Aryl hydrocarbon receptor agonist indigo protects against obesity-related insulin resistance through modulation of intestinal and metabolic tissue immunity

Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health

(2018) Jun Zou et al.   Cell Host & Microbe

Efficacy of Indigo Naturalis in a Multicenter Randomized Controlled Trial of Patients With Ulcerative Colitis

(2018) Makoto Naganuma et al.   GASTROENTEROLOGY

Aryl hydrocarbon receptor and intestinal immunity

(2018) Bruno Lamas et al.   Mucosal Immunology

Apoptotic cell–induced AhR activity is required for immunological tolerance and suppression of systemic lupus erythematosus in mice and humans

(2018) Rahul Shinde et al.   NATURE IMMUNOLOGY

Hyperglycemia drives intestinal barrier dysfunction and risk for enteric infection

(2018) Christoph A. Thaiss et al.   SCIENCE

Gut Microbiota-Derived Tryptophan Metabolites Modulate Inflammatory Response in Hepatocytes and Macrophages

(2018) Smitha Krishnan et al.   Cell Reports

Impaired Aryl Hydrocarbon Receptor Ligand Production by the Gut Microbiota Is a Key Factor in Metabolic Syndrome

(2018) Jane M. Natividad et al.   Cell Metabolism

Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection

(2018) Sue Tsai et al.   Cell Metabolism

Long term but not short term exposure to obesity related microbiota promotes host insulin resistance

(2018) Kevin P. Foley et al.   Nature Communications

Immunologic impact of the intestine in metabolic disease

(2017) Daniel A. Winer et al.   JOURNAL OF CLINICAL INVESTIGATION

Tryptophan metabolite activation of the aryl hydrocarbon receptor regulates IL-10 receptor expression on intestinal epithelia

(2017) J M Lanis et al.   Mucosal Immunology

The Aryl Hydrocarbon Receptor Preferentially Marks and Promotes Gut Regulatory T Cells

(2017) Jian Ye et al.   Cell Reports

Pathogenic Role of IL-17-Producing Immune Cells in Obesity, and Related Inflammatory Diseases

(2017) Marwa Chehimi et al.   Journal of Clinical Medicine

Obesity-induces Organ and Tissue Specific Tight Junction Restructuring and Barrier Deregulation by Claudin Switching

(2017) Rizwan Ahmad et al.   Scientific Reports

The Intestinal Immune System in Obesity and Insulin Resistance

(2016) Daniel A. Winer et al.   Cell Metabolism

Antimicrobial peptides

(2016) Ling-juan Zhang et al.   CURRENT BIOLOGY

AhR modulates the IL-22-producing cell proliferation/recruitment in imiquimod-induced psoriasis mouse model

(2016) Perrine M. Cochez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Aryl Hydrocarbon Receptor Plays Protective Roles against High Fat Diet (HFD)-induced Hepatic Steatosis and the Subsequent Lipotoxicity via Direct Transcriptional Regulation ofSocs3Gene Expression

(2016) Taira Wada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation

(2016) Shoichiro Kawai et al.   JOURNAL OF GASTROENTEROLOGY

High Fat Diets Induce Colonic Epithelial Cell Stress and Inflammation that is Reversed by IL-22

(2016) Max Gulhane et al.   Scientific Reports

Nucleic Acid-Targeting Pathways Promote Inflammation in Obesity-Related Insulin Resistance

(2016) Xavier S. Revelo et al.   Cell Reports

Expression of the aryl hydrocarbon receptor contributes to the establishment of intestinal microbial community structure in mice

(2016) Iain A. Murray et al.   Scientific Reports

Lack of soluble fiber drives diet-induced adiposity in mice

(2015) Benoit Chassaing et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Jejunal T Cell Inflammation in Human Obesity Correlates with Decreased Enterocyte Insulin Signaling

(2015) Milena Monteiro-Sepulveda et al.   Cell Metabolism

Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents

(2015) Helen Luck et al.   Cell Metabolism

The Gut Microbiota Regulates Intestinal CD4 T Cells Expressing RORγt and Controls Metabolic Disease

(2015) Lucile Garidou et al.   Cell Metabolism

Aryl hydrocarbon receptor deficiency protects mice from diet-induced adiposity and metabolic disorders through increased energy expenditure

(2015) C-X Xu et al.   INTERNATIONAL JOURNAL OF OBESITY

Ginger extract prevents high-fat diet-induced obesity in mice via activation of the peroxisome proliferator-activated receptor δ pathway

(2015) Koichi Misawa et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Anti-Obesity and Anti-Hyperglycemic Effects of Cinnamaldehyde via altered Ghrelin Secretion and Functional impact on Food Intake and Gastric Emptying

(2015) Susana Camacho et al.   Scientific Reports

Activation of the aryl hydrocarbon receptor affects activation and function of human monocyte-derived dendritic cells

(2014) C. Wang et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Perforin Is a Novel Immune Regulator of Obesity-Related Insulin Resistance

(2014) Xavier S. Revelo et al.   DIABETES

Characterization of Distinct Subpopulations of Hepatic Macrophages in HFD/Obese Mice

(2014) Hidetaka Morinaga et al.   DIABETES

Shuttling of information between the mucosal and luminal environment drives intestinal homeostasis

(2014) Claude Asselin et al.   FEBS LETTERS

The Aryl Hydrocarbon Receptor Promotes IL-10 Production by NK Cells

(2014) S. Wagage et al.   JOURNAL OF IMMUNOLOGY

Interleukin-22 alleviates metabolic disorders and restores mucosal immunity in diabetes

(2014) Xiaoting Wang et al.   NATURE

The Origins and Drivers of Insulin Resistance

(2013) Andrew M.F. Johnson et al.   CELL

Wogonin ameliorates hyperglycemia and dyslipidemia via PPARα activation in db/db mice

(2013) Eun-Jung Bak et al.   CLINICAL NUTRITION

Anti-inflammatory cytokines and risk of type 2 diabetes

(2013) C. Herder et al.   DIABETES OBESITY & METABOLISM

Morphological and Inflammatory Changes in Visceral Adipose Tissue During Obesity

(2013) Xavier S. Revelo et al.   ENDOCRINE PATHOLOGY

Tryptophan Catabolites from Microbiota Engage Aryl Hydrocarbon Receptor and Balance Mucosal Reactivity via Interleukin-22

(2013) Teresa Zelante et al.   IMMUNITY

Group 3 Innate Lymphoid Cells Inhibit T-Cell-Mediated Intestinal Inflammation through Aryl Hydrocarbon Receptor Signaling and Regulation of Microflora

(2013) Ju Qiu et al.   IMMUNITY

IL-22 Deficiency Alters Colonic Microbiota To Be Transmissible and Colitogenic

(2013) L. A. Zenewicz et al.   JOURNAL OF IMMUNOLOGY

The role of the immune system in governing host-microbe interactions in the intestine

(2013) Eric M Brown et al.   NATURE IMMUNOLOGY

Beige Adipocytes Are a Distinct Type of Thermogenic Fat Cell in Mouse and Human

(2012) Jun Wu et al.   CELL

Obesity Is Mediated by Differential Aryl Hydrocarbon Receptor Signaling in Mice Fed a Western Diet

(2012) Joanna S. Kerley-Hamilton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

IL-10 Promotes Production of Intestinal Mucus by Suppressing Protein Misfolding and Endoplasmic Reticulum Stress in Goblet Cells

(2012) Sumaira Z. Hasnain et al.   GASTROENTEROLOGY

Gut-derived lipopolysaccharide augments adipose macrophage accumulation but is not essential for impaired glucose or insulin tolerance in mice

(2012) Robert Caesar et al.   GUT

The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance

(2012) Shawn Winer et al.   IMMUNOLOGY AND CELL BIOLOGY

Aryl Hydrocarbon Receptor-Induced Signals Up-regulate IL-22 Production and Inhibit Inflammation in the Gastrointestinal Tract

(2011) Ivan Monteleone et al.   GASTROENTEROLOGY

Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut

(2011) Jörg H. Fritz et al.   NATURE

AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch

(2011) Jacob S Lee et al.   NATURE IMMUNOLOGY

Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22

(2011) Gregory F Sonnenberg et al.   NATURE IMMUNOLOGY

Activation of Aryl Hydrocarbon Receptor (AhR) Leads to Reciprocal Epigenetic Regulation of FoxP3 and IL-17 Expression and Amelioration of Experimental Colitis

(2011) Narendra P. Singh et al.   PLoS One

Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells

(2010) Jean-Marie Ramirez et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27

(2010) Lionel Apetoh et al.   NATURE IMMUNOLOGY

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

Regulatory T Cells Reinforce Intestinal Homeostasis

(2009) Michael J. Barnes et al.   IMMUNITY

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Intestinal, adipose, and liver inflammation in diet-induced obese mice

(2008) Hong Li et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

(2008) Marc Veldhoen et al.   NATURE

Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor

(2008) Francisco J. Quintana et al.   NATURE

Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells

(2008) A. Kimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA