期刊
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
卷 20, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/ijms20082029
关键词
alpha-synuclein; SNCA; major depression; Hamilton Scale of Depression
资金
- Forschungsstiftung Medizin at the University Hospital Erlangen
- Scholarship Program 'Equality for Women in Research and Teaching' at the Friedrich-Alexander-University Erlangen-Nurnberg (FAU)
Alpha-synuclein (SNCA) is a small membrane protein that plays an important role in neuro-psychiatric diseases. It is best known for its abnormal subcellular aggregation in Lewy bodies that serves as a hallmark of Parkinson's disease (PD). Due to the high comorbidity of PD with depression, we investigated the role of SNCA in patients suffering from major depressive disorder (MDD). SNCA mRNA expression levels were analyzed in peripheral blood cells of MDD patients and a healthy control group. SNCA mRNA expression was positively correlated with severity of depression as indicated by psychometric assessment. We found a significant increase in SNCA mRNA expression levels in severely depressed patients compared with controls. Thus, SNCA analysis could be a helpful target in the search for biomarkers of MDD.
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