Article
Marine & Freshwater Biology
Tianyu Wang, Shanshan Wu, Jianjie Chen, Lijuan Li, Jinling Cao
Summary: This study investigated the alleviating effects of sesamin on thyroid endocrine disruption caused by fluoride in zebrafish. Sesamin significantly improved growth performance and reduced mortality rate in adults, while also improving hatching rate and body length and alleviating spinal curvature and cyst formation in embryos and larvae. It also alleviated damage to thyroid tissues, reduced oxidative stress, improved thyroid hormone imbalance, and reversed the expression of endocrine-related genes.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Steve U. Ayobahan, Julia Alvincz, Hannes Reinwald, Jannis Strompen, Gabriela Salinas, Christoph Schaefers, Elke Eilebrecht, Sebastian Eilebrecht
Summary: Endocrine disruptors (EDs) have long-lasting negative effects on reproduction in humans and the environment, making them unsuitable for approval for marketing. However, regulatory testing for endocrine disruption is time-consuming, expensive, and requires animal testing. This study combines sublethal zebrafish embryo assays with transcriptomics and proteomics to identify predictive biomarkers for sexual endocrine disruption. Evaluation of these biomarkers in zebrafish embryo-based bioassays can help identify endocrine disrupting hazards and reduce animal testing.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Chao Xu, Honghong Gong, Lili Niu, Tianyang Li, Hangqin Guo, Chenjian Hu, Xiaohui Sun, Ling Li, Weiping Liu
Summary: In this study, the maternal transfer risk of uranium in zebrafish was evaluated. The results showed that uranium could transfer from the maternal fish to their offspring, leading to adverse effects on thyroid function, oxidative stress, and embryonic development.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Tianyu Zhao, Kai Triebner, Iana Markevych, Marie Standl, Hicran Altug, Kees de Hoogh, Tamara Schikowski, Dietrich Berdel, Sibylle Koletzko, Carl-Peter Bauer, Andrea von Berg, Dennis Nowak, Joachim Heinrich
Summary: The study found no significant associations between long-term exposure to air pollutants and pubertal development based on sex hormone concentrations among 10-year-old children. More longitudinal studies are needed to further assess this association due to the limited number of current studies on this topic.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Ecology
Sujin Lee, Kyunghee Ji
Summary: This study investigated the effects of the isothiazolinone preservative DCOIT on the embryonic growth and thyroid endocrine system in zebrafish. Exposure to DCOIT led to significant coagulation and delayed hatching in fish embryos, as well as decreased larval length. Lower levels of thyroid hormones triiodothyronine (T3) and thyroxine (T4) were observed, accompanied by changes in gene expression and microRNA levels related to the thyroid axis. The findings suggest that DCOIT-induced hypothyroidism may be associated with genetic and microRNA-level changes affecting development.
Article
Marine & Freshwater Biology
Rujian He, Dong Guo, Chun Lin, Wei-guang Zhang, Jun Fan
Summary: This study investigated the enantioselective toxicity, bioaccumulation, oxidative stress, and thyroid disruption of chiral metconazole pesticides using zebrafish as a model organism. The results showed that (1R, 5S)-metconazole exhibited stronger thyroid disruption ability and preferential bioaccumulation in zebrafish compared to (1S, 5R)-metconazole. Furthermore, molecular docking analysis supported the stronger interactions between (1R, 5S)-metconazole and thyroid hormone receptors. This study provides valuable information for the risk assessment of chiral pesticides on aquatic organisms.
AQUATIC TOXICOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Suhyun Park, Hyojin Kim, Kyunghee Ji
Summary: Exposure to PHMG-H resulted in increased T3 levels with downregulation of tsh beta gene, suggesting a feedback mechanism for the regulation of T3. Additionally, a decrease in T4 concentration, an increase in T3/T4 ratio, and upregulation of the deio2 gene indicated an increase in active T3 due to outer ring deiodination. Further research is needed to understand the differences in toxicity between the two counter ions of PHMG.
APPLIED SCIENCES-BASEL
(2021)
Article
Food Science & Technology
Chenyan Hu, Yachen Bai, Jing Li, Baili Sun, Lianguo Chen
Summary: Methylparaben (MeP), commonly used in daily products as a preservative, has become a concerning aquatic pollutant. This study exposed adult zebrafish to different concentrations of MeP to investigate its reproductive toxicity. The results showed that MeP exposure affected gonad development, disrupted hormone balance, and led to developmental deficits in offspring. This study provides insight into the antiestrogenic activity and reproductive toxicity of MeP.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Weirong Si, Mengjie Zhao, Huimin Che, Zaiwei Wu, Yuchun Xiao, Xinxin Xie, Jiayao Duan, Tong Shen, Dexiang Xu, Sujuan Zhao
Summary: This study investigates the intergenerational inheritance of MC-LR-induced thyroid toxicity in zebrafish and rat thyroid cells. Maternal exposure to MC-LR disrupts the hypothalamic-pituitary-thyroid axis and decreases thyroid hormone production in F0 generation. It also interferes with thyroid hormone homeostasis and development in the F1 offspring.
ENVIRONMENTAL POLLUTION
(2023)
Article
Ecology
Yujin Ka, Kyunghee Ji
Summary: This study evaluated the effects of avobenzone and octinoxate on the thyroid endocrine system in zebrafish. The results indicate that these chemicals can disrupt thyroid hormone receptor and the feedback mechanisms of the HPT axis.
Article
Environmental Sciences
Ming Jia, Miaomiao Teng, Sinuo Tian, Jin Yan, Zhiyuan Meng, Sen Yan, Ruisheng Li, Zhiqiang Zhou, Wentao Zhu
Summary: The study found that long-term low-dose exposure to PEN did not significantly affect the growth and spawning of zebrafish, but led to significant changes in important hormones and related gene expressions in zebrafish.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xuan Liu, Xianyi Xie, Hongling Liu
Summary: Exposure to environmental estrogen during the critical gonadal differentiation period not only affects the development of zebrafish, but also influences the population development, leading to a biased sex ratio in the fish population.
Article
Environmental Sciences
Chao Xu, Tianyang Li, Chenjian Hu, Hangqin Guo, Jing Ye, Ling Li, Weiping Liu, Lili Niu
Summary: The study found that uranium can bioaccumulate in zebrafish larvae, resulting in significant developmental toxicities and changes in locomotor activities. Uranium exposure also affects thyroid hormone levels and related gene expression, highlighting the potential toxicities and thyroid disruption of uranium on zebrafish.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Meifang Wu, Naying Zheng, Xiaoxiao Zhan, Jianzhang He, Min Xiao, Zhenghong Zuo, Chengyong He
Summary: This study demonstrates that Icariin may cause developmental toxicity by disrupting thyroid development and hormone synthesis, highlighting the importance of risk assessments in clinical practice.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Environmental Sciences
Yi-Feng Li, Joana Rodrigues, Marco A. Campinho
Summary: This study investigated the effects of chronic exposure to ioxynil and diethylstilbestrol on the physiology of the heart and thyroid follicles in juvenile zebrafish. The results showed that both chemicals caused changes in the morphology of the heart and thyroid, indicating their endocrine disruptive effects. The observed cardiac effects of ioxynil and diethylstilbestrol are likely the cause of altered thyroid status in these fish.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Review
Biotechnology & Applied Microbiology
Sergio Jarque, Michal Bittner, Ludek Blaha, Klara Hilscherova
TRENDS IN BIOTECHNOLOGY
(2016)
Article
Engineering, Environmental
Carolina Di Paolo, Richard Ottermanns, Steffen Keiter, Selim Ait-Aissa, Kerstin Bluhm, Werner Brack, Magnus Breitholtz, Sebastian Buchinger, Mario Carere, Carole Chalon, Xavier Cousin, Valeria Dulio, Beate I. Escher, Timo Hamers, Klara Hilscherova, Sergio Jarque, Adam Jonas, Emmanuelle Maillot-Marechal, Yves Marneffe, Mai Thao Nguyen, Pascal Pandard, Andrea Schifferli, Tobias Schulze, Sven Seidensticker, Thomas-Benjamin Seiler, Janet Tang, Ron van der Oost, Etienne Vermeirssen, Radka Zounkova, Nick Zwart, Henner Hollert
Article
Microbiology
Sergio Jarque, Petr Masner, Jana Klanova, Roman Prokes, Ludek Blaha
FRONTIERS IN MICROBIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Ross F. Waller, Phillip A. Cleves, Maria Rubio-Brotons, April Woods, Sara J. Bender, Virginia Edgcomb, Eric R. Gann, Adam C. Jones, Leonid Teytelman, Peter von Dassow, Steven W. Wilhelm, Jackie L. Collier
Review
Chemistry, Analytical
Chimi Wangmo, Sergio Jarque, Klara Hilscherova, Ludek Blaha, Michal Bittner
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2018)
Article
Multidisciplinary Sciences
Sergio Jarque, Eva Fetter, Wouter J. Veneman, Herman P. Spaink, Ravindra Peravali, Uwe Straehle, Stefan Scholz
Article
Toxicology
Sylvia Dyballa, Rafael Minana, Maria Rubio-Brotons, Carles Cornet, Tiziana Pederzani, Georgia Escaramis, Ricard Garcia-Serna, Jordi Mestres, Javier Terriente
TOXICOLOGICAL SCIENCES
(2019)
Article
Cell Biology
Anna Klingseisen, Ana-Maria Ristoiu, Linde Kegel, Diane L. Sherman, Maria Rubio-Brotons, Rafael G. Almeida, Sigrid Koudelka, Silvia K. Benito-Kwiecinski, Richard J. Poole, Peter J. Brophy, David A. Lyons
DEVELOPMENTAL CELL
(2019)
Article
Cell Biology
Katy L. H. Marshall-Phelps, Linde Kegel, Marion Baraban, Torben Ruhwedel, Rafael G. Almeida, Maria Rubio-Brotons, Anna Klingseisen, Silvia K. Benito-Kwiecinski, Jason J. Early, Jenea M. Bin, Daumante Suminaite, Matthew R. Livesey, Wiebke Moebius, Richard J. Poole, David A. Lyons
JOURNAL OF CELL BIOLOGY
(2020)
Article
Reproductive Biology
Sergio Jarque, Maria Rubio-Brotons, Jone Ibarra, Victor Ordonez, Sylvia Dyballa, Rafael Minana, Javier Terriente
REPRODUCTIVE TOXICOLOGY
(2020)
Meeting Abstract
Toxicology
C. C. Bartolome, S. Jarque, M. Rubio-Brotons, J. Ibarra, V. Ordonez, S. Dyballa, R. Minana, V. Di Donato, J. Terriente
TOXICOLOGY LETTERS
(2022)
Meeting Abstract
Toxicology
R. Minana-Prieto, S. Jarque, M. Rubio-Brotons, J. Ibarra, V. Ordonez, S. Dyballa, J. Terriente
TOXICOLOGY LETTERS
(2021)