro, Dayoung An, Soojin Lee
Summary: COVID-19 has led to a global pandemic affecting the entire world, with cytokine storms and vitamin D deficiency emerging as key factors influencing disease severity. An in silico analysis suggested a possible connection between vitamin D receptor, cell chemotaxis, and cytokine storms, providing insights into potential treatment strategies.
JOURNAL OF MEDICINAL FOOD
(2022)
Article
Chemistry, Multidisciplinary
Sanghoon Lee, Miseon Jeong, Soojin Lee, Sang Hun Lee, Jin-sil Choi
Summary: The mag-spinner system, combining magnets with a spinner system, is a new type of magnetic separation system for biological and medical sample preprocessing. It successfully captures targets quickly and efficiently, meeting the requirements for desirable separation systems.
NANOSCALE ADVANCES
(2022)
Article
Biochemistry & Molecular Biology
Ara Yoo, Yeonhee Joo, Yeongmi Cheon, Sung Joong Lee, Soojin Lee
Summary: Neuronal growth regulator 1 (NEGR1) is a membrane protein associated with obesity, depression, and autism, and it regulates cellular fat content by interacting with CD36.
JOURNAL OF LIPID RESEARCH
(2022)
Article
Cell Biology
Gyuri Sim, Moonkyung Jeong, Hyunseok Seo, Jangrae Kim, Soojin Lee
Summary: Neuronal growth regulator 1 (NEGR1) is involved in neural cell communication and synapse formation, and its N-glycan residues play important roles in the folding, trafficking, and homodimer formation of NEGR1 protein.
Article
Biotechnology & Applied Microbiology
You Jin Lee, Soojin Lee, Dong-Myung Kim
Summary: Gene expression can efficiently amplify DNA information into protein molecules. Cell-free protein synthesis (CFPS) offers a solution to analyze biomolecules in vitro without the problems associated with whole cell-based approaches. In this study, the authors developed a method to analyze indole using enzymatic conversion and amino acid-dependent CFPS, successfully estimating the indole concentration.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Immunology
Panida Sittipo, Jaeyoon Choi, Soojin Lee, Yun Kyung Lee
Summary: This review highlights the importance of microbiota in regulating gut-brain communication in immune-related neurological disorders. The bidirectional communication between gut microbiota and the brain affects human health and behavior, particularly in neurological disorders. Despite numerous studies, there are still limitations in translating this research to humans.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Chemistry, Physical
Seonyoung Jo, Sihyun Kim, Yena Lee, Gayoung Kim, Sehoon Kim, Soojin Lee, Taek Seung Lee
Summary: A pyrene-based fluorescent molecular probe, Py2-5EG, was synthesized for optical detection of viscosity variation. The probe showed blue fluorescence in high viscosity medium and greenish blue fluorescence in low viscosity medium. The fluorescence colors were used to observe microscopic changes in cellular viscosity.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
(2022)
Article
Plant Sciences
Rajeev K. Singla, Ronita De, Thomas Efferth, Bruno Mezzetti, Md Sahab Uddin, Sanusi, Fidele Ntie-Kang, Dongdong Wang, Fabien Schultz, Kiran R. Kharat, Hari Prasad Devkota, Maurizio Battino, Daniel Sur, Ronan Lordan, Sourav S. Patnaik, Christos Tsagkaris, Chandragiri Siva Sai, Surya Kant Tripathi, Mihnea-Alexandru Gaman, Mosa E. O. Ahmed, Elena Gonzalez-Burgos, Smith B. Babiaka, Shravan Kumar Paswan, Joy Ifunanya Odimegwu, Faizan Akram, Jesus Simal-Gandara, Magali S. Urquiza, Aleksei Tikhonov, Himel Mondal, Shailja Singla, Sara Di Lonardo, Eoghan J. Mulholland, Merisa Cenanovic, Abdulkadir Yusif Maigoro, Francesca Giampieri, Soojin Lee, Nikolay T. Tzvetkov, Anna Maria Louka, Pritt Verma, Hitesh Chopra, Scarlett Perez Olea, Johra Khan, Jose M. Alvarez Suarez, Xiaonan Zheng, Michal Tomczyk, Manoj Kumar Sabnani, Christhian Delfino Villanueva Medina, Garba M. Khalid, Hemanth Kumar Boyina, Milen Georgiev, Claudiu T. Supuran, Eduardo Sobarzo-Sanchez, Tai-Ping Fan, Valeria Pittala, Antoni Sureda, Nady Braidy, Gian Luigi Russo, Rosa Anna Vacca, Maciej Banach, Gerard Lizard, Amira Zarrouk, Sonia Hammami, Ilkay Erdogan Orhan, Bharat B. Aggarwal, George Perry, Mark J. S. Miller, Michael Heinrich, Anupam Bishayee, Anake Kijjoa, Nicolas Arkells, David Bredt, Michael Wink, Bernd L. Fiebich, Gangarapu Kiran, Andy Wai Kan Yeung, Girish Kumar Gupta, Antonello Santini, Massimo Lucarini, Alessandra Durazzo, Amr El-Demerdash, Albena T. Dinkova-Kostova, Alejandro Cifuentes, Eliana B. Souto, Muhammad Asim Masoom Zubair, Pravin Badhe, Javier Echeverria, Jaroslaw Olav Horbanczuk, Olaf K. Horbanczuk, Helen Sheridan, Sadeeq Muhammad Sheshe, Anna Maria Witkowska, Ibrahim M. Abu-Reidah, Muhammad Riaz, Hammad Ullah, Akolade R. Oladipupo, Victor Lopez, Neeraj Kumar Sethiya, Bhupal Govinda Shrestha, Palaniyandi Ravanan, Subash Chandra Gupta, Qushmua E. Alzahrani, Preethidan Dama Sreedhar, Jianbo Xiao, Mohammad Amin Moosavi, Parasuraman Aiya Subramani, Amit Kumar Singh, Ananda Kumar Chettupalli, Jayanta Kumar Patra, Gopal Singh, Tomasz M. Karpinski, Fuad Al-Rimawi, Rambod Abiri, Atallah F. Ahmed, Davide Barreca, Sharad Vats, Said Amrani, Carmela Fimognari, Andrei Mocan, Lucian Hritcu, Prabhakar Semwal, Md Shiblur Rahaman, Mila Emerald, Akinleye Stephen Akinrinde, Abhilasha Singh, Ashima Joshi, Tanuj Joshi, Shafaat Yar Khan, Gareeballah Osman Adam Balla, Aiping Lu, Sandeep Ramchandra Pai, Imen Ghzaiel, Niyazi Acar, Nour Eddine Es-Safi, Gokhan Zengin, Azazahemad A. Kureshi, Arvind Kumar Sharma, Bikash Baral, Neeraj Rani, Philippe Jeandet, Monica Gulati, Bhupinder Kapoor, Yugal Kishore Mohanta, Zahra Emam-Djomeh, Raphael Onuku, Jennifer R. Depew, Omar M. Atrooz, Bey Hing Goh, Jose Carlos Andrade, Bikramjit Konwar, V. J. Shine, Joao Miguel Lousa Dias Ferreira, Jamil Ahmad, Vivek K. Chaturvedi, Krystyna Skalicka-Wozniak, Rohit Sharma, Rupesh K. Gautam, Sebastian Granica, Salvatore Parisi, Rishabh Kumar, Atanas G. Atanasov, Bairong Shen
Summary: The development of digital technologies and open innovation approaches has enabled the creation of virtual organizations and enterprises. The International Natural Product Sciences Taskforce (INPST) is an open innovation platform that brings together individuals and organizations interested in natural product scientific research. This study presents an overview of INPST activities and showcases the use of Twitter as a powerful networking tool, demonstrated through the 2021 INPST Twitter Networking Event.
Article
Genetics & Heredity
Islam M. M. Saadeldin, Bereket Molla Tanga, Seonggyu Bang, Abdulkadir Y. Y. Maigoro, Heejae Kang, Dabin Cha, Soojin Lee, Sanghoon Lee, Jongki Cho
Summary: This study identified 29 known mature miRNAs and 17 novel miRNAs in honeybee royal jelly extracellular vesicles (RJEVs). Further investigation showed that RJEVs can reduce apoptosis and enhance cell vitality and healing ability. The findings suggest that RJEVs regulate gene expression to maintain cell survival and promote cell regeneration.
FUNCTIONAL & INTEGRATIVE GENOMICS
(2023)
Article
Nutrition & Dietetics
Su-In Yoon, Hye-Ri Moon, So Rok Lee, Jingnan Zhang, Soojin Lee, Jin Ah Cho
Summary: The study found that there is an association between diet and depression in young Korean adults. Individuals with depression had lower intake of energy and nutrients, particularly in men. This highlights the importance of improving the quantity and quality of meals for individuals with depressive symptoms.
Article
Biochemistry & Molecular Biology
Ara Yoo, Soojin Lee
Summary: NEGR1 interacts with IL-6R and negatively regulates IL-6 trans-signaling by attenuating the phosphorylation of STAT3 by sIL-6R. This may contribute to a molecular link underlying obesity, inflammation, and the depression cycle.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Multidisciplinary Sciences
Jisoo Lee, Soohyun Kim, Boram Lee, Yoo-Bin Kim, Kwang Hwan Kim, Gehoon Chung, Sung Joong Lee, Soojin Lee, Woong Sun, Hee-Kyung Park, Se-Young Choi
Summary: Salivary gland cells secrete water in response to neuronal stimulation and are closely connected to other neurons. These cells also express proteins responsible for neuronal function, but their exact role in salivary glands is largely unknown. In this study, the function of Neuronal growth regulator 1 (NEGR1) in salivary gland cells was investigated. NEGR1 was found to be expressed in both mouse and human salivary glands. Knockout of Negr1 gene in mice had no impact on the structure of salivary glands, but it did affect intracellular calcium levels and salivary secretion. NEGR1 was found to influence salivary secretion through muscarinic calcium signaling.
Article
Biotechnology & Applied Microbiology
Maria Kletecka-Pulker, Himel Mondal, Dongdong Wang, R. Gonzalo Parra, Abdulkadir Yusif Maigoro, Soojin Lee, Tushar Garg, Eoghan J. Mulholland, Hari Prasad Devkota, Bikramjit Konwar, Sourav S. Patnaik, Ronan Lordan, Faisal A. Nawaz, Christos Tsagkaris, Rehab A. Rayan, Anna Maria Louka, Ronita De, Pravin Badhe, Eva Schaden, Harald Willschke, Mathias Maleczek, Hemanth Kumar Boyina, Garba M. Khalid, Md Sahab Uddin, Sanusi, Johra Khan, Joy Odimegwu, Andy Wai Kan Yeung, Faizan Akram, Chandragiri Siva Sai, Sherri Bucher, Shravan Kumar Paswan, Rajeev K. Singla, Bairong Shen, Sara Di Lonardo, Anela Tosevska, Jesus Simal-Gandara, Manja Zec, Elena Gonzalez-Burgos, Marija Habijan, Maurizio Battino, Francesca Giampieri, Aleksei Tikhonov, Danila Cianciosi, Tamara Y. Forbes-Hernandez, Jose L. Quiles, Bruno Mezzetti, Smith B. Babiaka, Mosa E. O. Ahmed, Paula Piccard, Magali S. Urquiza, Jennifer R. Depew, Fabien Schultz, Daniel Sur, Sandeep R. Pai, Mihnea-Alexandru Gaman, Merisa Cenanovic, Nikolay T. Tzvetkov, Surya Kant Tripathi, Kiran R. Kharat, Alfonso T. Garcia-Sosa, Simon Sieber, Atanas G. Atanasov
Summary: The study demonstrates that the Twitter campaign centered on #DHPSP was successful in increasing visibility and engaging a large number of users interested in the DHPSP initiative, leading to new scientific collaborations.
CURRENT RESEARCH IN BIOTECHNOLOGY
(2021)