Article
Chemistry, Multidisciplinary
Rossana Galassi, Lorenzo Luciani, Valentina Gambini, Silvia Vincenzetti, Giulio Lupidi, Augusto Amici, Cristina Marchini, Junbiao Wang, Stefania Pucciarelli
Summary: Phosphane gold(I) compounds were evaluated for screening on breast cancer cell panels, with compounds showing specific environments and components displaying activity. These compounds exhibited strong cytotoxicity, varying enzymatic activities, and binding properties in different cell lines.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Jiri Schulz, Ivana Cisarova, Robert Gyepes, Petr Stepnicka
Summary: In this study, Au-I complexes combining hard oxygen and soft (diphenylphosphanyl)ferrocene (L) ligands were synthesized and structurally characterized. Unique metal complexes were obtained, including a crown-like mixed-valent Au-0/Au-I cluster. N-bridged complexes were also prepared and further studied using DFT calculations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Environmental Sciences
Carlos Martins-Gomes, Tiago E. Coutinho, Tania L. Silva, Tatiana Andreani, Amelia M. Silva
Summary: Pesticides have different effects on organs and tissues, with neurotoxic effects being particularly significant. Glyphosate shows specificity but low inhibitory capacity for AChE, while imidacloprid and lambda-cyhalothrin selectively inhibit AChE. Imazalil acts as a broad-spectrum cholinesterase inhibitor.
Article
Nanoscience & Nanotechnology
Matthew N. Creyer, Zhicheng Jin, Colman Moore, Wonjun Yim, Jiajing Zhou, Jesse Jokerst
Summary: Gold nanorods with tunable optical properties can be used to detect enzyme concentrations and specific inhibitors with low detection limits, making them suitable for detecting diseases such as cancer. The sensing mechanism involves using a dithiol peptide as an enzyme substrate during nanorod growth, with the optical response correlated to enzyme concentration.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Applied
Xue Li, Jingjing Cai, Jinglin Yu, Shuo Wang, Les Copeland, Shujun Wang
Summary: The study found that coffee extract can reduce the rate and extent of starch digestion in vitro, possibly by decreasing the binding affinity of enzymes to the substrate and their catalytic turnover. Fluorescence quenching and UV absorption results confirmed this effect.
Article
Biochemistry & Molecular Biology
Keyvan Pedrood, Maedeh Sherafati, Maryam Mohammadi-Khanaposhtani, Mohammad Sadegh Asgari, Samanesadat Hosseini, Hossein Rastegar, Bagher Larijani, Mohammad Mahdavi, Parham Taslimi, Yavuz Erden, Sevilay Gunay, Ilhami Gulcin
Summary: Novel quinazolinone derivatives were synthesized and evaluated for their inhibitory activities against various metabolic enzymes, showing high inhibitory activities. The most potent compounds against each enzyme were selected to evaluate their interaction modes in the active site, while cytotoxicity assays demonstrated that these compounds do not exhibit significant cytotoxic effects on cancer cell lines.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Nutrition & Dietetics
Chengdeng Chi, Miaomiao Shi, Yingting Zhao, Bilian Chen, Yongjin He, Meiying Wang
Summary: Dietary compounds have a significant impact on starch enzymatic digestion, mainly by limiting starch disruption and enzymatic binding, forming physical barriers, and reducing enzyme activities. This has important implications for regulating postprandial glucose response and preventing or treating type II diabetes.
FRONTIERS IN NUTRITION
(2022)
Article
Food Science & Technology
Daniel Batista, Gabriela de Matuoka e Chiocchetti, Juliana Alves Macedo
Summary: This study aimed to produce high-phenolic-content extracts from red grape pomace and evaluate their antioxidant capacity and ACE inhibitory potential. The results showed that enzymatic extraction increased the extraction yield and ACE inhibitory potential, demonstrating the viability of upcycling grape pomace.
Review
Biochemistry & Molecular Biology
Rossana Galassi, Lorenzo Luciani, Junbiao Wang, Silvia Vincenzetti, Lishan Cui, Augusto Amici, Stefania Pucciarelli, Cristina Marchini
Summary: This article reviews recent scientific findings on two classes of gold compounds containing phosphane or carbene ligands, as well as the recent developments in the application of Auranofin for breast cancers.
Article
Plant Sciences
Kandasamy Saravanakumar, Cengiz Sarikurkcu, Saliha Seyma Sahinler, Rabia Busra Sarikurkcu, Myeong-Hyeon Wang
Summary: Onosma species have a long history of being used as dye and medicinal plants, with differences in flavonoid and phenolic content between O. lycaonica and O. papillosa. Additionally, O. papillosa showed stronger phosphomolybdenum scavenging activity, while O. lycaonica contained potent antioxidant compounds. Further research on Onosma species for novel drug development is warranted.
Article
Plant Sciences
Seria Youssef, Luisa Custodio, Maria Joao Rodrigues, Catarina G. Pereira, Ricardo C. Calhelha, Jozsef Jeko, Zoltan Cziaky, Karim Ben Hamed
Summary: This study evaluated the potential of Limonium spathulatum as a source of natural ingredients for inhibiting enzymes related to human health disorders and food browning. The extracts showed inhibitory activity against several enzymes, with the hydroethanolic extract being the most effective. The study suggests that Limonium spathulatum should be further explored for its bioactive compounds in various industries.
Article
Biochemistry & Molecular Biology
Yan Liu, Fan Zhang, Ling Jiang, J. Jefferson P. Perry, Zhihe Zhao, Jiayu Liao
Summary: This study introduces a novel method to determine kinetics parameters of product inhibition using quantitative FRET(qFRET) assay, providing a convenient way to determine all kinetics parameters and a new approach to combine different measurements with mutually compatible results and errors for the first time.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Soil Science
Sahar Shar, Esmaeil Shahsavari, Frank Reith, Othman A. Alghamdi, Hanna Abbas Yamani, Awatif AlJudaibi, Erica Donner, Sotirios Vasileiadis, Andrew S. Ball
Summary: The study found that amendment of Australian soils with mobile platinum and gold had varying effects on soil respiration and enzyme activities, with platinum significantly reducing soil respiration and both platinum and gold inhibiting enzyme activities in most cases. However, the toxicity levels appeared to be mainly determined by soil properties, with gold being somewhat more toxic to soil microbial communities than platinum.
APPLIED SOIL ECOLOGY
(2021)
Article
Chemistry, Physical
Lidia Madalinska, Piotr Kielbasinski, Malgorzata Kwiatkowska
Summary: The enzyme-catalyzed monoacetylation of prochiral bis (2-hydroxymethylphenyl)methylphosphine and bis (2-hydroxymethylphenyl)phenylphosphine and their P-sulfides led to the formation of corresponding monoacetates in a single step, with moderate yields and high enantiomeric excess. The absolute configurations of the selected products were determined, revealing the enzyme's preference for producing compounds with the same spatial arrangement. These newly obtained compounds have potential applications as chiral catalysts/ligands.
Article
Multidisciplinary Sciences
Tozivepi Aaron Munyayi, Danielle Wingrove Mulder, Engela Helena Conradie, Barend Christiaan Vorster
Summary: Plasmonic colorimetric sensors are powerful analytical tools due to their localized surface plasmon resonance extinction. In this study, NAD(P)/NAD(P)H was used as redox agents in enzymatic plasmonic gold nanostar assays to quantify galactose. The presence of galactose was detected spectrophotometrically and by the naked eye.
ROYAL SOCIETY OPEN SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Rossana Galassi, Lorenzo Luciani, Valentina Gambini, Silvia Vincenzetti, Giulio Lupidi, Augusto Amici, Cristina Marchini, Junbiao Wang, Stefania Pucciarelli
Summary: Phosphane gold(I) compounds were evaluated for screening on breast cancer cell panels, with compounds showing specific environments and components displaying activity. These compounds exhibited strong cytotoxicity, varying enzymatic activities, and binding properties in different cell lines.
FRONTIERS IN CHEMISTRY
(2021)
Review
Nutrition & Dietetics
Silvia Vincenzetti, Giuseppe Santini, Valeria Polzonetti, Stefania Pucciarelli, Yulia Klimanova, Paolo Polidori
Summary: Donkey milk is considered a good alternative for cow milk in feeding children with milk protein allergy due to its close chemical composition to human milk. Donkey milk has unique advantages in terms of vitamin content, including lower fat-soluble vitamins, higher vitamin C, and higher B-complex vitamins compared to human milk. Further interdisciplinary clinical trials are needed to explore the positive health impact of donkey milk in different sensitive populations, especially children and the elderly.
Article
Chemistry, Inorganic & Nuclear
Zhou Lu, Alfredo Burini, Roy N. McDougald, Simone Ricci, Lorenzo Luciani, Vladimir N. Nesterov, Abdel-Monem M. Rawashdeh, Mohammad A. Omary, Rossana Galassi
Summary: The formation of heterobimetallic complexes from cyclic trinuclear complexes (CTCs) of gold(I) is a straightforward strategy that leads to strengthened bonding and improved optoelectronic properties. This study investigates a new gold(I)-vinylimidazolate CTC and its highly emissive sandwich adducts with soft metal cations. The research provides valuable insights for designing and synthesizing metal complexes with unique optoelectronic properties.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Rossana Galassi, Lorenzo Luciani, Claudia Graiff, Gabriele Manca
Summary: Coinage metal cyclic trinuclear compounds (CTCs) are a valuable class of metal coordination compounds for optoelectronic applications. This study investigates the effect of different substituents on the chemistry of Au(I) CTCs with imidazolate ligands. Experimental and computational results provide insights into the addition/oxidation reactions and propose a new interpretation of Au(I)-ligand bonding in the oxidized CTCs.
INORGANIC CHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Rossana Galassi, Lorenzo Luciani, Junbiao Wang, Silvia Vincenzetti, Lishan Cui, Augusto Amici, Stefania Pucciarelli, Cristina Marchini
Summary: This article reviews recent scientific findings on two classes of gold compounds containing phosphane or carbene ligands, as well as the recent developments in the application of Auranofin for breast cancers.
Article
Chemistry, Multidisciplinary
Lorenzo Luciani, Rossana Galassi, Junbiao Wang, Cristina Marchini, Alessia Cogo, Maria Luisa Di Paolo, Lisa Dalla Via
Summary: In the search for alternatives to platinum-based anticancer drugs, 11th group metal phosphane compounds have been considered. These compounds, particularly the tris-arylphosphane metal derivatives, have shown remarkable cytotoxic activities. By modifying the aryl moieties and phosphane ligands, the activity of the compounds can be enhanced. The resulting compounds exhibit intense emissive properties and have demonstrated significant antiproliferative effects on sensitive and cisplatin-resistant tumor cell lines.
FRONTIERS IN CHEMISTRY
(2022)
Article
Agriculture, Dairy & Animal Science
Sara Mangiaterra, Silvia Vincenzetti, Giacomo Rossi, Andrea Marchegiani, Alessandra Gavazza, Thierry Petit, Gianni Sagratini, Massimo Ricciutelli, Matteo Cerquetella
Summary: This study evaluates the fecal proteome in cheetahs with gastrointestinal disorders, aiming to identify potential new biomarkers for diagnosing and monitoring these diseases. The analysis reveals differences in the fecal proteome between healthy and diseased cheetahs, demonstrating the potential of fecal proteomics for understanding the gastrointestinal environment and discovering diagnostic markers.
Article
Chemistry, Applied
Diletta Piatti, Simone Angeloni, Filippo Maggi, Giovanni Caprioli, Massimo Ricciutelli, Lolita Arnoldi, Stefania Bosisio, Giacomo Mombelli, Ettore Drenaggi, Gianni Sagratini
Summary: The polar extracts and essential oils of sea fennel cultivated in central Italy were analyzed. The extracts contained 21 bioactive compounds, with 5-O-caffeoylquinic acid being the most abundant. Melatonin, a hormone that regulates sleep/wake cycle, was identified for the first time in sea fennel extract. The essential oil was mainly composed of monoterpene hydrocarbons and oxygenated monoterpenes. This study highlights the potential use of sea fennel as an edible plant and a source of nutraceutical compounds.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Veterinary Sciences
Matteo Cerquetella, Sara Mangiaterra, Giacomo Rossi, Alessandra Gavazza, Andrea Marchegiani, Gianni Sagratini, Massimo Ricciutelli, Simone Angeloni, Licia Fioretti, Carlotta Marini, Stefania Pucciarelli, Silvia Vincenzetti
Summary: This study used proteomic approach to investigate changes in the digestive environment of dogs suffering from acute uncomplicated diarrhea at different time points. Four groups of proteins showed significant differences, indicating a reaction of the organism to the disease. Further studies are needed for confirmation.
VETERINARY SCIENCES
(2023)
Article
Food Science & Technology
Maria Alessia Schouten, Agnese Santanatoglia, Simone Angeloni, Massimo Ricciutelli, Laura Acquaticci, Giovanni Caprioli, Sauro Vittori, Santina Romani
Summary: This study examined the impact of adding various ingredients to biscuits on the concentration of acrylamide (AA). The results showed that certain ingredients increased the AA levels in both sweet and savory biscuits, highlighting the need for further research in reducing AA content in bakery products.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Chemistry, Applied
Agnese Santanatoglia, Simone Angeloni, Marco Fiorito, Lauro Fioretti, Massimo Ricciutelli, Gianni Sagratini, Sauro Vittori, Giovanni Caprioli
Summary: Acidity is an important parameter in coffee, and this study proposes two analytical methods to quantify the content of organic acids, caffeine, and chlorogenic acids in coffee. The new methods show satisfactory recovery levels, good resolution, and excellent repeatability, sensitivity, and linearity. The study also investigates the effects of roasting on the content of organic and chlorogenic acids in coffee.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2024)