期刊
INORGANIC CHEMISTRY COMMUNICATIONS
卷 102, 期 -, 页码 95-103出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.inoche.2019.02.011
关键词
Supramolecular Pt(II) complexes; Anticancer effect of Pt(II) complexes; E. coli growth retardation; DNA interaction
资金
- Ministry of Science and Technology of the People's Republic of China [2013CB834501]
- Science and Technology Commission of Shanghai Municipality [13NM1400200]
- National Natural Science Foundation of China [21102017]
- China postdoctoral association
Two new monofunctional mono-metallic trans-Pt(II)(salicylaldimine)(pyridine)center dot BF4 (C1) and supramolecular dimetallic trans-(Pt(II)(salicylaldimine))(2)(4,4-bipyridine)center dot 2BF(4) (C2) complexes were designed and synthesized through ancillary chloride ligand exchange strategy and structurally characterized by spectroscopic, spectrophotometric and single crystal X-ray analyses. The solid-state structure analyses revealed interactions between the coordination planes, inter-molecular H-bonding, bonding in the ligand hydrogen and BF4 anions and supramolecular interactions with solvent molecules in crystal packing. The in vitro anticancer effect of these complexes was investigated in breast (MCF-7) and liver (HepG2) cancer cells. Both these complexes showed significant anticancer effect comparable to cisplatin. Similarly, the effect of these complexes on Escherichia coli (E. coli) growth retardation was also analyzed and the results revealed stronger growth retardation effect and elongated morphology of bacterial cells in similar fashion as observed for cisplatin. The DNA interaction of C1 and C2 was investigated by gel electrophoresis using pET28 as target DNA. These complexes retarded migration of DNA across the gel showing their interaction with DNA.
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