期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 9, 页码 -出版社
MDPI
DOI: 10.3390/ijms20092180
关键词
liver fibrosis; extracellular vesicles; hepatocytes; macrophages
资金
- Baylor Scott & White Institute
- Hickam Endowed Chair, Gastroenterology, Medicine, Indiana University, a VA Research Senior Career Scientist Award
- VA Merit award [5I01BX000574, 1I01BX003031, 1I01BX001724, I01CX000361]
- NIH [DK054811, DK076898, DK107310, DK110035, DK062975, AA025997, DK108959, AA025208, DK107682, AA026917, AA026903, AA025157, AA026385]
- PSC Partners Seeking a Cure
Liver diseases are perpetuated by the orchestration of hepatocytes and other hepatic non-parenchymal cells. These cells communicate and regulate with each other by secreting mediators such as peptides, hormones, and cytokines. Extracellular vesicles (EVs), small particles secreted from cells, contain proteins, DNAs, and RNAs as cargos. EVs have attracted recent research interests since they can communicate information from donor cells to recipient cells thereby regulating physiological events via delivering of specific cargo mediators. Previous studies have demonstrated that liver cells secrete elevated numbers of EVs during diseased conditions, and those EVs are internalized into other liver cells inducing disease-related reactions such as inflammation, angiogenesis, and fibrogenesis. Reactions in recipient cells are caused by proteins and RNAs carried in disease-derived EVs. This review summarizes cell-to-cell communication especially via EVs in the pathogenesis of liver diseases and their potential as a novel therapeutic target.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据