G‐protein coupled receptors and ligands that organize humoral immune responses

S-Geranylgeranyl-l-glutathione is a ligand for human B cell-confinement receptor P2RY8

(2019) Erick Lu et al.   NATURE

Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3

(2018) Philip M. Murphy et al.   CYTOKINE

CXCR4-CXCL12 interaction is important for plasma cell homing and survival in NZB/W mice

(2018) Qingyu Cheng et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate

(2018) Wataru Ise et al.   IMMUNITY

Single-Cell RNA Sequencing of Lymph Node Stromal Cells Reveals Niche-Associated Heterogeneity

(2018) Lauren B. Rodda et al.   IMMUNITY

Atypical chemokine receptor 4 shapes activated B cell fate

(2018) Ervin E. Kara et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neutrophils recruited through high endothelial venules of the lymph nodes via PNAd intercept disseminatingStaphylococcus aureus

(2018) Ania Bogoslowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of a new subset of lymph node stromal cells involved in regulating plasma cell homeostasis

(2018) Hsin-Ying Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-microbial Functions of Group 3 Innate Lymphoid Cells in Gut-Associated Lymphoid Tissues Are Regulated by G-Protein-Coupled Receptor 183

(2018) Coco Chu et al.   Cell Reports

Gαi Signaling Promotes Marginal Zone B Cell Development by Enabling Transitional B Cell ADAM10 Expression

(2018) Il-Young Hwang et al.   Frontiers in Immunology

High-Speed Single-Molecule Tracking of CXCL13 in the B-Follicle

(2018) Helen Miller et al.   Frontiers in Immunology

The Chemokine Receptor CCR8 Promotes the Migration of Dendritic Cells into the Lymph Node Parenchyma to Initiate the Allergic Immune Response

(2018) Caroline L. Sokol et al.   IMMUNITY

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

(2018) Imogen Moran et al.   Nature Communications

B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

(2018) Sheng Hong et al.   IMMUNITY

The establishment of resident memory B cells in the lung requires local antigen encounter

(2018) S. Rameeza Allie et al.   NATURE IMMUNOLOGY

Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses

(2017) David Druzd et al.   IMMUNITY

CCR6 Defines Memory B Cell Precursors in Mouse and Human Germinal Centers, Revealing Light-Zone Location and Predominant Low Antigen Affinity

(2017) Dan Suan et al.   IMMUNITY

CCL28-Deficient Mice Have Reduced IgA Antibody–Secreting Cells and an Altered Microbiota in the Colon

(2017) Kazuhiko Matsuo et al.   JOURNAL OF IMMUNOLOGY

Vγ4 γδ T Cells Provide an Early Source of IL-17A and Accelerate Skin Graft Rejection

(2017) Yashu Li et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Essential role of immobilized chemokine CXCL12 in the regulation of the humoral immune response

(2017) Aleksandr Barinov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ephrin B1–mediated repulsion and signaling control germinal center T cell territoriality and function

(2017) Peiwen Lu et al.   SCIENCE

Bioluminescence imaging of G protein-coupled receptor activation in living mice

(2017) Mari Kono et al.   Nature Communications

Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center

(2017) Hu Yan et al.   Cell Reports

c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses

(2017) Dana Piovesan et al.   Cell Reports

Solution structure of CXCL13 and heparan sulfate binding show that GAG binding site and cellular signalling rely on distinct domains

(2017) Yoan R. Monneau et al.   Open Biology

Chemokines and Chemokine Receptors in Lymphoid Tissue Dynamics

(2016) Olga Schulz et al.   Annual Review of Immunology

G Protein–Coupled Receptor Heteromers

(2016) Ivone Gomes et al.   Annual Review of Pharmacology and Toxicology

Adrenergic control of the adaptive immune response by diurnal lymphocyte recirculation through lymph nodes

(2016) Kazuhiro Suzuki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD26/dipeptidylpeptidase IV-chemokine interactions: double-edged regulation of inflammation and tumor biology

(2016) Anneleen Mortier et al.   JOURNAL OF LEUKOCYTE BIOLOGY

EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells

(2016) Jianhua Li et al.   NATURE

Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response

(2016) Victoria Fang et al.   NATURE IMMUNOLOGY

IgA production requires B cell interaction with subepithelial dendritic cells in Peyers patches

(2016) A. Reboldi et al.   SCIENCE

Heparan sulfate differentially controls CXCL12 - and CXCL12 -mediated cell migration through differential presentation to their receptor CXCR4

(2016) B. J. Connell et al.   Science Signaling

Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity

(2016) Samuele Calabro et al.   Cell Reports

Migratory and adhesive cues controlling innate-like lymphocyte surveillance of the pathogen-exposed surface of the lymph node

(2016) Yang Zhang et al.   eLife

Heparan sulfate differentially controls CXCL12 - and CXCL12 -mediated cell migration through differential presentation to their receptor CXCR4

(2016) B. J. Connell et al.   Science Signaling

Selectins: initiators of leucocyte adhesion and signalling at the vascular wall

(2015) Rodger P. McEver   CARDIOVASCULAR RESEARCH

Navigating in tissue mazes: chemoattractant interpretation in complex environments

(2015) Milka Sarris et al.   CURRENT OPINION IN CELL BIOLOGY

T Follicular Helper Cells Have Distinct Modes of Migration and Molecular Signatures in Naive and Memory Immune Responses

(2015) Dan Suan et al.   IMMUNITY

The G protein–coupled receptor P2RY8 and follicular dendritic cells promote germinal center confinement of B cells, whereas S1PR3 can contribute to their dissemination

(2015) Jagan R. Muppidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

c-Myb is required for plasma cell migration to bone marrow after immunization or infection

(2015) Kim L. Good-Jacobson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Phenotypic and Morphological Properties of Germinal Center Dark ZoneCxcl12-Expressing Reticular Cells

(2015) Lauren B. Rodda et al.   JOURNAL OF IMMUNOLOGY

A Reassessment of IgM Memory Subsets in Humans

(2015) Davide Bagnara et al.   JOURNAL OF IMMUNOLOGY

A perisinusoidal niche for extramedullary haematopoiesis in the spleen

(2015) Christopher N. Inra et al.   NATURE

Integrated molecular analysis of adult T cell leukemia/lymphoma

(2015) Keisuke Kataoka et al.   NATURE GENETICS

A map of the distribution of sphingosine 1-phosphate in the spleen

(2015) Willy D Ramos-Perez et al.   NATURE IMMUNOLOGY

Transcriptional profiling of mouse B cell terminal differentiation defines a signature for antibody-secreting plasma cells

(2015) Wei Shi et al.   NATURE IMMUNOLOGY

Exit Strategies: S1P Signaling and T Cell Migration

(2015) Audrey Baeyens et al.   TRENDS IN IMMUNOLOGY

Phenotypic Tfh development promoted by CXCR5-controlled re-localization and IL-6 from radiation-resistant cells

(2015) Xin Chen et al.   Protein & Cell

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

(2014) Jason W. Griffith et al.   Annual Review of Immunology

Sphingosine-1-phosphate receptor 1 reporter mice reveal receptor activation sites in vivo

(2014) Mari Kono et al.   JOURNAL OF CLINICAL INVESTIGATION

Gain-of-functionCCR4mutations in adult T cell leukemia/lymphoma

(2014) Masao Nakagawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Control of lymphocyte egress from lymph nodes through β2-adrenergic receptors

(2014) Akiko Nakai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CXCR4 and a cell-extrinsic mechanism control immature B lymphocyte egress from bone marrow

(2014) Thomas C. Beck et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Sphingosine 1-Phosphate Regulates the Egress of IgA Plasmablasts from Peyer's Patches for Intestinal IgA Responses

(2014) M. Gohda et al.   JOURNAL OF IMMUNOLOGY

Autotaxin Produced by Stromal Cells Promotes LFA-1–Independent and Rho-Dependent Interstitial T Cell Motility in the Lymph Node Paracortex

(2014) Tomoya Katakai et al.   JOURNAL OF IMMUNOLOGY

Loss of signalling via Gα13 in germinal centre B-cell-derived lymphoma

(2014) Jagan R. Muppidi et al.   NATURE

The atypical chemokine receptor CCRL1 shapes functional CCL21 gradients in lymph nodes

(2014) Maria H Ulvmar et al.   NATURE IMMUNOLOGY

Generation of colonic IgA-secreting cells in the caecal patch

(2014) Kazunori Masahata et al.   Nature Communications

CXCR7 influences the migration of B cells during maturation

(2013) Marie-Luise Humpert et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

(2013) Oliver Bannard et al.   IMMUNITY

CXCR4 promotes B cell egress from Peyer’s patches

(2013) Timothy H. Schmidt et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive Lymphocyte Transmigration across the Basal Lamina of High Endothelial Venules Is Regulated by the Autotaxin/Lysophosphatidic Acid Axis

(2013) Z. Bai et al.   JOURNAL OF IMMUNOLOGY

The chemotactic receptor EBI2 regulates the homeostasis, localization and immunological function of splenic dendritic cells

(2013) Dominique Gatto et al.   NATURE IMMUNOLOGY

Interstitial Dendritic Cell Guidance by Haptotactic Chemokine Gradients

(2013) M. Weber et al.   SCIENCE

EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture

(2013) Tangsheng Yi et al.   eLife

Germinal Centers

(2012) Gabriel D. Victora et al.   Annual Review of Immunology

A Spatially-Organized Multicellular Innate Immune Response in Lymph Nodes Limits Systemic Pathogen Spread

(2012) Wolfgang Kastenmüller et al.   CELL

Oxysterol Gradient Generation by Lymphoid Stromal Cells Guides Activated B Cell Movement during Humoral Responses

(2012) Tangsheng Yi et al.   IMMUNITY

CXCR3 Chemokine Receptor-Ligand Interactions in the Lymph Node Optimize CD4+ T Helper 1 Cell Differentiation

(2012) Joanna R. Groom et al.   IMMUNITY

S1PR2 links germinal center confinement and growth regulation

(2012) Jesse A. Green et al.   IMMUNOLOGICAL REVIEWS

A germinal center–independent pathway generates unswitched memory B cells early in the primary response

(2012) Justin J. Taylor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Visualization of splenic marginal zone B-cell shuttling and follicular B-cell egress

(2012) Tal I. Arnon et al.   NATURE

TGFα shedding assay: an accurate and versatile method for detecting GPCR activation

(2012) Asuka Inoue et al.   NATURE METHODS

Subcapsular Sinus Macrophage Fragmentation and CD169+ Bleb Acquisition by Closely Associated IL-17-Committed Innate-Like Lymphocytes

(2012) Elizabeth E. Gray et al.   PLoS One

Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection

(2012) T. Onodera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCR3 promotes the production of IgG1 autoantibodies but is not essential for the development of lupus nephritis in NZB/NZW mice

(2011) Katrin Moser et al.   ARTHRITIS AND RHEUMATISM

The CXCR7 chemokine receptor promotes B-cell retention in the splenic marginal zone and serves as a sink for CXCL12

(2011) H. Wang et al.   BLOOD

Lymph node B lymphocyte trafficking is constrained by anatomy and highly dependent upon chemoattractant desensitization

(2011) C. Park et al.   BLOOD

Decoding the Signaling of a GPCR Heteromeric Complex Reveals a Unifying Mechanism of Action of Antipsychotic Drugs

(2011) Miguel Fribourg et al.   CELL

Integrin inside-out signaling and the immunological synapse

(2011) Timothy A Springer et al.   CURRENT OPINION IN CELL BIOLOGY

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

(2011) Steven M. Kerfoot et al.   IMMUNITY

Bcl6 Protein Expression Shapes Pre-Germinal Center B Cell Dynamics and Follicular Helper T Cell Heterogeneity

(2011) Masahiro Kitano et al.   IMMUNITY

Cannabinoid receptor 2 positions and retains marginal zone B cells within the splenic marginal zone

(2011) Jagan R. Muppidi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EBI2 Operates Independently of but in Cooperation with CXCR5 and CCR7 To Direct B Cell Migration and Organization in Follicles and the Germinal Center

(2011) D. Gatto et al.   JOURNAL OF IMMUNOLOGY

EBI2 Guides Serial Movements of Activated B Cells and Ligand Activity Is Detectable in Lymphoid and Nonlymphoid Tissues

(2011) L. M. Kelly et al.   JOURNAL OF IMMUNOLOGY

The sphingosine 1-phosphate receptor S1P2 maintains the homeostasis of germinal center B cells and promotes niche confinement

(2011) Jesse A Green et al.   NATURE IMMUNOLOGY

Long-lived autoreactive plasma cells drive persistent autoimmune inflammation

(2011) Falk Hiepe et al.   Nature Reviews Rheumatology

Critical roles of chemokine receptor CCR10 in regulating memory IgA responses in intestines

(2011) S. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GRK2-Dependent S1PR1 Desensitization Is Required for Lymphocytes to Overcome Their Attraction to Blood

(2011) T. I. Arnon et al.   SCIENCE

Th17 and Regulatory T Cells in Mediating and Restraining Inflammation

(2010) Dan R. Littman et al.   CELL

Development and Migration of Plasma Cells in the Mouse Lymph Node

(2010) David R. Fooksman et al.   IMMUNITY

CD69 Suppresses Sphingosine 1-Phosophate Receptor-1 (S1P1) Function through Interaction with Membrane Helix 4

(2010) Alexander J. Bankovich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

S1P1 receptor directs the release of immature B cells from bone marrow into blood

(2010) Maria L. Allende et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B cell follicles and antigen encounters of the third kind

(2010) Jason G Cyster   NATURE IMMUNOLOGY

A Role for S1P and S1P1 in Immature-B Cell Egress from Mouse Bone Marrow

(2010) João Pedro Pereira et al.   PLoS One

Lymph node cortical sinus organization and relationship to lymphocyte egress dynamics and antigen exposure

(2010) I. L. Grigorova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preferential localization of IgG memory B cells adjacent to contracted germinal centers

(2010) Y. Aiba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The microanatomy of B cell activation

(2009) Tri Giang Phan et al.   CURRENT OPINION IN IMMUNOLOGY

B Lymphocytes Exit Lymph Nodes through Cortical Lymphatic Sinusoids by a Mechanism Independent of Sphingosine-1-Phosphate-Mediated Chemotaxis

(2009) Rajesh K. Sinha et al.   IMMUNITY

Initial Clonal Expansion of Germinal Center B Cells Takes Place at the Perimeter of Follicles

(2009) Francis Coffey et al.   IMMUNITY

Guidance of B Cells by the Orphan G Protein-Coupled Receptor EBI2 Shapes Humoral Immune Responses

(2009) Dominique Gatto et al.   IMMUNITY

Germinal center reutilization by newly activated B cells

(2009) Tanja A. Schwickert et al.   JOURNAL OF EXPERIMENTAL MEDICINE

EBI2 mediates B cell segregation between the outer and centre follicle

(2009) João P. Pereira et al.   NATURE

Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation

(2009) Serge A van de Pavert et al.   NATURE IMMUNOLOGY

Dynamics of Neutrophil Migration in Lymph Nodes during Infection

(2008) Tatyana Chtanova et al.   IMMUNITY

Cortical sinus probing, S1P1-dependent entry and flow-based capture of egressing T cells

(2008) Irina L Grigorova et al.   NATURE IMMUNOLOGY

Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs

(2008) Hidenobu Kanda et al.   NATURE IMMUNOLOGY

Follicular dendritic cell networks of primary follicles and germinal centers: Phenotype and function

(2008) Christopher D.C. Allen et al.   SEMINARS IN IMMUNOLOGY